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机构 日期 题名 作者
國家衛生研究院 2018-05-10 Design and synthesis of BPR1K653 derivatives targeting the back pocket of Aurora kinases for selective isoform inhibition Ke, YY;Chang, CP;Lin, WH;Tsai, CH;Chiu, IC;Wang, WP;Wang, PC;Chen, PY;Lin, WH;Chang, CF;Kuo, PC;Song, JS;Shih, C;Hsieh, HP;Chi, YH
國家衛生研究院 2018-01 Discovery and development of DBPR112 as a clinical candidate: A novel EGFR inhibitor for non-small cell lung cancer Hsieh, HP;Hsu, JTA;Yeh, TK;Chen, CT
國家衛生研究院 2017-08-11 Targeting P-glycoprotein: Investigation of piperine analogs for overcoming drug resistance in cancer Syed, SB;Arya, H;Fu, IH;Yeh, TK;Periyasamy, L;Hsieh, HP;Coumar, MS
國家衛生研究院 2017-07 Drug repurposing for chronic myeloid leukemia: In silico and in vitro investigation of DrugBank database for allosteric Bcr-Abl inhibitors Singh, VK;Chang, HH;Kuo, CC;Shiao, HY;Hsieh, HP;Coumar, MS
國家衛生研究院 2017-04 Toward the total syntheses of natural products containing trans-decalin skeleton from masked o-benzoquinone Li, MC;Shiao, HY;Hsieh, HP
國家衛生研究院 2017-04 Discovery of BPR1K871-a quinazoline based multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, in vitro and in vivo evaluation Hsieh, HP;Wang, WC;Shiao, HY;Ke, YY;Lin, WH;Hsu, JTA;Chen, CT;Yeh, TK
國家衛生研究院 2017-04 One-pot tandem oxidative dearomatization/ 4+3 cycloaddition: Masked o-benzoquinone with diaza-oxyallyl cation Lee, KH;Hsieh, HP
國家衛生研究院 2017-01-13 Fused bicyclic pyrimidine compounds as aurora kinase inhibitors Hsieh, HP;Coumar, MS;Hsu, TA;Wu, SY;Chao, YS
國家衛生研究院 2016-12 Discovery of BPR1K871, a quinazoline based, multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, in vitro and in vivo evaluation Chang Hsu, Y;Selvaraj Coumar, M;Wang, WC;Shiao, HY;Ke, YY;Lin, WH;Kuo, CC;Chang, CW;Kuo, FM;Chen, PY;Wang, SY;Li, AS;Chen, CH;Kuo, PC;Chen, CP;Wu, MH;Huang, CL;Yen, KJ;Chang, YI;Hsu, JT;Chen, CT;Yeh, TK;Song, JS;Shih, C;Hsieh, HP
國家衛生研究院 2016-11-29 Discovery of novel inhibitors of Aurora kinases with indazole scaffold: In silico fragment-based and knowledge-based drug design Chang, CF;Lin, WH;Ke, YY;Lin, YS;Wang, WC;Chen, CH;Kuo, PC;Hsu, JTA;Uang, BJ;Hsieh, HP
國家衛生研究院 2016-11-23 Fused bicyclic pyrimidine compounds as aurora kinase inhibitors Hsieh, HP;Coumar, MS;Hsu, TA;Wu, SY;Chao, YS
國家衛生研究院 2016-07 Therapeutic polymeric nanoparticles and the methods of making and using thereof: A patent evaluation of WO2015036792 Sarvagalla, S;Hsieh, HP;Coumar, MS
國家衛生研究院 2016-06-07 Fused bicyclic pyrimidine compounds as aurora kinase inhibitors Hsieh, HP;Coumar, MS;Hsu, TA;Wu, SY;Chao, YS
國家衛生研究院 2016-03 Disruption of protein-protein interactions: Hot spot detection, structure-based virtual screening and in vitro testing for the anti-cancer drug target survivin Sarvagalla, S;Cheung, CHA;Tsai, JY;Hsieh, HP;Coumar, MS
國家衛生研究院 2015-08-20 Fused bicyclic pyrimidine compounds as Aurora kinase inhibitors Coumar, MS;Chao, YS;Hsu, TA;Wu, SY;Hsieh, HP
國家衛生研究院 2015-08 BPR2P001S0, a Coumarin derivative, induced cell cycle arrest in A549 through inhibiting PDPK1 activity Lin, PH;Jao, TM;Hung, YL;Hsieh, HP;Yang, YC;Chang, SY
國家衛生研究院 2015-08 Optimization of quinazoline-based kinase inhibitors: Identification of a dual FLT3/AURKA kinase inhibitor for the treatment of acute myeloid leukemia Hsieh, HP;Hsu, YC;Ke, YY;Shiao, HY;Chang, CW;Lin, WH;Hsu, TA;Yeh, TK;Chen, CT
國家衛生研究院 2015-08 Optimization of furanopyrimidine-based kinase inhibitors: Identification of a BTK kinase inhibitor for the treatment of B cell lymphoma Wang, WC;Hsu, YC;Shiao, HY;Hung, HC;Kuo, CC;Lee, JC;Hsu, TA;Hsieh, HP
國家衛生研究院 2015-08 Discovery of 2,4-diaminopyrimidines bearing a unique pharmacophore as anaplastic lymphoma kinase inhibitors Shiao, HY;Wang, WC;Hsu, YC;Ke, YY;Hsu, TA;Hsieh, HP
國家衛生研究院 2015-07-31 作為極光激酶抑制劑的稠合雙環嘧啶化合物 Hsieh, HP;Coumar, MS;Wu, SY;Hsu, TA;Chao, YS
國家衛生研究院 2015-07-22 作为酪胺酸激酶抑制剂的稠合双环及多环嘧啶化合物 Hsieh, HP;Coumar, MS;Hsu, TA;Lin, WH;Chen, YR;Chao, YS
國家衛生研究院 2015-06-29 Homology modeling of DFG-in FMS-like tyrosine kinase 3 (FLT3) and structure-based virtual screening for inhibitor identification Ke, YY;Singh, VK;Coumar, MS;Hsu, YC;Wang, WC;Song, JS;Chen, CH;Lin, WH;Wu, SH;Hsu, JT;Shih, C;Hsieh, HP
國家衛生研究院 2015-04-14 Fused multicyclic compounds as protein kinase inhibitors Hsieh, HP;Coumar, MS;Chao, YS
國家衛生研究院 2015-02 Function-oriented development of CXCR4 antagonists as selective human immunodeficiency virus (HIV)-1 entry inhibitors Wu, CH;Wang, CJ;Chang, CP;Cheng, YC;Song, JS;Jan, JJ;Chou, MC;Ke, YY;Ma, J;Wong, YC;Hsieh, TC;Tien, YC;Gullen, EA;Lo, CF;Cheng, CY;Liu, YW;Sadani, AA;Tsai, CH;Hsieh, HP;Tsou, LK;Shia, KS
國家衛生研究院 2015-01 Identification of ligand efficient, fragment-like hits from an HTS library: Structure-based virtual screening and docking investigations of 2H- and 3H-pyrazolo tautomers for Aurora kinase A selectivity Sarvagalla, S;Singh, VK;Ke, YY;Shiao, HY;Lin, WH;Hsieh, HP;Hsu, JTA;Coumar, MS

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