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Institution	Date	Title	Author
國家衛生研究院	2023-02-07	Development of furanopyrimidine-based orally active third- generation EGFR inhibitors for the treatment of non-small cell lung cancer	Li, MC;Coumar, MS;Lin, SY;Lin, YS;Huang, GL;Chen, CH;Lien, TW;Wu, YW;Chen, YT;Chen, CP;Huang, YC;Yeh, KC;Yang, CM;Kalita, B;Pan, SL;Hsu, TA;Yeh, TK;Chen, CT;Hsieh, HP
國家衛生研究院	2022-09-26	Targeting the phosphatidylserine-immune checkpoint with a small-molecule maytansinoid conjugate	Lo, CF;Chiu, TY;Liu, YT;Pan, PY;Liu, KL;Hsu, CY;Fang, MY;Huang, YC;Yeh, TK;Hsu, TA;Chen, CT;Huang, LR;Tsou, LK
國家衛生研究院	2022-06-21	Synthesis and evaluation of small molecule drug conjugates harnessing thioester-linked maytansinoids	Lo, CF;Chiu, TY;Liu, YT;Huang, LR;Yeh, TK;Huang, KH;Liu, KL;Hsu, CY;Fang, MY;Huang, YC;Hsu, TA;Chen, CT;Tsou, LK
國家衛生研究院	2022-02-07	Development of furanopyrimidine-based orally active third-generation EGFR inhibitors for the treatment of non-small cell lung cancer	Li, MC;Coumar, MS;Lin, SY;Lin, YS;Huang, GL;Chen, CH;Lien, TW;Wu, YW;Chen, YT;Chen, CP;Huang, YC;Yeh, KC;Yang, CM;Kalita, B;Pan, SL;Hsu, TA;Yeh, TK;Chen, CT;Hsieh, HP
國家衛生研究院	2022-01-18	Acyl-coenzyme a synthetase long-chain family member 4 is involved in viral replication organelle formation and facilitates virus replication via ferroptosis	Kung, YA;Chiang, HJ;Li, ML;Gong, YN;Chiu, HP;Hung, CT;Huang, PN;Huang, SY;Wang, PY;Hsu, TA;Brewer, G;Shih, SR
國家衛生研究院	2021-07-16	Colloidal assemblies composed of polymeric micellar/emulsified systems integrate cancer therapy combining a tumor-associated antigen vaccine and chemotherapeutic regimens	Huang, CY;Lin, SY;Hsu, TA;Hsieh, HP;Huang, MH
國家衛生研究院	2020-05-23	Repurposing old drugs as antiviral agents for coronaviruses	Yang, CW;Peng, TT;Hsu, HY;Lee, YZ;Wu, SH;Lin, WH;Ke, YY;Hsu, TA;Yeh, TK;Huang, WZ;Lin, JH;Sytwu, HK;Chen, CT;Lee, SJ
國家衛生研究院	2020-05-15	Artificial intelligence approach fighting COVID-19 with repurposing drugs	Ke, YY;Peng, TT;Yeh, TK;Huang, WZ;Chang, SE;Wu, SH;Hung, HC;Hsu, TA;Lee, SJ;Song, JS;Lin, WH;Chiang, TJ;Lin, JH;Sytwu, HK;Chen, CT
國家衛生研究院	2019-12-17	Endothelial-mesenchymal transition harnesses HSP90alpha-secreting M2-macrophages to exacerbate pancreatic ductal adenocarcinoma	Fan, CS;Chen, LL;Hsu, TA;Chen, CC;Chua, KV;Li, CP;Huang, TS
國家衛生研究院	2019-10	Discovery of clinical candidate DBPR112, a furanopyrimidine-based epidermal growth factor receptor inhibitor for the treatment of non-small cell lung cancer	Hsieh, HP;Chang, JY;Yeh, CT;Lin, SY;Ke, YY;Lin, WH;Hsu, TA;Wu, SY;Yeh, TK
國家衛生研究院	2019-09-27	Discovery of a furanopyrimidine-based epidermal growth factor receptor inhibitor (DBPR112) as a clinical candidate for the treatment of non-small cell lung cancer	Lin, SY;Chang Hsu, Y;Peng, YH;Ke, YY;Lin, WH;Sun, HY;Shiao, HY;Kuo, FM;Chen, PY;Lien, TW;Chen, CH;Chu, CY;Wang, SY;Yeh, KC;Chen, CP;Hsu, TA;Wu, SY;Yeh, TK;Chen, CT;Hsieh, HP
國家衛生研究院	2019-07-11	Linker optimization and therapeutic evaluation of phosphatidylserine-targeting zinc dipicolylamine-based drug conjugates	Liu, YW;Chen, YY;Hsu, CY;Chiu, TY;Liu, KL;Lo, CF;Fang, MY;Huang, YC;Yeh, TK;Pak, KY;Gray, BD;Hsu, TA;Huang, KH;Shih, C;Shia, KS;Chen, CT;Tsou, LK
國家衛生研究院	2019-05-28	Identification of novel anti-liver cancer small molecules with better therapeutic index than sorafenib via zebrafish drug screening platform	Lin, HS;Huang, YL;Wang, YS;Hsiao, E;Hsu, TA;Shiao, HY;Jiaang, WT;Sampurna, BP;Lin, KH;Wu, MS;Lai, GM;Yuh, CH
國家衛生研究院	2019-04-01	A novel, potent, and orally bioavailable thiazole HCV NS5A inhibitor for the treatment of hepatitis C virus	Yeh, TK;Kang, IJ;Hsu, TA;Lee, YC;Lee, CC;Hsu, SJ;Tian, YW;Yang, HY;Chen, CT;Chao, YS;Yueh, A;Chern, JH
國家衛生研究院	2018-12	Dendritic cell-derived exosomes increase the efficacy of anti-PD-L1 antibody in melanoma model	Chao, PK;Hsu, TA
國家衛生研究院	2018-12	Targeting RSPO3 reduces stem cell function in RSPO3-Fusion-positive colon cancer and RSPO3 high lung cancer	Hung, HC;Yen, WC;Chang, TY;Yen, GJ;Huang, CT;Fang, MY;Lai, YL;Tsai, YR;Chen, CT;Shih, C;Hsu, TA
國家衛生研究院	2017-07	Targeting tumor associated phosphatidylserine with new zinc dipicolylamine-based drug conjugates	Liu, YW;Shia, KS;Wu, CH;Liu, KL;Yeh, YC;Lo, CF;Chen, CT;Chen, YY;Yeh, TK;Chen, WH;Jan, JJ;Huang, YC;Huang, CL;Fang, MY;Gray, BD;Pak, KY;Hsu, TA;Huang, KH;Tsou, LK
國家衛生研究院	2017-01	A potent, selective, and orally bioavailable HCV NS5A inhibitor for treatment of Hepatitis C Virus: (S)-1-((R)-2-(Cyclopropanecarboxamido)-2-phenylacetyl)-N-(4-phenylthiazo l-2-yl)pyrrolidine-2-carboxamide	Kang, IJ;Hsu, SJ;Yang, HY;Yeh, TK;Lee, CC;Lee, YC;Tian, YW;Song, JS;Hsu, TA;Chao, YS;Yueh, A;Chern, JH
國家衛生研究院	2016-07-28	Design and synthesis of 1,2,3-triazole-containing N-acyl zanamivir analogs as potent neuraminidase inhibitors	Das, A;Adak, AK;Ponnapalli, K;Lin, CH;Hsu, KC;Yang, JM;Hsu, TA;Lin, CC
國家衛生研究院	2015-08	Optimization of quinazoline-based kinase inhibitors: Identification of a dual FLT3/AURKA kinase inhibitor for the treatment of acute myeloid leukemia	Hsieh, HP;Hsu, YC;Ke, YY;Shiao, HY;Chang, CW;Lin, WH;Hsu, TA;Yeh, TK;Chen, CT
國家衛生研究院	2015-08	Optimization of furanopyrimidine-based kinase inhibitors: Identification of a BTK kinase inhibitor for the treatment of B cell lymphoma	Wang, WC;Hsu, YC;Shiao, HY;Hung, HC;Kuo, CC;Lee, JC;Hsu, TA;Hsieh, HP
國家衛生研究院	2015-08	Discovery of 2,4-diaminopyrimidines bearing a unique pharmacophore as anaplastic lymphoma kinase inhibitors	Shiao, HY;Wang, WC;Hsu, YC;Ke, YY;Hsu, TA;Hsieh, HP
國家衛生研究院	2015-07-31	作為極光激酶抑制劑的稠合雙環嘧啶化合物	Hsieh, HP;Coumar, MS;Wu, SY;Hsu, TA;Chao, YS
國家衛生研究院	2015-07-22	作为酪胺酸激酶抑制剂的稠合双环及多环嘧啶化合物	Hsieh, HP;Coumar, MS;Hsu, TA;Lin, WH;Chen, YR;Chao, YS
國立交通大學	2014-12-08T15:06:23Z	ON SOME OPTIMAL SELECTION PROCEDURES FOR WEIBULL POPULATIONS	HSU, TA
國立交通大學	2014-12-08T15:06:15Z	SOME OPTIMAL SUBSET-SELECTION PROCEDURES WITH APPLICATIONS	HSU, TA
國家衛生研究院	2014-11	Discovery of multiple kinases inhibitors, DBPR114, as the novel anti-cancer agent	Hsieh, HP;Kuo, CC;Chiu, JJ;Hsu, TA;Yeh, TK;Chen, CT
國家衛生研究院	2014-10-29	作為極光激酶抑制劑的稠合雙環嘧啶化合物	Hsieh, HP;Coumar, MS;Hsu, TA;Wu, SY;Chao, YS
國家衛生研究院	2014-10-21	化合物於製造治療病毒感染的藥物之用途	Hsieh, HP;Hsu, TA;Yeh, JY;Horng, JT;Shih, SR;Chang, SY;Chao, YS
國家衛生研究院	2014-10	Novel irreversible EGFR tyrosine kinase inhibitor, DBPR112, as a therapeutic candidate for lung adenocarcinoma	Shiao, HY;Hsu, TA;Lin, WH;Yang, TT;Hsieh, HF;Chen, CT;Yeh, TK;Hsieh, HP
國家衛生研究院	2014-04-29	Quinoline compounds and their use for treating viral infection	Hsieh, HP;Hsu, TA;Yeh, JY;Chao, YS
國家衛生研究院	2014-04-21	作為蛋白質激酶抑制劑之吡唑化合物及噻唑化合物、其醫藥組成物及用途	Jiaang, WT;Hsu, TA;Lin, WH;Chao, YS
國家衛生研究院	2014-03-20	Fused bicyclic pyrimidine compounds as aurora kinase inhibitors	Hsieh, HP;Coumar, MS;Hsu, TA;Wu, SY;Chao, YS
國家衛生研究院	2013-10-01	喹啉化合物及包含其之治療病毒感染之醫藥組成物	Hsieh, HP;Hsu, TA;Yeh, JY;Chao, YS
國家衛生研究院	2013-08-13	Fused bicyclic and tricyclic pyrimidine compounds as tyrosine kinase inhibitors	Hsieh, HP;Coumar, SM;Hsu, TA;Lin, WH;Chen, YR;Chao, YS
國家衛生研究院	2013-06	Synthesis of acylguanidine zanamivir derivatives as neuraminidase inhibitors and the evaluation of their bio-activities	Lin, CH;Chang, TC;Das, A;Fang, MY;Hung, HC;Hsu, KC;Yang, JM;Von Itzstein, M;Mong, KKT;Hsu, TA;Lin, CC
國家衛生研究院	2013-02-11	作為酪胺酸激酶抑制劑之稠合雙環及多環嘧啶化合物	Hsieh, HP;Coumar, MS;Chao, YS;Hsu, TA;Lin, WH;Chen, YR
國家衛生研究院	2013-02	Resistance studies of a di-thiazol analogue, DBPR110, as a potential hepatitis C virus NS5A inhibitor in replicon systems	Lin, HM;Wang, JC;Hu, HS;Wu, PS;Wang, WH;Wu, SY;Yang, CC;Yeh, TK;Hsu, TA;Jiaang, WT;Chao, YS;Chern, JH;Yueh, A
國家衛生研究院	2012-05-11	作為極光激酶抑制劑之稠合雙環嘧啶化合物	Hsieh, HP;Coumar, MS;Hsu, TA;Wu, SY;Chao, YS
國家衛生研究院	2012-04-11	咪唑啉酮及咪唑啉硫酮衍生物	Chern, JH;Hsu, TA;Kang, IJ;Wang, LW;Lee, CC;Lee, YC;Wu, YS;Hsu, SJ;Yueh, YA;Chao, YS
國家衛生研究院	2012-03-20	Fused bicyclic pyrimidine compounds as aurora kinase inhibitors	Hsieh, HP;Coumar, MS;Hsu, TA;Wu, SY;Chao, YS
國家衛生研究院	2012-03-01	C型肝炎病毒抑制劑	Chern, JH;Hsu, TA;Kang, IJ;Wang, LW;Lee, CC;Lee, YC;Chao, YS
國家衛生研究院	2012-02	Synthesis and biological evaluation of 2-amino-1-thiazolyl imidazoles as orally active anticancer agents	Li, WT;Hwang, DR;Song, JS;Chen, CP;Chen, TW;Lin, CH;Chuu, JJ;Lien, TW;Hsu, TA;Huang, CL;Tseng, HY;Lin, CC;Lin, HL;Chang, CM;Chao, YS;Chen, CT
國家衛生研究院	2012-01	Resistance analysis and characterization of a thiazole analogue, BP008, as a potent hepatitis C virus NS5A inhibitor	Lin, HM;Wang, JC;Hu, HS;Wu, PS;Yang, CC;Wu, CP;Pu, SY;Hsu, TA;Jiaang, WT;Chao, YS;Chern, JH;Yeh, TK;Yueh, A
國家衛生研究院	2011-12	Development of a whole-cell screening system for evaluation of the human CYP1A2-mediated metabolism	Chu, CC;Pan, KL;Yao, HT;Hsu, TA
國家衛生研究院	2011-09-23	BPR1K653, a novel Aurora Kinase Inhibitor, exhibits potent anti-proliferative activity in P-gp170 (MDR1)-mediated VX680-resistant cancer cells in vitro and in vivo	Hsieh, HP;Cheung, CHA;Lin, WH;Hsu, TA;Coumar, MS;Chao, YS;Chang, JY
國家衛生研究院	2011-08	BPR1K653, a novel aurora kinase inhibitor, exhibits potent anti-proliferative activity in MDR1 (P-gp170)-mediated multidrug-resistant cancer cells	Cheung, CH;Lin, WH;Hsu, TA;Hour, TC;Yeh, TK;Ko, S;Lien, TW;Coumar, MS;Liu, JF;Lai, WY;Shiao, HY;Lee, TR;Hsieh, HP;Chang, JY
國家衛生研究院	2011-07-26	Hepatitis C virus inhibitors	Wang, LW;Hsu, TA;Lee, YC;Kang, IJ;Lee, CC;Chao, YS;Chern, JH
國家衛生研究院	2011-07-11	抑制C型肝炎病毒感染之倍半帖內酯類化合物及其醫藥組成物	Hsieh, HP;Hsu, TA;Hwang, DR
國家衛生研究院	2011-06-21	抑制冠狀病毒之醫藥組合物	Hsu, TA;Hsieh, HP;Chao, YS;Chen, CM;Jan, JT;Liu, HW

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