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Institution Date Title Author
國家衛生研究院 2024-07-04 Development of a humanized antibody targeting extracellular HSP90alpha to suppress endothelial-mesenchymal transition-enhanced tumor growth of pancreatic adenocarcinoma cells Fan, CS;Hung, HC;Chen, CC;Chen, LL;Ke, YY;Yeh, TK;Huang, CT;Chang, TY;Yen, KJ;Chen, CH;Chua, KV;Hsu, JTA;Huang, TS
國家衛生研究院 2024-04 Reducing brain Abeta burden ameliorates high-fat diet-induced fatty liver disease in APP/PS1 mice Tsay, HJ;Gan, YL;Su, YH;Sun, YY;Yao, HH;Chen, HW;Hsu, YT;Hsu, JTA;Wang, HD;Shie, FS
國家衛生研究院 2023-10 Discovery of novel AXL and MER inhibitors as potential anticancer and immune modulator drugs Hsieh, HP;Li, MC;Yen, WC;Hsu, JTA;Yeh, TK;Li, WS;Wu, HC
國家衛生研究院 2022-01-11 Extracellular HSP90alpha induces MyD88−IRAK complex-associated IKKalpha/Beta−NF-κB/IRF3 and JAK2/TYK2−STAT-3 signaling in macrophages for tumor-promoting M2-polarization Fan, CS;Chen, CC;Chen, LL;Chua, KV;Hung, HC;Hsu, JTA;Huang, TS
國家衛生研究院 2022-01-05 The beneficial effects of combining anti-Abeta antibody NP106 and curcumin analog TML-6 on the treatment of Alzheimer’s disease in APP/PS1 mice Su, IJ;Hsu, CY;Shen, S;Chao, PK;Hsu, JTA;Hsueh, JT;Liang, JJ;Hsu, YT;Shie, FS
國家衛生研究院 2021-07-30 The effects of Abeta1-42 binding to the SARS-CoV-2 spike protein S1 subunit and angiotensin-converting enzyme 2 Hsu, JTA;Tien, CF;Yu, GY;Shen, S;Lee, YH;Hsu, PC;Wang, Y;Chao, PK;Tsay, HJ;Shie, FS
國家衛生研究院 2020-06-02 Zika virus NS3 protease pharmacophore anchor model and drug discovery Pathak, N;Kuo, YP;Chang, TY;Huang, CT;Hung, HC;Hsu, JTA;Yu, GY;Yang, JM
國家衛生研究院 2020-05 Drug-like property optimization: Discovery of orally bioavailable quinazoline-based multi-targeted kinase inhibitors Lin, SY;Chang, CF;Coumar, MS;Chen, PY;Kuo, FM;Chen, CH;Li, MC;Lin, WH;Kuo, PC;Wang, SY;Li, AS;Lin, CY;Yang, CM;Yeh, TK;Song, JS;Hsu, JTA;Hsieh, HP
國家衛生研究院 2019-10 Inhibition of Rspo-Wnt pathway facilitates checkpoint blockade therapy by anti-RSPO3 antibody (DBPR117) Hsu, JTA;Hung, HC;Chen, CT;Yen, WC;Chang, TY;Chao, PK;Chin-Ting, H;Yen, KJ;Tsai, YR;Chang, CY;Fang, MY;Lai, YL;Shih, JC
國家衛生研究院 2018-12 Targeting RSPO3 reduces stem cell function in RSPO3-Fusion-positive colon cancer and RSPO3 high lung cancer Hsu, J;Hung, HC;Yen, WC;Chang, TY;Yen, GJ;Huang, CT;Fnag, MY;Lai, YL;Tsai, YR;Chen, CT;Shih, JC;Hsu, JTA
國家衛生研究院 2018-10 Identification of novel Cdc7 kinase inhibitors as anti-cancer agents that target the interaction with Dbf4 by the fragment complementation and drug repositioning approach Cheng, AN;Lo, YK;Lin, YS;Tang, TK;Hsu, CH;Hsu, JTA;Lee, AYL
國家衛生研究院 2018-01 Discovery and development of DBPR112 as a clinical candidate: A novel EGFR inhibitor for non-small cell lung cancer Hsieh, HP;Hsu, JTA;Yeh, TK;Chen, CT
國家衛生研究院 2017-04 Discovery of BPR1K871-a quinazoline based multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, in vitro and in vivo evaluation Hsieh, HP;Wang, WC;Shiao, HY;Ke, YY;Lin, WH;Hsu, JTA;Chen, CT;Yeh, TK
國家衛生研究院 2016-11-29 Discovery of novel inhibitors of Aurora kinases with indazole scaffold: In silico fragment-based and knowledge-based drug design Chang, CF;Lin, WH;Ke, YY;Lin, YS;Wang, WC;Chen, CH;Kuo, PC;Hsu, JTA;Uang, BJ;Hsieh, HP
國家衛生研究院 2016-05-19 Non-small-cell lung cancer cells combat epidermal growth factor receptor tyrosine kinase inhibition through immediate adhesion-related responses Wang, HY;Hsu, MK;Wang, KH;Tseng, CP;Chen, FC;Hsu, JTA
國家衛生研究院 2015-07 Identification of a potent 5-phenyl-thiazol-2-ylamine-based inhibitor of FLT3 with activity against drug resistance-conferring point mutations Chen, CT;Hsu, JTA;Lin, WH;Lu, CT;Yen, SC;Hsu, T;Huang, YL;Song, JS;Chen, CH;Chou, LH;Yen, KJ;Chen, CP;Kuo, PC;Huang, CL;Eugene Liu, H;Chao, YS;Yeh, TK;Jiaang, WT
國家衛生研究院 2015-01 Identification of ligand efficient, fragment-like hits from an HTS library: Structure-based virtual screening and docking investigations of 2H- and 3H-pyrazolo tautomers for Aurora kinase A selectivity Sarvagalla, S;Singh, VK;Ke, YY;Shiao, HY;Lin, WH;Hsieh, HP;Hsu, JTA;Coumar, MS
國立交通大學 2014-12-08T15:39:10Z Anti-HCV activities of selective polyunsaturated fatty acids Leu, GZ; Lin, TY; Hsu, JTA
國立交通大學 2014-12-08T15:19:20Z Anti-HCV activities of selective polyunsaturated fatty acids (vol 318, pg 275, 2004) Leu, GZ; Lin, TY; Hsu, JTA
國立交通大學 2014-12-08T15:18:14Z Inhibition of hepatitis C virus replication by antimonial compounds Hwang, DR; Lin, RK; Leu, GZ; Lin, TY; Lien, TW; Yu, MC; Yeh, CT; Hsu, JTA
國家衛生研究院 2014-12 BPR-3P0128 inhibits RNA-dependent RNA polymerase elongation and VPg uridylylation activities of Enterovirus 71 Balaji, VA;Chen, GW;Hsieh, PT;Horng, JT;Hsu, JTA;Hsieh, HP;Chen, TC;Weng, KF;Shih, SR
國家衛生研究院 2014-11-20 The combination effects of LiCl and the active leflunomide metabolite, A771726, on viral-induced interleukin 6 production and EV-A71 replication Hung, HC;Shih, SR;Chang, TY;Fang, MY;Hsu, JTA
國家衛生研究院 2014-11 Reticulon 3 interacts with NS4B of the hepatitis C virus and negatively regulates viral replication by disrupting NS4B self-interaction Wu, MJ;Ke, PY;Hsu, JTA;Yeh, CT;Horng, JT
國家衛生研究院 2014-10 Optimization of 5,6-fused pyrimidine-based kinase inhibitors by computer-aided drug design for the treatment of AML Hsu, YC;Shiao, HY;Ke, YY;Hsu, JTA;Lin, WH;Chen, CH;Hsieh, HP
國家衛生研究院 2014-05 Facile identification of dual FLT3-Aurora A inhibitors: A computer-guided drug design approach ChangHsu, Y;Ke, YY;Shiao, HY;Lee, CC;Lin, WH;Chen, CH;Yen, KJ;Hsu, JTA;Chang, C;Hsieh, HP

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