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"yeh tk"的相关文件
显示项目 21-70 / 169 (共4页)
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| 國家衛生研究院 |
2022-12-05 |
2,6-Difluorobenzamide derivatives as store-operated calcium channel (SOC) inhibitors
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Wang, YS;Yeh, TK;Chang, WC;Liou, JP;Liu, YM;Huang, WC |
| 國家衛生研究院 |
2022-10-03 |
Protective effect of CXCR4 antagonist DBPR807 against ischemia-reperfusion injury in a rat and porcine model of myocardial infarction: Potential adjunctive therapy for percutaneous coronary intervention
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Yeh, KC;Lee, CJ;Song, JS;Wu, CH;Yeh, TK;Wu, SH;Hsieh, TC;Chen, YT;Tseng, HY;Huang, CL;Chen, CT;Jan, JJ;Chou, MC;Shia, KS;Chiang, KH |
| 國家衛生研究院 |
2022-09-26 |
Targeting the phosphatidylserine-immune checkpoint with a small-molecule maytansinoid conjugate
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Lo, CF;Chiu, TY;Liu, YT;Pan, PY;Liu, KL;Hsu, CY;Fang, MY;Huang, YC;Yeh, TK;Hsu, TA;Chen, CT;Huang, LR;Tsou, LK |
| 國家衛生研究院 |
2022-07-24 |
Hesperetin promotes longevity and delays aging via activation of Cisd2 in naturally aged mice
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Yeh, CH;Shen, ZQ;Wang, TW;Kao, CH;Teng, YC;Yeh, TK;Lu, CK;Tsai, TF |
| 國家衛生研究院 |
2022-07 |
Rejuvenating hepatic tumor microenvironment immunity with a phosphatidylserine-targeting small molecule drug conjugate
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Huang, KH;Liu, YT;Pan, PY;Lo, CF;Liu, KL;Yeh, TK;Huang, LR;Tsou, LK |
| 國家衛生研究院 |
2022-06-21 |
Synthesis and evaluation of small molecule drug conjugates harnessing thioester-linked maytansinoids
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Lo, CF;Chiu, TY;Liu, YT;Huang, LR;Yeh, TK;Huang, KH;Liu, KL;Hsu, CY;Fang, MY;Huang, YC;Hsu, TA;Chen, CT;Tsou, LK |
| 國家衛生研究院 |
2022-02-15 |
Click chemistry and multicomponent reaction for linker diversification of zinc dipicolylamine-based drug conjugates
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Tsai, CH;Chiu, TY;Chen, CT;Hsu, CY;Tsai, YR;Yeh, TK;Huang, KH;Tsou, LK |
| 國家衛生研究院 |
2022-02-07 |
Development of furanopyrimidine-based orally active third-generation EGFR inhibitors for the treatment of non-small cell lung cancer
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Li, MC;Coumar, MS;Lin, SY;Lin, YS;Huang, GL;Chen, CH;Lien, TW;Wu, YW;Chen, YT;Chen, CP;Huang, YC;Yeh, KC;Yang, CM;Kalita, B;Pan, SL;Hsu, TA;Yeh, TK;Chen, CT;Hsieh, HP |
| 國家衛生研究院 |
2022-02-05 |
Discovery and development of a novel N-(3-bromophenyl)-{[(phenylcarbamoyl)amino]methyl}-N-hydroxythiophene-2-carboximidamide indoleamine 2,3-dioxygenase inhibitor using knowledge-based drug design
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Yeh, TK;Song, JS;Chang, PW;Yu, JC;Chang, CH;Liao, FY;Tien, YW;Kuppusamy, R;Li, AS;Chen, CH;Chen, CW;Lin, LM;Chang, HH;Huang, CH;Yao, JY;Wu, MH;Peng, YH;Hsueh, CC;Hsiao, WC;Chen, PH;Lin, CY;Hsieh, SH;Shih, C;Hung, MS;Wu, SY;Kuo, CC;Ueng, SH |
| 國家衛生研究院 |
2021-10-04 |
Discovery of BPR1R024, an orally active and selective CSF1R inhibitor that exhibits antitumor and immunomodulatory activity in a murine colon tumor model
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Lee, KH;Yen, WC;Lin, WH;Wang, PC;Lai, YL;Su, YC;Chang, CY;Wu, CS;Huang, YC;Yang, CM;Chou, LH;Yeh, TK;Chen, CT;Shih, C;Hsieh, HP |
| 國家衛生研究院 |
2021-08-01 |
DBPR108, a novel dipeptidyl peptidase-4 inhibitor with antihyperglycemic activity
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Yeh, KC;Yeh, TK;Huang, CY;Hu, CB;Wang, MH;Huang, YW;Chou, LH;Ho, HH;Song, JS;Hsu, T;Jiaang, WT;Chao, YS;Chen, CT |
| 國家衛生研究院 |
2021-06-29 |
Design and synthesis of novel orally selective and type II pan-TRK inhibitors to overcome mutations by property-driven optimization
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Li, MC;Lin, WH;Wang, PC;Su, YC;Chen, PY;Fan, CM;Chen, CP;Huang, CL;Chiu, CH;Chang, L;Chen, CT;Yeh, TK;Hsieh, HP |
| 國家衛生研究院 |
2021-05-19 |
Discovery and synthesis of a pyrimidine-based aurora kinase inhibitor to reduce levels of MYC oncoproteins
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Chi, YH;Yeh, TK;Ke, YY;Lin, WH;Tsai, CH;Wang, WP;Chen, YT;Su, YC;Wang, PC;Chen, YF;Wu, ZW;Yeh, JY;Hung, MC;Wu, MH;Wang, JY;Chen, CP;Song, JS;Shih, C;Chen, CT;Chang, CP |
| 國家衛生研究院 |
2021-03-30 |
A highly selective and potent CXCR4 antagonist for hepatocellular carcinoma treatment
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Song, JS;Chang, CC;Wu, CH;Dinh, TK;Jan, JJ;Huang, KW;Chou, MC;Shiue, TY;Yeh, KC;Ke, YY;Yeh, TK;Ta, YNN;Lee, CJ;Huang, JK;Sung, YC;Shia, KS;Chen, Y |
| 國家衛生研究院 |
2021-03-02 |
Discovery of potential neuroprotective agents against paclitaxel-induced peripheral neuropathy
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Chen, YF;Wu, CH;Chen, LH;Lee, HW;Lee, JC;Yeh, TK;Chang, JY;Chou, MC;Wu, HL;Lai, YP;Song, JS;Yeh, KC;Chen, CT;Lee, CJ;Shia, KS;Shen, MR |
| 國家衛生研究院 |
2021-01 |
BPRDP056, a novel small molecule drug conjugate specifically targeting phosphatidylserine for cancer therapy
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Chen, YY;Lo, CF;Chiu, TY;Hsu, CY;Yeh, TK;Chen, CP;Huang, CL;Huang, CY;Wang, MH;Huang, YC;Ho, HH;Chao, YS;Shih, JC;Tsou, LK;Chen, CT |
| 國家衛生研究院 |
2020-10-16 |
Potent and orally active purine-based fetal hemoglobin inducers for treating Beta-thalassemia and sickle cell disease
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Lai, ZS;Yeh, TK;Chou, YC;Hsu, T;Lu, CT;Kung, FC;Hsieh, MY;Lin, CH;Chen, CT;James Shen, CK;Jiaang, WT |
| 國家衛生研究院 |
2020-08 |
BPR6K609: An Aurora kinase inhibitor targeting small cell lung cancer with MYC amplification
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Chi, YH;Chang, CP;Ke, YY;Lin, WH;Wang, WP;Tsai, CH;Chen, YT;Su, YJ;Hung, MC;Wu, ZW;Wu, MH;Yeh, TK;Chen, CP;Song, JS;Chen, CT;Shih, C |
| 國家衛生研究院 |
2020-07-07 |
Overcoming vincristine resistance in cancer: Computational design and discovery of piperine-inspired P-glycoprotein inhibitors
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Syed, SB;Lin, SY;Arya, H;Fu, IH;Yeh, TK;Charles, MRC;Periyasamy, L;Hsieh, HP;Coumar, MS |
| 國家衛生研究院 |
2020-05-23 |
Repurposing old drugs as antiviral agents for coronaviruses
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Yang, CW;Peng, TT;Hsu, HY;Lee, YZ;Wu, SH;Lin, WH;Ke, YY;Hsu, TA;Yeh, TK;Huang, WZ;Lin, JH;Sytwu, HK;Chen, CT;Lee, SJ |
| 國家衛生研究院 |
2020-05-15 |
Artificial intelligence approach fighting COVID-19 with repurposing drugs
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Ke, YY;Peng, TT;Yeh, TK;Huang, WZ;Chang, SE;Wu, SH;Hung, HC;Hsu, TA;Lee, SJ;Song, JS;Lin, WH;Chiang, TJ;Lin, JH;Sytwu, HK;Chen, CT |
| 國家衛生研究院 |
2020-05 |
Drug-like property optimization: Discovery of orally bioavailable quinazoline-based multi-targeted kinase inhibitors
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Lin, SY;Chang, CF;Coumar, MS;Chen, PY;Kuo, FM;Chen, CH;Li, MC;Lin, WH;Kuo, PC;Wang, SY;Li, AS;Lin, CY;Yang, CM;Yeh, TK;Song, JS;Hsu, JTA;Hsieh, HP |
| 國家衛生研究院 |
2020-02-18 |
Impacts of intralipid on nanodrug abraxane therapy and on the innate immune system
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Chen, YJ;Tsai, CY;Cheng, YM;Nieh, SW;Yeh, TK;Chen, CP;Wang, MH;Chou, LH;Chiu, TY;Liu, L;Ho, C;Chen, CT;Liu, TW |
| 國家衛生研究院 |
2020-02-10 |
Unique sulfur-aromatic interactions contribute to the binding of potent imidazothiazole indoleamine 2,3-Dioxygenase inhibitors
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Peng, YH;Liao, FY;Tseng, CT;Kuppusamy, R;Li, AS;Chen, CH;Fan, YS;Wang, SY;Wu, MH;Hsueh, CC;Chang, JY;Lee, LC;Shih, C;Shia, KS;Yeh, TK;Hung, MS;Kuo, CC;Song, JS;Wu, SY;Ueng, SH |
| 國家衛生研究院 |
2020-02-01 |
Protective effects of 10,11-dihydro-5H-dibenzo[b,f]azepine hydroxamates on vascular cognitive impairment
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Kaur, N;Fang, YC;Lee, HY;Singh, A;Nepali, K;Lin, MH;Yeh, TK;Lai, MJ;Chan, L;Tu, YK;Banerjee, S;Hu, CJ;Liou, JP |
| 國家衛生研究院 |
2019-12 |
Identification of a multitargeted tyrosine kinase inhibitor for the treatment of gastrointestinal stromal tumors and acute myeloid leukemia
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Lin, WH;Wu, SY;Yeh, TK;Chen, CT;Song, JS;Shiao, HY;Kuo, CC;Hsu, T;Lu, CT;Wang, PC;Wu, TS;Peng, YH;Lin, HY;Chen, CP;Weng, YL;Kung, FC;Wu, MH;Su, YC;Huang, KW;Chou, LH;Hsueh, CC;Yen, KJ;Kuo, PC;Huang, CL;Chen, LT;Shih, C;Tsai, HJ;Jiaang, WT |
| 國家衛生研究院 |
2019-10 |
Discovery of clinical candidate DBPR112, a furanopyrimidine-based epidermal growth factor receptor inhibitor for the treatment of non-small cell lung cancer
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Hsieh, HP;Chang, JY;Yeh, CT;Lin, SY;Ke, YY;Lin, WH;Hsu, TA;Wu, SY;Yeh, TK |
| 國家衛生研究院 |
2019-09-27 |
Discovery of a furanopyrimidine-based epidermal growth factor receptor inhibitor (DBPR112) as a clinical candidate for the treatment of non-small cell lung cancer
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Lin, SY;Chang Hsu, Y;Peng, YH;Ke, YY;Lin, WH;Sun, HY;Shiao, HY;Kuo, FM;Chen, PY;Lien, TW;Chen, CH;Chu, CY;Wang, SY;Yeh, KC;Chen, CP;Hsu, TA;Wu, SY;Yeh, TK;Chen, CT;Hsieh, HP |
| 國家衛生研究院 |
2019-07-11 |
Linker optimization and therapeutic evaluation of phosphatidylserine-targeting zinc dipicolylamine-based drug conjugates
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Liu, YW;Chen, YY;Hsu, CY;Chiu, TY;Liu, KL;Lo, CF;Fang, MY;Huang, YC;Yeh, TK;Pak, KY;Gray, BD;Hsu, TA;Huang, KH;Shih, C;Shia, KS;Chen, CT;Tsou, LK |
| 國家衛生研究院 |
2019-07-03 |
BPR1M97, a dual mu opioid receptor/nociceptin-orphanin FQ peptide receptor agonist, produces potent antinociceptive effects with safer properties than morphine
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Chao, PK;Chang, HF;Chang, WT;Yeh, TK;Ou, LC;Chuang, JY;Tsu-An Hsu, J;Tao, PL;Loh, HH;Shih, C;Ueng, SH;Yeh, SH |
| 國家衛生研究院 |
2019-07 |
BPRDP056, a novel small molecule drug conjugate specifically targeting phosphatidylserine for cancer therapy
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Hsu, CY;Chen, YY;Lo, CF;Chiu, TY;Chen, CP;Huang, CL;Huang, CY;Wang, MH;Chao, YS;Shih, JC;Yeh, TK;Tsou, LK;Chen, CT |
| 國家衛生研究院 |
2019-07 |
An Aurora kinase inhibitor BPR6K471 inhibits tumor growth and reduces the cancer stem cell-like properties of small cell lung cancer
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Chang, CP;Ke, YY;Lin, WH;Jhuo, DH;Wang, WP;Tsai, CH;Chen, YT;Su, YJ;Hung, MC;Wu, ZW;Kuo, PC;Yeh, TK;Chen, CP;Song, JS;Chen, CT;Shih, C;Chi, YH |
| 國家衛生研究院 |
2019-06-05 |
Delta-opioid receptor antagonist naltrindole reduces oxycodone addiction and constipation in mice
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Yang, PP;Yeh, TK;Loh, HH;Law, PY;Wang, Y;Tao, PL |
| 國家衛生研究院 |
2019-04-10 |
Discovery of Conformational Control Inhibitors Switching off the Activated c-KIT and Targeting a Broad Range of Clinically Relevant c-KIT Mutants
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Wu, TS;Lin, WH;Tsai, HJ;Hsueh, CC;Hsu, T;Wang, PC;Lin, HY;Peng, YH;Lu, CT;Lee, LC;Tu, CH;Kung, FC;Shiao, HY;Yeh, TK;Song, JS;Chang, JY;Su, YC;Chen, LT;Chen, CT;Jiaang, WT;Wu, SY |
| 國家衛生研究院 |
2019-04-01 |
A novel, potent, and orally bioavailable thiazole HCV NS5A inhibitor for the treatment of hepatitis C virus
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Yeh, TK;Kang, IJ;Hsu, TA;Lee, YC;Lee, CC;Hsu, SJ;Tian, YW;Yang, HY;Chen, CT;Chao, YS;Yueh, A;Chern, JH |
| 國家衛生研究院 |
2019-03 |
Synthesis and biological evaluation of N-glucosyl indole derivatives as sodium-dependent glucose co-transporter 2 inhibitors
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Chu, KF;Song, JS;Chen, CT;Yeh, TK;Hsieh, TC;Huang, CY;Wang, MH;Wu, SH;Yao, CH;Chao, YS;Lee, JC |
| 國家衛生研究院 |
2019-02-21 |
Synthesis and evaluation of novel 7H-pyrrolo-[2,3-d]pyrimidine derivatives as potential anticancer agents
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Liu, YM;Chen, CH;Yeh, TK;Liou, JP |
| 國家衛生研究院 |
2018-08-23 |
5-aroylindoles act as selective histone deacetylase 6 inhibitors ameliorating alzheimer's disease phenotypes
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Lee, HY;Fan, SJ;Huang, FI;Chao, HY;Hsu, KC;Lin, TE;Yeh, TK;Lai, MJ;Li, YH;Huang, HL;Yang, CR;Liou, JP |
| 國家衛生研究院 |
2018-07 |
4-Bromophenylhydrazinyl benzenesulfonylphenylureas inhibit indoleamine 2,3-dioxygenase in vitro and in vivo
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Ueng, SH;Kuo, CC;Lin, SY;Yeh, TK;Song, JS;Hung, MS;Chen, CT |
| 國家衛生研究院 |
2018-06-15 |
2-Aroylquinoline-5,8-diones as potent anticancer agents displaying tubulin and heat shock protein 90 (HSP90) inhibition [Erratum: Organic and Biomolecular Chemistry. 2016 Jan;14(2):716-723.]
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Nepali, K;Kumar, S;Huang, HL;Kuo, FC;Lee, CH;Kuo, CC;Yeh, TK;Li, YH;Chang, JY;Liou, JP;Lee, HY |
| 國家衛生研究院 |
2018-04 |
4-Bromophenylhydrazinyl benzenesulfonylphenylureas as indoleamine 2,3-dioxygenase inhibitors with in vivo target inhibition and anti-tumor efficacy
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Lin, SY;Yeh, TK;Song, JS;Hung, MS;Cheng, MF;Liao, FY;Li, AS;Cheng, SY;Lin, LM;Chiu, CH;Wu, MH;Lin, YJ;Hsiao, W;Sun, M;Wang, YH;Huang, CH;Tang, YC;Chang, HH;Huang, ZT;Chao, YS;Shih, C;Pan, SL;Wu, SY;Kuo, CC;Ueng, SH |
| 國家衛生研究院 |
2018-02-08 |
Development of stem-cell-mobilizing agents targeting CXCR4 receptor for peripheral blood stem cell transplantation and beyond
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Wu, CH;Song, JS;Kuan, HH;Wu, SH;Chou, MC;Jan, JJ;Tsou, LK;Ke, YY;Chen, CT;Yeh, KC;Wang, SY;Yeh, TK;Tseng, CT;Huang, CL;Wu, MH;Kuo, PC;Lee, CJ;Shia, KS |
| 國家衛生研究院 |
2018-01-01 |
Identification of an oxime-containing C-glucosylarene as a potential inhibitor of sodium-dependent glucose co-transporter 2
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Yuan, MC;Yeh, TK;Chen, CT;Song, JS;Huang, YC;Hsieh, TC;Huang, CY;Huang, YL;Wang, MH;Wu, SH;Yao, CH;Chao, YS;Lee, JC |
| 國家衛生研究院 |
2018-01 |
Discovery and development of DBPR112 as a clinical candidate: A novel EGFR inhibitor for non-small cell lung cancer
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Hsieh, HP;Hsu, JTA;Yeh, TK;Chen, CT |
| 國家衛生研究院 |
2017-08-11 |
Targeting P-glycoprotein: Investigation of piperine analogs for overcoming drug resistance in cancer
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Syed, SB;Arya, H;Fu, IH;Yeh, TK;Periyasamy, L;Hsieh, HP;Coumar, MS |
| 國家衛生研究院 |
2017-07 |
Design, synthesis, and evaluation of thiazolidine-2,4-dione derivatives as a novel class of glutaminase inhibitors
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Yeh, TK;Kuo, CC;Lee, YZ;Ke, YY;Chu, KF;Hsu, HY;Chang, HY;Liu, YW;Song, JS;Yang, CW;Lin, LM;Sun, MW;Wu, SH;Kuo, PC;Shih, C;Chen, CT;Tsou, LK;Lee, SJ |
| 國家衛生研究院 |
2017-07 |
Targeting tumor associated phosphatidylserine with new zinc dipicolylamine-based drug conjugates
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Liu, YW;Shia, KS;Wu, CH;Liu, KL;Yeh, YC;Lo, CF;Chen, CT;Chen, YY;Yeh, TK;Chen, WH;Jan, JJ;Huang, YC;Huang, CL;Fang, MY;Gray, BD;Pak, KY;Hsu, TA;Huang, KH;Tsou, LK |
| 國家衛生研究院 |
2017-05 |
1-(2,4-Dibromophenyl)-3,6,6-trimethyl-1,5,6,7-tetrahydro-4H-indazol-4-one: A novel opioid receptor agonist with less accompanying gastrointestinal dysfunction than morphine
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Chao, PK;Ueng, SH;Ou, LC;Yeh, TK;Chang, WT;Chang, HF;Chen, SC;Tao, PL;Law, PY;Loh, HH;Cheng, MF;Chuang, JY;Chen, CT;Shih, C;Yeh, SH |
| 國家衛生研究院 |
2017-04 |
Discovery of BPR1K871-a quinazoline based multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, in vitro and in vivo evaluation
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Hsieh, HP;Wang, WC;Shiao, HY;Ke, YY;Lin, WH;Hsu, JTA;Chen, CT;Yeh, TK |
| 國家衛生研究院 |
2017-01 |
Discovery, structure-activity relationship studies, and anti-nociceptive effects of N-(1,2,3,4-tetrahydro-1-isoquinolinylmethyl)benzamides as novel opioid receptor agonists
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Chen, SR;Ke, YY;Yeh, TK;Lin, SY;Ou, LC;Chen, SC;Chang, WT;Chang, HF;Wu, ZH;Hsieh, CC;Law, PY;Loh, HH;Shih, C;Lai, YK;Yeh, SH;Ueng, SH |
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