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机构 日期 题名 作者
國家衛生研究院 2021-04-01 Heterocyclic compounds and use thereof Shih, C;Shia, KS;Wu, CH;Choi, Ming Chen;Song, JS;Wang, Y
國家衛生研究院 2021-03-30 A highly selective and potent CXCR4 antagonist for hepatocellular carcinoma treatment Song, JS;Chang, CC;Wu, CH;Dinh, TK;Jan, JJ;Huang, KW;Chou, MC;Shiue, TY;Yeh, KC;Ke, YY;Yeh, TK;Ta, YNN;Lee, CJ;Huang, JK;Sung, YC;Shia, KS;Chen, Y
國家衛生研究院 2021-03-02 Total synthesis of landomycins Q and R and related core structures for exploration of the cytotoxicity and antibacterial properties Lai, YH;Mondal, S;Su, HT;Huang, SC;Wu, MH;Huang, I;Yang Lauderdale, TL;Song, JS;Shia, KS;Mong, KK
國家衛生研究院 2021-03-02 Discovery of potential neuroprotective agents against paclitaxel-induced peripheral neuropathy Chen, YF;Wu, CH;Chen, LH;Lee, HW;Lee, JC;Yeh, TK;Chang, JY;Chou, MC;Wu, HL;Lai, YP;Song, JS;Yeh, KC;Chen, CT;Lee, CJ;Shia, KS;Shen, MR
國家衛生研究院 2021-01-05 Heterocyclic compounds and use thereof Shia, KS;Wu, CH;Chou, MC;Song, JS;Wang, Y;Shih, C
國家衛生研究院 2020-10-08 Comparative study between deep learning and QSAR classifications for TNBC inhibitors and novel GPCR agonist discovery Tsou, LK;Yeh, SH;Ueng, SH;Chang, CP;Song, JS;Wu, MH;Chang, HF;Chen, SR;Shih, C;Chen, CT;Ke, YY
國家衛生研究院 2020-09-25 Protective effect of CXCR4 antagonist CX807 in a rat model of hemorrhagic stroke Yu, SJ;Wu, KJ;Wang, YS;Song, JS;Wu, CH;Jan, JJ;Bae, E;Chen, H;Shia, KS;Wang, Y
國家衛生研究院 2020-08 BPR6K609: An Aurora kinase inhibitor targeting small cell lung cancer with MYC amplification Chi, YH;Chang, CP;Ke, YY;Lin, WH;Wang, WP;Tsai, CH;Chen, YT;Su, YJ;Hung, MC;Wu, ZW;Wu, MH;Yeh, TK;Chen, CP;Song, JS;Chen, CT;Shih, C
國家衛生研究院 2020-05-15 Artificial intelligence approach fighting COVID-19 with repurposing drugs Ke, YY;Peng, TT;Yeh, TK;Huang, WZ;Chang, SE;Wu, SH;Hung, HC;Hsu, TA;Lee, SJ;Song, JS;Lin, WH;Chiang, TJ;Lin, JH;Sytwu, HK;Chen, CT
國家衛生研究院 2020-05 Drug-like property optimization: Discovery of orally bioavailable quinazoline-based multi-targeted kinase inhibitors Lin, SY;Chang, CF;Coumar, MS;Chen, PY;Kuo, FM;Chen, CH;Li, MC;Lin, WH;Kuo, PC;Wang, SY;Li, AS;Lin, CY;Yang, CM;Yeh, TK;Song, JS;Hsu, JTA;Hsieh, HP
國家衛生研究院 2020-02-10 Unique sulfur-aromatic interactions contribute to the binding of potent imidazothiazole indoleamine 2,3-Dioxygenase inhibitors Peng, YH;Liao, FY;Tseng, CT;Kuppusamy, R;Li, AS;Chen, CH;Fan, YS;Wang, SY;Wu, MH;Hsueh, CC;Chang, JY;Lee, LC;Shih, C;Shia, KS;Yeh, TK;Hung, MS;Kuo, CC;Song, JS;Wu, SY;Ueng, SH
國家衛生研究院 2019-12-09 Design, synthesis and anticancer evaluation of beta-carboline-1-one hydantoins Yao, CH;Hsieh, TC;Song, JS;Lee, JC
國家衛生研究院 2019-12 Identification of a multitargeted tyrosine kinase inhibitor for the treatment of gastrointestinal stromal tumors and acute myeloid leukemia Lin, WH;Wu, SY;Yeh, TK;Chen, CT;Song, JS;Shiao, HY;Kuo, CC;Hsu, T;Lu, CT;Wang, PC;Wu, TS;Peng, YH;Lin, HY;Chen, CP;Weng, YL;Kung, FC;Wu, MH;Su, YC;Huang, KW;Chou, LH;Hsueh, CC;Yen, KJ;Kuo, PC;Huang, CL;Chen, LT;Shih, C;Tsai, HJ;Jiaang, WT
國家衛生研究院 2019-10-22 A novel flavivirus entry inhibitor, BP34610, discovered through high-throughput screening with dengue reporter viruses Yang, CC;Hu, HS;Lin, HM;Wu, PS;Wu, RH;Tian, JN;Wu, SH;Tsou, LK;Song, JS;Chen, HW;Chern, JH;Chen, CT;Yueh, A
國家衛生研究院 2019-09 Effects of boschnaloside from Boschniakia rossica on dysglycemia and islet dysfunction in severely diabetic mice through modulating the action of glucagon-like peptide-1 Lin, LC;Lee, LC;Huang, C;Chen, CT;Song, JS;Shiao, YJ;Liu, HK
國家衛生研究院 2019-07 An Aurora kinase inhibitor BPR6K471 inhibits tumor growth and reduces the cancer stem cell-like properties of small cell lung cancer Chang, CP;Ke, YY;Lin, WH;Jhuo, DH;Wang, WP;Tsai, CH;Chen, YT;Su, YJ;Hung, MC;Wu, ZW;Kuo, PC;Yeh, TK;Chen, CP;Song, JS;Chen, CT;Shih, C;Chi, YH
國家衛生研究院 2019-04-10 Discovery of Conformational Control Inhibitors Switching off the Activated c-KIT and Targeting a Broad Range of Clinically Relevant c-KIT Mutants Wu, TS;Lin, WH;Tsai, HJ;Hsueh, CC;Hsu, T;Wang, PC;Lin, HY;Peng, YH;Lu, CT;Lee, LC;Tu, CH;Kung, FC;Shiao, HY;Yeh, TK;Song, JS;Chang, JY;Su, YC;Chen, LT;Chen, CT;Jiaang, WT;Wu, SY
國家衛生研究院 2019-03 Synthesis and biological evaluation of N-glucosyl indole derivatives as sodium-dependent glucose co-transporter 2 inhibitors Chu, KF;Song, JS;Chen, CT;Yeh, TK;Hsieh, TC;Huang, CY;Wang, MH;Wu, SH;Yao, CH;Chao, YS;Lee, JC
國家衛生研究院 2019-02-28 Characterization, dynamics, and mechanism of CXCR4 antagonists on a constitutively active mutant Rosenberg, EM, Jr.;Harrison, RES;Tsou, LK;Drucker, N;Humphries, B;Rajasekaran, D;Luker, KE;Wu, CH;Song, JS;Wang, CJ;Murphy, JW;Cheng, YC;Shia, KS;Luker, GD;Morikis, D;Lolis, EJ
國家衛生研究院 2019-01-01 Fluorine-18 isotope labeling for positron emission tomography imaging. Direct evidence for DBPR211 as a peripherally restricted CB1 inverse agonist Chang, CP;Huang, HL;Huang, JK;Hung, MS;Wu, CH;Song, JS;Lee, CJ;Yu, CS;Shia, KS
國家衛生研究院 2018-07 4-Bromophenylhydrazinyl benzenesulfonylphenylureas inhibit indoleamine 2,3-dioxygenase in vitro and in vivo Ueng, SH;Kuo, CC;Lin, SY;Yeh, TK;Song, JS;Hung, MS;Chen, CT
國家衛生研究院 2018-05-10 Design and synthesis of BPR1K653 derivatives targeting the back pocket of Aurora kinases for selective isoform inhibition Ke, YY;Chang, CP;Lin, WH;Tsai, CH;Chiu, IC;Wang, WP;Wang, PC;Chen, PY;Lin, WH;Chang, CF;Kuo, PC;Song, JS;Shih, C;Hsieh, HP;Chi, YH
國家衛生研究院 2018-04 4-Bromophenylhydrazinyl benzenesulfonylphenylureas as indoleamine 2,3-dioxygenase inhibitors with in vivo target inhibition and anti-tumor efficacy Lin, SY;Yeh, TK;Song, JS;Hung, MS;Cheng, MF;Liao, FY;Li, AS;Cheng, SY;Lin, LM;Chiu, CH;Wu, MH;Lin, YJ;Hsiao, W;Sun, M;Wang, YH;Huang, CH;Tang, YC;Chang, HH;Huang, ZT;Chao, YS;Shih, C;Pan, SL;Wu, SY;Kuo, CC;Ueng, SH
國家衛生研究院 2018-02-08 Development of stem-cell-mobilizing agents targeting CXCR4 receptor for peripheral blood stem cell transplantation and beyond Wu, CH;Song, JS;Kuan, HH;Wu, SH;Chou, MC;Jan, JJ;Tsou, LK;Ke, YY;Chen, CT;Yeh, KC;Wang, SY;Yeh, TK;Tseng, CT;Huang, CL;Wu, MH;Kuo, PC;Lee, CJ;Shia, KS
國家衛生研究院 2018-01-01 Identification of an oxime-containing C-glucosylarene as a potential inhibitor of sodium-dependent glucose co-transporter 2 Yuan, MC;Yeh, TK;Chen, CT;Song, JS;Huang, YC;Hsieh, TC;Huang, CY;Huang, YL;Wang, MH;Wu, SH;Yao, CH;Chao, YS;Lee, JC
國家衛生研究院 2017-09 trans-stilbene C-glycosides: Synthesis by a microwave-assisted heck reaction and evaluation of the SGLT-2 inhibitory activity KumarPonnapalli, K;KumarAdak, A;Das, A;Song, JS;Wu, SH;Sun, CM;Lin, CC
國家衛生研究院 2017-08-02 Harnessing CXCR4 antagonists in stem cell mobilization, HIV infection, ischemic diseases, and oncology Tsou, LK;Huang, YH;Song, JS;Ke, YY;Huang, JK;Shia, KS
國家衛生研究院 2017-07 Design, synthesis, and evaluation of thiazolidine-2,4-dione derivatives as a novel class of glutaminase inhibitors Yeh, TK;Kuo, CC;Lee, YZ;Ke, YY;Chu, KF;Hsu, HY;Chang, HY;Liu, YW;Song, JS;Yang, CW;Lin, LM;Sun, MW;Wu, SH;Kuo, PC;Shih, C;Chen, CT;Tsou, LK;Lee, SJ
國家衛生研究院 2017-01 A potent, selective, and orally bioavailable HCV NS5A inhibitor for treatment of Hepatitis C Virus: (S)-1-((R)-2-(Cyclopropanecarboxamido)-2-phenylacetyl)-N-(4-phenylthiazo l-2-yl)pyrrolidine-2-carboxamide Kang, IJ;Hsu, SJ;Yang, HY;Yeh, TK;Lee, CC;Lee, YC;Tian, YW;Song, JS;Hsu, TA;Chao, YS;Yueh, A;Chern, JH
國家衛生研究院 2016-12 Discovery of BPR1K871, a quinazoline based, multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, in vitro and in vivo evaluation Chang Hsu, Y;Selvaraj Coumar, M;Wang, WC;Shiao, HY;Ke, YY;Lin, WH;Kuo, CC;Chang, CW;Kuo, FM;Chen, PY;Wang, SY;Li, AS;Chen, CH;Kuo, PC;Chen, CP;Wu, MH;Huang, CL;Yen, KJ;Chang, YI;Hsu, JT;Chen, CT;Yeh, TK;Song, JS;Shih, C;Hsieh, HP
國家衛生研究院 2016-12 Phenyl benzenesulfonylhydrazides: Selective indoleamine 2,3-dioxygenase inhibitors with potent in vivo pharmacodynamic activity and antitumor efficacy Ueng, SH;Yeh, TK;Song, JS;Wu, SY;Kuo, CC;Shih, C;Pan, SL;Hung, MS
國家衛生研究院 2016-05 N-Indolylglycosides bearing modifications at the glucose C6-Position as Sodium-Dependent Glucose Co-transporter 2 inhibitors Chu, KF;Yao, CH;Song, JS;Chen, CT;Yeh, TK;Hsieh, TC;Huang, CY;Wang, MH;Wu, SH;Chang, WE;Chao, YS;Lee, JC
國家衛生研究院 2016-01 Synthesis of (E)-oxindolylidene acetate using tandem palladium-catalyzed Heck and alkoxycarbonylation reactions Lin, WJ;Shia, KS;Song, JS;Wu, MH;Li, WT
國家衛生研究院 2016-01 Important hydrogen bond networks in Indoleamine 2,3-Dioxygenase 1 (IDO1) inhibitor design revealed by crystal structures of imidazoleisoindole derivatives with IDO1 Peng, YH;Ueng, SH;Tseng, CT;Hung, MS;Song, JS;Wu, JS;Liao, FY;Fan, YS;Wu, MH;Hsiao, WC;Hsueh, CC;Lin, SY;Cheng, CY;Tu, CH;Lee, LC;Cheng, MF;Shia, KS;Shih, C;Wu, SY
國家衛生研究院 2016-01 Phenyl benzenesulfonylhydrazides exhibit selective Indoleamine 2,3-Dioxygenase inhibition with potent in vivo pharmacodynamic activity and antitumor efficacy Lin, SY;Yeh, TK;Kuo, CC;Song, JS;Cheng, MF;Liao, FY;Chao, MW;Huang, HL;Chen, YL;Yang, CY;Wu, MH;Hsieh, CL;Hsiao, WC;Peng, YH;Wu, JS;Lin, LM;Sun, MW;Chao, YS;Shih, C;Wu, SY;Pan, SL;Hung, MS;Ueng, SH
國家衛生研究院 2015-10 Identification of substituted naphthotriazolediones as novel tryptophan 2,3-dioxygenase (TDO) inhibitors through structure-based virtual screening Wu, JS;Lin, SY;Liao, FY;Hsiao, WC;Lee, LC;Peng, YH;Hsieh, CL;Wu, MH;Song, JS;Yueh, A;Chen, CH;Yeh, SH;Liu, CY;Lin, SY;Yeh, TK;Hsu, JT;Shih, C;Ueng, SH;Hung, MS;Wu, SY
國家衛生研究院 2015-07 Development and application of a fluorescent glucose uptake assay for the high-throughput screening of non-glycoside SGLT2 inhibitors Wu, SH;Yao, CH;Hsieh, CJ;Liu, YW;Chao, YS;Song, JS;Lee, JC
國家衛生研究院 2015-07 Pharmacological induction of human fetal globin gene in hydroxyurea-resistant primary adult erythroid cells Chou, YC;Chen, RL;Lai, ZS;Song, JS;Chao, YS;Shen, CK
國家衛生研究院 2015-07 Identification of a potent 5-phenyl-thiazol-2-ylamine-based inhibitor of FLT3 with activity against drug resistance-conferring point mutations Chen, CT;Hsu, JTA;Lin, WH;Lu, CT;Yen, SC;Hsu, T;Huang, YL;Song, JS;Chen, CH;Chou, LH;Yen, KJ;Chen, CP;Kuo, PC;Huang, CL;Eugene Liu, H;Chao, YS;Yeh, TK;Jiaang, WT
國家衛生研究院 2015-06-29 Homology modeling of DFG-in FMS-like tyrosine kinase 3 (FLT3) and structure-based virtual screening for inhibitor identification Ke, YY;Singh, VK;Coumar, MS;Hsu, YC;Wang, WC;Song, JS;Chen, CH;Lin, WH;Wu, SH;Hsu, JT;Shih, C;Hsieh, HP
國家衛生研究院 2015-06-15 Synthesis and evaluation of 3-ylideneoxindole acetamides as potent anticancer agents Chiou, CT;Lee, WC;Liao, JH;Cheng, JJ;Lin, LC;Chen, CY;Song, JS;Wu, MH;Shia, KS;Li, WT
國家衛生研究院 2015-03 Stem cell mobilizers targeting chemokine receptor CXCR4: Renoprotective application in acute kidney injury Wu, CH;Song, JS;Chang, KH;Jan, JJ;Chen, CT;Chou, MC;Yeh, KC;Wong, YC;Tseng, CT;Wu, SH;Yeh, CF;Huang, CY;Wang, MH;Sadani, AA;Chang, CP;Cheng, CY;Tsou, LK;Shia, KS
國家衛生研究院 2015-02 Function-oriented development of CXCR4 antagonists as selective human immunodeficiency virus (HIV)-1 entry inhibitors Wu, CH;Wang, CJ;Chang, CP;Cheng, YC;Song, JS;Jan, JJ;Chou, MC;Ke, YY;Ma, J;Wong, YC;Hsieh, TC;Tien, YC;Gullen, EA;Lo, CF;Cheng, CY;Liu, YW;Sadani, AA;Tsai, CH;Hsieh, HP;Tsou, LK;Shia, KS
國家衛生研究院 2014-08 Discovery and structure-activity relationships of phenyl benzenesulfonylhydrazides as novel indoleamine 2,3-dioxygenase inhibitors Cheng, MF;Hung, MS;Song, JS;Lin, SY;Liao, FY;Wu, MH;Hsiao, W;Hsieh, CL;Wu, JS;Chao, YS;Shih, C;Wu, SY;Ueng, SH
國家衛生研究院 2014-08 Ligand efficiency based approach for efficient virtual screening of compound libraries Ke, YY;Coumar, MS;Shiao, HY;Wang, WC;Chen, CW;Song, JS;Chen, CH;Lin, WH;Wu, SH;Hsu, JT;Chang, CM;Hsieh, HP
國家衛生研究院 2013-11-13 Discovery of 1-(2,4-Dichlorophenyl)-N-(piperidin-1-yl)-4-((pyrrolidine-1-sulfonamido)methyl)-5 -(5-((4-(trifluoromethyl)phenyl)ethynyl)thiophene-2-yl)-1H-pyrazole-3-carboxamide as a novel peripherally restricted cannabinoid-1 receptor antagonist with significant weight-loss efficacy in diet-induced obese mice Chang, CP;Wu, CH;Song, JS;Chou, MC;Wong, YC;Lin, Y;Yeh, TK;Sadani, AA;Ou, MH;Chen, KH;Chen, PH;Kuo, PC;Tseng, CT;Chang, KH;Tseng, SL;Chao, YS;Hung, MS;Shia, KS
國家衛生研究院 2013-11 Synthesis and biological evaluation of novel C-aryl d-glucofuranosides as sodium-dependent glucose co-transporter 2 inhibitors Lin, TS;Liw, YW;Song, JS;Hsieh, TC;Yeh, HW;Hsu, LC;Lin, CJ;Wu, SH;Liang, PH
國家衛生研究院 2013-11 BPR0C305, an orally active microtubule-disrupting anticancer agent Li, WT;Yeh, TK;Song, JS;Yang, YN;Chen, TW;Lin, CH;Chen, CP;Shen, CC;Hsieh, CC;Lin, HL;Chao, YS;Chen, CT
國家衛生研究院 2013-06 Discovery of 3-phenyl-1H-5-pyrazolylamine derivatives containing a urea pharmacophore as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3) Lin, WH;Hsu, JTA;Hsieh, SY;Chen, CT;Song, JS;Yen, SC;Hsu, T;Lu, CT;Chen, CH;Chou, LH;Yang, YN;Chiu, CH;Chen, CP;Tseng, YJ;Yen, KJ;Yeh, CF;Chao, YS;Yeh, TK;Jiaang, WT
國家衛生研究院 2013-05 Characterization of an efficient dengue virus replicon for development of assays of discovery of small molecules against dengue virus Yang, CC;Tsai, MH;Hu, HS;Pu, SY;Wu, RH;Wu, SH;Lin, HM;Song, JS;Chao, YS;Yueh, A

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