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Institution Date Title Author
國家衛生研究院 2025-01 Advancing precision therapy for colorectal cancer: Developing clinical indications for multi-target kinase inhibitor BPR1J481 using patient-derived xenograft models Tang, YC;Ou, JJ;Hsu, SC;Huang, CH;Lin, LM;Chang, HH;Wang, YH;Huang, ZT;Sun, M;Liu, KJ;Hung, YM;Lai, CY;Shih, C;Chen, CT;Chang, JY;Hsieh, HP;Jiaang, WT;Kuo, CC
國家衛生研究院 2024-11-26 Development of potent and selective inhibitors of methylenetetrahydrofolate dehydrogenase 2 for targeting acute myeloid leukemia: Sar, structural insights, and biological characterization Chang, HH;Lee, LC;Hsu, T;Peng, YH;Huang, CH;Yeh, TK;Lu, CT;Huang, ZT;Hsueh, CC;Kung, FC;Lin, LM;Huang, YC;Wang, YH;Li, LH;Tang, YC;Chang, L;Hsieh, CC;Jiaang, WT;Kuo, CC;Wu, SY
國家衛生研究院 2024-02-15 Aminothiazole compounds as protein kinase inhibitors Tsai, HJ;Jiaang, WT;Shih, C
國家衛生研究院 2023-04-19 Aminothiazole compounds as protein kinase inhibitors Shih, C;Jiaang, WT;Tsai, HJ
國家衛生研究院 2023-03-21 Aminothiazole compounds as protein kinase inhibitors Shih, C;Jiaang, WT;Tsai, HJ
國家衛生研究院 2022-10-21 氨基噻唑化合物及其用途 Jiaang, WT;Hsu, T
國家衛生研究院 2022-07-25 Aminothiazole compounds as protein kinase inhibitors Shih, C;Jiaang, WT;Tsai, HJ
國家衛生研究院 2022-07-15 Compuestos de aminotiazol como inhibidores de la proteina quinasa Shih, C;Jiaang, WT;Tsai, HJ
國家衛生研究院 2022-04-12 Thiazole compounds as protein kinase inhibitors Jiaang, WT;Chao, YS
國家衛生研究院 2022-03-02 Aminothiazole compounds and use thereof Jiaang, WT;Hsu, T
國家衛生研究院 2021-11-30 Aminothiazole compounds as protein kinase inhibitors Shih, C;Jiaang, WT;Tsai, HJ
國家衛生研究院 2021-10-07 Aminothiazole compounds as protein kinase inhibitors Shih, C;Jiaang, WT;Tsai, HJ
國家衛生研究院 2021-08-12 Xanthine derivatives reveal an allosteric binding site in methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) Lee, LC;Peng, YH;Chang, HH;Hsu, T;Lu, CT;Huang, CH;Hsueh, CC;Kung, FC;Kuo, CC;Jiaang, WT;Wu, SY
國家衛生研究院 2021-08-01 DBPR108, a novel dipeptidyl peptidase-4 inhibitor with antihyperglycemic activity Yeh, KC;Yeh, TK;Huang, CY;Hu, CB;Wang, MH;Huang, YW;Chou, LH;Ho, HH;Song, JS;Hsu, T;Jiaang, WT;Chao, YS;Chen, CT
國家衛生研究院 2020-12-23 Aminothiazole compounds as protein kinase inhibitors Shih, C;Jiaang, WT;Tsai, HJ
國家衛生研究院 2020-10-16 Potent and orally active purine-based fetal hemoglobin inducers for treating Beta-thalassemia and sickle cell disease Lai, ZS;Yeh, TK;Chou, YC;Hsu, T;Lu, CT;Kung, FC;Hsieh, MY;Lin, CH;Chen, CT;James Shen, CK;Jiaang, WT
國家衛生研究院 2019-12 Identification of a multitargeted tyrosine kinase inhibitor for the treatment of gastrointestinal stromal tumors and acute myeloid leukemia Lin, WH;Wu, SY;Yeh, TK;Chen, CT;Song, JS;Shiao, HY;Kuo, CC;Hsu, T;Lu, CT;Wang, PC;Wu, TS;Peng, YH;Lin, HY;Chen, CP;Weng, YL;Kung, FC;Wu, MH;Su, YC;Huang, KW;Chou, LH;Hsueh, CC;Yen, KJ;Kuo, PC;Huang, CL;Chen, LT;Shih, C;Tsai, HJ;Jiaang, WT
國家衛生研究院 2019-11-12 Composto Tsai, TY;Hsu, T;Jiaang, WT;Chao, YS
國家衛生研究院 2019-07 Use of integrated genomic analyses in patient-derived tumor model to discover new clinical indications for the multikinase inhibitor drug candidate, DBPR216 Kuo, CC;Jiaang, WT;Ou, JJ;Chen, CT;Hsu, SC;Shih, C;Lin, LM;Sun, M;Wang, YH;Huang, ZT;Chang, JY;Ueng, SH
國家衛生研究院 2019-05-28 Identification of novel anti-liver cancer small molecules with better therapeutic index than sorafenib via zebrafish drug screening platform Lin, HS;Huang, YL;Wang, YS;Hsiao, E;Hsu, TA;Shiao, HY;Jiaang, WT;Sampurna, BP;Lin, KH;Wu, MS;Lai, GM;Yuh, CH
國家衛生研究院 2019-05-28 Aminothiazole compounds as protein kinase inhibitors Jiaang, WT;Shih, C;Tsai, HJ
國家衛生研究院 2019-04-10 Discovery of Conformational Control Inhibitors Switching off the Activated c-KIT and Targeting a Broad Range of Clinically Relevant c-KIT Mutants Wu, TS;Lin, WH;Tsai, HJ;Hsueh, CC;Hsu, T;Wang, PC;Lin, HY;Peng, YH;Lu, CT;Lee, LC;Tu, CH;Kung, FC;Shiao, HY;Yeh, TK;Song, JS;Chang, JY;Su, YC;Chen, LT;Chen, CT;Jiaang, WT;Wu, SY
國家衛生研究院 2018-08-24 BPR1J373, a novel multi-targeted kinase inhibitor, effectively suppresses the growth of gastrointestinal stromal tumor Tsai, HJ;Jiaang, WT;Shih, NY;Fletcher, JA;Lin, MJ;Yang, MY;Chen, CT;Hsu, TJ;Wu, CC;Lin, HY;Chen, LT
國家衛生研究院 2018-08-24 BPR1J373, a novel multitargeted kinase inhibitor, effectively suppresses the growth of gastrointestinal stromal tumor Tsai, HJ;Jiaang, WT;Shih, NY;Fletcher, JA;Lin, MJ;Yang, MY;Chen, CT;Hsu, TAJ;Wu, CC;Lin, HY;Chen, LT
國家衛生研究院 2018-08-14 Aminothiazole compounds Jiaang, WT;Hsu, T
國家衛生研究院 2017-03-21 Pyrrolidine derivatives Jiaang, WT;Chao, YS;Tsai, TY;Hsu, T
國家衛生研究院 2016-12 Novel cKIT kinase inhibitor, BPRCKJ001, as an advanced therapeutic candidate for GIST Shiao, HY;Tsai, HJ;Lin, WH;Tsu, TA;Yeh, TK;Chen, CT;Jiaang, WT
國家衛生研究院 2016-10 BPR1J373, an oral multiple tyrosine kinase inhibitor, targets c-KIT for the treatment of c-KIT driven myeloid leukemia Chen, LT;Chen, CT;Jiaang, WT;Chen, TY;Butterfield, JH;Shih, NY;Hsu, JT;Lin, HY;Lin, SF;Tsai, HJ
國家衛生研究院 2016-08-30 Pyrrolidine derivatives Jiaang, WT;Chao, YS;Tsai, TY;Hsu, T
國家衛生研究院 2016-04-12 Pyrazolylamine derivatives reveal the conformational switching between type I and type II binding modes of Anaplastic Lymphoma Kinase (ALK) Tu, CH;Lin, WH;Peng, YH;Hsu, T;Wu, JS;Chang, CY;Lu, CT;Lyu, PC;Shih, C;Jiaang, WT;Wu, SY
國家衛生研究院 2016-02-09 Pyrazole compounds and thiazole compounds as protein kinases inhibitors Jiaang, WT;Hsu, TA;Lin, WH;Chao, YS
國家衛生研究院 2015-11-13 Pyrrolidine derivatives Jiaang, WT;Chao, YS;Tsai, TY;Hsu, T
國家衛生研究院 2015-07 Identification of a potent 5-phenyl-thiazol-2-ylamine-based inhibitor of FLT3 with activity against drug resistance-conferring point mutations Chen, CT;Hsu, JTA;Lin, WH;Lu, CT;Yen, SC;Hsu, T;Huang, YL;Song, JS;Chen, CH;Chou, LH;Yen, KJ;Chen, CP;Kuo, PC;Huang, CL;Eugene Liu, H;Chao, YS;Yeh, TK;Jiaang, WT
國家衛生研究院 2014-08-01 Pyrrolidine derivatives Jiaang, WT;Chao, YS;Tsai, TY;Hsu, T
國家衛生研究院 2014-05-12 Pyrrolidine derivatives Jiaang, WT;Chao, YS;Tsai, TY;Hsu, T
國家衛生研究院 2014-05-08 Pyrrolidine derivatives Jiaang, WT;Chao, YS;Tsai, TY;Hsu, T
國家衛生研究院 2014-04-25 Pyrrolidine derivatives Jiaang, WT;Chao, YS;Tsai, TY;Hsu, T
國家衛生研究院 2014-04-21 作為蛋白質激酶抑制劑之吡唑化合物及噻唑化合物、其醫藥組成物及用途 Jiaang, WT;Hsu, TA;Lin, WH;Chao, YS
國家衛生研究院 2014-02-19 Pyrrolidine derivatives Jiaang, WT;Chao, YS;Tsai, TY;Hsu, T
國家衛生研究院 2014-02 Fibroblast activation protein (FAP) is essential for the migration of bone marrow mesenchymal stem cells through RhoA activation Chung, KM;Hsu, SC;Chu, YR;Lin, MY;Jiaang, WT;Chen, RH;Chen, X
國家衛生研究院 2014-01-08 Evaluation of the antitumor effects of BPR1J-340, a potent and selective FLT3 inhibitor, alone or in combination with an HDAC inhibitor, vorinostat, in AML cancer Lin, WH;Yeh, TK;Jiaang, WT;Yen, KJ;Chen, CH;Huang, CT;Yen, SC;Hsieh, SY;Chou, LH;Chen, CP;Chiu, CH;Kao, LC;Chao, YS;Chen, CT;Hsu, JTA
國家衛生研究院 2014-01 A novel dengue virus inhibitor, BP13944, discovered by high-throughput screening with dengue virus replicon cells selects for resistance in the viral NS2B/NS3 protease Yang, CC;Hu, HS;Wu, RH;Wu, SH;Lee, SJ;Jiaang, WT;Chern, JH;Huang, ZS;Wu, HN;Chang, CM;Yueh, A
國家衛生研究院 2013-12-18 吡咯烷化合物 Jiaang, WT;Chao, YS;Tsai, TY;Hsu, T
國家衛生研究院 2013-09-27 Pyrrolidine derivatives Jiaang, WT;Chao, YS;Tsai, TY;Hsu, T
國家衛生研究院 2013-06-28 Optimization of ligand and lipophilic efficiency to identify an in vivo active furano-pyrimidine aurora kinase inhibitor Shiao, HY;Coumar, MS;Chang, CW;Ke, YY;Chi, YH;Chu, CY;Sun, HY;Chen, CH;Lin, WH;Fung, KS;Kuo, PC;Huang, CT;Chang, KY;Lu, CT;Hsu, JT;Chen, CT;Jiaang, WT;Chao, YS;Hsieh, HP
國家衛生研究院 2013-06 Discovery of 3-phenyl-1H-5-pyrazolylamine derivatives containing a urea pharmacophore as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3) Lin, WH;Hsu, JTA;Hsieh, SY;Chen, CT;Song, JS;Yen, SC;Hsu, T;Lu, CT;Chen, CH;Chou, LH;Yang, YN;Chiu, CH;Chen, CP;Tseng, YJ;Yen, KJ;Yeh, CF;Chao, YS;Yeh, TK;Jiaang, WT
國家衛生研究院 2013-04-30 Pyrrolidine derivatives Jiaang, WT;Chao, YS;Tsai, TY;Hsu, T
國家衛生研究院 2013-02-11 吡咯啉啶化合物 Jiaang, WT;Tsai, TY;Hsu, T;Chao, YS
國家衛生研究院 2013-02-11 吡咯啶化合物 Jiaang, WT;Chen, X
國家衛生研究院 2013-02 Resistance studies of a di-thiazol analogue, DBPR110, as a potential hepatitis C virus NS5A inhibitor in replicon systems Lin, HM;Wang, JC;Hu, HS;Wu, PS;Wang, WH;Wu, SY;Yang, CC;Yeh, TK;Hsu, TA;Jiaang, WT;Chao, YS;Chern, JH;Yueh, A

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