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| 國家衛生研究院 |
2024-11-08 |
Endosomes serve as signaling platforms for RIG-I ubiquitination and activation
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Chen, KR;Yang, CY;Shu, SG;Lo, YC;Lee, KW;Wang, LC;Chen, JB;Shih, MC;Chang, HC;Hsiao, YJ;Wu, CL;Tan, TH;Ling, P |
| 國家衛生研究院 |
2024-09 |
The role of dual specificity phosphatase 22 (DUSP22) in rheumatoid arthritis: Mechanism and genetic investigations
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Hung, WT;Chen, YM;Huang, WN;Yen, TH;Tan, TH;Chuang, HC |
| 國家衛生研究院 |
2024-06-14 |
DUSP22 inhibits lung tumorigenesis by suppression of EGFR/c-Met signaling
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Lin, HH;Chang, CW;Liao, YT;Yeh, SD;Lin, HP;Ho, HM;Cheung, CHY;Juan, HF;Chen, YR;Su, YW;Chen, LM;Tan, TH;Lin, WJ |
| 國家衛生研究院 |
2024-06 |
UHRF1P contributes to IL-17A-mediated systemic lupus erythematosus via UHRF1-MAP4K3 axis
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Chuang, HC;Lan, KY;Hsu, PM;Chen, MH;Chen, YM;Yen, JH;Liao, BY;Tan, TH |
| 國家衛生研究院 |
2024-05-01 |
Sequential regulation of Lck K63-ubiquitination and autophosphorylation by the E3 ligase UBR2 and the phosphatase DUSP22 in TCR signaling
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Tan, TH;Chuang, HC |
| 國家衛生研究院 |
2024-05-01 |
DUSP8 promotes IL-9 transcription by inactivating Pur-alpha leading to asthma and atopic dermatitis
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Chuang, HC;Tan, TH |
| 國家衛生研究院 |
2024-05-01 |
Machine learning reveals UHRF-X as a biomarker for systemic lupus erythematosus and an antagonistic protein against UHRF1 E3 ligase
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Chuang, HC;Tan, TH |
| 國家衛生研究院 |
2024-03-27 |
Association of TRAIL receptor with phosphatase SHP-1 enables repressing T cell receptor signaling and T cell activation through inactivating Lck
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Chyuan, IT;Liao, HJ;Tan, TH;Chuang, HC;Chu, YC;Pan, MH;Wu, CS;Chu, CL;Sheu, BC;Hsu, PN |
| 國家衛生研究院 |
2024-01-15 |
The phosphatase DUSP22 inhibits UBR2-mediated K63-ubiquitination and activation of Lck downstream of TCR signalling
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Shih, YC;Chen, HF;Wu, CY;Ciou, YR;Wang, CW;Chuang, HC;Tan, TH |
| 國家衛生研究院 |
2023-12-05 |
Dual-specificity phosphatase 6 deficiency attenuates arterial-injury-induced intimal hyperplasia in mice
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Hamdin, CD;Wu, ML;Chen, CM;Ho, YC;Jiang, WC;Gung, PY;Ho, HH;Chuang, HC;Tan, TH;Yet, SF |
| 國家衛生研究院 |
2023-11-01 |
DUSP8 induces TGF-beta–stimulated IL-9 transcription and Th9-mediated allergic inflammation by promoting nuclear export of Pur-Alpha
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Chuang, HC;Hsueh, CH;Hsu, PM;Tsai, CY;Shih, YC;Chiu, HY;Chen, YM;Yu, WK;Chen, MH;Tan, TH |
| 國家衛生研究院 |
2023-08-22 |
ACE2 in chronic disease and COVID-19: Gene regulation and post-translational modification
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Wang, CW;Chuang, HC;Tan, TH |
| 國家衛生研究院 |
2023-05-04 |
Hematopoietic progenitor kinase 1 inhibits the development and progression of pancreatic intraepithelial neoplasia
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Wang, H;Moniruzzaman, R;Li, L;Ji, B;Liu, Y;Zuo, X;Abbasgholizadeh, R;Zhao, J;Liu, G;Wang, R;Tang, H;Sun, R;Su, X;Tan, TH;Maitra, A;Wang, H |
| 國家衛生研究院 |
2023-05-01 |
DUSP8 induces TGF-Beta-stimulated IL-9 transcription and Th9-mediated immune responses by inactivating a transcriptional repressor
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Chuang, HC;Tan, TH |
| 國家衛生研究院 |
2023-04-22 |
DUSP6 deficiency attenuates neurodegeneration after global cerebral ischemia
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Weng, YC;Huang, YT;Chiang, IC;Chuang, HC;Lee, TH;Tan, TH;Chou, WH |
| 國家衛生研究院 |
2023-02-10 |
Dual-specificity phosphatases 22-deficient T cells contribute to the pathogenesis of ankylosing spondylitis
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Chen, MH;Chuang, HC;Yeh, YC;Chou, CT;Tan, TH |
| 國家衛生研究院 |
2022-07-27 |
SARS-CoV-2 spike protein enhances MAP4K3/GLK-induced ACE2 stability in COVID-19
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Chuang, HC;Hsueh, CH;Hsu, PM;Huang, RH;Tsai, CY;Chung, NH;Chow, YH;Tan, TH |
| 國家衛生研究院 |
2022-07-18 |
MAP4K3/GLK inhibits Treg differentiation by direct phosphorylating IKK beta and inducing IKK beta-mediated FoxO1 nuclear export and Foxp3 downregulation
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Chi, JN;Yang, JY;Hsueh, CH;Tsai, CY;Chuang, HC;Tan, TH |
| 國家衛生研究院 |
2022-06-15 |
DUSP3 regulates phosphorylation-mediated degradation of occludin and is required for maintaining epithelial tight junction
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Chou, HC;Cheng, CM;Yang, CH;Lin, TY;Liu, YW;Tan, TH;Chen, YR |
| 國家衛生研究院 |
2022-06-14 |
AhR-ROR-γt complex as a biomarker and therapeutic target for autoimmune disease and IL-17A-associated disease
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Tan, TH;Chuang, HC |
| 國家衛生研究院 |
2022-02-18 |
Single-cell RNA sequencing uncovers the individual alteration of intestinal mucosal immunocytes in Dusp6 knockout mice
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Chang, CS;Yu, WH;Su, CC;Ruan, JW;Lin, CM;Huang, CT;Tsai, YT;Lin, IJ;Lai, CY;Chuang, TH;Lin, WJ;Tan, TH;Huang, HC;Juan, HF;Kao, CY |
| 國家衛生研究院 |
2021-11-23 |
Identification of a gut microbiota member that ameliorates DSS-induced colitis in intestinal barrier enhanced Dusp6-deficient mice
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Chang, CS; Liao, YC; Huang, CT; Lin, CM; Cheung, CHY; Ruan, JW; Yu, WH; Tsai, YT; Lin, IJ; Huang, CH; Liou, JS; Chou, YH; Chien, HJ; Chuang, HL; Juan, HF; Huang, HC; Chan, HL; Liao, YC; Tang, SC; Su, YW; Tan, TH; Bäumler, AJ; Kao, CY |
| 國家衛生研究院 |
2021-10-25 |
BPI overexpression suppresses Treg differentiation and induces exosome-mediated inflammation in systemic lupus erythematosus
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Chuang, HC;Chen, MH;Chen, YM;Yang, HY;Ciou, YR;Hsueh, CH;Tsai, CY;Tan, TH |
| 國家衛生研究院 |
2021-10-05 |
Genomic sequencing and functional analyses identify MAP4K3/GLK germline and somatic variants associated with systemic lupus erythematosus
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Chuang, HC;Hung, WT;Chen, YM;Hsu, PM;Yen, JH;Lan, JL;Tan, TH |
| 國家衛生研究院 |
2021-07-05 |
ECP overexpression in T cells and exosomes induces IFN-gamma production and tissue inflammation
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Chuang, HC;Chen, MH;Chen, YM;Ciou, YR;Hsueh, CH;Tsai, CY;Tan, TH |
| 國家衛生研究院 |
2020-10-12 |
Structural insights into the active site formation of dusp22 in n-loop-containing protein tyrosine phosphatases
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Lai, CH;Chang, CC;Chuang, HC;Tan, TH;Lyu, PC |
| 國家衛生研究院 |
2020-08-12 |
DUSP11 attenuates lipopolysaccharide-induced macrophage activation by targeting TAK1
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Yang, CY;Chuang, HC;Tsai, CY;Xiao, YZ;Yang, JY;Huang, RH;Shih, YC;Tan, TH |
| 國家衛生研究院 |
2019-12 |
DUSP22 suppresses prostate cancer proliferation by targeting the EGFR-AR axis
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Lin, HP;Ho, HM;Chang, CW;Yeh, SD;Su, YW;Tan, TH;Lin, WJ |
| 國家衛生研究院 |
2019-11-13 |
MAP4K family kinases and DUSP family phosphatases in T-Cell signaling and systemic lupus erythematosus
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Chuang, HC;Tan, TH |
| 國家衛生研究院 |
2019-10-22 |
MAP4K3/GLK in autoimmune disease, cancer and aging
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Chuang, HC;Tan, TH |
| 國家衛生研究院 |
2019-08-20 |
MAP4K3/GLK promotes lung cancer metastasis by phosphorylating and activating IQGAP1
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Chuang, HC;Chang, CC;Teng, CF;Hsueh, CH;Chiu, LL;Hsu, PM;Lee, MC;Hsu, CP;Chen, YR;Liu, YC;Lyu, PC;Tan, TH |
| 國家衛生研究院 |
2019-07-18 |
AhR-ROR-gammat complex is a therapeutic target for MAP4K3/GLK(high)IL-17A(high) subpopulation of systemic lupus erythematosus
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Chuang, HC;Chen, YM;Chen, MH;Hung, WT;Yang, HY;Tseng, YH;Tan, TH |
| 國家衛生研究院 |
2019-05-30 |
Regulation of Dual-Specificity Phosphatase (DUSP) ubiquitination and protein stability
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Chen, HF;Chuang, HC;Tan, TH |
| 國家衛生研究院 |
2019-05 |
MAP4K3/GLK-induced AhR-RORyt complex is a novel therapeutic target for GLIC(high)IL-17A(high) subpopulation of SLE patients
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Chuang, HC;Tan, TH |
| 國家衛生研究院 |
2019-05 |
Control of mucosal barrier functions and gut microbiome homeostasis by DUSP6 in colitis
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Kao, CY;Chang, CS;Liao, YC;Huang, CT;Ruan, JW;Lin, CM;Tan, TH;Liao, YC |
| 國家衛生研究院 |
2019-05 |
T-cell signaling in Th17-mediated inflammation
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Tan, TH;Chuang, HC |
| 國家衛生研究院 |
2019-03-01 |
MAP4K4 inhibition promotes survival of human stem cell-derived cardiomyocytes and reduces infarct size in vivo
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Fiedler, LR;Chapman, K;Xie, M;Maifoshie, E;Jenkins, M;Golforoush, PA;Bellahcene, M;Noseda, M;Faust, D;Jarvis, A;Newton, G;Paiva, MA;Harada, M;Stuckey, DJ;Song, W;Habib, J;Narasimham, P;Aqil, R;Sanmugalingam, D;Yan, R;Pavanello, L;Sano, M;Wang, SC;Sampson, RD;Kanayaganam, S;Taffet, GE;Michael, LH;Entman, ML;Tan, TH;Harding, SE;Low, CMR;Tralau-Stewart, C;Perrior, T;Schneider, MD |
| 國家衛生研究院 |
2018-2018 |
MAP4K3 (GLK)
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Chuang, HC;Tan, TH |
| 國家衛生研究院 |
2018-12 |
RBM4-SRSF3-MAP4K4 splicing cascade modulates the metastatic signature of colorectal cancer cell
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Lin, JC;Lee, YC;Tan, TH;Liang, YC;Chuang, HC;Fann, YC;Johnson, KR;Lin, YJ |
| 國家衛生研究院 |
2018-09-20 |
PP4 deficiency leads to DNA replication stress that impairs immunoglobulin class switch efficiency
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Chen, MY;Hsu, WC;Hsu, SC;Yang, YS;Chuang, TH;Lin, WJ;Tan, TH;Su, YW |
| 國家衛生研究院 |
2018-09-12 |
GLK-IKKbeta signaling induces dimerization and translocation of the AhR-RORgammat complex in IL-17A induction and autoimmune disease
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Chuang, HC;Tsai, CY;Hsueh, CH;Tan, TH |
| 國家衛生研究院 |
2018-09-06 |
RBM4A-SRSF3-MAP4K4 splicing cascade constitutes a molecular mechanism for regulating brown adipogenesis
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Peng, HY;Liang, YC;Tan, TH;Chuang, HC;Lin, YJ;Lin, JC |
| 國家衛生研究院 |
2018-08-21 |
DUSP6 mediates T cell receptor-engaged glycolysis and restrains TFH cell differentiation
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Hsu, WC;Chen, MY;Hsu, SC;Huang, LR;Kao, CY;Cheng, WH;Pan, CH;Wu, MS;Yu, GY;Hung, MS;Leu, CM;Tan, TH;Su, YW |
| 國家衛生研究院 |
2018-06-19 |
Induction of DUSP14 ubiquitination by PRMT5-mediated arginine methylation
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Yang, CY;Chiu, LL;Chang, CC;Chuang, HC;Tan, TH |
| 國家衛生研究院 |
2017-11 |
Deficiency in VHR/DUSP3, a suppressor of focal adhesion kinase, reveals its role in regulating cell adhesion and migration
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Chen, YR;Chou, HC;Yang, CH;Chen, HY;Liu, YW;Lin, TY;Yeh, CL;Chao, WT;Tsou, HH;Chuang, HC;Tan, TH |
| 國家衛生研究院 |
2017-07-19 |
MAP4k3 as a biomarker and therapetic target for autoimmune disease, cancer, inflammation and il-17- associated disease
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Tan, TH;Chuang, HC |
| 國家衛生研究院 |
2017-02 |
Dual-specificity phosphatase 6 deficiency regulates gut microbiome and transcriptome response against diet-induced obesity in mice
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Ruan, JW;Statt, S;Huang, CT;Tsai, YT;Kuo, CC;Chan, HL;Liao, YC;Tan, TH;Kao, CY |
| 國家衛生研究院 |
2017-01-07 |
MAP4K4 and IL-6+ Th17 cells play important roles in non-obese type 2 diabetes
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Chuang, HC;Tan, TH |
| 國家衛生研究院 |
2016-08 |
Downregulation of the phosphatase JKAP/DUSP22 in T Cells as a potential new biomarker of systemic lupus erythematosus nephritis
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Chuang, HC;Chen, YM;Hung, WT;Li, JP;Chen, DY;Lan, JL;Tan, TH |
| 國家衛生研究院 |
2016-08 |
Roles of innate immune regulator TAPE in RIG-I signaling and antiviral defenses
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Chen, KR;Yang, CY;Lin, CY;Lin, WY;Lo, YC;Chuang, HC;Tan, TH;Ling, P |
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