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Institution	Date	Title	Author
國家衛生研究院	2012-12	An efficient, mild and scalable synthesis of bioactive compounds containing the angelicin scaffold	Shiao, HY;Kuo, CC;Horng, JT;Shih, SR;Chang, SY;Liao, CC;Hsu, JTA;Kumar, AP;Chao, YS;Hsieh, HP
國家衛生研究院	2012-09	Anti-influenza drug discovery: Identification of an orally bioavailable quinoline derivative through activity- and property-guided lead optimization	Yeh, JY;Coumar, MS;Shiao, HY;Lin, TJ;Lee, YC;Hung, HC;Ko, S;Kuo, FM;Fang, MY;Huang, YL;Hsu, JT;Yeh, TK;Shih, SR;Chao, YS;Horng, JT;Hsieh, HP
國家衛生研究院	2012-08-24	Tubulin-destabilizing agent BPR0L075 induces vascular-disruption in human breast cancer mammary fat pad xenografts	Liu, L;Beck, H;Wang, X;Hsieh, HP;Mason, RP;Liu, X
國家衛生研究院	2012-05-11	作為極光激酶抑制劑之稠合雙環嘧啶化合物	Hsieh, HP;Coumar, MS;Hsu, TA;Wu, SY;Chao, YS
國家衛生研究院	2012-04-21	吡咯啉啶化合物	Jiaang, WT;Chao, YS;Hsieh, HP
國家衛生研究院	2012-03-25	Design, synthesis, and SAR studies of duel FLT-3 and Aurora kinase inhibitors	Hsieh, HP;Shiao, HY;Lin, WH;Hsu, JTA;Chao, YS
國家衛生研究院	2012-03-20	Fused bicyclic pyrimidine compounds as aurora kinase inhibitors	Hsieh, HP;Coumar, MS;Hsu, TA;Wu, SY;Chao, YS
國家衛生研究院	2012-03-06	Indole compounds	Hsieh, HP;Liou, JP;Chang, JY;Chang, CW
國家衛生研究院	2012-02	Identification of BPR3P0128 as an Inhibitor of cap-snatching activities of influenza virus	Hsu, JT;Yeh, JY;Lin, TJ;Li, ML;Wu, MS;Hsieh, CF;Chou, YC;Tang, WF;Lau, KS;Hung, HC;Fang, MY;Ko, S;Hsieh, HP;Horng, JT
國家衛生研究院	2012-01-17	Pyrrolidine compounds	Jiaang, WT;Chen, X;Wu, SY;Hsieh, HP;Chao, YS
國家衛生研究院	2012-01	A High-throughput cell-based screening for L858R/T790M mutant epidermal growth factor receptor inhibitors	Lin, WH;Song, JS;Lien, TW;Chang, CY;Wu, SH;Huang, YW;Chang, TY;Fang, MY;Yen, KJ;Chen, CH;Chu, CY;Hsieh, HP;Chen, YR;Chao, YS;Hsu, JT
國家衛生研究院	2011-11-15	Coumarin compounds and their use for treating cancer	Hsieh, HP;Chang, JY;Kuo, CC;Chao, YS
國家衛生研究院	2011-09-23	BPR1K653, a novel Aurora Kinase Inhibitor, exhibits potent anti-proliferative activity in P-gp170 (MDR1)-mediated VX680-resistant cancer cells in vitro and in vivo	Hsieh, HP;Cheung, CHA;Lin, WH;Hsu, TA;Coumar, MS;Chao, YS;Chang, JY
國家衛生研究院	2011-09	Synthesis and biological evaluation of 1-(4′-Indolyl and 6′-Quinolinyl) indoles as a new class of potent anticancer agents	Lai, MJ;Chang, JY;Lee, HY;Kuo, CC;Lin, MH;Hsieh, HP;Chang, CY;Wu, JS;Wu, SY;Shey, KS;Liou, JP
國家衛生研究院	2011-09	Inhibition of HIV-1 Tat-mediated transcription by a coumarin derivative, BPRHIV001, through the Akt pathway	Lin, PH;Ke, YY;Su, CT;Shiao, HY;Hsieh, HP;Chao, YK;Lee, CN;Kao, CL;Chao, YS;Chang, SY
國家衛生研究院	2011-08	BPR1K653, a novel aurora kinase inhibitor, exhibits potent anti-proliferative activity in MDR1 (P-gp170)-mediated multidrug-resistant cancer cells	Cheung, CH;Lin, WH;Hsu, TA;Hour, TC;Yeh, TK;Ko, S;Lien, TW;Coumar, MS;Liu, JF;Lai, WY;Shiao, HY;Lee, TR;Hsieh, HP;Chang, JY
國家衛生研究院	2011-07-11	抑制C型肝炎病毒感染之倍半帖內酯類化合物及其醫藥組成物	Hsieh, HP;Hsu, TA;Hwang, DR
國家衛生研究院	2011-06-21	抑制冠狀病毒之醫藥組合物	Hsu, TA;Hsieh, HP;Chao, YS;Chen, CM;Jan, JT;Liu, HW
國家衛生研究院	2011-06-21	抑制冠狀病毒之醫藥組合物	Hsu, TA;Hsieh, HP;Chao, YS;Chen, CM;Jan, JT;Liu, HW
國家衛生研究院	2011-06-21	抑制冠狀病毒之醫藥組合物	Hsu, TA;Hsieh, HP;Chao, YS;Chen, CM;Jan, JT;Liu, HW
國家衛生研究院	2011-06	Aurora kinase inhibitor patents and agents in clinical testing: an update (2009-10)	Cheung, CHA;Coumar, MS;Chang, JY;Hsieh, HP
國家衛生研究院	2011-04-28	Scaffold-hopping strategy: Synthesis and biological evaluation of 5,6-Fused bicyclic heteroaromatics to identify orally bioavailable anticancer agents	Tung, YS;Coumar, MS;Wu, YS;Shiao, HY;Chang, JY;Liou, JP;Shukla, P;Chang, CW;Chang, CY;Kuo, CC;Yeh, TK;Lin, CY;Wu, JS;Wu, SY;Liao, CC;Hsieh, HP
國家衛生研究院	2011-04-06	Indole compounds as inhibitors of tubulin polymerisation for the treatment of angiogenesis related disorders	Hsieh, HP;Chang, JY;Liou, JP;Chang, CW
國家衛生研究院	2011-04	Antivascular activities of novel tubulin binding agent BPR0L075	Liu, XL;Liu, L;Beck, H;Hsieh, HP;Boreddy, S;Srivastava, S;Mason, RP
國家衛生研究院	2011-03-27	Design and synthesis of potent Aurora kinase inhibitors	Chu, CY;Mohane, CS;Hsu, JTA;Yeh, TK;Chen, CT;Chao, YS;Hsieh, HP
國家衛生研究院	2011-03-07	2-Amino-3,4,5-Trimethoxybenzophenones as Potent Tubulin Polymerization Inhibitors	Chuang, HY;Chang, JY;Lai, MJ;Kuo, CC;Lee, HY;Hsieh, HP;Chen, YJ;Chen, LT;Pan, WY;Liou, JP
國家衛生研究院	2011-03	Potent EGFR tyrosine kinase inhibitors as anticancer agents	Shiao, HY;Chu, CY;Hsu, JTA;Yeh, TK;Hsieh, HP
國家衛生研究院	2011-03	SAR studies of quinoline derivatives as novel anti-influenza agents	Ko,SK;Yeh, JY;Horng, JT;Hsu, TA;Hsieh HP
高雄醫學大學	2011	2-amino-3,4,5-trimethoxybenzophenones as potent tubulin polymerization inhibitors.	陳立宗; Chuang HY;Chang JY;Lai MJ;Kuo CC;Lee HY;Hsieh HP;Chen YJ;Chen LT;Pan WY;Liou JP.
臺北醫學大學	2011	2-Amino-3,4,5-Trimethoxybenzophenones as Potent Tubulin Polymerization Inhibitors	Chuang, HY;Chang, JY;Lai, MJ;Kuo, CC;Lee, HY;Hsieh, HP;Chen, YJ;Chen, LT;Pan, WY;Liou, JP
臺北醫學大學	2011	Synthesis and Biological Evaluation of 1-(4’-Indolyl and 6’-Quinolinyl)indoles as a New Class of Potent Anticancer Agents	Lia, MJ;Chang, JY;Lee, HY;Kuo, CC;Lin, MH;Hsieh, HP;Chang, CY;Wu, JS;Wu, SY;Shey, KS;Liou, JP
臺北醫學大學	2011	Synthesis and biological evaluation of 1-(40-Indolyl and 60-Quinolinyl) indoles as a new class of potent anticancer agents.	Lai, MJ;Chang, JY;Lee, HY;Kuo, CC;Lin, MH;Hsieh, HP;Chang, CY;Wu, JS;Wu, SY;Shey;KS;Liou, JP
國家衛生研究院	2010-12-01	吲哚化合物	Hsieh, HP;Mahindroo, N;Hsu, TA;Huang, CF;Chen, X;Chao, YS
國家衛生研究院	2010-12-01	抗肿瘤化合物	Hsieh, HP;Chao, YS;Liou, JP;Chang, JY;Tung, YS
國家衛生研究院	2010-10-28	Design and synthesis of tetrahydropyridothieno[2,3-d]pyrimidine scaffold based epidermal growth factor receptor (EGFR) kinase inhibitors: the role of side chain chirality and michael acceptor group for maximal potency	Wu, CH;Coumar, MS;Chu, CY;Lin, WH;Chen, YR;Chen, CT;Shiao, HY;Rafi, S;Wang, SY;Hsu, H;Chen, CH;Chang, CY;Chang, TY;Lien, TW;Fang, MY;Yeh, KC;Chen, CP;Yeh, TK;Hsieh, SH;Hsu, JT;Liao, CC;Chao, YS;Hsieh, HP
國家衛生研究院	2010-10-06	吡咯烷化合物	Jiaang, WT;Chen, X;Wu, SY;Hsieh, HP;Chao, YS
國家衛生研究院	2010-10	Structural basis for the improved potency of peroxisome proliferator-activated receptor (PPAR) agonists	Peng, YH;Coumar, MS;Leou, JS;Wu, JS;Shiao, HY;Lin, CH;Lin, WH;Lien, TW;Chen, X;Hsu, JT;Chao, YS;Huang, CF;Lyu, PC;Hsieh, HP;Wu, SY
國家衛生研究院	2010-09	Cancer cells acquire mitotic drug resistance properties through beta i-tubulin mutations and alterations in the expression of beta-tubulin isotypes	Cheung, CHA;Wu, SY;Lee, TR;Chang, CY;Wu, JS;Hsieh, HP;Chang, JY
國家衛生研究院	2010-08	Lead optimization of furanopyrimidine Aurora kinase inhibitors: Development of in vivo active agents in tumor xenograft models	Hsieh, HP;Chu, CY;Coumar, MS;Lin, WH;Chen, CT;Hsu, TA;Wu, SY;Chao, YS
國家衛生研究院	2010-07	Antiangiogenic Activities and Cisplatin-combined Antitumor Activities of BPR0L075	Chen, CP;Hu, CB;Yeh, KC;Song, JS;Yeh, TK;Tung, FF;Hwang, LL;Tseng, HY;Huang, YC;Shy, HS;Hsieh, SH;Shen, CC;Wang, HS;Hsieh, HP;Liou, JP;Chao, YS;Chen, CT
國家衛生研究院	2010-06-15	Fast-forwarding hit to lead: Aurora and epidermal growth factor receptor kinase inhibitor lead identification	Coumar, MS;Chu, CY;Lin, CW;Shiao, HY;Ho, YL;Reddy, R;Lin, WH;Chen, CH;Peng, YH;Leou, JS;Lien, TW;Huang, CT;Fang, MY;Wu, SH;Wu, JS;Chittimalla, SK;Song, JS;Hsu, JT;Wu, SY;Liao, CC;Chao, YS;Hsieh, HP
國家衛生研究院	2010-06	Design and synthesis of alpha-ketoamides as cathepsin S inhibitors with potential applications against tumor invasion and angiogenesis	Chen, JC;Uang, BJ;Lyu, PC;Chang, JY;Liu, KJ;Kuo, CC;Hsieh, HP;Wang, HC;Cheng, CS;Chang, YH;Chang, MDT;Chang, WSW;Lin, CC
國家衛生研究院	2010-03-30	Pyrrolidine compounds	Jiaang, WT;Chen, X;Wu, SY;Chao, YS;Hsieh, HP
國家衛生研究院	2010-03-11	5-Amino-2-Aroylquinolines as Highly Potent Tubulin Polymerization Inhibitors	Nien, CY;Chen, YC;Kuo, CC;Hsieh, HP;Chang, CY;Wu, JS;Wu, SY;Liou, JP;Chang, JY
國家衛生研究院	2010-02-25	Anti-influenza drug discovery: structure-activity relationship and mechanistic insight into novel angelicin derivatives	Yeh, JY;Coumar, MS;Horng, JT;Shiao, HY;Kuo, FM;Lee, HL;Chen, IC;Chang, CW;Tang, WF;Tseng, SN;Chen, CJ;Shih, SR;Hsu, JT;Liao, CC;Chao, YS;Hsieh, HP
國家衛生研究院	2010-02-23	Pyrazole compound BPR1P0034 with potent and selective anti-influenza virus activity	Shih, SR;Chu, TY;Reddy, GR;Tseng, SN;Chen, HL;Tang, WF;Wu, MS;Yeh, JY;Chao, YS;Hsu, JTA;Hsieh, HP;Horng, JT
國家衛生研究院	2010-02-01	Identification, SAR studies, and X-ray Co-crystallographic analysis of a novel furanopyrimidine aurora kinase a inhibitor	Coumar, MS;Tsai, MT;Chu, CY;Uang, BJ;Lin, WH;Chang, CY;Chang, TY;Leou, JS;Teng, CH;Wu, JS;Fang, MY;Chen, CH;Hsu, JTA;Wu, SY;Chao, YS;Hsieh, HP
國家衛生研究院	2010-02	Comparative molecular field analysis of anti-tubulin agents with indole ring binding at the colchicine binding site	Lin, IH;Hsu, CC;Wang, SH;Hsieh, HP;Sun, YC
國家衛生研究院	2010-01	BPR2-D2 targeting viral ribonucleoprotein complex-associated function inhibits oseltamivir-resistant influenza viruses	Shih, SR;Horng, JT;Poon, LL;Chen, TC;Yeh, JY;Hsieh, HP;Tseng, SN;Chiang, C;Li, WL;Chao, YS;Hsu, JT
臺北醫學大學	2010	5-Amino-2-Aroylquinolines as Highly Potent Tubulin Polymerization Inhibitors	Nien, CY;Chen, YC;Kuo, CC;Hsieh, HP;Chang, CY;Wu, JS;Wu, SY;Liou, JP;Chang, JY

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