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机构 日期 题名 作者
國家衛生研究院 2020-03-01 A selective Aurora-A 5'-UTR siRNA inhibits tumor growth and metastasis Lai, CH;Chen, RY;Hsieh, HP;Tsai, SJ;Chang, KC;Yen, CJ;Huang, YC;Liu, YW;Lee, JC;Lai, YC;Hung, LY;Lin, BW
國家衛生研究院 2020-01 Identification of novel quinoline inhibitor for EHMT2/G9a through virtual screening Chandar Charles, MR;Mahesh, A;Lin, SY;Hsieh, HP;Dhayalan, A;Coumar, MS
國家衛生研究院 2019-10-08 Identification of two novel small compounds that inhibit liver cancer formation in zebrafish and analysis of their conjugation to nanodiamonds to further reduce toxicity Tseng, PH;Sie, ZL;Liu, MC;Lin, HS;Yang, WY;Lin, TY;Hsieh, HP;Hung, SC;Cheng, CL;Wang, HD;Chang, HH;Yuh, CH
國家衛生研究院 2019-10 The molecular mechanisms of EpCAM in regulating tumor progression and development of anti-EpCAM antibodies for colon cancer diagnosis and therapy Wu, HC;Liang, KH;Hsieh, HP;Li, WS
國家衛生研究院 2019-10 Discovery of clinical candidate DBPR112, a furanopyrimidine-based epidermal growth factor receptor inhibitor for the treatment of non-small cell lung cancer Hsieh, HP;Chang, JY;Yeh, CT;Lin, SY;Ke, YY;Lin, WH;Hsu, TA;Wu, SY;Yeh, TK
國家衛生研究院 2019-09-28 Design of drug-like hepsin inhibitors against prostate cancer and kidney stones Blay, V;Li, MC;Ho, SP;Stoller, ML;Hsieh, HP;Houston, DR
國家衛生研究院 2019-09-27 Discovery of a furanopyrimidine-based epidermal growth factor receptor inhibitor (DBPR112) as a clinical candidate for the treatment of non-small cell lung cancer Lin, SY;Chang Hsu, Y;Peng, YH;Ke, YY;Lin, WH;Sun, HY;Shiao, HY;Kuo, FM;Chen, PY;Lien, TW;Chen, CH;Chu, CY;Wang, SY;Yeh, KC;Chen, CP;Hsu, TA;Wu, SY;Yeh, TK;Chen, CT;Hsieh, HP
國家衛生研究院 2019-09 Design of a potent anticancer lead inspired by natural products from traditional Indian medicine Arya, H;Yadav, CS;Lin, SY;Syed, SB;Charles, MRC;Kannadasan, S;Hsieh, HP;Singh, SS;Gajurel, PR;Coumar, MS
國家衛生研究院 2019-07-21 Lysosomal cysteine protease cathepsin S is involved in cancer cell motility by regulating store-operated Ca(2+) entry Lin, HH;Chen, SJ;Shen, MR;Huang, YT;Hsieh, HP;Lin, SY;Lin, CC;Chang, WW;Chang, JY
國家衛生研究院 2019-07 Dual Kit/Aur inhibitors as chemosensitizing agents for the treatment of melanoma: Design, synthesis, docking studies and functional investigation Quattrini, L;Coviello, V;Sartini, S;Di Desidero, T;Orlandi, P;Ke, YY;Liu, KL;Hsieh, HP;Bocci, G;La Motta, C
國家衛生研究院 2019-05-29 Insights for the design of protein lysine methyltransferase G9a inhibitors Charles, MRC;Dhayalan, A;Hsieh, HP;Coumar, MS
國家衛生研究院 2018-11 Biomimetic Syntheses of (±)‐Isopalhinine A, (±)‐Palhinine A, and (±)‐Palhinine D Chen, CM;Shiao, HY;Uang, BJ;Hsieh, HP
國家衛生研究院 2018-07-26 Delineating the active site architecture of G9a lysine methyltransferase through substrate and inhibitor binding mode analysis: A molecular dynamics study M, RCC;Hsieh, HP;Coumar, MS
國家衛生研究院 2018-07 Clinical candidate DBPR112: A novel epidermal growth factor receptor inhibitor as a promising treatment for non-small cell lung cancer Hsieh, HP;Chang, JY;Kuo, CC;Hsu, J
國家衛生研究院 2018-07 Blockage of EGFR signaling repurposes tumor metabolism through suppression of glycolysis and Kreb cycle in head and neck cancer Kuo, CC;Chang, JY;Hsieh, HP;Kung, HJ;Chang, HH;Huang, CH;Kuo, CC;Ke, YY
國家衛生研究院 2018-05-10 Design and synthesis of BPR1K653 derivatives targeting the back pocket of Aurora kinases for selective isoform inhibition Ke, YY;Chang, CP;Lin, WH;Tsai, CH;Chiu, IC;Wang, WP;Wang, PC;Chen, PY;Lin, WH;Chang, CF;Kuo, PC;Song, JS;Shih, C;Hsieh, HP;Chi, YH
國家衛生研究院 2018-01 Discovery and development of DBPR112 as a clinical candidate: A novel EGFR inhibitor for non-small cell lung cancer Hsieh, HP;Hsu, JTA;Yeh, TK;Chen, CT
國家衛生研究院 2017-08-11 Targeting P-glycoprotein: Investigation of piperine analogs for overcoming drug resistance in cancer Syed, SB;Arya, H;Fu, IH;Yeh, TK;Periyasamy, L;Hsieh, HP;Coumar, MS
國家衛生研究院 2017-07 Drug repurposing for chronic myeloid leukemia: In silico and in vitro investigation of DrugBank database for allosteric Bcr-Abl inhibitors Singh, VK;Chang, HH;Kuo, CC;Shiao, HY;Hsieh, HP;Coumar, MS
國家衛生研究院 2017-04 Toward the total syntheses of natural products containing trans-decalin skeleton from masked o-benzoquinone Li, MC;Shiao, HY;Hsieh, HP
國家衛生研究院 2017-04 Discovery of BPR1K871-a quinazoline based multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, in vitro and in vivo evaluation Hsieh, HP;Wang, WC;Shiao, HY;Ke, YY;Lin, WH;Hsu, JTA;Chen, CT;Yeh, TK
國家衛生研究院 2017-04 One-pot tandem oxidative dearomatization/ 4+3 cycloaddition: Masked o-benzoquinone with diaza-oxyallyl cation Lee, KH;Hsieh, HP
國家衛生研究院 2017-01-13 Fused bicyclic pyrimidine compounds as aurora kinase inhibitors Hsieh, HP;Coumar, MS;Hsu, TA;Wu, SY;Chao, YS
國家衛生研究院 2016-12 Discovery of BPR1K871, a quinazoline based, multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, in vitro and in vivo evaluation Chang Hsu, Y;Selvaraj Coumar, M;Wang, WC;Shiao, HY;Ke, YY;Lin, WH;Kuo, CC;Chang, CW;Kuo, FM;Chen, PY;Wang, SY;Li, AS;Chen, CH;Kuo, PC;Chen, CP;Wu, MH;Huang, CL;Yen, KJ;Chang, YI;Hsu, JT;Chen, CT;Yeh, TK;Song, JS;Shih, C;Hsieh, HP
國家衛生研究院 2016-11-29 Discovery of novel inhibitors of Aurora kinases with indazole scaffold: In silico fragment-based and knowledge-based drug design Chang, CF;Lin, WH;Ke, YY;Lin, YS;Wang, WC;Chen, CH;Kuo, PC;Hsu, JTA;Uang, BJ;Hsieh, HP

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