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机构 日期 题名 作者
國家衛生研究院 2011-06 Cleavage-site specificity of prolyl endopeptidase FAP investigated with a full-length protein substrate Huang, CH;Suen, CS;Lin, CT;Chien, CH;Lee, HY;Chung, KM;Tsai, TY;Jiaang, WT;Hwang, MJ;Chen, X
國家衛生研究院 2011-06 Current advances and therapeutic potential of agents targeting dipeptidyl peptidases-IV, -II, 8/9 and fibroblast activation protein Chen, SJ;Jiaang, WT
國家衛生研究院 2011-05-25 Pyrrolidine derivatives Jiaang, WT;Chao, YS;Tsai, TY;Hsu, T
國家衛生研究院 2011-02 Synthesis of 3,3-dimethylglutamic acid derivatives as DPP-IV inhibitors and evaluation of their chemical stability Hsu, T;Tsai, TY;Tseng, YJ;Chiou, MC;Lu, CT;Chao, YS;Jiaang, WT
國家衛生研究院 2010-10-06 吡咯烷化合物 Jiaang, WT;Chen, X;Wu, SY;Hsieh, HP;Chao, YS
國家衛生研究院 2010-09 The dimeric transmembrane domain of prolyl dipeptidase DPP-IV contributes to its quaternary structure and enzymatic activities Chung, KM;Cheng, JH;Suen, CS;Huang, CH;Tsai, CH;Huang, LH;Chen, YR;Wang, AH; Jiaang, WT; Hwang, MJ;Chen, X
國家衛生研究院 2010-08 Substituted 4-carboxymethylpyroglutamic acid diamides as potent and selective inhibitors of fibroblast activation protein Tsai, TY;Yeh, TK;Chen, X;Hsu, T;Jao, YC;Huang, CH;Song, JS;Huang, YC;Chien, CH;Chiu, JH;Yen, SC;Tang, HK;Chao, YS;Jiaang, WT
國家衛生研究院 2010-06-15 (2S,4S)-1-[2-(1,1-Dimethyl-3-oxo-3-pyrrolidin-1-yl-propylamino)acetyl]-4-fluoro-pyrrolidine-2-carbonitrile: A potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV Yeh, TK;Tsai, TY;Hsu, T;Cheng, JH;Chen, X;Song, JS;Shy, HS;Chiou, MC;Chien, CH;Tseng, YJ;Huang, CY;Yeh, KC;Huang, YL;Huang, CH;Huang, YW;Wang, MH;Tang, HK;Chao, YS;Chen, CT;Jiaang, WT
國家衛生研究院 2010-03-30 Pyrrolidine compounds Jiaang, WT;Chen, X;Wu, SY;Chao, YS;Hsieh, HP
國家衛生研究院 2009-10 (1,3-Diphenyl-1H-pyrazol-4-yl)-methylamine analogues as inhibitors of dipeptidyl peptidases Hsu, T;Chen, CT;Tsai, TY;Cheng, JH;Wu, SY;Chang, CN;Chien, CH;Yeh, KC;Huang, YW;Huang, CL;Huang, CY;Wu, SH;Chiang, YK;Wang, MH;Chao, YS;Chen, X;Jiaang, WT
國家衛生研究院 2009-07-15 Biochemistry, pharmacokinetics, and toxicology of a potent and selective DPP8/9 inhibitor Wu, JJ;Tang, HK;Yeh, TK;Chen, CM;Shy, HS;Chu, YR;Chien, CH;Tsai, TY;Huang, YC;Huang, YL;Huang, CH;Tseng, HY;Jiaang, WT;Chao, YS;Chen, X
國家衛生研究院 2009-06 A three-dimensional pharmacophore model for dipeptidyl peptidase IV inhibitiors [Erratum: European Journal of Medicinal Chemistry. 2008 Aug;43(8):1603-1611.] Lu, IL;Tsai, KC;Chiang, YK;Jiaang, WT;Wu, SH;Mahindroo, N;Chien, CH;Lee, SJ;Chen, X;Chao, YS;Wu, SY
國家衛生研究院 2009-04-01 Rational design and synthesis of potent and long-lasting glutamic acid-based dipeptidyl peptidase IV inhibitors Tsai, TY;Hsu, T;Chen, CT;Cheng, JH;Chiou, MC;Huang, CH;Tseng, YJ;Yeh, TK;Huang, CY;Yeh, KC;Huang, YW;Wu, SH;Wang, MH;Chen, X;Chao, YS;Jiaang, WT
國家衛生研究院 2009-03-15 Novel trans-2-aryl-cyclopropylamine analogues as potent and selective dipeptidyl peptidase IV inhibitors Tsai, TY;Hsu, T;Chen, CT;Cheng, JH;Yeh, TK;Chen, X;Huang, CY;Chang, CN;Yeh, KC;Hsieh, SH;Chien, CH;Chang, YW;Huang, CH;Huang, YW;Huang, CL;Wu, SH;Wang, MH;Lu, CT;Chao, YS;Jiaang, WT
國家衛生研究院 2009-01-22 Pyrrolidine compounds Chao, YS;Chen, X;Hsieh, HP;Jiaang, WT;Wu, SY
國家衛生研究院 2008-09-16 Pyrrolidine compounds Jiaang, WT;Chao, YS;Hsieh, HP
國家衛生研究院 2008-08 A three-dimensional pharmacophore model for dipeptidyl peptidase IV inhibitors Lu, IL;Tsai, KC;Chiang, YK;Jiaang, WT;Wu, SH;Mahindroo, N;Chien, CH;Lee, SJ;Chen, X;Chao, YS;Wu, SY
國家衛生研究院 2008-07-21 吡咯啉啶化合物 Jiaang, WT;Wu, SY;Chen, X;Chao, YS;Hsieh, HP
國家衛生研究院 2008-07-01 Pyrrolidine compounds Jiaang, WT;Chen, X;Wu, SY;Hsieh, HP;Chao, YS
國家衛生研究院 2007-03-01 3-[2-((2S)-2-Cyano-pyrrolidin-1-yl)-2-oxo-ethylamino]-3-methyl-butyramide analogues as selective DPP-IV inhibitors for the treatment of type-II diabetes Coumar, MS; Chang, CN; Chen, CT; Chen, X; Chien, CH; Tsai, TY; Cheng, JH; Wu, HY; Han, CH; Wu, SH; Huang, YW; Hsu, T; Hsu, LJ; Chao, YS; Hsieh, HP; Jiaang, WT
國家衛生研究院 2006-09 MEDI 416-3- 2-((2S)-2-Cyano-pyrrolidin-1-yl)-2-oxo-ethylamino -3-methyl-butyr amide analogs as DPP-IV inhibitors for the treatment of type-II diabetes Hsieh, HP;Coumar, MS;Chang, CN;Wu, SH;Chen, X;Chen, CT;Jiaang, WT
國家衛生研究院 2006-06-15 Substituted pyrrolidine-2,4-dicarboxylic acid amides as potent dipeptidyl peptidase IV inhibitors Tsai, TY; Coumar, MS; Hsu, T; Hsieh, HP; Chien, CH; Chen, CT; Chang, CN; Lo, YK; Wu, SH; Huang, CY; Huang, YW; Wang, MH; Wu, HY; Lee, HJ; Chen, X; Chao, YS; Jiaang, WT
國家衛生研究院 2006-01-12 2-[3-[2-[(2S)-2-cyano-1-pyrrolidinyl]-2-oxoethylamino]-3-methyl-1-oxobutyl]-1,2,3,4-tetrahydroisoquinoline: A potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV Tsu, H; Chen, X; Chen, CT; Lee, SJ; Chang, CN; Kao, KH; Coumar, MS; Yeh, YT; Chien, CH; Wang, HS; Lin, KT; Chang, YY; Wu, SH; Chen, YS; Lu, IL; Wu, SY; Tsai, TY; Chen, WC; Hsieh, HP; Chao, YS; Jiaang, WT
國家衛生研究院 2005-07-01 Glutamic acid analogues as potent dipeptidyl peptidase IV and 8 inhibitors Lu, IL; Lee, SJ; Tsu, H; Wu, SY; Kao, KH; Chien, CH; Chang, YY; Chen, YS; Cheng, JH; Chang, CN; Chen, TW; Chang, SP; Chen, X; Jiaang, WT
國家衛生研究院 2005-04-15 Benzothiazolium compounds: Novel classes of inhibitors that suppress the nitric oxide production in RAW264.7 cells stimulated by LPS/IFN gamma Tseng, HY; Wu, SH; Huang, WH; Wang, SF; Yang, YN; Mahindroo, N; Hsu, T; Jiaang, WT; Lee, SJ

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