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Institution	Date	Title	Author
國家衛生研究院	2015-07-22	作为酪胺酸激酶抑制剂的稠合双环及多环嘧啶化合物	Hsieh, HP;Coumar, MS;Hsu, TA;Lin, WH;Chen, YR;Chao, YS
國家衛生研究院	2015-06-29	Homology modeling of DFG-in FMS-like tyrosine kinase 3 (FLT3) and structure-based virtual screening for inhibitor identification	Ke, YY;Singh, VK;Coumar, MS;Hsu, YC;Wang, WC;Song, JS;Chen, CH;Lin, WH;Wu, SH;Hsu, JT;Shih, C;Hsieh, HP
國家衛生研究院	2015-04-14	Fused multicyclic compounds as protein kinase inhibitors	Hsieh, HP;Coumar, MS;Chao, YS
國家衛生研究院	2015-02	Function-oriented development of CXCR4 antagonists as selective human immunodeficiency virus (HIV)-1 entry inhibitors	Wu, CH;Wang, CJ;Chang, CP;Cheng, YC;Song, JS;Jan, JJ;Chou, MC;Ke, YY;Ma, J;Wong, YC;Hsieh, TC;Tien, YC;Gullen, EA;Lo, CF;Cheng, CY;Liu, YW;Sadani, AA;Tsai, CH;Hsieh, HP;Tsou, LK;Shia, KS
國家衛生研究院	2015-01	Identification of ligand efficient, fragment-like hits from an HTS library: Structure-based virtual screening and docking investigations of 2H- and 3H-pyrazolo tautomers for Aurora kinase A selectivity	Sarvagalla, S;Singh, VK;Ke, YY;Shiao, HY;Lin, WH;Hsieh, HP;Hsu, JTA;Coumar, MS
國家衛生研究院	2014-12	BPR-3P0128 inhibits RNA-dependent RNA polymerase elongation and VPg uridylylation activities of Enterovirus 71	Balaji, VA;Chen, GW;Hsieh, PT;Horng, JT;Hsu, JTA;Hsieh, HP;Chen, TC;Weng, KF;Shih, SR
國家衛生研究院	2014-11	Discovery of multiple kinases inhibitors, DBPR114, as the novel anti-cancer agent	Hsieh, HP;Kuo, CC;Chiu, JJ;Hsu, TA;Yeh, TK;Chen, CT
國家衛生研究院	2014-10-29	作為極光激酶抑制劑的稠合雙環嘧啶化合物	Hsieh, HP;Coumar, MS;Hsu, TA;Wu, SY;Chao, YS
國家衛生研究院	2014-10-21	化合物於製造治療病毒感染的藥物之用途	Hsieh, HP;Hsu, TA;Yeh, JY;Horng, JT;Shih, SR;Chang, SY;Chao, YS
國家衛生研究院	2014-10	Small-molecule EGFR tyrosine kinase inhibitors for the treatment of cancer	Lee, CC;Shiao, HY;Wang, WC;Hsieh, HP
國家衛生研究院	2014-10	Optimization of 5,6-fused pyrimidine-based kinase inhibitors by computer-aided drug design for the treatment of AML	Hsu, YC;Shiao, HY;Ke, YY;Hsu, JTA;Lin, WH;Chen, CH;Hsieh, HP
國家衛生研究院	2014-10	Novel irreversible EGFR tyrosine kinase inhibitor, DBPR112, as a therapeutic candidate for lung adenocarcinoma	Shiao, HY;Hsu, TA;Lin, WH;Yang, TT;Hsieh, HF;Chen, CT;Yeh, TK;Hsieh, HP
國家衛生研究院	2014-08	CDKN1A-mediated responsiveness of MLL-AF4-positive acute lymphoblastic leukemia to Aurora kinase-A inhibitors	Chen, YP;Lin, HJ;Chen, JS;Tsai, MY;Hsieh, HP;Chang, JY;Chen, NF;Chang, KC;Huang, WT;Su, WC;Yang, ST;Chang, WC;Hung, LY;Chen, TY
國家衛生研究院	2014-08	Ligand efficiency based approach for efficient virtual screening of compound libraries	Ke, YY;Coumar, MS;Shiao, HY;Wang, WC;Chen, CW;Song, JS;Chen, CH;Lin, WH;Wu, SH;Hsu, JT;Chang, CM;Hsieh, HP
國家衛生研究院	2014-07	Anaplastic lymphoma kinase (ALK) inhibitors: A review of design and discovery	Wang, WC;Shiao, HY;Lee, CC;Fung, KS;Hsieh, HP
國家衛生研究院	2014-05	Facile identification of dual FLT3-Aurora A inhibitors: A computer-guided drug design approach	ChangHsu, Y;Ke, YY;Shiao, HY;Lee, CC;Lin, WH;Chen, CH;Yen, KJ;Hsu, JTA;Chang, C;Hsieh, HP
國家衛生研究院	2014-05	Cover Picture: Facile identification of dual FLT3–aurora a inhibitors: A computer-guided drug design approach (ChemMedChem 5/2014)	Chang Hsu, Y;Ke, YY;Shiao, HY;Lee, CC;Lin, WH;Chen, CH;Yen, KJ;Hsu, JTA;Chang, C;Hsieh, HP
國家衛生研究院	2014-04-29	Quinoline compounds and their use for treating viral infection	Hsieh, HP;Hsu, TA;Yeh, JY;Chao, YS
國家衛生研究院	2014-03-20	Fused bicyclic pyrimidine compounds as aurora kinase inhibitors	Hsieh, HP;Coumar, MS;Hsu, TA;Wu, SY;Chao, YS
國家衛生研究院	2014-03	DBPR112, a potent and selective EGFR kinase inhibitor in preclinical study	Shiao, HY;Hsu, TAJ;Chen, CT;Yeh, TK;Hsieh, HP
國家衛生研究院	2014-03	Efficient virtual screening using ligand efficiency based approach	Hsieh, HP;Ke, YY;Coumar, MS;Lin, WH;Wang, WC;Shiao, HY;Hsu, TAJ
臺北醫學大學	2014	CDKN1A-mediated Responsiveness of MLL-AF4-positive Acute Lymphoblastic Leukemia to Aurora Kinase-A Inhibitors	Chen, YP;Lin, HJ;Chen, JS;Tsai, MY;Hsieh, HP;Chang, JY;Chen, NF;Chang, KC;Huang, WT;Su, WC;Yang, ST;Chang, WC;Hung, LY;Chen, TY
國家衛生研究院	2013-11-21	治療癌症的醫藥組成物	Hsieh, HP;Chang, JY;Kuo, CC;Chao, YS
國家衛生研究院	2013-11	A development drug candidate targeting EGFR kinase for lung cancer: DBPR112	Hsieh, HP;Shiao, HY;Chen, CT;Yeh, TK
國家衛生研究院	2013-11	Peptide-mediated liposomal doxorubicin enhances drug delivery efficiency and therapeutic efficacy in lung cancer animal models	Wu, HC;Chang, DK;Li, PC;Hsieh, HP
國家衛生研究院	2013-10-01	喹啉化合物及包含其之治療病毒感染之醫藥組成物	Hsieh, HP;Hsu, TA;Yeh, JY;Chao, YS
國家衛生研究院	2013-09-22	A novel Aurora-A inhibitor, BPR1K0609S1, sensitizes colorectal tumor cells to 5-fluorofracil (5-FU) treatment [Erratum:International Journal of Biological Sciences. 2013 Apr 29;9(4):403-411]	Shionome, Y;Lin, WH;Shiao, HY;Hsieh, HP;Hsu, JTA;Ouchi, T
國家衛生研究院	2013-08-21	Fused multicyclic compounds as protein kinase inhibitors	Hsieh, HP;Coumar, SM;Chao, YS
國家衛生研究院	2013-08-13	Fused bicyclic and tricyclic pyrimidine compounds as tyrosine kinase inhibitors	Hsieh, HP;Coumar, SM;Hsu, TA;Lin, WH;Chen, YR;Chao, YS
國家衛生研究院	2013-07-25	Pronounced induction of endoplasmic reticulum stress and tumor suppression by surfactant-free poly(lactic-co-glycolic acid) nanoparticles via modulation of the PI3K signaling pathway	Hou, CC;Tsai, TL;Su, WP;Hsieh, HP;Yeh, CS;Shieh, DB;Su, WC
國家衛生研究院	2013-07-01	做為蛋白質激酶抑制劑之稠合多環化合物	Hsieh, HP;Coumar, MS;Chao, YS
國家衛生研究院	2013-06-28	Optimization of ligand and lipophilic efficiency to identify an in vivo active furano-pyrimidine aurora kinase inhibitor	Shiao, HY;Coumar, MS;Chang, CW;Ke, YY;Chi, YH;Chu, CY;Sun, HY;Chen, CH;Lin, WH;Fung, KS;Kuo, PC;Huang, CT;Chang, KY;Lu, CT;Hsu, JT;Chen, CT;Jiaang, WT;Chao, YS;Hsieh, HP
國家衛生研究院	2013-06	An antimitotic and antivascular agent BPR0L075 overcomes multidrug resistance and induces mitotic catastrophe in paclitaxel-resistant ovarian cancer cells	Wang, X;Wu, E;Wu, J;Wang, TL;Hsieh, HP;Liu, X
國家衛生研究院	2013-05	Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules	Wu, JM;Chen, CT;Coumar, MS;Lin, WH;Chen, ZJ;Hsu, JT;Peng, YH;Shiao, HY;Chu, CY;Wu, JS;Lin, CT;Chen, CP;Hsueh, CC;Chang, KY;Kao, LP;Huang, CY;Chao, YS;Wu, SY;Hsieh, HP;Chi, YH
國家衛生研究院	2013-05	Protein kinase inhibitor design by targeting the Asp-Phe-Gly (DFG) motif: The role of the DFG motif in the design of epidermal growth factor receptor inhibitors	Peng, YH;Shiao, HY;Tu, CH;Liu, PM;Hsu, JT;Amancha, PK;Wu, JS;Coumar, MS;Chen, CH;Wang, SY;Lin, WH;Sun, HY;Chao, YS;Lyu, PC;Hsieh, HP;Wu, SY
國家衛生研究院	2013-04-29	A novel Aurora-A inhibitor, BPR1K0609S1, sensitizes colorectal tumor cells to 5-fluorofracil (5-FU) treatment	Shionome, Y;Lin, WH;Shiao, HY;Hsieh, HP;Hsu, JTA;Ouchi, T
國家衛生研究院	2013-04-07	BPR000K, a novel Aurora kinase inhibitor	Chao, YS;Hsu, JTA;Chen, CT;Yeh, TK;Pan, SL;Hsieh, HP
國家衛生研究院	2013-04-07	Kinase-focused library: Design and synthesis of pyrimidines derivatives bearing amino substituents using high throughput parallel synthesis	Wang, WC;Hsieh, HP
國家衛生研究院	2013-04-07	3D-QSAR assisted drug design: Identification of a potent quinazoline based Aurora kinase inhibitor	Ke, YY;Shiao, HY;Hsu, YC;Chang-Chu, Y;Wang, WC;Lee, YC;Lin, WH;Hsu, JTA;Chang, CW;Lin, CW;Yeh, TK;Chao, YS;Coumar, MS;Hsieh, HP
國家衛生研究院	2013-04-07	Development drug candidate targeting EGFR kinase: DBPR112	Sun, HY;Hsu, JTA;Chen, CT;Yeh, TK;Pan, SL;Chao, YS;Hsieh, HP
國家衛生研究院	2013-04	Design and synthesis of Aurora kinase inhibitors as anticancer agents	Hsu, YC;Shiao, HY;Lin, WH;Hsu, JTA;Chen, CT;Chao, YS;Hsieh, HP
國家衛生研究院	2013-02-20	Parallel screening of Wild-Type and drug-resistant targets for anti-resistance neuraminidase inhibitors	Hsu, KC;Hung, HC;Horng, JT;Fang, MY;Chang, CY;Li, LT;Chen, IJ;Chen, YC;Chou, DL;Chang, CW;Hsieh, HP;Yang, JM;Hsu, JT
國家衛生研究院	2013-02-11	作為酪胺酸激酶抑制劑之稠合雙環及多環嘧啶化合物	Hsieh, HP;Coumar, MS;Chao, YS;Hsu, TA;Lin, WH;Chen, YR
國家衛生研究院	2013-01	3D-QSAR-assisted drug design: Identification of a potent quinazoline-based aurora kinase inhibitor	Ke, YY;Shiao, HY;Hsu, YC;Chu, CY;Wang, WC;Lee, YC;Lin, WH;Chen, CH;Hsu, JTA;Chang, CW;Lin, CW;Yeh, TK;Chao, YS;Coumar, MS;Hsieh, HP
國家衛生研究院	2013-01	Substituent effects on the photorearrangements of unsymmetrically substituted diazinobarrelenes	Hsieh, HP;Chen, AC;Villarante, NR;Chuang, GJ;Liao, CC
國家衛生研究院	2012-12	An efficient, mild and scalable synthesis of bioactive compounds containing the angelicin scaffold	Shiao, HY;Kuo, CC;Horng, JT;Shih, SR;Chang, SY;Liao, CC;Hsu, JTA;Kumar, AP;Chao, YS;Hsieh, HP
國家衛生研究院	2012-09	Anti-influenza drug discovery: Identification of an orally bioavailable quinoline derivative through activity- and property-guided lead optimization	Yeh, JY;Coumar, MS;Shiao, HY;Lin, TJ;Lee, YC;Hung, HC;Ko, S;Kuo, FM;Fang, MY;Huang, YL;Hsu, JT;Yeh, TK;Shih, SR;Chao, YS;Horng, JT;Hsieh, HP
國家衛生研究院	2012-08-24	Tubulin-destabilizing agent BPR0L075 induces vascular-disruption in human breast cancer mammary fat pad xenografts	Liu, L;Beck, H;Wang, X;Hsieh, HP;Mason, RP;Liu, X
國家衛生研究院	2012-05-11	作為極光激酶抑制劑之稠合雙環嘧啶化合物	Hsieh, HP;Coumar, MS;Hsu, TA;Wu, SY;Chao, YS
國家衛生研究院	2012-04-21	吡咯啉啶化合物	Jiaang, WT;Chao, YS;Hsieh, HP

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