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Showing items 1-50 of 93 (2 Page(s) Totally)
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| 國家衛生研究院 |
2025-10-01 |
Synthesis and biological evaluation of indoline derivatives as CDGSH iron sulfur domain 2 activators
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Yao, CH;Wang, LY;Shen, ZQ;Huang, YW;Tsai, CH;Song, JS;Chen, CH;Chen, YC;Tsai, TF;Lee, JC |
| 國家衛生研究院 |
2025-03-10 |
CXCR4 antagonist-loaded nanoparticles reprogram the tumor microenvironment and enhance immunotherapy in hepatocellular carcinoma
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Cheng, SL;Wu, CH;Tsai, YJ;Song, JS;Chen, HM;Yeh, TK;Shen, CT;Chiang, JC;Lee, HM;Huang, KW;Chen, Y;Qiu, JT;Yen, YT;Shia, KS;Chen, Y |
| 國家衛生研究院 |
2023-11-15 |
Analysis of structure–activity relationship of indol-3-yl-N-phenylcarbamic amides as potent STING inhibitors
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Chang, PW;Wang, JY;Wang, WP;Huang, WC;Wu, MH;Song, JS;Chen, LY;Tung, CW;Chi, YH;Ueng, SH |
| 國家衛生研究院 |
2023-11-15 |
Analysis of structure-activity relationship of indol-3-yl-N-phenylcarbamic amides as potent STING inhibitors
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Chang, PW;Wang, JY;Wang, WP;Huang, WC;Wu, MH;Song, JS;Chen, LY;Tung, CW;Chi, YH;Ueng, SH |
| 國家衛生研究院 |
2023-10-05 |
Discovery of tetrasubstituted thiophenes as Cisd2 activators: A potential novel therapeutic option in nonalcoholic fatty liver disease
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Yao, CH;Shen, ZQ;Rajan, YC;Huang, YW;Lin, CY;Song, JS;Shiao, HY;Ke, YY;Fan, YS;Tsai, CH;Yeh, TK;Tsai, TF;Lee, JC |
| 國家衛生研究院 |
2023-02-03 |
Design, synthesis, and anticancer evaluation of 1-benzo[1,3]dioxol-5-yl-3-N-fused heteroaryl indoles
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Yao, CH;Wu, MH;Chang, PW;Wu, SH;Song, JS;Huang, HH;Chen, YC;Lee, JC |
| 國家衛生研究院 |
2023-01 |
Modulating the affinity and signaling bias of cannabinoid receptor 1 antagonists
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Hsiao, WC;Hsin, KY;Wu, ZW;Song, JS;Yeh, YN;Chen, YF;Tsai, CH;Chen, PH;Shia, KS;Chang, CP;Hung, MS |
| 國家衛生研究院 |
2022-10-03 |
Protective effect of CXCR4 antagonist DBPR807 against ischemia-reperfusion injury in a rat and porcine model of myocardial infarction: Potential adjunctive therapy for percutaneous coronary intervention
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Yeh, KC;Lee, CJ;Song, JS;Wu, CH;Yeh, TK;Wu, SH;Hsieh, TC;Chen, YT;Tseng, HY;Huang, CL;Chen, CT;Jan, JJ;Chou, MC;Shia, KS;Chiang, KH |
| 國家衛生研究院 |
2022-08-09 |
Chemical interference with DSIF complex formation lowers synthesis of mutant huntingtin gene products and curtails mutant phenotypes
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Deng, N;Wu, YY;Feng, Y;Hsieh, WC;Song, JS;Lin, YS;Tseng, YH;Liao, WJ;Chu, YF;Liu, YC;Chang, EC;Liu, CR;Sheu, SY;Su, MT;Kuo, HC;Cohen, SN;Cheng, TH |
| 國家衛生研究院 |
2022-02-05 |
Discovery and development of a novel N-(3-bromophenyl)-{[(phenylcarbamoyl)amino]methyl}-N-hydroxythiophene-2-carboximidamide indoleamine 2,3-dioxygenase inhibitor using knowledge-based drug design
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Yeh, TK;Song, JS;Chang, PW;Yu, JC;Chang, CH;Liao, FY;Tien, YW;Kuppusamy, R;Li, AS;Chen, CH;Chen, CW;Lin, LM;Chang, HH;Huang, CH;Yao, JY;Wu, MH;Peng, YH;Hsueh, CC;Hsiao, WC;Chen, PH;Lin, CY;Hsieh, SH;Shih, C;Hung, MS;Wu, SY;Kuo, CC;Ueng, SH |
| 國家衛生研究院 |
2021-10-20 |
Heterocyclic compounds and use thereof
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Shih, C;Shih, C;Wu, CH;Choi, Ming Chen;Song, JS;Wang, Y |
| 國家衛生研究院 |
2021-09-24 |
Heterocyclic compounds and their application
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Shih, C;Shia, KS;Wu, CH;Choi, Ming Chen;Song, JS;Wang, Y |
| 國家衛生研究院 |
2021-08-31 |
Heterocyclic compounds and use thereof
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Shih, C;Shia, KS;Wu, CH;Choi, Ming Chen;Song, JS;Wang, Y |
| 國家衛生研究院 |
2021-08-01 |
DBPR108, a novel dipeptidyl peptidase-4 inhibitor with antihyperglycemic activity
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Yeh, KC;Yeh, TK;Huang, CY;Hu, CB;Wang, MH;Huang, YW;Chou, LH;Ho, HH;Song, JS;Hsu, T;Jiaang, WT;Chao, YS;Chen, CT |
| 國家衛生研究院 |
2021-05-19 |
Discovery and synthesis of a pyrimidine-based aurora kinase inhibitor to reduce levels of MYC oncoproteins
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Chi, YH;Yeh, TK;Ke, YY;Lin, WH;Tsai, CH;Wang, WP;Chen, YT;Su, YC;Wang, PC;Chen, YF;Wu, ZW;Yeh, JY;Hung, MC;Wu, MH;Wang, JY;Chen, CP;Song, JS;Shih, C;Chen, CT;Chang, CP |
| 國家衛生研究院 |
2021-04-01 |
Heterocyclic compounds and use thereof
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Shih, C;Shia, KS;Wu, CH;Choi, Ming Chen;Song, JS;Wang, Y |
| 國家衛生研究院 |
2021-03-30 |
A highly selective and potent CXCR4 antagonist for hepatocellular carcinoma treatment
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Song, JS;Chang, CC;Wu, CH;Dinh, TK;Jan, JJ;Huang, KW;Chou, MC;Shiue, TY;Yeh, KC;Ke, YY;Yeh, TK;Ta, YNN;Lee, CJ;Huang, JK;Sung, YC;Shia, KS;Chen, Y |
| 國家衛生研究院 |
2021-03-02 |
Total synthesis of landomycins Q and R and related core structures for exploration of the cytotoxicity and antibacterial properties
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Lai, YH;Mondal, S;Su, HT;Huang, SC;Wu, MH;Huang, I;Yang Lauderdale, TL;Song, JS;Shia, KS;Mong, KK |
| 國家衛生研究院 |
2021-03-02 |
Discovery of potential neuroprotective agents against paclitaxel-induced peripheral neuropathy
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Chen, YF;Wu, CH;Chen, LH;Lee, HW;Lee, JC;Yeh, TK;Chang, JY;Chou, MC;Wu, HL;Lai, YP;Song, JS;Yeh, KC;Chen, CT;Lee, CJ;Shia, KS;Shen, MR |
| 國家衛生研究院 |
2021-01-05 |
Heterocyclic compounds and use thereof
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Shia, KS;Wu, CH;Chou, MC;Song, JS;Wang, Y;Shih, C |
| 國家衛生研究院 |
2020-10-08 |
Comparative study between deep learning and QSAR classifications for TNBC inhibitors and novel GPCR agonist discovery
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Tsou, LK;Yeh, SH;Ueng, SH;Chang, CP;Song, JS;Wu, MH;Chang, HF;Chen, SR;Shih, C;Chen, CT;Ke, YY |
| 國家衛生研究院 |
2020-09-25 |
Protective effect of CXCR4 antagonist CX807 in a rat model of hemorrhagic stroke
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Yu, SJ;Wu, KJ;Wang, YS;Song, JS;Wu, CH;Jan, JJ;Bae, E;Chen, H;Shia, KS;Wang, Y |
| 國家衛生研究院 |
2020-08 |
BPR6K609: An Aurora kinase inhibitor targeting small cell lung cancer with MYC amplification
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Chi, YH;Chang, CP;Ke, YY;Lin, WH;Wang, WP;Tsai, CH;Chen, YT;Su, YJ;Hung, MC;Wu, ZW;Wu, MH;Yeh, TK;Chen, CP;Song, JS;Chen, CT;Shih, C |
| 國家衛生研究院 |
2020-05-15 |
Artificial intelligence approach fighting COVID-19 with repurposing drugs
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Ke, YY;Peng, TT;Yeh, TK;Huang, WZ;Chang, SE;Wu, SH;Hung, HC;Hsu, TA;Lee, SJ;Song, JS;Lin, WH;Chiang, TJ;Lin, JH;Sytwu, HK;Chen, CT |
| 國家衛生研究院 |
2020-05 |
Drug-like property optimization: Discovery of orally bioavailable quinazoline-based multi-targeted kinase inhibitors
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Lin, SY;Chang, CF;Coumar, MS;Chen, PY;Kuo, FM;Chen, CH;Li, MC;Lin, WH;Kuo, PC;Wang, SY;Li, AS;Lin, CY;Yang, CM;Yeh, TK;Song, JS;Hsu, JTA;Hsieh, HP |
| 國家衛生研究院 |
2020-02-10 |
Unique sulfur-aromatic interactions contribute to the binding of potent imidazothiazole indoleamine 2,3-Dioxygenase inhibitors
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Peng, YH;Liao, FY;Tseng, CT;Kuppusamy, R;Li, AS;Chen, CH;Fan, YS;Wang, SY;Wu, MH;Hsueh, CC;Chang, JY;Lee, LC;Shih, C;Shia, KS;Yeh, TK;Hung, MS;Kuo, CC;Song, JS;Wu, SY;Ueng, SH |
| 國家衛生研究院 |
2019-12-09 |
Design, synthesis and anticancer evaluation of beta-carboline-1-one hydantoins
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Yao, CH;Hsieh, TC;Song, JS;Lee, JC |
| 國家衛生研究院 |
2019-12 |
Identification of a multitargeted tyrosine kinase inhibitor for the treatment of gastrointestinal stromal tumors and acute myeloid leukemia
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Lin, WH;Wu, SY;Yeh, TK;Chen, CT;Song, JS;Shiao, HY;Kuo, CC;Hsu, T;Lu, CT;Wang, PC;Wu, TS;Peng, YH;Lin, HY;Chen, CP;Weng, YL;Kung, FC;Wu, MH;Su, YC;Huang, KW;Chou, LH;Hsueh, CC;Yen, KJ;Kuo, PC;Huang, CL;Chen, LT;Shih, C;Tsai, HJ;Jiaang, WT |
| 國家衛生研究院 |
2019-10-22 |
A novel flavivirus entry inhibitor, BP34610, discovered through high-throughput screening with dengue reporter viruses
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Yang, CC;Hu, HS;Lin, HM;Wu, PS;Wu, RH;Tian, JN;Wu, SH;Tsou, LK;Song, JS;Chen, HW;Chern, JH;Chen, CT;Yueh, A |
| 國家衛生研究院 |
2019-09 |
Effects of boschnaloside from Boschniakia rossica on dysglycemia and islet dysfunction in severely diabetic mice through modulating the action of glucagon-like peptide-1
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Lin, LC;Lee, LC;Huang, C;Chen, CT;Song, JS;Shiao, YJ;Liu, HK |
| 國家衛生研究院 |
2019-07 |
An Aurora kinase inhibitor BPR6K471 inhibits tumor growth and reduces the cancer stem cell-like properties of small cell lung cancer
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Chang, CP;Ke, YY;Lin, WH;Jhuo, DH;Wang, WP;Tsai, CH;Chen, YT;Su, YJ;Hung, MC;Wu, ZW;Kuo, PC;Yeh, TK;Chen, CP;Song, JS;Chen, CT;Shih, C;Chi, YH |
| 國家衛生研究院 |
2019-04-10 |
Discovery of Conformational Control Inhibitors Switching off the Activated c-KIT and Targeting a Broad Range of Clinically Relevant c-KIT Mutants
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Wu, TS;Lin, WH;Tsai, HJ;Hsueh, CC;Hsu, T;Wang, PC;Lin, HY;Peng, YH;Lu, CT;Lee, LC;Tu, CH;Kung, FC;Shiao, HY;Yeh, TK;Song, JS;Chang, JY;Su, YC;Chen, LT;Chen, CT;Jiaang, WT;Wu, SY |
| 國家衛生研究院 |
2019-03 |
Synthesis and biological evaluation of N-glucosyl indole derivatives as sodium-dependent glucose co-transporter 2 inhibitors
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Chu, KF;Song, JS;Chen, CT;Yeh, TK;Hsieh, TC;Huang, CY;Wang, MH;Wu, SH;Yao, CH;Chao, YS;Lee, JC |
| 國家衛生研究院 |
2019-02-28 |
Characterization, dynamics, and mechanism of CXCR4 antagonists on a constitutively active mutant
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Rosenberg, EM, Jr.;Harrison, RES;Tsou, LK;Drucker, N;Humphries, B;Rajasekaran, D;Luker, KE;Wu, CH;Song, JS;Wang, CJ;Murphy, JW;Cheng, YC;Shia, KS;Luker, GD;Morikis, D;Lolis, EJ |
| 國家衛生研究院 |
2019-01-01 |
Fluorine-18 isotope labeling for positron emission tomography imaging. Direct evidence for DBPR211 as a peripherally restricted CB1 inverse agonist
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Chang, CP;Huang, HL;Huang, JK;Hung, MS;Wu, CH;Song, JS;Lee, CJ;Yu, CS;Shia, KS |
| 國家衛生研究院 |
2018-07 |
4-Bromophenylhydrazinyl benzenesulfonylphenylureas inhibit indoleamine 2,3-dioxygenase in vitro and in vivo
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Ueng, SH;Kuo, CC;Lin, SY;Yeh, TK;Song, JS;Hung, MS;Chen, CT |
| 國家衛生研究院 |
2018-05-10 |
Design and synthesis of BPR1K653 derivatives targeting the back pocket of Aurora kinases for selective isoform inhibition
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Ke, YY;Chang, CP;Lin, WH;Tsai, CH;Chiu, IC;Wang, WP;Wang, PC;Chen, PY;Lin, WH;Chang, CF;Kuo, PC;Song, JS;Shih, C;Hsieh, HP;Chi, YH |
| 國家衛生研究院 |
2018-04 |
4-Bromophenylhydrazinyl benzenesulfonylphenylureas as indoleamine 2,3-dioxygenase inhibitors with in vivo target inhibition and anti-tumor efficacy
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Lin, SY;Yeh, TK;Song, JS;Hung, MS;Cheng, MF;Liao, FY;Li, AS;Cheng, SY;Lin, LM;Chiu, CH;Wu, MH;Lin, YJ;Hsiao, W;Sun, M;Wang, YH;Huang, CH;Tang, YC;Chang, HH;Huang, ZT;Chao, YS;Shih, C;Pan, SL;Wu, SY;Kuo, CC;Ueng, SH |
| 國家衛生研究院 |
2018-02-08 |
Development of stem-cell-mobilizing agents targeting CXCR4 receptor for peripheral blood stem cell transplantation and beyond
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Wu, CH;Song, JS;Kuan, HH;Wu, SH;Chou, MC;Jan, JJ;Tsou, LK;Ke, YY;Chen, CT;Yeh, KC;Wang, SY;Yeh, TK;Tseng, CT;Huang, CL;Wu, MH;Kuo, PC;Lee, CJ;Shia, KS |
| 國家衛生研究院 |
2018-01-01 |
Identification of an oxime-containing C-glucosylarene as a potential inhibitor of sodium-dependent glucose co-transporter 2
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Yuan, MC;Yeh, TK;Chen, CT;Song, JS;Huang, YC;Hsieh, TC;Huang, CY;Huang, YL;Wang, MH;Wu, SH;Yao, CH;Chao, YS;Lee, JC |
| 國家衛生研究院 |
2017-09 |
trans-stilbene C-glycosides: Synthesis by a microwave-assisted heck reaction and evaluation of the SGLT-2 inhibitory activity
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KumarPonnapalli, K;KumarAdak, A;Das, A;Song, JS;Wu, SH;Sun, CM;Lin, CC |
| 國家衛生研究院 |
2017-08-02 |
Harnessing CXCR4 antagonists in stem cell mobilization, HIV infection, ischemic diseases, and oncology
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Tsou, LK;Huang, YH;Song, JS;Ke, YY;Huang, JK;Shia, KS |
| 國家衛生研究院 |
2017-07 |
Design, synthesis, and evaluation of thiazolidine-2,4-dione derivatives as a novel class of glutaminase inhibitors
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Yeh, TK;Kuo, CC;Lee, YZ;Ke, YY;Chu, KF;Hsu, HY;Chang, HY;Liu, YW;Song, JS;Yang, CW;Lin, LM;Sun, MW;Wu, SH;Kuo, PC;Shih, C;Chen, CT;Tsou, LK;Lee, SJ |
| 國家衛生研究院 |
2017-01 |
A potent, selective, and orally bioavailable HCV NS5A inhibitor for treatment of Hepatitis C Virus: (S)-1-((R)-2-(Cyclopropanecarboxamido)-2-phenylacetyl)-N-(4-phenylthiazo l-2-yl)pyrrolidine-2-carboxamide
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Kang, IJ;Hsu, SJ;Yang, HY;Yeh, TK;Lee, CC;Lee, YC;Tian, YW;Song, JS;Hsu, TA;Chao, YS;Yueh, A;Chern, JH |
| 國家衛生研究院 |
2016-12 |
Discovery of BPR1K871, a quinazoline based, multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, in vitro and in vivo evaluation
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Chang Hsu, Y;Selvaraj Coumar, M;Wang, WC;Shiao, HY;Ke, YY;Lin, WH;Kuo, CC;Chang, CW;Kuo, FM;Chen, PY;Wang, SY;Li, AS;Chen, CH;Kuo, PC;Chen, CP;Wu, MH;Huang, CL;Yen, KJ;Chang, YI;Hsu, JT;Chen, CT;Yeh, TK;Song, JS;Shih, C;Hsieh, HP |
| 國家衛生研究院 |
2016-12 |
Phenyl benzenesulfonylhydrazides: Selective indoleamine 2,3-dioxygenase inhibitors with potent in vivo pharmacodynamic activity and antitumor efficacy
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Ueng, SH;Yeh, TK;Song, JS;Wu, SY;Kuo, CC;Shih, C;Pan, SL;Hung, MS |
| 國家衛生研究院 |
2016-05 |
N-Indolylglycosides bearing modifications at the glucose C6-Position as Sodium-Dependent Glucose Co-transporter 2 inhibitors
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Chu, KF;Yao, CH;Song, JS;Chen, CT;Yeh, TK;Hsieh, TC;Huang, CY;Wang, MH;Wu, SH;Chang, WE;Chao, YS;Lee, JC |
| 國家衛生研究院 |
2016-01 |
Synthesis of (E)-oxindolylidene acetate using tandem palladium-catalyzed Heck and alkoxycarbonylation reactions
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Lin, WJ;Shia, KS;Song, JS;Wu, MH;Li, WT |
| 國家衛生研究院 |
2016-01 |
Important hydrogen bond networks in Indoleamine 2,3-Dioxygenase 1 (IDO1) inhibitor design revealed by crystal structures of imidazoleisoindole derivatives with IDO1
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Peng, YH;Ueng, SH;Tseng, CT;Hung, MS;Song, JS;Wu, JS;Liao, FY;Fan, YS;Wu, MH;Hsiao, WC;Hsueh, CC;Lin, SY;Cheng, CY;Tu, CH;Lee, LC;Cheng, MF;Shia, KS;Shih, C;Wu, SY |
| 國家衛生研究院 |
2016-01 |
Phenyl benzenesulfonylhydrazides exhibit selective Indoleamine 2,3-Dioxygenase inhibition with potent in vivo pharmacodynamic activity and antitumor efficacy
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Lin, SY;Yeh, TK;Kuo, CC;Song, JS;Cheng, MF;Liao, FY;Chao, MW;Huang, HL;Chen, YL;Yang, CY;Wu, MH;Hsieh, CL;Hsiao, WC;Peng, YH;Wu, JS;Lin, LM;Sun, MW;Chao, YS;Shih, C;Wu, SY;Pan, SL;Hung, MS;Ueng, SH |
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