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Institution	Date	Title	Author
臺北醫學大學	2011	Synthesis and Biological Evaluation of 1-(4’-Indolyl and 6’-Quinolinyl)indoles as a New Class of Potent Anticancer Agents	Lia, MJ;Chang, JY;Lee, HY;Kuo, CC;Lin, MH;Hsieh, HP;Chang, CY;Wu, JS;Wu, SY;Shey, KS;Liou, JP
臺北醫學大學	2011	Synthesis and biological evaluation of 1-(40-Indolyl and 60-Quinolinyl) indoles as a new class of potent anticancer agents.	Lai, MJ;Chang, JY;Lee, HY;Kuo, CC;Lin, MH;Hsieh, HP;Chang, CY;Wu, JS;Wu, SY;Shey;KS;Liou, JP
國家衛生研究院	2010-12-01	吲哚化合物	Hsieh, HP;Mahindroo, N;Hsu, TA;Huang, CF;Chen, X;Chao, YS
國家衛生研究院	2010-12-01	抗肿瘤化合物	Hsieh, HP;Chao, YS;Liou, JP;Chang, JY;Tung, YS
國家衛生研究院	2010-10-28	Design and synthesis of tetrahydropyridothieno[2,3-d]pyrimidine scaffold based epidermal growth factor receptor (EGFR) kinase inhibitors: the role of side chain chirality and michael acceptor group for maximal potency	Wu, CH;Coumar, MS;Chu, CY;Lin, WH;Chen, YR;Chen, CT;Shiao, HY;Rafi, S;Wang, SY;Hsu, H;Chen, CH;Chang, CY;Chang, TY;Lien, TW;Fang, MY;Yeh, KC;Chen, CP;Yeh, TK;Hsieh, SH;Hsu, JT;Liao, CC;Chao, YS;Hsieh, HP
國家衛生研究院	2010-10-06	吡咯烷化合物	Jiaang, WT;Chen, X;Wu, SY;Hsieh, HP;Chao, YS
國家衛生研究院	2010-10	Structural basis for the improved potency of peroxisome proliferator-activated receptor (PPAR) agonists	Peng, YH;Coumar, MS;Leou, JS;Wu, JS;Shiao, HY;Lin, CH;Lin, WH;Lien, TW;Chen, X;Hsu, JT;Chao, YS;Huang, CF;Lyu, PC;Hsieh, HP;Wu, SY
國家衛生研究院	2010-09	Cancer cells acquire mitotic drug resistance properties through beta i-tubulin mutations and alterations in the expression of beta-tubulin isotypes	Cheung, CHA;Wu, SY;Lee, TR;Chang, CY;Wu, JS;Hsieh, HP;Chang, JY
國家衛生研究院	2010-08	Lead optimization of furanopyrimidine Aurora kinase inhibitors: Development of in vivo active agents in tumor xenograft models	Hsieh, HP;Chu, CY;Coumar, MS;Lin, WH;Chen, CT;Hsu, TA;Wu, SY;Chao, YS
國家衛生研究院	2010-07	Antiangiogenic Activities and Cisplatin-combined Antitumor Activities of BPR0L075	Chen, CP;Hu, CB;Yeh, KC;Song, JS;Yeh, TK;Tung, FF;Hwang, LL;Tseng, HY;Huang, YC;Shy, HS;Hsieh, SH;Shen, CC;Wang, HS;Hsieh, HP;Liou, JP;Chao, YS;Chen, CT
國家衛生研究院	2010-06-15	Fast-forwarding hit to lead: Aurora and epidermal growth factor receptor kinase inhibitor lead identification	Coumar, MS;Chu, CY;Lin, CW;Shiao, HY;Ho, YL;Reddy, R;Lin, WH;Chen, CH;Peng, YH;Leou, JS;Lien, TW;Huang, CT;Fang, MY;Wu, SH;Wu, JS;Chittimalla, SK;Song, JS;Hsu, JT;Wu, SY;Liao, CC;Chao, YS;Hsieh, HP
國家衛生研究院	2010-06	Design and synthesis of alpha-ketoamides as cathepsin S inhibitors with potential applications against tumor invasion and angiogenesis	Chen, JC;Uang, BJ;Lyu, PC;Chang, JY;Liu, KJ;Kuo, CC;Hsieh, HP;Wang, HC;Cheng, CS;Chang, YH;Chang, MDT;Chang, WSW;Lin, CC
國家衛生研究院	2010-03-30	Pyrrolidine compounds	Jiaang, WT;Chen, X;Wu, SY;Chao, YS;Hsieh, HP
國家衛生研究院	2010-03-11	5-Amino-2-Aroylquinolines as Highly Potent Tubulin Polymerization Inhibitors	Nien, CY;Chen, YC;Kuo, CC;Hsieh, HP;Chang, CY;Wu, JS;Wu, SY;Liou, JP;Chang, JY
國家衛生研究院	2010-02-25	Anti-influenza drug discovery: structure-activity relationship and mechanistic insight into novel angelicin derivatives	Yeh, JY;Coumar, MS;Horng, JT;Shiao, HY;Kuo, FM;Lee, HL;Chen, IC;Chang, CW;Tang, WF;Tseng, SN;Chen, CJ;Shih, SR;Hsu, JT;Liao, CC;Chao, YS;Hsieh, HP
國家衛生研究院	2010-02-23	Pyrazole compound BPR1P0034 with potent and selective anti-influenza virus activity	Shih, SR;Chu, TY;Reddy, GR;Tseng, SN;Chen, HL;Tang, WF;Wu, MS;Yeh, JY;Chao, YS;Hsu, JTA;Hsieh, HP;Horng, JT
國家衛生研究院	2010-02-01	Identification, SAR studies, and X-ray Co-crystallographic analysis of a novel furanopyrimidine aurora kinase a inhibitor	Coumar, MS;Tsai, MT;Chu, CY;Uang, BJ;Lin, WH;Chang, CY;Chang, TY;Leou, JS;Teng, CH;Wu, JS;Fang, MY;Chen, CH;Hsu, JTA;Wu, SY;Chao, YS;Hsieh, HP
國家衛生研究院	2010-02	Comparative molecular field analysis of anti-tubulin agents with indole ring binding at the colchicine binding site	Lin, IH;Hsu, CC;Wang, SH;Hsieh, HP;Sun, YC
國家衛生研究院	2010-01	BPR2-D2 targeting viral ribonucleoprotein complex-associated function inhibits oseltamivir-resistant influenza viruses	Shih, SR;Horng, JT;Poon, LL;Chen, TC;Yeh, JY;Hsieh, HP;Tseng, SN;Chiang, C;Li, WL;Chao, YS;Hsu, JT
臺北醫學大學	2010	5-Amino-2-Aroylquinolines as Highly Potent Tubulin Polymerization Inhibitors	Nien, CY;Chen, YC;Kuo, CC;Hsieh, HP;Chang, CY;Wu, JS;Wu, SY;Liou, JP;Chang, JY
國家衛生研究院	2009-12-15	Indole compounds	Hsieh, HP;Liou, JP;Chang, JY;Chang, CW
國家衛生研究院	2009-12-01	芳香羰吲哚化合物	Hsieh, HP;Liou, JP;Chang, JY;Chang, CW
國家衛生研究院	2009-09	Fast-forwarding kinase drug discovery: aurora and EGFR kinase inhibitor lead development	Hsieh, HP;Coumarrs, MS;Chu, CY;Ho, YL;Tsai, MT;Lin, WH;Chen, CH;Song, JS;Hsu, JTA;Chao, YS
國家衛生研究院	2009-08-13	Synthesis and evaluation of 3-aroylindoles as anticancer agents: Metabolite approach	Wu, YS;Coumar, MS;Chang, JY;Sun, HY;Kuo, FM;Kuo, CC;Chen, YJ;Chang, CY;Hsiao, CL;Liou, JP;Chen, CP;Yao, HT;Chiang, YK;Tan, UK;Chen, CT;Chu, CY;Wu, SY;Yeh, TK;Lin, CY;Hsieh, HP
中國醫藥大學	2009-08	Synthesis and Evaluation of 3-Aroylindoles as Anticancer Agents: Metabolite Approach.	(Wu YS); (Coumar MS); (Chang JY); (Sun HY); (Kuo FM); (Kuo CC); (Chen YJ); (Chang CY); (Hsiao CL); (Liou JP); (Chen CP); 姚賢宗(Hsien-Tsung Yao); (Chiang YK); (Tan UK); (Chen CT); (Chu CY); (Wu SY); (Yeh TK); (Lin CY); (Hsieh HP)*
國家衛生研究院	2009-07-23	Generation of ligand-based pharmacophore model and virtual screening for identification of novel tubulin inhibitors with potent anticancer activity	Chiang, YK;Kuo, CC;Wu, YS;Chen, CT;Coumar, MS;Wu, JS;Hsieh, HP;Chang, CY;Jseng, HY;Wu, MH;Leou, JS;Song, JS;Chang, JY;Lyu, PC;Chao, YS;Wu, SY
國家衛生研究院	2009-07-03	Survivin counteracts the therapeutic effect of microtubule de-stabilizers by stabilizing tubulin polymers	Cheung, CH;Chen, HH;Kuo, CC;Chang, CY;Coumar, MS;Hsieh, HP;Chang, JY
國家衛生研究院	2009-06-09	Treatment of coronavirus infection	Hsu, TA;Hsieh, HP;Chao, YS;Chen, CM;Jan, JT;Liu, HW
國家衛生研究院	2009-05-05	Indole compounds	Hsieh, HP;Liou, JP;Chang, JY;Chang, CW
國家衛生研究院	2009-05	Down-regulation of survivin enhances sensitivity to BPROL075 in human cancer cells via caspase-independent mechanisms	Cheung, CHA;Chang, CY;Hsieh, HP;Chang, JY
國家衛生研究院	2009-04-24	Bortezomib overcomes tumor necrosis factor-related apoptosis-inducing ligand resistance in hepatocellular carcinoma cells in part through the inhibition of the phosphatidylinositol 3-kinase/Akt pathway	Chen, KF;Yeh, PY;Hsu, C;Hsu, CH;Lu, YS;Hsieh, HP;Chen, PJ;Cheng, AL
國家衛生研究院	2009-04-23	Design and structural analysis of novel pharmacophores for potent and selective peroxisome proliferator-activated receptor gamma agonists	Lin, CH;Peng, YH;Coumar, MS;Chittimalla, SK;Liao, CC;Lyn, PC;Huang, CC;Lien, TW;Lin, WH;Hsu, JT;Cheng, JH;Chen, X;Wu, JS;Chao, YS;Lee, HJ;Juo, CG;Wu, SY;Hsieh, HP
國家衛生研究院	2009-04-17	Synthesis and structure-activity relationships of 1-benzyl-4,5,6-trimethoxyindoles as a novel class of potent antimitotic agents	Lai, MJ;Kuo, CC;Yeh, TK;Hsieh, HP;Chen, LT;Pan, WY;Hsu, KY;Chang, JY;Liou, JP
國家衛生研究院	2009-04	Aurora kinase inhibitors in preclinical and clinical testing	Cheung, CH;Coumar, MS;Hsieh, HP;Chang, JY
國家衛生研究院	2009-03	Advances in Aurora kinase inhibitor patents	Coumar, MS;Cheung, CHA;Chang, JY;Hsieh, HP
國家衛生研究院	2009-03	Discovery and development of novel furano-pyrimidine analogs as Aurora kinase inhibitors	Hsieh, HP;Coumar, MS;Lin, CW;Reddy, GR;Tsai, MT;Lin, WH;Hsu, TA;Wu, SY
國家衛生研究院	2009-02-26	Structure-based drug design of novel aurora kinase a inhibitors: Structural basis for potency and specificity	Coumar, MS;Leou, JS;Shukla, P;Wu, JS;Dixit, AK;Lin, WH;Chang, CY;Lien, TW;Tan, UK;Chen, CH;Hsu, JTA;Chao, YS;Wu, SY;Hsieh, HP
國家衛生研究院	2009-02	Aurintricarboxylic acid inhibits influenza virus neuraminidase	Hung, HC;Tseng, CP;Yang, JM;Ju, YW;Tseng, SN;Chen, YF;Chao, YS;Hsieh, HP;Shih, SR;Hsu, JTA
國家衛生研究院	2009-01-22	Pyrrolidine compounds	Chao, YS;Chen, X;Hsieh, HP;Jiaang, WT;Wu, SY
國家衛生研究院	2008-12-25	Synthesis and structure-activity relationships of 2-amino-1-aroylnaphthalene and 2-hydroxy-1-aroylnaphthalenes as potent antitubulin agents	Reddy, GR;Kuo, CC;Tan, UK;Coumar, MS;Chang, CY;Chiang, YK;Lai, MJ;Yeh, JY;Wu, SY;Chang, JY;Liou, JP;Hsieh, HP
國家衛生研究院	2008-12-11	吲哚化合物	Hsieh, HP;Mahindroo, N;Hsu, TA;Huang, CF;Chen, X;Chao, YS
國家衛生研究院	2008-11-25	Anti-tumor compounds	Hsieh, HP;Chao, YS;Liou, JP;Chang, JY;Tung, YS
國家衛生研究院	2008-11-11	Indole compounds	Hsieh, HP;Mahindroo, NH;Hsu, TA;Huang, CF;Chen, X;Chao, YS
國家衛生研究院	2008-09-16	Pyrrolidine compounds	Jiaang, WT;Chao, YS;Hsieh, HP
國家衛生研究院	2008-07-24	Discovery of 4-amino and 4-hydroxy-1-aroylindoles as potent tubulin polymerization inhibitors	Liou, JP; Wu, ZY; Kuo, CC; Chang, CY; Lu, PY; Chen, CM; Hsieh, HP; Chang, JY
國家衛生研究院	2008-07-21	吡咯啉啶化合物	Jiaang, WT;Wu, SY;Chen, X;Chao, YS;Hsieh, HP
國家衛生研究院	2008-07-01	Pyrrolidine compounds	Jiaang, WT;Chen, X;Wu, SY;Hsieh, HP;Chao, YS
國家衛生研究院	2008-07	Anti-HSV activity of digitoxin and its possible mechanisms	Su, CT; Hsu, JTA; Hsieh, HP; Lin, PH; Chen, TC; Kao, CL; Lee, CN; Chang, SY
國立臺灣大學	2008-07	Anti-HSV activity of digitoxin and its possible mechanisms	Su, CT; Hsu, JT; Hsieh, HP; Lin, PH; Chen, TC; Kao, CL; Lee, CN; Chang, SY
國家衛生研究院	2008-06-01	A cell-based high-throughput screen for epidermal growth factor receptor pathway inhibitors	Lin, WH; Song, JS; Chang, TY; Chang, CY; Fu, YN; Yeh, CL; Wu, SH; Huang, YW; Fang, MY; Lien, TW; Hsieh, HP; Chao, YS; Huang, SF; Tsai, SF; Wang, LM; Hsu, JTA; Chen, YR

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