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"yeh tk"
Showing items 36-85 of 169 (4 Page(s) Totally)
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| 國家衛生研究院 |
2021-01 |
BPRDP056, a novel small molecule drug conjugate specifically targeting phosphatidylserine for cancer therapy
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Chen, YY;Lo, CF;Chiu, TY;Hsu, CY;Yeh, TK;Chen, CP;Huang, CL;Huang, CY;Wang, MH;Huang, YC;Ho, HH;Chao, YS;Shih, JC;Tsou, LK;Chen, CT |
| 國家衛生研究院 |
2020-10-16 |
Potent and orally active purine-based fetal hemoglobin inducers for treating Beta-thalassemia and sickle cell disease
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Lai, ZS;Yeh, TK;Chou, YC;Hsu, T;Lu, CT;Kung, FC;Hsieh, MY;Lin, CH;Chen, CT;James Shen, CK;Jiaang, WT |
| 國家衛生研究院 |
2020-08 |
BPR6K609: An Aurora kinase inhibitor targeting small cell lung cancer with MYC amplification
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Chi, YH;Chang, CP;Ke, YY;Lin, WH;Wang, WP;Tsai, CH;Chen, YT;Su, YJ;Hung, MC;Wu, ZW;Wu, MH;Yeh, TK;Chen, CP;Song, JS;Chen, CT;Shih, C |
| 國家衛生研究院 |
2020-07-07 |
Overcoming vincristine resistance in cancer: Computational design and discovery of piperine-inspired P-glycoprotein inhibitors
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Syed, SB;Lin, SY;Arya, H;Fu, IH;Yeh, TK;Charles, MRC;Periyasamy, L;Hsieh, HP;Coumar, MS |
| 國家衛生研究院 |
2020-05-23 |
Repurposing old drugs as antiviral agents for coronaviruses
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Yang, CW;Peng, TT;Hsu, HY;Lee, YZ;Wu, SH;Lin, WH;Ke, YY;Hsu, TA;Yeh, TK;Huang, WZ;Lin, JH;Sytwu, HK;Chen, CT;Lee, SJ |
| 國家衛生研究院 |
2020-05-15 |
Artificial intelligence approach fighting COVID-19 with repurposing drugs
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Ke, YY;Peng, TT;Yeh, TK;Huang, WZ;Chang, SE;Wu, SH;Hung, HC;Hsu, TA;Lee, SJ;Song, JS;Lin, WH;Chiang, TJ;Lin, JH;Sytwu, HK;Chen, CT |
| 國家衛生研究院 |
2020-05 |
Drug-like property optimization: Discovery of orally bioavailable quinazoline-based multi-targeted kinase inhibitors
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Lin, SY;Chang, CF;Coumar, MS;Chen, PY;Kuo, FM;Chen, CH;Li, MC;Lin, WH;Kuo, PC;Wang, SY;Li, AS;Lin, CY;Yang, CM;Yeh, TK;Song, JS;Hsu, JTA;Hsieh, HP |
| 國家衛生研究院 |
2020-02-18 |
Impacts of intralipid on nanodrug abraxane therapy and on the innate immune system
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Chen, YJ;Tsai, CY;Cheng, YM;Nieh, SW;Yeh, TK;Chen, CP;Wang, MH;Chou, LH;Chiu, TY;Liu, L;Ho, C;Chen, CT;Liu, TW |
| 國家衛生研究院 |
2020-02-10 |
Unique sulfur-aromatic interactions contribute to the binding of potent imidazothiazole indoleamine 2,3-Dioxygenase inhibitors
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Peng, YH;Liao, FY;Tseng, CT;Kuppusamy, R;Li, AS;Chen, CH;Fan, YS;Wang, SY;Wu, MH;Hsueh, CC;Chang, JY;Lee, LC;Shih, C;Shia, KS;Yeh, TK;Hung, MS;Kuo, CC;Song, JS;Wu, SY;Ueng, SH |
| 國家衛生研究院 |
2020-02-01 |
Protective effects of 10,11-dihydro-5H-dibenzo[b,f]azepine hydroxamates on vascular cognitive impairment
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Kaur, N;Fang, YC;Lee, HY;Singh, A;Nepali, K;Lin, MH;Yeh, TK;Lai, MJ;Chan, L;Tu, YK;Banerjee, S;Hu, CJ;Liou, JP |
| 國家衛生研究院 |
2019-12 |
Identification of a multitargeted tyrosine kinase inhibitor for the treatment of gastrointestinal stromal tumors and acute myeloid leukemia
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Lin, WH;Wu, SY;Yeh, TK;Chen, CT;Song, JS;Shiao, HY;Kuo, CC;Hsu, T;Lu, CT;Wang, PC;Wu, TS;Peng, YH;Lin, HY;Chen, CP;Weng, YL;Kung, FC;Wu, MH;Su, YC;Huang, KW;Chou, LH;Hsueh, CC;Yen, KJ;Kuo, PC;Huang, CL;Chen, LT;Shih, C;Tsai, HJ;Jiaang, WT |
| 國家衛生研究院 |
2019-10 |
Discovery of clinical candidate DBPR112, a furanopyrimidine-based epidermal growth factor receptor inhibitor for the treatment of non-small cell lung cancer
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Hsieh, HP;Chang, JY;Yeh, CT;Lin, SY;Ke, YY;Lin, WH;Hsu, TA;Wu, SY;Yeh, TK |
| 國家衛生研究院 |
2019-09-27 |
Discovery of a furanopyrimidine-based epidermal growth factor receptor inhibitor (DBPR112) as a clinical candidate for the treatment of non-small cell lung cancer
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Lin, SY;Chang Hsu, Y;Peng, YH;Ke, YY;Lin, WH;Sun, HY;Shiao, HY;Kuo, FM;Chen, PY;Lien, TW;Chen, CH;Chu, CY;Wang, SY;Yeh, KC;Chen, CP;Hsu, TA;Wu, SY;Yeh, TK;Chen, CT;Hsieh, HP |
| 國家衛生研究院 |
2019-07-11 |
Linker optimization and therapeutic evaluation of phosphatidylserine-targeting zinc dipicolylamine-based drug conjugates
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Liu, YW;Chen, YY;Hsu, CY;Chiu, TY;Liu, KL;Lo, CF;Fang, MY;Huang, YC;Yeh, TK;Pak, KY;Gray, BD;Hsu, TA;Huang, KH;Shih, C;Shia, KS;Chen, CT;Tsou, LK |
| 國家衛生研究院 |
2019-07-03 |
BPR1M97, a dual mu opioid receptor/nociceptin-orphanin FQ peptide receptor agonist, produces potent antinociceptive effects with safer properties than morphine
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Chao, PK;Chang, HF;Chang, WT;Yeh, TK;Ou, LC;Chuang, JY;Tsu-An Hsu, J;Tao, PL;Loh, HH;Shih, C;Ueng, SH;Yeh, SH |
| 國家衛生研究院 |
2019-07 |
BPRDP056, a novel small molecule drug conjugate specifically targeting phosphatidylserine for cancer therapy
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Hsu, CY;Chen, YY;Lo, CF;Chiu, TY;Chen, CP;Huang, CL;Huang, CY;Wang, MH;Chao, YS;Shih, JC;Yeh, TK;Tsou, LK;Chen, CT |
| 國家衛生研究院 |
2019-07 |
An Aurora kinase inhibitor BPR6K471 inhibits tumor growth and reduces the cancer stem cell-like properties of small cell lung cancer
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Chang, CP;Ke, YY;Lin, WH;Jhuo, DH;Wang, WP;Tsai, CH;Chen, YT;Su, YJ;Hung, MC;Wu, ZW;Kuo, PC;Yeh, TK;Chen, CP;Song, JS;Chen, CT;Shih, C;Chi, YH |
| 國家衛生研究院 |
2019-06-05 |
Delta-opioid receptor antagonist naltrindole reduces oxycodone addiction and constipation in mice
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Yang, PP;Yeh, TK;Loh, HH;Law, PY;Wang, Y;Tao, PL |
| 國家衛生研究院 |
2019-04-10 |
Discovery of Conformational Control Inhibitors Switching off the Activated c-KIT and Targeting a Broad Range of Clinically Relevant c-KIT Mutants
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Wu, TS;Lin, WH;Tsai, HJ;Hsueh, CC;Hsu, T;Wang, PC;Lin, HY;Peng, YH;Lu, CT;Lee, LC;Tu, CH;Kung, FC;Shiao, HY;Yeh, TK;Song, JS;Chang, JY;Su, YC;Chen, LT;Chen, CT;Jiaang, WT;Wu, SY |
| 國家衛生研究院 |
2019-04-01 |
A novel, potent, and orally bioavailable thiazole HCV NS5A inhibitor for the treatment of hepatitis C virus
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Yeh, TK;Kang, IJ;Hsu, TA;Lee, YC;Lee, CC;Hsu, SJ;Tian, YW;Yang, HY;Chen, CT;Chao, YS;Yueh, A;Chern, JH |
| 國家衛生研究院 |
2019-03 |
Synthesis and biological evaluation of N-glucosyl indole derivatives as sodium-dependent glucose co-transporter 2 inhibitors
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Chu, KF;Song, JS;Chen, CT;Yeh, TK;Hsieh, TC;Huang, CY;Wang, MH;Wu, SH;Yao, CH;Chao, YS;Lee, JC |
| 國家衛生研究院 |
2019-02-21 |
Synthesis and evaluation of novel 7H-pyrrolo-[2,3-d]pyrimidine derivatives as potential anticancer agents
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Liu, YM;Chen, CH;Yeh, TK;Liou, JP |
| 國家衛生研究院 |
2018-08-23 |
5-aroylindoles act as selective histone deacetylase 6 inhibitors ameliorating alzheimer's disease phenotypes
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Lee, HY;Fan, SJ;Huang, FI;Chao, HY;Hsu, KC;Lin, TE;Yeh, TK;Lai, MJ;Li, YH;Huang, HL;Yang, CR;Liou, JP |
| 國家衛生研究院 |
2018-07 |
4-Bromophenylhydrazinyl benzenesulfonylphenylureas inhibit indoleamine 2,3-dioxygenase in vitro and in vivo
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Ueng, SH;Kuo, CC;Lin, SY;Yeh, TK;Song, JS;Hung, MS;Chen, CT |
| 國家衛生研究院 |
2018-06-15 |
2-Aroylquinoline-5,8-diones as potent anticancer agents displaying tubulin and heat shock protein 90 (HSP90) inhibition [Erratum: Organic and Biomolecular Chemistry. 2016 Jan;14(2):716-723.]
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Nepali, K;Kumar, S;Huang, HL;Kuo, FC;Lee, CH;Kuo, CC;Yeh, TK;Li, YH;Chang, JY;Liou, JP;Lee, HY |
| 國家衛生研究院 |
2018-04 |
4-Bromophenylhydrazinyl benzenesulfonylphenylureas as indoleamine 2,3-dioxygenase inhibitors with in vivo target inhibition and anti-tumor efficacy
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Lin, SY;Yeh, TK;Song, JS;Hung, MS;Cheng, MF;Liao, FY;Li, AS;Cheng, SY;Lin, LM;Chiu, CH;Wu, MH;Lin, YJ;Hsiao, W;Sun, M;Wang, YH;Huang, CH;Tang, YC;Chang, HH;Huang, ZT;Chao, YS;Shih, C;Pan, SL;Wu, SY;Kuo, CC;Ueng, SH |
| 國家衛生研究院 |
2018-02-08 |
Development of stem-cell-mobilizing agents targeting CXCR4 receptor for peripheral blood stem cell transplantation and beyond
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Wu, CH;Song, JS;Kuan, HH;Wu, SH;Chou, MC;Jan, JJ;Tsou, LK;Ke, YY;Chen, CT;Yeh, KC;Wang, SY;Yeh, TK;Tseng, CT;Huang, CL;Wu, MH;Kuo, PC;Lee, CJ;Shia, KS |
| 國家衛生研究院 |
2018-01-01 |
Identification of an oxime-containing C-glucosylarene as a potential inhibitor of sodium-dependent glucose co-transporter 2
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Yuan, MC;Yeh, TK;Chen, CT;Song, JS;Huang, YC;Hsieh, TC;Huang, CY;Huang, YL;Wang, MH;Wu, SH;Yao, CH;Chao, YS;Lee, JC |
| 國家衛生研究院 |
2018-01 |
Discovery and development of DBPR112 as a clinical candidate: A novel EGFR inhibitor for non-small cell lung cancer
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Hsieh, HP;Hsu, JTA;Yeh, TK;Chen, CT |
| 國家衛生研究院 |
2017-08-11 |
Targeting P-glycoprotein: Investigation of piperine analogs for overcoming drug resistance in cancer
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Syed, SB;Arya, H;Fu, IH;Yeh, TK;Periyasamy, L;Hsieh, HP;Coumar, MS |
| 國家衛生研究院 |
2017-07 |
Design, synthesis, and evaluation of thiazolidine-2,4-dione derivatives as a novel class of glutaminase inhibitors
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Yeh, TK;Kuo, CC;Lee, YZ;Ke, YY;Chu, KF;Hsu, HY;Chang, HY;Liu, YW;Song, JS;Yang, CW;Lin, LM;Sun, MW;Wu, SH;Kuo, PC;Shih, C;Chen, CT;Tsou, LK;Lee, SJ |
| 國家衛生研究院 |
2017-07 |
Targeting tumor associated phosphatidylserine with new zinc dipicolylamine-based drug conjugates
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Liu, YW;Shia, KS;Wu, CH;Liu, KL;Yeh, YC;Lo, CF;Chen, CT;Chen, YY;Yeh, TK;Chen, WH;Jan, JJ;Huang, YC;Huang, CL;Fang, MY;Gray, BD;Pak, KY;Hsu, TA;Huang, KH;Tsou, LK |
| 國家衛生研究院 |
2017-05 |
1-(2,4-Dibromophenyl)-3,6,6-trimethyl-1,5,6,7-tetrahydro-4H-indazol-4-one: A novel opioid receptor agonist with less accompanying gastrointestinal dysfunction than morphine
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Chao, PK;Ueng, SH;Ou, LC;Yeh, TK;Chang, WT;Chang, HF;Chen, SC;Tao, PL;Law, PY;Loh, HH;Cheng, MF;Chuang, JY;Chen, CT;Shih, C;Yeh, SH |
| 國家衛生研究院 |
2017-04 |
Discovery of BPR1K871-a quinazoline based multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, in vitro and in vivo evaluation
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Hsieh, HP;Wang, WC;Shiao, HY;Ke, YY;Lin, WH;Hsu, JTA;Chen, CT;Yeh, TK |
| 國家衛生研究院 |
2017-01 |
Discovery, structure-activity relationship studies, and anti-nociceptive effects of N-(1,2,3,4-tetrahydro-1-isoquinolinylmethyl)benzamides as novel opioid receptor agonists
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Chen, SR;Ke, YY;Yeh, TK;Lin, SY;Ou, LC;Chen, SC;Chang, WT;Chang, HF;Wu, ZH;Hsieh, CC;Law, PY;Loh, HH;Shih, C;Lai, YK;Yeh, SH;Ueng, SH |
| 國家衛生研究院 |
2017-01 |
A potent, selective, and orally bioavailable HCV NS5A inhibitor for treatment of Hepatitis C Virus: (S)-1-((R)-2-(Cyclopropanecarboxamido)-2-phenylacetyl)-N-(4-phenylthiazo l-2-yl)pyrrolidine-2-carboxamide
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Kang, IJ;Hsu, SJ;Yang, HY;Yeh, TK;Lee, CC;Lee, YC;Tian, YW;Song, JS;Hsu, TA;Chao, YS;Yueh, A;Chern, JH |
| 國家衛生研究院 |
2016-12 |
Discovery of BPR1K871, a quinazoline based, multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, in vitro and in vivo evaluation
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Chang Hsu, Y;Selvaraj Coumar, M;Wang, WC;Shiao, HY;Ke, YY;Lin, WH;Kuo, CC;Chang, CW;Kuo, FM;Chen, PY;Wang, SY;Li, AS;Chen, CH;Kuo, PC;Chen, CP;Wu, MH;Huang, CL;Yen, KJ;Chang, YI;Hsu, JT;Chen, CT;Yeh, TK;Song, JS;Shih, C;Hsieh, HP |
| 國家衛生研究院 |
2016-12 |
Phenyl benzenesulfonylhydrazides: Selective indoleamine 2,3-dioxygenase inhibitors with potent in vivo pharmacodynamic activity and antitumor efficacy
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Ueng, SH;Yeh, TK;Song, JS;Wu, SY;Kuo, CC;Shih, C;Pan, SL;Hung, MS |
| 國家衛生研究院 |
2016-12 |
Novel cKIT kinase inhibitor, BPRCKJ001, as an advanced therapeutic candidate for GIST
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Shiao, HY;Tsai, HJ;Lin, WH;Tsu, TA;Yeh, TK;Chen, CT;Jiaang, WT |
| 國家衛生研究院 |
2016-09 |
Activation of delta-opioid receptor contributes to the antinociceptive effect of oxycodone in mice
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Yang, PP;Yeh, GC;Yeh, TK;Xi, J;Loh, HH;Law, PY;Tao, PL |
| 國家衛生研究院 |
2016-07 |
In vitro and in vivo studies of a potent capsid-binding inhibitor of enterovirus 71
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Ho, JY;Chern, JH;Hsieh, CF;Liu, ST;Liu, CJ;Wang, YS;Kuo, TW;Hsu, SJ;Yeh, TK;Shih, SR;Hsieh, PW;Chiu, CH;Horng, JT |
| 國家衛生研究院 |
2016-05 |
N-Indolylglycosides bearing modifications at the glucose C6-Position as Sodium-Dependent Glucose Co-transporter 2 inhibitors
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Chu, KF;Yao, CH;Song, JS;Chen, CT;Yeh, TK;Hsieh, TC;Huang, CY;Wang, MH;Wu, SH;Chang, WE;Chao, YS;Lee, JC |
| 國家衛生研究院 |
2016-01 |
2-Aroylquinoline-5,8-diones as potent anticancer agents displaying tubulin and heat shock protein 90 (HSP90) inhibition
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Nepali, K;Kumar, S;Huang, HL;Kuo, FC;Lee, CH;Kuo, CC;Yeh, TK;Li, YH;Chang, JY;Liou, JP;Lee, HY |
| 國家衛生研究院 |
2016-01 |
Phenyl benzenesulfonylhydrazides exhibit selective Indoleamine 2,3-Dioxygenase inhibition with potent in vivo pharmacodynamic activity and antitumor efficacy
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Lin, SY;Yeh, TK;Kuo, CC;Song, JS;Cheng, MF;Liao, FY;Chao, MW;Huang, HL;Chen, YL;Yang, CY;Wu, MH;Hsieh, CL;Hsiao, WC;Peng, YH;Wu, JS;Lin, LM;Sun, MW;Chao, YS;Shih, C;Wu, SY;Pan, SL;Hung, MS;Ueng, SH |
| 國家衛生研究院 |
2015-10 |
Identification of substituted naphthotriazolediones as novel tryptophan 2,3-dioxygenase (TDO) inhibitors through structure-based virtual screening
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Wu, JS;Lin, SY;Liao, FY;Hsiao, WC;Lee, LC;Peng, YH;Hsieh, CL;Wu, MH;Song, JS;Yueh, A;Chen, CH;Yeh, SH;Liu, CY;Lin, SY;Yeh, TK;Hsu, JT;Shih, C;Ueng, SH;Hung, MS;Wu, SY |
| 國家衛生研究院 |
2015-08 |
Novel Nrf2/ARE activator, trans-coniferylaldehyde, induces a HO-1-mediated defense mechanism through a dual p38alpha/MAPKAPK-2 and PK-N3 signaling pathway
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Chen, HH;Wang, TC;Lee, YC;Shen, PT;Chang, JY;Yeh, TK;Huang, CH;Chang, HH;Cheng, SY;Lin, CY;Shih, C;Chen, CT;Liu, WM;Chen, CH;Kuo, CC |
| 國家衛生研究院 |
2015-08 |
Zinc-dipicolylamine directed pharmaceutical delivery system (ZAPS) as an innovative cancer drug delivery platform
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Tsou, LK;Liu, YW;Chen, YY;Lo, CF;Yeh, TK;Wu, CH;Shia, KS;Shih, JC;Gary, BD;Pek, KY;Chen, CT |
| 國家衛生研究院 |
2015-08 |
Optimization of quinazoline-based kinase inhibitors: Identification of a dual FLT3/AURKA kinase inhibitor for the treatment of acute myeloid leukemia
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Hsieh, HP;Hsu, YC;Ke, YY;Shiao, HY;Chang, CW;Lin, WH;Hsu, TA;Yeh, TK;Chen, CT |
| 國家衛生研究院 |
2015-07 |
Identification of a potent 5-phenyl-thiazol-2-ylamine-based inhibitor of FLT3 with activity against drug resistance-conferring point mutations
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Chen, CT;Hsu, JTA;Lin, WH;Lu, CT;Yen, SC;Hsu, T;Huang, YL;Song, JS;Chen, CH;Chou, LH;Yen, KJ;Chen, CP;Kuo, PC;Huang, CL;Eugene Liu, H;Chao, YS;Yeh, TK;Jiaang, WT |
| 國家衛生研究院 |
2015-01 |
1-Arylsulfonyl-5-(N-hydroxyacrylamide)tetrahydroquinolines as potent histone deacetylase inhibitors suppressing the growth of prostate cancer cells
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Liu, YM;Lee, HY;Chen, CH;Lee, CH;Wang, LT;Pan, SL;Lai, MJ;Yeh, TK;Liou, JP |
Showing items 36-85 of 169 (4 Page(s) Totally)
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