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Institution	Date	Title	Author
臺北醫學大學	2008	Synthesis and Structure-Activity Relationships of 2-Amino and 2-Hydroxy-1-Aroylnaphthalenes as Potent Antitubulin Agents	劉景平; Reddy GR; Kuo CC; Tan UK; Coumar MS; Chang CY; Lai MJ; Wu SY; Chang JY; Liou JP; Hsieh HP
國立臺灣大學	2008	Thiopurine analogues inhibit papain-like protease of severe acute respiratory syndrome coronavirus	Chou CY; Chien CH; Han YS; Prebanda MT; Hsieh HP; Turk B; Chang GG; Chen X
國家衛生研究院	2007-12	Strategies of development of antiviral agents directed against influenza virus replication	Hsieh, HP;Hsu, JTA
國家衛生研究院	2007-09-06	4-and 5-aroylindoles as novel classes of potent antitubulin agents	Liou, JP; Wu, CY; Hsieh, HP; Chang, CY; Chen, CM; Kuo, CC; Chang, JY
國家衛生研究院	2007-07-31	Combined modalities of resistance in an oxaliplatin-resistant human gastric cancer cell line with enhanced sensitivity to 5-fluorouracil	Chen, CC; Chen, LT; Tsou, TC; Pan, WY; Kuo, CC; Liu, JF; Yeh, SC; Tsai, FY; Hsieh, HP; Chang, JY
國家衛生研究院	2007-07	Biotransformation of 6-methoxy-3-(3 ',4 ',5 '-trimethoxy-benzoyl)-1-hindole (BPR0L075), a novel antimicrotubule agent, by mouse, rat, dog, and human liver microsomes	Yao, HT; Wu, YS; Chang, YW; Hsieh, HP; Chen, WC; Lan, SJ; Chen, CT; Chao, YS; Chang, L; Sun, HY; Yeh, TK
國家衛生研究院	2007-07	Anti-influenza drug discovery	Hsu, JTA;Hsieh, HP;Hung, HC;Ju, YW;Tseng, SN;Tseng, CP;Yang, JM;Chang, CW;Fang, MY;Lin, CC;Homg, JT;Shih, SR;Chao, YS
國家衛生研究院	2007-07	From bench to drug candidate: Design and synthesis of 5,6-fused heteroaromatics as anticancer agents	Hsieh, HP
國立臺灣大學	2007-04	Urine sediment examination: a comparison of automated urinalysis systems and manual microscopy.	Chien, TI; Kao, JT; Liu, HL; Lin, PC; Hong, JS; Hsieh, HP; Chien, MJ.
國家衛生研究院	2007-03-01	3-[2-((2S)-2-Cyano-pyrrolidin-1-yl)-2-oxo-ethylamino]-3-methyl-butyramide analogues as selective DPP-IV inhibitors for the treatment of type-II diabetes	Coumar, MS; Chang, CN; Chen, CT; Chen, X; Chien, CH; Tsai, TY; Cheng, JH; Wu, HY; Han, CH; Wu, SH; Huang, YW; Hsu, T; Hsu, LJ; Chao, YS; Hsieh, HP; Jiaang, WT
國家衛生研究院	2007-02-08	Isocostunolide, a sesquiterpene lactone, induces mitochondrial membrane depolarization and caspase-dependent apoptosis in human melanoma cells	Chen, CN; Huang, HH; Wu, CL; Lin, CPC; Hsu, JTA; Hsieh, HP; Chuang, SE; Lai, GM
國家衛生研究院	2007-02-01	Development and validation of a liquid chromatography-tandem mass spectrometry for the determination of BPR0L075, a novel antimicrotuble agent, in rat plasma: Application to a pharmacokinetic study	Chang, YW; Chen, WC; Lin, KT; Chang, L; Yao, HT; Hsieh, HP; Lan, SJ; Chen, CT; Chao, YS; Yeh, TK
臺北醫學大學	2007	Isocostunolide, a sesquiterpene lactone, induces mitochondrial membrane depolarization and caspase-dependent apoptosis in human melanoma cells.	賴基銘; Chen CN; Huang HH; Wu CL; Lin CP; Hsu JT; Hsieh HP; Chuang SE; Lai GM
臺北醫學大學	2007	4- and 5-Aroylindoles as Novel Classes of Potent Antitubulin Agents.	劉景平; Liou JP; Wu CY; Hsieh HP; Chang CY; Chen CM; Kuo CC; Chang JY
國家衛生研究院	2006-12	Pharmacokinetics of anti-SARS-CoV agent niclosamide and its analogs in rats	Chang, YW; Yeh, TK; Lin, KT; Chen, WC; Yao, HT; Lan, SJ; Wu, YS; Hsieh, HP; Chen, CM; Chen, CT
國家衛生研究院	2006-11-16	7-aroyl-aminoindoline-1-sulfonamides as a novel class of potent antitubulin agents	Chang, JY; Hsieh, HP; Chang, CY; Hsu, KS; Chiang, YF; Chen, CM; Kuo, CC; Liou, JP
國家衛生研究院	2006-10-19	Structural basis for the structure-activity relationships of peroxisome proliferator-activated receptor agonists	Mahindroo, N; Peng, YH; Lin, CH; Tan, UK; Prakash, E; Lien, TW; Lu, IL; Lee, HJ; Hsu, JTA; Chen, X; Liao, CC; Lyu, PC; Chao, YS; Wu, SY; Hsieh, HP
國家衛生研究院	2006-10	Structure-activity relationship studies of 3-aroylindoles as potent antimitotic agents	Liou, JP;Mahindroo, N;Chang, CW;Guo, FM;Lee, SWH;Tan, UK;Yeh, TK;Kuo, CC;Chang, YW;Lu, PH;Tung, YS;Lin, KT;Chang, JY;Hsieh, HP
國家衛生研究院	2006-09	MEDI 416-3- 2-((2S)-2-Cyano-pyrrolidin-1-yl)-2-oxo-ethylamino -3-methyl-butyr amide analogs as DPP-IV inhibitors for the treatment of type-II diabetes	Hsieh, HP;Coumar, MS;Chang, CN;Wu, SH;Chen, X;Chen, CT;Jiaang, WT
國家衛生研究院	2006-08-24	Structure-based drug design and structural biology study of novel nonpeptide inhibitors of severe acute respiratory syndrome coronavirus main protease	Lu, IL; Mahindroo, N; Liang, PH; Peng, YH; Kuo, CJ; Tsai, KC; Hsieh, HP; Chao, YS; Wu, SY
國家衛生研究院	2006-07	Antiviral drug discovery against SARS-CoV	Wu, YS;Lin, WH;Hsu, JTA;Hsieh, HP
國家衛生研究院	2006-06-15	Discovery of a novel family of SARS-CoV protease inhibitors by virtual screening and 3D-QSAR studies	Tsai, KC; Chen, SY; Liang, PH; Lu, IL; Mahindroo, N; Hsieh, HP; Chao, YS; Liu, L; Liu, D; Lien, W; Lin, TH; Wu, SY
國家衛生研究院	2006-06-15	Substituted pyrrolidine-2,4-dicarboxylic acid amides as potent dipeptidyl peptidase IV inhibitors	Tsai, TY; Coumar, MS; Hsu, T; Hsieh, HP; Chien, CH; Chen, CT; Chang, CN; Lo, YK; Wu, SH; Huang, CY; Huang, YW; Wang, MH; Wu, HY; Lee, HJ; Chen, X; Chao, YS; Jiaang, WT
國家衛生研究院	2006-05-04	Structure-based drug design of a novel family of PPAR gamma partial agonists: Virtual screening, X-ray crystallography, and in vitro/in vivo biological activities	Lu, IL; Huang, CF; Peng, YH; Lin, YT; Hsieh, HP; Chen, CT; Lien, TW; Lee, HJ; Mahindroo, N; Prakash, E; Yueh, A; Chen, HY; Goparaju, CMV; Chen, X; Liao, CC; Chao, YS; Hsu, JTA; Wu, SY
國家衛生研究院	2006-05	Antitubulin agents for the treatment of cancer - a medicinal chemistry update	Mahindroo, N; Liou, JP; Chang, JY; Hsieh, HP
國家衛生研究院	2006-02-09	Indol-1-yl acetic acids as peroxisome proliferator-activated receptor agonists: Design, synthesis, structural biology, and molecular docking studies	Mahindroo, N; Wang, CC; Liao, CC; Huang, CF; Lu, IL; Lien, TW; Peng, YH; Huang, WJ; Lin, YT; Hsu, MC; Lin, CH; Tsai, CH; Hsu, JTA; Chen, X; Lyu, PC; Chao, YS; Wu, SY; Hsieh, HP
國家衛生研究院	2006-01-12	2-[3-[2-[(2S)-2-cyano-1-pyrrolidinyl]-2-oxoethylamino]-3-methyl-1-oxobutyl]-1,2,3,4-tetrahydroisoquinoline: A potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV	Tsu, H; Chen, X; Chen, CT; Lee, SJ; Chang, CN; Kao, KH; Coumar, MS; Yeh, YT; Chien, CH; Wang, HS; Lin, KT; Chang, YY; Wu, SH; Chen, YS; Lu, IL; Wu, SY; Tsai, TY; Chen, WC; Hsieh, HP; Chao, YS; Jiaang, WT
國家衛生研究院	2006-01-01	Synthesis and anti-viral activity of a series of sesquiterpene lactones and analogues in the subgenomic HCV replicon system	Hwang, DR;Wu, YS;Chang, CW;Lien, TW;Chen, WC;Tan, UK;Hsu, JTA;Hsieh, HP
臺北醫學大學	2006	7-Aroyl-aminoindoline-1-sulfonamides as a Novel Class of Potent Antitubulin Agents	劉景平; 陳繼明; Chang JY; Hsieh HP; Chang CY; Hsu KS; Chiang YF; Chen CM; Kuo CC; Liou JP*
臺北醫學大學	2006	Antitubulin agents for the treatment of cancer-a medicinal chemistry update	劉景平; Mahindroo N; Liou JP; Chang JY; Hsieh HP
國家衛生研究院	2005-12-29	Novel indole-based peroxisome proliferator-activated receptor agonists: Design, SAR, structural biology, and biological activities	Mahindroo, N; Huang, CF; Peng, YH; Wang, CC; Liao, CC; Lien, TW; Chittimalla, SK; Huang, WJ; Chai, CH; Prakash, E; Chen, CP; Hsu, TA; Peng, CH; Lu, IL; Lee, LH; Chang, YW; Chen, WC; Chou, YC; Chen, CT; Goparaju, CMV; Chen, YS; Lan, SJ; Yu, MC; Chen, X; Chao, YS; Wu, SY; Hsieh, HP
國家衛生研究院	2005-08-23	Indole compounds	Hsieh, HP;Liou, JP;Chang, JY;Chang, CW
國家衛生研究院	2005-05	Shear stress inhibits smooth muscle cell-induced inflammatory gene expression in endothelial cells - Role of NF-kappa B	Chiu, JJ; Chang, SF; Lee, PL; Lee, CI; Tsai, MC; Lee, DY; Hsieh, HP; Usami, S; Chien, S
國家衛生研究院	2005-05	Pharmaceutical design of antimitotic agents based on combretastatins	Hsieh, HP;Liou, JP;Mahindroo, N
國家衛生研究院	2005-03	Promazine analogues as potential anti SARS-CoV drugs	Hsieh, HP;Wu, YS;Lu, PH;Chen, CM;Chao, YC;Jan, JT;Huei-Ru, L;Ma, SH;Chao, YS;Hsu, TA
國家衛生研究院	2005-03	Design, synthesis and sar of indole-based PPAR agonists	Hsieh, HP;Mahindroo, N;Coumar, MS;Wang, CC;Huang, CF;Lien, TW;Tsai, CH;Lin, YT;Lee, LH;Prakash, E;Hsu, TA;Chen, X;Wu, SY;Chen, CT;Chao, YS
國家衛生研究院	2005-03	Design and structure-activity relationships of novel indole-based PPAR agonists as antidiabetic agents	Hsieh, HP;Mahindroo, N;Wang, CC;Huang, CF;Lien, TW;Tsai, CH;Peng, YH;Lee, LH;Prakash, E;Chen, WC;Chang, YW;Hsu, TA;Chen, X;Wu, SY;Chen, CT;Lan, SJ;Chao, YS
國家衛生研究院	2005	Inhibition of SARS-CoV 3C-like protease activity by theaflavin-3,3 '- digallate (TF3)	Chen, CN; Lin, CPC; Huang, KK; Chen, WC; Hsieh, HP; Liang, PH; Hsu, JTA
國家衛生研究院	2004-09-10	Evaluation of metal-conjugated compounds as inhibitors of 3CL protease of SARS-CoV	Hsu, JTA; Kuo, CJ; Hsieh, HP; Wang, YC; Huang, KK; Lin, CPC; Huang, PF; Chen, X; Liang, PH
國家衛生研究院	2004-09	Drug design of BPR0L075 as an anticancer agent	Hsieh, HP;Liou, JP;Chang, CW;Kuo, CC;Chang, YL;Kuo, FM;Tseng, HY;Pan, WY;Chen, CP;Yang, YN;Chen, CT;Lee, SJ;Chang, JY
國家衛生研究院	2004-08-22	Concise synthesis and structure-activity relationships of combretastatin A-4 analogues, 1-aroylindoles and 3-aroylindoles, as novel classes of potent antitubulin agents	Hsieh, HP;Liou, JP;Chang, YL;Lee, SJ
國家衛生研究院	2004-08-12	Concise synthesis and structure-activity relationships of combretastatin A-4 analogues, 1-aroylindoles and 3-aroylindoles, as novel classes of potent antitubulin agents	Liou, JP; Chang, YL; Kuo, FM; Chang, CW; Tseng, HY; Wang, CC; Yang, YN; Chang, JY; Lee, SJ; Hsieh, HP
國家衛生研究院	2004-07-15	A novel bis-benzylidenecyclopentanone derivative, BPR0Y007, inducing a rapid caspase activation involving upregulation of Fas (CD95/APO-1) and wild-type p53 in human oral epidermoid carcinoma cells	Juang, SH; Pan, WY; Kuo, CC; Liou, JP; Hung, YM; Chen, LT; Hsieh, HP; Chang, JY
國家衛生研究院	2004-07-01	BPR0L075, a novel synthetic indole compound with antimitotic activity in human cancer cells, exerts effective antitumoral activity in vivo	Kuo, CC; Hsieh, HP; Pan, WY; Chen, CP; Lion, JP; Lee, SJ; Chang, YL; Chen, LT; Chen, CT; Chang, JY
國家衛生研究院	2004-07	Inhibition of severe acute respiratory syndrome coronavirus replication by niclosamide	Wu, CJ; Jan, JT; Chen, CM; Hsieh, HP; Hwang, DR; Liu, HW; Liu, CY; Huang, HW; Chen, SC; Hong, CF; Lin, RK; Chao, YS; Hsu, JTA
國家衛生研究院	2004-07	Drug design for BPR0L075 as an anticancer agent	Hsieh, HP;Liou, JP;W., CC;Kuo, CC;Chang, YL;Kuo, FM;Tseng, HY;Pan, WY;Chen, CP;Yang, YN;Chen, CT;Lee, SJ;Chang, JY
國立臺灣海洋大學	2004-07	Inhibition of SARS-CoV replication by niclosamide	Wu CJ1; Jan JT; Chen CM; Hsieh HP; Hwang DR; Liu HW; Liu CY; Huang HW; Chen SC; Hong CF; Lin RK; Chao YS; Hsu JT
國家衛生研究院	2004-05-20	Synthesis and structure-activity relationships of 3-aminobenzophenones as antimitotic agents	Liou, JP; Chang, JY; Chang, CW; Chang, CY; Mahindroo, N; Kuo, FM; Hsieh, HP
國家衛生研究院	2003-12-01	Substituent effects on di-pi-methane and aza-di-pi-methane rearrangements of dibenzo[f,h]quinoxalinobarrelenes	Lin, SY; Hsieh, HP; Peddinti, RK; Liao, CC
國家衛生研究院	2003-06-15	Dual inhibition of topoisomerase I and tubulin polymerization by BPR0Y007, a novel cytotoxic agent	Chang, JY; Hsieh, HP; Pan, WY; Liou, JP; Bey, SJ; Chen, LT; Liu, JF; Song, JS

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