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机构 日期 题名 作者
國家衛生研究院 2013-10-01 喹啉化合物及包含其之治療病毒感染之醫藥組成物 Hsieh, HP;Hsu, TA;Yeh, JY;Chao, YS
國家衛生研究院 2013-09-22 A novel Aurora-A inhibitor, BPR1K0609S1, sensitizes colorectal tumor cells to 5-fluorofracil (5-FU) treatment [Erratum:International Journal of Biological Sciences. 2013 Apr 29;9(4):403-411] Shionome, Y;Lin, WH;Shiao, HY;Hsieh, HP;Hsu, JTA;Ouchi, T
國家衛生研究院 2013-08-21 Fused multicyclic compounds as protein kinase inhibitors Hsieh, HP;Coumar, SM;Chao, YS
國家衛生研究院 2013-08-13 Fused bicyclic and tricyclic pyrimidine compounds as tyrosine kinase inhibitors Hsieh, HP;Coumar, SM;Hsu, TA;Lin, WH;Chen, YR;Chao, YS
國家衛生研究院 2013-07-25 Pronounced induction of endoplasmic reticulum stress and tumor suppression by surfactant-free poly(lactic-co-glycolic acid) nanoparticles via modulation of the PI3K signaling pathway Hou, CC;Tsai, TL;Su, WP;Hsieh, HP;Yeh, CS;Shieh, DB;Su, WC
國家衛生研究院 2013-07-01 做為蛋白質激酶抑制劑之稠合多環化合物 Hsieh, HP;Coumar, MS;Chao, YS
國家衛生研究院 2013-06-28 Optimization of ligand and lipophilic efficiency to identify an in vivo active furano-pyrimidine aurora kinase inhibitor Shiao, HY;Coumar, MS;Chang, CW;Ke, YY;Chi, YH;Chu, CY;Sun, HY;Chen, CH;Lin, WH;Fung, KS;Kuo, PC;Huang, CT;Chang, KY;Lu, CT;Hsu, JT;Chen, CT;Jiaang, WT;Chao, YS;Hsieh, HP
國家衛生研究院 2013-06 An antimitotic and antivascular agent BPR0L075 overcomes multidrug resistance and induces mitotic catastrophe in paclitaxel-resistant ovarian cancer cells Wang, X;Wu, E;Wu, J;Wang, TL;Hsieh, HP;Liu, X
國家衛生研究院 2013-05 Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules Wu, JM;Chen, CT;Coumar, MS;Lin, WH;Chen, ZJ;Hsu, JT;Peng, YH;Shiao, HY;Chu, CY;Wu, JS;Lin, CT;Chen, CP;Hsueh, CC;Chang, KY;Kao, LP;Huang, CY;Chao, YS;Wu, SY;Hsieh, HP;Chi, YH
國家衛生研究院 2013-05 Protein kinase inhibitor design by targeting the Asp-Phe-Gly (DFG) motif: The role of the DFG motif in the design of epidermal growth factor receptor inhibitors Peng, YH;Shiao, HY;Tu, CH;Liu, PM;Hsu, JT;Amancha, PK;Wu, JS;Coumar, MS;Chen, CH;Wang, SY;Lin, WH;Sun, HY;Chao, YS;Lyu, PC;Hsieh, HP;Wu, SY
國家衛生研究院 2013-04-29 A novel Aurora-A inhibitor, BPR1K0609S1, sensitizes colorectal tumor cells to 5-fluorofracil (5-FU) treatment Shionome, Y;Lin, WH;Shiao, HY;Hsieh, HP;Hsu, JTA;Ouchi, T
國家衛生研究院 2013-04-07 BPR000K, a novel Aurora kinase inhibitor Chao, YS;Hsu, JTA;Chen, CT;Yeh, TK;Pan, SL;Hsieh, HP
國家衛生研究院 2013-04-07 Kinase-focused library: Design and synthesis of pyrimidines derivatives bearing amino substituents using high throughput parallel synthesis Wang, WC;Hsieh, HP
國家衛生研究院 2013-04-07 3D-QSAR assisted drug design: Identification of a potent quinazoline based Aurora kinase inhibitor Ke, YY;Shiao, HY;Hsu, YC;Chang-Chu, Y;Wang, WC;Lee, YC;Lin, WH;Hsu, JTA;Chang, CW;Lin, CW;Yeh, TK;Chao, YS;Coumar, MS;Hsieh, HP
國家衛生研究院 2013-04-07 Development drug candidate targeting EGFR kinase: DBPR112 Sun, HY;Hsu, JTA;Chen, CT;Yeh, TK;Pan, SL;Chao, YS;Hsieh, HP
國家衛生研究院 2013-04 Design and synthesis of Aurora kinase inhibitors as anticancer agents Hsu, YC;Shiao, HY;Lin, WH;Hsu, JTA;Chen, CT;Chao, YS;Hsieh, HP
國家衛生研究院 2013-02-20 Parallel screening of Wild-Type and drug-resistant targets for anti-resistance neuraminidase inhibitors Hsu, KC;Hung, HC;Horng, JT;Fang, MY;Chang, CY;Li, LT;Chen, IJ;Chen, YC;Chou, DL;Chang, CW;Hsieh, HP;Yang, JM;Hsu, JT
國家衛生研究院 2013-02-11 作為酪胺酸激酶抑制劑之稠合雙環及多環嘧啶化合物 Hsieh, HP;Coumar, MS;Chao, YS;Hsu, TA;Lin, WH;Chen, YR
國家衛生研究院 2013-01 3D-QSAR-assisted drug design: Identification of a potent quinazoline-based aurora kinase inhibitor Ke, YY;Shiao, HY;Hsu, YC;Chu, CY;Wang, WC;Lee, YC;Lin, WH;Chen, CH;Hsu, JTA;Chang, CW;Lin, CW;Yeh, TK;Chao, YS;Coumar, MS;Hsieh, HP
國家衛生研究院 2013-01 Substituent effects on the photorearrangements of unsymmetrically substituted diazinobarrelenes Hsieh, HP;Chen, AC;Villarante, NR;Chuang, GJ;Liao, CC
國家衛生研究院 2012-12 An efficient, mild and scalable synthesis of bioactive compounds containing the angelicin scaffold Shiao, HY;Kuo, CC;Horng, JT;Shih, SR;Chang, SY;Liao, CC;Hsu, JTA;Kumar, AP;Chao, YS;Hsieh, HP
國家衛生研究院 2012-09 Anti-influenza drug discovery: Identification of an orally bioavailable quinoline derivative through activity- and property-guided lead optimization Yeh, JY;Coumar, MS;Shiao, HY;Lin, TJ;Lee, YC;Hung, HC;Ko, S;Kuo, FM;Fang, MY;Huang, YL;Hsu, JT;Yeh, TK;Shih, SR;Chao, YS;Horng, JT;Hsieh, HP
國家衛生研究院 2012-08-24 Tubulin-destabilizing agent BPR0L075 induces vascular-disruption in human breast cancer mammary fat pad xenografts Liu, L;Beck, H;Wang, X;Hsieh, HP;Mason, RP;Liu, X
國家衛生研究院 2012-05-11 作為極光激酶抑制劑之稠合雙環嘧啶化合物 Hsieh, HP;Coumar, MS;Hsu, TA;Wu, SY;Chao, YS
國家衛生研究院 2012-04-21 吡咯啉啶化合物 Jiaang, WT;Chao, YS;Hsieh, HP

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