| 中國醫藥大學 |
2012-07-31 |
開發脂氧脢抑制劑於治療腦中風與巴金森氏症之應用
|
劉宏輝;侯曼貞(Hour, Mann-Jen) |
| 中國醫藥大學 |
2012-05 |
Novel Quinazolinone MJ-29 Triggers Endoplasmic Reticulum Stress and Intrinsic Apoptosis in Murine Leukemia WEHI-3 Cells and Inhibits Leukemic Mice
|
呂?誠(Lu CC);楊家欣(Yang, Jai-Sing);江若華(Chiang JH);侯曼貞(Hour, Mann-Jen);(Kuei-Li Lin); 林楨智(Jen-Jyn Lin);黃雯雯(Wenwen Huang); (Minoru Tsuzuki);李宗翰(Tsung-Han Lee)*;鍾景光(Jing-Gung Chung)* |
| 中國醫藥大學 |
2012-03-18 |
BHE Induces p53-dependent Trans-activation and Fas/CD95-dependent Apoptosis Pathway in HCT 116 human Colorectal Cancer Cells
|
張庭嘉(Ting-Chia Chang)*;邱宇任(Yu-Jen Chiu);賴光啟(Kuang-Chi Lai);林奎利(Kuei-Li Lin);彭淑芬(Shu-Fen Peng);侯曼貞(Hour Mann-Jen);李昭瑩(Lee Chao-Ying);金益安(Yih-An King);鍾景光(Jing-Gung Chung);黃雯雯(Wenwen Huang);楊家欣(Yang Jai-Sing) |
| 中國醫藥大學 |
2012-02 |
Development of a fast LC-MS/MS assay for the determination of deferiprone in human plasma and application to pharmacokinetics
|
宋達樞;謝右文(Yow-Wen Hsieh);彭慶添(Ching-Tien Peng);(Cheng-Hsiung Liu);(Tai-Lin Chen);侯曼貞(Hour Mann-Jen)* |
| 中國醫藥大學 |
2011-07-31 |
合成2,4,6,7-substituted quinazoline derivatives做為第一型類胰島素生長因子受體抑制劑
|
侯曼貞(Hour Mann-Jen); 楊家欣(Yang Jai-Sing) |
| 中國醫藥大學 |
2011-07-31 |
新穎抗癌藥物HMJ-30對U-2 OS骨癌細胞株抑制上皮-間質細胞轉換過程與轉移，經由抑制第一型類胰島素生長因子受體之訊息傳遞
|
楊家欣(Yang, Jai-Sing);鍾景光(Jing-Gung Chung);侯曼貞(Hour, Mann-Jen) |
| 中國醫藥大學 |
2011-06 |
The novel synthesized 6-fluoro-(3-fluorophenyl)-4-(3-methoxyanilino)quinazoline (LJJ-10) compound exhibits anti-metastatic effects in human osteosarcoma U-2 OS cells through targeting insulin-like growth factor-I receptor
|
陳冠廷(KUAN-TIN CHEN); 侯曼貞(Hour Mann-Jen); 蔡士彰(Shih-Chang Tsai); 鍾景光(Jing-Gung Chung); 郭盛助(Sheng-Chu Kuo); 呂啟誠(CHI-CHENG LU); 邱宇任(YU-JEN CHIU); 莊貽(YI-HSUAN CHUANG); 楊家欣(Yang Jai-Sing)* |
| 中國醫藥大學 |
2011-03-31 |
以材料工程暨天然物萃取技術開發血管塗支架，子計畫2：利用電腦輔助藥物設計系統開發塗藥支架
|
侯曼貞(Hour Mann-Jen) |
| 中國醫藥大學 |
2011-03 |
The synthesized novel fluorinated compound (LJJ-10) induces death receptor- and mitochondriadependent apoptotic cell death in the human osteogenic sarcoma U-2 OS cells
|
侯曼貞(Hour Mann-Jen)*; 楊家欣(Yang Jai-Sing); 陳冠霖(Tai-Lin Chen); 陳冠廷(Kuan-Tin Chen); 郭盛助(Sheng-Chu Kuo); 鍾景光(Jing-Gung Chung); 呂啟誠(Chi-Cheng Lu); 陳佳儀(Chia-Yi Chen); 莊貽媗(Yi-Hsuan Chuang) |
| 中國醫藥大學 |
2011-02 |
Novel Quinazoline HMJ-30 Induces U-2 OS Human Osteogenic Sarcoma Cell Apoptosis Through Induction of Oxidative Stress and Up-Regulation of ATM/p53 Signaling Pathway
|
邱宇任(Yu-Jen Chiu); 侯曼貞(Hour Mann-Jen); 呂啟誠(Chi-Cheng Lu); 鍾景光(Jing-Gung Chung); 郭盛助(Sheng-Chu Kuo); 黃雯雯(Wenwen Huang); 陳慧婕(Hui-Jye Chen); Yi-An Jin(金益安); 楊家欣(Yang Jai-Sing)* |
| 中國醫藥大學 |
2011 |
2-(Naphthalene-1-yl)-6-pyrrolidinyl-4-quinazolinone inhibits skin cancer M21 cell proliferation through aberrant expression of microtubule and cell cycle
|
吳永昌; 侯曼貞(Hour Mann-Jen); 梁永昌; 吳吉育; 劉文治; 張育豪; 李鳳琴(Hong-Zin Lee)* |
| 中國醫藥大學 |
2010-09 |
Photodynamic activity of aloe-emodin induces resensitization of lung cancer cells to anoikis
|
李鳳琴(Hong-Zin Lee)*; 楊文惠(Yang, Wen-Hui); 侯曼貞(Hour Mann-Jen); (Chi-Yu Wu); 彭文煌(Wen-Huang Peng); 鮑柏穎(Bo-Ying Bao); (Ping-Hsiu Han); 包大靝(Da-Tian Bau)* |
| 中國醫藥大學 |
2010-07-31 |
利用同位素標記相對絕對定量蛋白質體技術探討HMJ-33衍生物抗血管新生機制
|
楊家欣(Yang Jai-Sing); 鍾景光(Jing-Gung Chung); 侯曼貞(Hour Mann-Jen) |
| 中國醫藥大學 |
2010-05 |
MJ-29 inhibits tubulin polymerization, induces mitotic arrest and triggers apoptosis via CDK1-mediated Bcl-2 phosphorylation in human leukemia U937 cells
|
楊家欣(Yang Jai-Sing); 侯曼貞(Hour Mann-Jen); 黃雯雯(Wenwen Huang); 林奎利; 郭盛助(Sheng-Chu Kuo)*; 鍾景光(Jing-Gung Chung)* |
| 中國醫藥大學 |
2010-05 |
MJ-29 inhibits tubulin polymerization, induces mitotic arrest and triggers apoptosis via CDK1-mediated Bcl-2 phosphorylation in human leukemia U937 cells
|
楊家欣(Yang Jai-Sing); 侯曼貞(Hour Mann-Jen); 黃雯雯(Wenwen Huang); 林奎利; 郭盛助(Sheng-Chu Kuo)*; 鍾景光(Jing-Gung Chung)* |
| 中國醫藥大學 |
2009-07-31 |
利用同位素標記相對絕對定量蛋白質體技術探討6-pyrrolidinyl-4-quinazolinone衍生物對大腸直腸癌細胞之抗轉移、抗血管新生機制及衍生物對小鼠體內抗大腸直腸癌作用之評估
|
楊家欣(Yang Jai-Sing); 鍾景光(Jing-Gung Chung); 侯曼貞(Hour Mann-Jen); 賴光啟(Kuang-Chi Lai); 黃雯雯(Wenwen Huang) |
| 中國醫藥大學 |
2009-03-21 |
CHM-1 Suppresses MMP-2/9 via Inhibit PKB/Akt、NF-kB Signaling Pathways in EGF-induced metastasis of HT-29 Colorectal Cancer Cell cells.
|
李坤宏(Kun-Hong Li); 侯曼貞(Hour Mann-Jen); 郭盛助(Sheng-Chu Kuo); 賴光啟(Kuang-Chi Lai); 張琬若(Wan-Juo Chang); 邱宇任(Yu-Jen Chiu); 吳長霖(Chang-LinWu); 鍾景光(Jing-Gung Chung); 楊家欣(Yang Jai-Sing)* |
| 中國醫藥大學 |
2009-03-21 |
Selective Induction of G2/M Arrest and Apoptosis in U2OS by a Potent Anticancer Agent, Nrf-2.
|
呂啟誠(Chi-Cheng Lu); 李宗翰(Tsung-Han Lee); 江若華(Jo-Hua Chiang); 郭盛助(Sheng-Chu Kuo); 侯曼貞(Hour Mann-Jen); 李坤鴻(Kun-Hong Li); 邱宇任(Yu-Jen Chiu); 鍾景光(Jing-Gung Chung); 楊家欣(Yang Jai-Sing)* |
| 中國醫藥大學 |
2009-01-29 |
MJ-33 Suppresses VEGF Secretion and MMP-2/9 via Inhibit PKB/Akt、NF-kB and ERK Signaling Pathways in EGF-induced metastasis of HT-29 Colorectal Cancer Cells
|
楊家欣(Yang Jai-Sing)*; 侯曼貞(Hour Mann-Jen); 鍾景光(Jing-Gung Chung) |
| 中國醫藥大學 |
2008-11-07 |
The Assessment of supplying sterile syringes with needles to prevent the spread of AIDS by community pharmacists in Taichung County
|
郭啟文(CHI-WEN KUO); 侯曼貞(Hour Mann-Jen) |
| 中國醫藥大學 |
2008-11 |
P38-associated pathway involvement in apoptosis induced by photodynamic therapy with Lonicera japonica in human lung squamous carcinoma CH27 cells.
|
梁永昌(Leung Wing-Cheung); 侯曼貞(Hour Mann-Jen); 張文德(Wen-Te Chang); (Y.-C. Wu); 賴妙英(Miao-Ying Lai); (M.-Y. Wang); 李鳳琴(Hong-Zin Lee)* |
| 中國醫藥大學 |
2008-10-17 |
HMJ-30 Suppresses MMP-2 Expression via Receptor Tyrosine Kinase Inhibition and PKB/Akt、NF-kB、ERK Signaling Pathways in U2OS cells
|
楊家欣(Yang Jai-Sing); 邱宇任; 陳冠廷; 侯曼貞(Hour Mann-Jen); 黃雯雯(Wenwen Huang); 鍾景光(Jing-Gung Chung)* |
| 中國醫藥大學 |
2008-10-17 |
HMJ-38 interacts with microtubule polymerization, induces G2/M arrest and apoptosis in human tongue cancer CAL27 cell line
|
呂啟誠; 楊家欣(Yang Jai-Sing); 郭盛助(Sheng-Chu Kuo); 高銘欽(Ming-Ching Kao); 侯曼貞(Hour Mann-Jen); 鍾景光(Jing-Gung Chung)* |
| 中國醫藥大學 |
2008-08 |
Synthesis of 2,3-Disubstituted 1,4-naphthoquinones as Antiplatelet Agents
|
連金城(Lien Jin Cherng)*; 吳啟瑞(Chi-Rei Wu); 侯曼貞(Hour Mann-Jen); 黃麗嬌(Li-Jiau Huang); (Tur-Fu Huang); 郭盛助(Sheng-Chu Kuo) |
| 中國醫藥大學 |
2008-07-31 |
開發具有潛能之生物活性化合物作為準新藥
|
郭盛助(Sheng-Chu Kuo); 黃麗嬌(Li-Jiau Huang); 連金城; 張誌祥(Chih-Shiang Chang); 林煇章(Hui-Chang Lin); 陳水田; 孫仲銘; 顧記華; 陳香惠; 鍾景光; 莊聲宏(Shin-Hun Juang); 侯曼貞(Hour Mann-Jen); 魏宗德(Tzong-Der Way) |
| 中國醫藥大學 |
2008-07-31 |
2-芳環羥基奎唑林類緣化合物之合成與利用蛋白質體技術分析其抗癌機制
|
侯曼貞(Hour Mann-Jen); 李鳳琴(Hong-Zin Lee) |
| 中國醫藥大學 |
2008-07-28 |
Oral Antithrombotic Profile of P886, a Novel Dual Inhibitor on Platelet and Intrinsic Coagulation Activity
|
連金城(Lien Jin Cherng); 侯曼貞(Hour Mann-Jen) |
| 中國醫藥大學 |
2008-07-28 |
Synthesis of Phenylquinazolinones as Anticancer Agents
|
侯曼貞(Hour Mann-Jen); 郭啟文(CHI-WEN KUO); 楊家欣(Yang Jai-Sing) |
| 中國醫藥大學 |
2008-05-06 |
DNA microarray analysis of gene expression profiles in anti-cancer machanisms of the 6-pyrrolidinyl-2-(2-substituted phenyl)-4-quinazolinones derivative on U937 leukemia cells and study of the anticancer activity in leukemia animal model
|
楊家欣(Yang Jai-Sing); 侯曼貞(Hour Mann-Jen); 郭盛助(Sheng-Chu Kuo); 鍾景光(Jing-Gung Chung); 楊家欣(Yang Jai-Sing) |
| 中國醫藥大學 |
2008-05-06 |
DNA Microarray Analysis of Gene Expression Profiles in Anti-cancer Mechanisms of the 6-pyrrolidinyl-2-(2-substituted phenyl)-4- quinazolinones Derivative on U937 Leukemia Cells and Study of the Anticancer Activity in Leukemia Animal Model
|
楊家欣(Yang Jai-Sing); 侯曼貞(Hour Mann-Jen); 郭盛助(Sheng-Chu Kuo); 鍾景光(Jing-Gung Chung); 楊家欣(Yang Jai-Sing) |
| 中國醫藥大學 |
2008-05-03 |
Synthesis and antiproliferative evaluation of 6-fluoro-4-anilinoquinazoline derivatives
|
陳泰霖; 侯曼貞(Hour Mann-Jen); 連金城(Lien Jin Cherng); 吳宗翰; 林子正; 朱千晟; 施婷徽; 郭盛助(Sheng-Chu Kuo); 楊家欣(Yang Jai-Sing); 黃麗嬌(Li-Jiau Huang) |
| 中國醫藥大學 |
2008-05-03 |
NP-184, a Dual Thromboxane A2 Synthase Inhibitor and Thromboxane A2 Receptor Antagonist
|
連金城(Lien Jin Cherng); 侯曼貞(Hour Mann-Jen); 黃麗嬌(Li-Jiau Huang); 吳宗翰; 陳泰霖; 何佳凌; 郭正偉; 楊君皓; 黃德富; 郭盛助(Sheng-Chu Kuo) |
| 中國醫藥大學 |
2008-05-01 |
HMJ-30 suppresses MMP-2 and MMP-9 expression through PKB, NF-kB and MAPKs signaling pathways in U2OS human osteosarcoma cells
|
邱宇任; 陳冠廷; 侯曼貞(Hour Mann-Jen); 黃雯雯(Wenwen Huang); 吳長霖; 鍾景光(Jing-Gung Chung); 楊家欣(Yang Jai-Sing)* |
| 中國醫藥大學 |
2008-05-01 |
HMJ-53A Accelerates Slow Inactivation Gating of Voltage-Gated K+ Channels in Mouse Neuroblastoma N2A Cells
|
(Chia-Chia Chao); (Jeffrey Shieh); (Sheng-Chu Kuo); (Bor-Tsang Wu); 侯曼貞(Hour Mann-Jen); 梁育民; (Chia-Chia Chao) |
| 中國醫藥大學 |
2008-05-01 |
HMJ-30 Suppresses MMP-2 and MMP-9 Expression through PKB/Akt, NF-kB and MAPKs Signaling Pathways in U2OS Human Osteosarcoma cells
|
邱宇任; 陳冠廷; 侯曼貞(Hour Mann-Jen); 黃雯雯(Wenwen Huang); 吳長霖; 鍾景光(Jing-Gung Chung); 楊家欣(Yang Jai-Sing) |
| 中國醫藥大學 |
2008-04-25 |
Synthesis of 2,3-disubstituted 1,4-naphthoquinones as antiplatelet agents
|
連金城(Lien Jin Cherng); 侯曼貞(Hour Mann-Jen) |
| 中國醫藥大學 |
2008-04-25 |
Development of anilinoquinazoline derivatives as multi-target anticancer agents
|
侯曼貞(Hour Mann-Jen); 陳泰霖; 連金城(Lien Jin Cherng); 吳宗翰; 張淯淵; 林宏儒; 黃麗嬌(Li-Jiau Huang); 郭盛助(Sheng-Chu Kuo) |
| 中國醫藥大學 |
2008-03 |
HMJ-53A accelerates slow inactivation gating of voltage-gated K+ channels in mouse neuroblastoma N2A cells
|
(Chia-Chia Chao); (Jeffrey Shieh); 郭盛助(Sheng-Chu Kuo); 吳柏蒼(Bor-Tsang Wu); 侯曼貞(Hour Mann-Jen)*; 梁育民* |
| 中國醫藥大學 |
2007-12-08 |
Development of 4-substituted anilino-2-phenylquinazoline derivatives as TNF-α inhibitors
|
陳泰霖; 侯曼貞(Hour Mann-Jen)*; 黃麗嬌(Li-Jiau Huang); 連金城(Lien Jin Cherng); 黃俊緯; 郭盛助(Sheng-Chu Kuo) |
| 中國醫藥大學 |
2007-12-08 |
Synthesis of 2,3-disubstituted 1,4-naphthoquinones as anti-inflammatory and antiallergic agents
|
連金城(Lien Jin Cherng); 侯曼貞(Hour Mann-Jen); 黃麗嬌(Li-Jiau Huang); 王繼平; 吳宗翰; 陳泰霖; 林佩蓉; 江芳書; 郭盛助(Sheng-Chu Kuo) |
| 中國醫藥大學 |
2007-12-08 |
Involvement of Cytoskeleton-Associated Pathway in Apoptotic Induction by Photodynamic Therapy with Hedyotis corymbosa in Skin Cancer Cells
|
陳美宇(Chen Mei-Yu); 侯曼貞(Hour Mann-Jen); 賴妙英(Miao-Ying Lai); 劉文治(Liu Wen-Zhi); 李鳳琴(Hong-Zin Lee)* |
| 中國醫藥大學 |
2007-12-08 |
P38-Associated Pathway Involvement in Photodynamic Therapy with Lonicera japonica-Induced Apoptosis in Human Lung Carcinoma Cells
|
王孟宜(Wang Meng-Yi); 楊雅雯(Yang Ya-Win); 賴妙英(Miao-Ying Lai); 侯曼貞(Hour Mann-Jen); 李鳳琴(Hong-Zin Lee)* |
| 中國醫藥大學 |
2007-12-08 |
某區域教學醫院Zolpidem門診處方型態分析
|
郭啟文(CHI-WEN KUO); 楊蕙菁; 謝惠芳; 林明薰; 潘美如; 侯曼貞(Hour Mann-Jen) |
| 中國醫藥大學 |
2007-11-16 |
HMJ-38 interacts with microtubule polymerization and induces mitotic arrest following apoptosis in human tongue cancer CAL27 cell line.
|
楊家欣(Yang Jai-Sing); 郭盛助(Sheng-Chu Kuo); 高銘欽(Ming-Ching Kao); 江若華; 呂啟誠; 吳長霖; 古偉聰; 侯曼貞(Hour Mann-Jen); 鍾景光* |
| 中國醫藥大學 |
2007-11-16 |
MJ-56 suppresses cell invasion, migration, and metastasis via inhibition of matrix metalloproteinase-2/-7/-9 signal pathways in human colorectal adenocarcinoma cell line HT-29.
|
江羿霖; 侯曼貞(Hour Mann-Jen); 林孟葳; 郭盛助(Sheng-Chu Kuo); 賴光啟(Kuang-Chi Lai); 楊家欣(Yang Jai-Sing)*; 鍾景光 |
| 中國醫藥大學 |
2007-11-16 |
MJ-56 suppresses cell invasion, migration, and metastasis via inhibition of matrix metalloproteinase-2/-7/-9 signal pathways in human colorectal adenocarcinoma cell line HT-29
|
江羿霖; 侯曼貞(Hour Mann-Jen); 林孟威; 郭盛助(Sheng-Chu Kuo); 賴光啟(Kuang-Chi Lai); 楊家欣(Yang Jai-Sing)*; 鍾景光 |
| 中國醫藥大學 |
2007-11-16 |
HMJ-38 interacts with microtubule polymerization and induces mitotic arresr following apoptosis in human tongue cancer CAL27 cell line
|
楊家欣(Yang Jai-Sing); 郭盛助(Sheng-Chu Kuo); 高銘欽(Ming-Ching Kao); 江若華; 呂啟誠; 吳長霖; 古偉聰; 侯曼貞(Hour Mann-Jen)*; 鍾景光 |
| 中國醫藥大學 |
2007-07-31 |
設計合成phenylquinolone 類緣化合物做為抗癌藥
|
郭盛助(Kuo,Sheng-Chu); 黃麗嬌(Li-Jiau Huang); 陳勝智(Sheng-Chih Chen); 林宗平; 連金城(Lien Jin Cherng); 蔡尚元(Shang-Yuan Tsai); 侯曼貞(Hour Mann-Jen) |
| 中國醫藥大學 |
2007-07-31 |
利用蛋白質體技術分析4-ANILINO-2-PHENYLQUINAZOLINE 衍生物對HL-60血癌細胞與HT-29大腸癌細胞之抗癌機制及衍生物對小鼠體內抗癌作用之探討
|
楊家欣(Yang Jai-Sing);侯曼貞(Hour,Mann-Jen);鍾景光;黃麗嬌 |
| 中國醫藥大學 |
2007-07-31 |
Synthesis of 6-pyrollidinyl-4-anilinoquinazoline derivatives as anticancer agents
|
侯曼貞(Hour,Mann-Jen) |
