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| 臺大學術典藏 |
2022-05-12T05:25:29Z |
Drug Repurposing for the Identification of Compounds with Anti-SARS-CoV-2 Capability via Multiple Targets
|
Yu, Pei-Chen; Huang, Chen-Hao; Kuo, Chih-Jung; Liang, Po-Huang; Wang, Lily Hui-Ching; Pan, Max Yu-Chen; SUI-YUAN CHANG; Chao, Tai-Ling; Ieong, Si-Man; Fang, Jun-Tung; Huang, Hsuan-Cheng; Juan, Hsueh-Fen |
| 臺大學術典藏 |
2022-02-14T23:55:36Z |
Drug Repurposing for the Identification of Compounds with Anti-SARS-CoV-2 Capability via Multiple Targets
|
YU-PEI CHEN; Huang, Chen Hao; Kuo, Chih Jung; Liang, Po Huang; Wang, Lily Hui Ching; Pan, Max Yu Chen; SUI-YUAN CHANG; Chao, Tai Ling; Ieong, Si Man; Fang, Jun Tung; Huang, Hsuan Cheng; HSUEH-FEN JUAN |
| 臺大學術典藏 |
2021-11-07T07:34:09Z |
Kinetic Characterization and Inhibitor Screening for the Proteases Leading to Identification of Drugs against SARS-CoV-2
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Kuo, Chih-Jung; Chao, Tai-Ling; Kao, Han-Chieh; Tsai, Ya-Min; Liu, Yi-Kai; Wang, Lily Hui-Ching; Hsieh, Ming-Chang; SUI-YUAN CHANG; Liang, Po-Huang |
| 臺大學術典藏 |
2021-03-17T02:29:26Z |
Uncovering Flexible Active Site Conformations of SARS-CoV-2 3CL Proteases through Protease Pharmacophore Clusters and COVID-19 Drug Repurposing
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Pathak, Nikhil; Chen, Yun-Ti; Hsu, Yen-Chao; Hsu, Nung-Yu; Kuo, Chih-Jung; Tsai, Hui Ping; Huang, Chih-Heng; SUI-YUAN CHANG; Chang, Yu-Hsiu; Liang, Po-Huang; Yang, Jinn-Moon; JAW-JOU KANG |
| 臺大學術典藏 |
2018-09-10T08:36:28Z |
Fluorescent substrate analog for monitoring chain elongation by undecaprenyl pyrophosphate synthase in real time
|
Teng, Kuo-Hsun;Chen, Annie P.-C.;Kuo, Chih-Jung;Li, Yu-Chin;Liu, Hon-Ge;Chen, Chao-Tsen;Liang, Po-Huang; Teng, Kuo-Hsun; Chen, Annie P.-C.; Kuo, Chih-Jung; Li, Yu-Chin; Liu, Hon-Ge; Chen, Chao-Tsen; Liang, Po-Huang; CHAO-TSEN CHEN |
| 臺大學術典藏 |
2018-09-10T06:38:40Z |
Specific plant terpenoids and lignoids possess potent antiviral activities against severe acute respiratory syndrome coronavirus
|
Wen, Chih-Chun; Kuo, Yueh-Hsiung; Jan, Jia-Tsrong; Liang, Po-Huang; Wang, Sheng-Yang; Liu, Hong-Gi; Lee, Ching-Kuo; Chang, Shang-Tzen; Kuo, Chih-Jung; Lee, Shoei-Sheng; Hou, Chia-Chung; Hsiao, Pei-Wen; Chien, Shih-Chang; Shyur, Lie-Fen; Yang, Ning-Sun; Wen, C.-C.; SHOEI-SHENG LEE et al.; Wen, Chih-Chun; Kuo, Yueh-Hsiung; Jan, Jia-Tsrong; Liang, Po-Huang; Wang, Sheng-Yang; Liu, Hong-Gi; Lee, Ching-Kuo; Chang, Shang-Tzen; Kuo, Chih-Jung; Lee, Shoei-Sheng; Hou, Chia-Chung; Hsiao, Pei-Wen; Chien, Shih-Chang; Shyur, Lie-Fen; Yang, Ning-Sun |
| 國立交通大學 |
2014-12-12T02:39:21Z |
蛋白質間交互作用小分子抑制劑選擇性促使化學藥劑抗藥性或缺乏半胱胺酸蛋白酶-3之癌細胞死亡
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陳世勳; Chen, Shih-Hsun; 楊進木; 梁博煌; Yang, Jinn-Moon; Liang, Po-Huang |
| 國立交通大學 |
2014-12-08T15:34:25Z |
Moiety-Linkage Map Reveals Selective Nonbisphosphonate Inhibitors of Human Geranylgeranyl Diphosphate Synthase
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Chen, Shih-Hsun; Lin, Sheng-Wei; Lin, Shen-Rong; Liang, Po-Huang; Yang, Jinn-Moon |
| 國立交通大學 |
2014-12-08T15:34:09Z |
Conjugation of Benzylvanillin and Benzimidazole Structure Improves DNA Binding with Enhanced Antileukemic Properties
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Al-Mudaris, Zena A.; Majid, Aman S. A.; Ji, Dan; Al-Mudarris, Ban A.; Chen, Shih-Hsun; Liang, Po-Huang; Osman, Hasnah; Din, Shah Kamal Khan Jamal; Majid, Amin M. S. Abdul |
| 國立交通大學 |
2014-12-08T15:32:27Z |
Targeting the XIAP/caspase-7 complex selectively kills caspase-3-deficient malignancies
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Lin, Yuan-Feng; Lai, Tsung-Ching; Chang, Chih-Kang; Chen, Chi-Long; Huang, Ming-Shyan; Yang, Chih-Jen; Liu, Hon-Ge; Dong, Jhih-Jhong; Chou, Yi-An; Teng, Kuo-Hsun; Chen, Shih-Hsun; Tian, Wei-Ting; Jan, Yi-Hua; Hsiao, Michael; Liang, Po-Huang |
| 國立交通大學 |
2014-12-08T15:22:42Z |
Roles of Amino Acids in the Escherichia coli Octaprenyl Diphosphate Synthase Active Site Probed by Structure-Guided Site-Directed Mutagenesis
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Chang, Keng-Ming; Chen, Shih-Hsun; Kuo, Chih-Jung; Chang, Chi-Kang; Guo, Rey-Ting; Yang, Jinn-Moon; Liang, Po-Huang |
| 國立交通大學 |
2014-12-08T15:09:45Z |
Combined Experimental and Theoretical Study of Long-Range Interactions Modulating Dimerization and Activity of Yeast Geranylgeranyl Diphosphate Synthase
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Lo, Chia-Hsiang; Chang, Ying-Hsuan; Wright, Jon D.; Chen, Shih-Hsun; Kan, Daphne; Lim, Carmay; Liang, Po-Huang |
| 國立臺灣大學 |
2012 |
Roles of Amino Acids in the Escherichia coli Octaprenyl Diphosphate Synthase Active Site Probed by Structure-Guided Site-Directed Mutagenesis
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Chang, Keng-Ming; Chen, Shih-Hsun; Kuo, Chih-Jung; Chang, Chi-Kang; Guo, Rey-Ting; Yang, Jinn-Moon; Liang, Po-Huang |
| 國立臺灣大學 |
2011 |
Fluorescent substrate analog for monitoring chain elongation by undecaprenyl pyrophosphate synthase in real time
|
Teng, Kuo-Hsun; Chen, Annie P.-C.; Kuo, Chih-Jung; Li, Yu-Chin; Liu, Hon-Ge; Chen, Chao-Tsen; Liang, Po-Huang |
| 國立臺灣大學 |
2011 |
Structural and functional analysis of three beta-glucosidases from bacterium Clostridium cellulovorans, fungus Trichoderma reesei and termite Neotermes koshunensis
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Jeng, Wen-Yih; Wang, Nai-Chen; Lin, Man-Hua; Lin, Cheng-Tse; Liaw, Yen-Chywan; Chang, Wei-Jung; Liu, Chia-I; Liang, Po-Huang; Wang, Andrew H-J. |
| 國立臺灣大學 |
2010 |
Synthesis and evaluation of pyrazolone compounds as SARS-coronavirus 3C-like protease inhibitors
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Ramajayam, R.; Tan, Kian-Pin; Liu, Hun-Ge; Liang, Po-Huang |
| 國立臺灣大學 |
2010 |
Mechanism of cis-prenyltransferase reaction probed by substrate analogues
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Lu, Yen-Pin; Liu, Hon-Ge; Teng, Kuo-Hsun; Liang, Po-Huang |
| 國立臺灣大學 |
2010 |
Synthesis, docking studies, and evaluation of pyrimidines as inhibitors of SARS-CoV 3CL protease
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Ramajayam, R.; Tan, Kian-Pin; Liu, Hun-Ge; Liang, Po-Huang |
| 國立臺灣大學 |
2010 |
Structure of a Heterotetrameric Geranyl Pyrophosphate Synthase from Mint (Mentha piperita) Reveals Intersubunit Regulation
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Chang, Tao-Hsin; Hsieh, Fu-Lien; Ko, Tzu-Ping; Teng, Kuo-Hsun; Liang, Po-Huang; Wang, Andrew H-J. |
| 國立臺灣大學 |
2009 |
Different reaction mechanisms for cis- and trans-prenyltransferases
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Lu, Yen-Pin; Liu, Hun-Ge; Liang, Po-Huang |
| 國立臺灣大學 |
2009 |
Corrigendum to “Individual and common inhibitors of coronavirus and picornavirus main proteases” [FEBS Lett. 583 (2009) 549–555]
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Kuo, Chih-Jung; Liu, Hun-Ge; Lo, Yueh-Kuei; Seong, Churl-Min; Lee, Kee-In; Jung, Young-Sik; Liang, Po-Huang |
| 國立臺灣大學 |
2009 |
Combined Experimental and Theoretical Study of Long-Range Interactions Modulating Dimerization and Activity of Yeast Geranylgeranyl Diphosphate Synthase
|
Lo, Chia-Hsiang; Chang, Ying-Hsuan; Wright, Jon D.; Chen, Shih-Hsun; Kan, Daphne; Lim, Carmay; Liang, Po-Huang |
| 國立臺灣大學 |
2009 |
Structural Basis of Inhibition Specificities of 3C and 3C-like Proteases by Zinc-coordinating and Peptidomimetic Compounds
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Lee, Cheng-Chung; Kuo, Chih-Jung; Ko, Tzu-Ping; Hsu, Min-Feng; Tsui, Yao-Chen; Chang, Shih-Cheng; Yang, Syaulan; Chen, Shu-Jen; Chen, Hua-Chien; Hsu, Ming-Chu; Shih, Shin-Ru; Liang, Po-Huang; Wang, Andrew H.-J. |
| 國立臺灣大學 |
2008 |
A mammalian cell-based reverse two-hybrid system for functional analysis of 3C viral protease of human enterovirus 71
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Lee, Jin-Ching; Shih, Shin-Ru; Chang, Ten-Yuan; Tseng, Huan-Yi; Shih, Ya-Feng; Yen, Kuei-Jung; Chen, Wei-Chun; Shie, Jiun-Jie; Fang, Jim-Min; Liang, Po-Huang; Chao, Yu-Sheng; Hsu, John T-A. |
| 國立臺灣大學 |
2008 |
Design, synthesis, and evaluation of trifluoromethyl ketones as inhibitors of SARS-CoV 3CL protease
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Shao, Yi-Ming; Yang, Wen-Bin; Kuo, Tun-Hsun; Tsai, Keng-Chang; Lin, Chun-Hung; Yang, An-Suei; Liang, Po-Huang; Wong, Chi-Huey |
| 國立臺灣大學 |
2008 |
Design, synthesis, and evaluation of 3C protease inhibitors as anti-enterovirus 71 agents
|
Kuo, Chih-Jung; Shie, Jiun-Jie; Fang, Jim-Min; Yen, Guei-Rung; Hsu, John T.-A.; Liu, Hun-Ge; Tseng, Sung-Nain; Chang, Shih-Cheng; Lee, Ching-Yin; Shih, Shin-Ru; Liang, Po-Huang |
| 國立臺灣大學 |
2008 |
Structure-based inhibitors exhibit differential activities against Helicobacter pylori and Escherichia coli undecaprenyl pyrophosphate synthases
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Kuo, Chih-Jung; Guo, Rey-Ting; Lu, I-Lin; Liu, Hun-Ge; Wu, Su-Ying; Ko, Tzu-Ping; Wang, Andrew H.-J.; Liang, Po-Huang |
| 國立臺灣大學 |
2008 |
Inhibition of Geranylgeranyl Diphosphate Synthase by Bisphosphonates: A Crystallographic and Computational Investigation
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Chen, Cammy K.-M.; Hudock, Michael P.; Zhang, Yonghui; Guo, Rey-Ting; Cao, Rong; No, Joo Hwan; Liang, Po-Huang; Ko, Tzu-Ping; Chang, Tao-Hsin; Chang, Shiou-chi; Song, Yongcheng; Axelson, Jordan; Kumar, Anup; Wang, Andrew H.-J.; Oldfield, Eric |
| 臺大學術典藏 |
2008 |
Structure-based inhibitors exhibit differential activities against Helicobacter pylori and Escherichia coli undecaprenyl pyrophosphate synthases
|
Kuo, Chih-Jung; Guo, Rey-Ting; Lu, I-Lin; Liu, Hun-Ge; Wu, Su-Ying; Ko, Tzu-Ping; Wang, Andrew H.-J.; Liang, Po-Huang; Kuo, Chih-Jung; Guo, Rey-Ting; Lu, I-Lin; Liu, Hun-Ge; Wu, Su-Ying; Ko, Tzu-Ping; Wang, Andrew H.-J.; Liang, Po-Huang |
| 國立臺灣大學 |
2007 |
Specific Plant Terpenoids and Lignoids Possess Potent Antiviral Activities against Severe Acute Respiratory Syndrome Coronavirus
|
Wen, Chih-Chun; Kuo, Yueh-Hsiung; Jan, Jia-Tsrong; Liang, Po-Huang; Wang, Sheng-Yang; Liu, Hong-Gi; Lee, Ching-Kuo; Chang, Shang-Tzen; Kuo, Chih-Jung; Lee, Shoei-Sheng; Hou, Chia-Chung; Hsiao, Pei-Wen; Chien, Shih-Chang; Shyur, Lie-Fen; Yang, Ning-Sun |
| 國立臺灣大學 |
2007 |
Structural basis of mercury- and zinc-conjugated complexes as SARS-CoV 3C-like protease inhibitors
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Lee, Cheng-Chung; Kuo, Chih-Jung; Hsu, Min-Feng; Liang, Po-Huang; Fang, Jim-Min; Shie, Jiun-Jie; Wang, Andrew H.-J. |
| 國立臺灣大學 |
2007 |
Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases
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Guo, Rey-Ting; Cao, Rong; Liang, Po-Huang; Ko, Tzu-Ping; Chang, Tao-Hsin; Hudock, Michael P.; Jeng, Wen-Yih; Chen, Cammy K.-M.; Zhang, Yonghui; Song, Yongcheng; Kuo, Chih-Jung; Yin, Fenglin; Oldfield, Eric; Wang, Andrew H.-J. |
| 國立臺灣大學 |
2007 |
Structure-Based Design and Synthesis of Highly Potent SARS-CoV 3CL Protease Inhibitors
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Shao, Yi-Ming; Yang, Wen-Bin; Peng, Hung-Pin; Hsu, Min-Feng; Tsai, Keng-Chang; Kuo, Tun-Hsun; Wang, Andrew H.-J.; Liang, Po-Huang; Lin, Chun-Hung; Yang, An-Suei; Wong, Chi-Huey |
| 國立臺灣大學 |
2007 |
Novel Small-Molecule Inhibitors of Transmissible Gastroenteritis Virus
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Yang, Cheng-Wei; Yang, Yung-Ning; Liang, Po-Huang; Chen, Chi-Min; Chen, Wei-Liang; Chang, Hwan-You; Chao, Yu-Sheng; Lee, Shiow-Ju |
| 國立臺灣大學 |
2007 |
Drug discovery for SARS and other human coronaviruses targeting 3C proteases
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Liang, Po-Huang |
| 國立臺灣大學 |
2006 |
Stable Benzotriazole Esters as Mechanism-Based Inactivators of the Severe Acute Respiratory Syndrome 3CL Protease
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Wu, Chung-Yi; King, Ke-Yung; Kuo, Chih-Jung; Fang, Jim-Min; Wu, Ying-Ta; Ho, Ming-Yi; Liao, Chung-Lin; Shie, Jiun-Jie; Liang, Po-Huang; Wong, Chi-Huey |
| 國立臺灣大學 |
2006 |
Ligand specificities and structural requirements of two Tachypleus plasma lectins for bacterial trapping
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Kuo, Tun-Hsun; Chuang, Shiao-Cheng; Chang, Sing-Yang; Liang, Po-Huang |
| 國立臺灣大學 |
2006 |
Crystal Structure of Type-III Geranylgeranyl Pyrophosphate Synthase from Saccharomyces cerevisiae and the Mechanism of Product Chain Length Determination
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Chang, Tao-Hsin; Guo, Rey-Ting; Ko, Tzu-Ping; Wang, Andrew H.-J.; Liang, Po-Huang |
| 國立臺灣大學 |
2006 |
Characterization and inhibition of SARS-coronavirus main protease
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Liang, Po-Huang |
| 國立臺灣大學 |
2006 |
The critical roles of polyamines in regulating ColE7 production and restricting ColE7 uptake of the colicin producing Escherichia coli
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Pan, Yi-Hsuan; Liao, Chen-Chung; Kuo, Chou-Chiang; Duan, Kow-Jen; Liang, Po-Huang; Yuan, Hanna S.; Hu, Shiau-Ting; Chak, Kin-Fu |
| 國立臺灣大學 |
2006 |
Discovery of a novel family of SARS-CoV protease inhibitors by virtual screening and 3D-QSAR studies
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Tsai, Keng-Chang; Chen, Shih-Yuan; Liang, Po-Huang; Lu, I-Lin; Mahindroo, Neeraj; Hsieh, Hsing-Pang; Chao, Yu-Sheng; Liu, Lincoln; Liu, Donald; Lien, Wei; Lin, Thy-Hou; Wu, Su-Ying |
| 國立臺灣大學 |
2006 |
An E. coli lon mutant conferring partial resistance to colicin may reveal a novel role in regulating proteins involved in the translocation of colicin
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Lee, Yuan-Yu; Hu, Hsiao-Tin; Liang, Po-Huang; Chak, Kin-Fu |
| 國立臺灣大學 |
2006 |
Structure-Based Drug Design and Structural Biology Study of Novel Nonpeptide Inhibitors of Severe Acute Respiratory Syndrome Coronavirus Main Protease
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Lu, I-Lin; Mahindroo, Neeraj; Liang, Po-Huang; Peng, Yi-Hui; Kuo, Chih-Jung; Tsai, Keng-Chang; Hsieh, Hsing-Pang; Chao, Yu-Sheng; Wu, Su-Ying |
| 國立臺灣大學 |
2006 |
Pharmacophores and biological activities of severe acute respiratory syndrome viral protease inhibitors
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Wang, Hui-Min; Liang, Po-Huang |
| 臺大學術典藏 |
2006 |
Stable Benzotriazole Esters as Mechanism-Based Inactivators of the Severe Acute Respiratory Syndrome 3CL Protease
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Shie, Jiun-Jie; Ho, Ming-Yi; Liao, Chung-Lin; Wu, Ying-Ta; Fang, Jim-Min; Kuo, Chih-Jung; King, Ke-Yung; Wu, Chung-Yi; Wu, Chung-Yi; King, Ke-Yung; Kuo, Chih-Jung; Fang, Jim-Min; Wu, Ying-Ta; Ho, Ming-Yi; Liao, Chung-Lin; Shie, Jiun-Jie; Liang, Po-Huang; Wong, Chi-Huey; Liang, Po-Huang; Wong, Chi-Huey |
| 臺大學術典藏 |
2006 |
Discovery of a novel family of SARS-CoV protease inhibitors by virtual screening and 3D-QSAR studies
|
Tsai, Keng-Chang; Chen, Shih-Yuan; Liang, Po-Huang; Lu, I-Lin; Mahindroo, Neeraj; Hsieh, Hsing-Pang; Chao, Yu-Sheng; Liu, Lincoln; Liu, Donald; Lien, Wei; Lin, Thy-Hou; Wu, Su-Ying; Tsai, Keng-Chang; Chen, Shih-Yuan et al. |
| 國立臺灣大學 |
2005 |
Inhibition of the severe acute respiratory syndrome 3CL protease by peptidomimetic α,β-unsaturated esters
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Shie, Jiun-Jie; Fang, Jim-Min; Kuo, Tun-Hsun; Kuo, Chih-Jung; Liang, Po-Huang; Huang, Hung-Jyun; Wu, Yin-Ta; Jan, Jia-Tsrong; Cheng, Yih-Shyun E.; Wong, Chi-Huey |
| 國立臺灣大學 |
2005 |
Discovery of Potent Anilide Inhibitors against the Severe Acute Respiratory Syndrome 3CL Protease
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Shie, Jiun-Jie; Fang, Jim-Min; Kuo, Chih-Jung; Kuo, Tun-Hsun; Liang, Po-Huang; Huang, Hung-Jyun; Yang, Wen-Bin; Lin, Chun-Hung; Chen, Jiun-Ling; Wu, Yin-Ta; Wong, Chi-Huey |
| 國立臺灣大學 |
2005 |
Mechanism of the Maturation Process of SARS-CoV 3CL Protease
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Hsu, Min-Feng; Kuo, Chih-Jung; Chang, Kai-Ti; Chang, Hui-Chuan; Chou, Chia-Cheng; Ko, Tzu-Ping; Shr, Hui-Lin; Chang, Gu-Gang; Wang, Andrew H.-J.; Liang, Po-Huang |
| 國立臺灣大學 |
2005 |
Crystal Structures of Undecaprenyl Pyrophosphate Synthase in Complex with Magnesium, Isopentenyl Pyrophosphate, and Farnesyl Thiopyrophosphate-ROLES OF THE METAL ION AND CONSERVED RESIDUES IN CATALYSIS
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Guo, Rey-Ting; Ko, Tzu-Ping; Chen, Annie P.-C.; Kuo, Chih-Jung; Wang, Andrew H.-J.; Liang, Po-Huang |
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