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"hsu jta"的相关文件
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| 國家衛生研究院 |
2024-07-04 |
Development of a humanized antibody targeting extracellular HSP90alpha to suppress endothelial-mesenchymal transition-enhanced tumor growth of pancreatic adenocarcinoma cells
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Fan, CS;Hung, HC;Chen, CC;Chen, LL;Ke, YY;Yeh, TK;Huang, CT;Chang, TY;Yen, KJ;Chen, CH;Chua, KV;Hsu, JTA;Huang, TS |
| 國家衛生研究院 |
2024-04 |
Reducing brain Abeta burden ameliorates high-fat diet-induced fatty liver disease in APP/PS1 mice
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Tsay, HJ;Gan, YL;Su, YH;Sun, YY;Yao, HH;Chen, HW;Hsu, YT;Hsu, JTA;Wang, HD;Shie, FS |
| 國家衛生研究院 |
2023-10 |
Discovery of novel AXL and MER inhibitors as potential anticancer and immune modulator drugs
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Hsieh, HP;Li, MC;Yen, WC;Hsu, JTA;Yeh, TK;Li, WS;Wu, HC |
| 國家衛生研究院 |
2022-01-11 |
Extracellular HSP90alpha induces MyD88−IRAK complex-associated IKKalpha/Beta−NF-κB/IRF3 and JAK2/TYK2−STAT-3 signaling in macrophages for tumor-promoting M2-polarization
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Fan, CS;Chen, CC;Chen, LL;Chua, KV;Hung, HC;Hsu, JTA;Huang, TS |
| 國家衛生研究院 |
2022-01-05 |
The beneficial effects of combining anti-Abeta antibody NP106 and curcumin analog TML-6 on the treatment of Alzheimer’s disease in APP/PS1 mice
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Su, IJ;Hsu, CY;Shen, S;Chao, PK;Hsu, JTA;Hsueh, JT;Liang, JJ;Hsu, YT;Shie, FS |
| 國家衛生研究院 |
2021-07-30 |
The effects of Abeta1-42 binding to the SARS-CoV-2 spike protein S1 subunit and angiotensin-converting enzyme 2
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Hsu, JTA;Tien, CF;Yu, GY;Shen, S;Lee, YH;Hsu, PC;Wang, Y;Chao, PK;Tsay, HJ;Shie, FS |
| 國家衛生研究院 |
2020-06-02 |
Zika virus NS3 protease pharmacophore anchor model and drug discovery
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Pathak, N;Kuo, YP;Chang, TY;Huang, CT;Hung, HC;Hsu, JTA;Yu, GY;Yang, JM |
| 國家衛生研究院 |
2020-05 |
Drug-like property optimization: Discovery of orally bioavailable quinazoline-based multi-targeted kinase inhibitors
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Lin, SY;Chang, CF;Coumar, MS;Chen, PY;Kuo, FM;Chen, CH;Li, MC;Lin, WH;Kuo, PC;Wang, SY;Li, AS;Lin, CY;Yang, CM;Yeh, TK;Song, JS;Hsu, JTA;Hsieh, HP |
| 國家衛生研究院 |
2019-10 |
Inhibition of Rspo-Wnt pathway facilitates checkpoint blockade therapy by anti-RSPO3 antibody (DBPR117)
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Hsu, JTA;Hung, HC;Chen, CT;Yen, WC;Chang, TY;Chao, PK;Chin-Ting, H;Yen, KJ;Tsai, YR;Chang, CY;Fang, MY;Lai, YL;Shih, JC |
| 國家衛生研究院 |
2018-12 |
Targeting RSPO3 reduces stem cell function in RSPO3-Fusion-positive colon cancer and RSPO3 high lung cancer
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Hsu, J;Hung, HC;Yen, WC;Chang, TY;Yen, GJ;Huang, CT;Fnag, MY;Lai, YL;Tsai, YR;Chen, CT;Shih, JC;Hsu, JTA |
| 國家衛生研究院 |
2018-10 |
Identification of novel Cdc7 kinase inhibitors as anti-cancer agents that target the interaction with Dbf4 by the fragment complementation and drug repositioning approach
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Cheng, AN;Lo, YK;Lin, YS;Tang, TK;Hsu, CH;Hsu, JTA;Lee, AYL |
| 國家衛生研究院 |
2018-01 |
Discovery and development of DBPR112 as a clinical candidate: A novel EGFR inhibitor for non-small cell lung cancer
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Hsieh, HP;Hsu, JTA;Yeh, TK;Chen, CT |
| 國家衛生研究院 |
2017-04 |
Discovery of BPR1K871-a quinazoline based multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, in vitro and in vivo evaluation
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Hsieh, HP;Wang, WC;Shiao, HY;Ke, YY;Lin, WH;Hsu, JTA;Chen, CT;Yeh, TK |
| 國家衛生研究院 |
2016-11-29 |
Discovery of novel inhibitors of Aurora kinases with indazole scaffold: In silico fragment-based and knowledge-based drug design
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Chang, CF;Lin, WH;Ke, YY;Lin, YS;Wang, WC;Chen, CH;Kuo, PC;Hsu, JTA;Uang, BJ;Hsieh, HP |
| 國家衛生研究院 |
2016-05-19 |
Non-small-cell lung cancer cells combat epidermal growth factor receptor tyrosine kinase inhibition through immediate adhesion-related responses
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Wang, HY;Hsu, MK;Wang, KH;Tseng, CP;Chen, FC;Hsu, JTA |
| 國家衛生研究院 |
2015-07 |
Identification of a potent 5-phenyl-thiazol-2-ylamine-based inhibitor of FLT3 with activity against drug resistance-conferring point mutations
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Chen, CT;Hsu, JTA;Lin, WH;Lu, CT;Yen, SC;Hsu, T;Huang, YL;Song, JS;Chen, CH;Chou, LH;Yen, KJ;Chen, CP;Kuo, PC;Huang, CL;Eugene Liu, H;Chao, YS;Yeh, TK;Jiaang, WT |
| 國家衛生研究院 |
2015-01 |
Identification of ligand efficient, fragment-like hits from an HTS library: Structure-based virtual screening and docking investigations of 2H- and 3H-pyrazolo tautomers for Aurora kinase A selectivity
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Sarvagalla, S;Singh, VK;Ke, YY;Shiao, HY;Lin, WH;Hsieh, HP;Hsu, JTA;Coumar, MS |
| 國立交通大學 |
2014-12-08T15:39:10Z |
Anti-HCV activities of selective polyunsaturated fatty acids
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Leu, GZ; Lin, TY; Hsu, JTA |
| 國立交通大學 |
2014-12-08T15:19:20Z |
Anti-HCV activities of selective polyunsaturated fatty acids (vol 318, pg 275, 2004)
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Leu, GZ; Lin, TY; Hsu, JTA |
| 國立交通大學 |
2014-12-08T15:18:14Z |
Inhibition of hepatitis C virus replication by antimonial compounds
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Hwang, DR; Lin, RK; Leu, GZ; Lin, TY; Lien, TW; Yu, MC; Yeh, CT; Hsu, JTA |
| 國家衛生研究院 |
2014-12 |
BPR-3P0128 inhibits RNA-dependent RNA polymerase elongation and VPg uridylylation activities of Enterovirus 71
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Balaji, VA;Chen, GW;Hsieh, PT;Horng, JT;Hsu, JTA;Hsieh, HP;Chen, TC;Weng, KF;Shih, SR |
| 國家衛生研究院 |
2014-11-20 |
The combination effects of LiCl and the active leflunomide metabolite, A771726, on viral-induced interleukin 6 production and EV-A71 replication
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Hung, HC;Shih, SR;Chang, TY;Fang, MY;Hsu, JTA |
| 國家衛生研究院 |
2014-11 |
Reticulon 3 interacts with NS4B of the hepatitis C virus and negatively regulates viral replication by disrupting NS4B self-interaction
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Wu, MJ;Ke, PY;Hsu, JTA;Yeh, CT;Horng, JT |
| 國家衛生研究院 |
2014-10 |
Optimization of 5,6-fused pyrimidine-based kinase inhibitors by computer-aided drug design for the treatment of AML
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Hsu, YC;Shiao, HY;Ke, YY;Hsu, JTA;Lin, WH;Chen, CH;Hsieh, HP |
| 國家衛生研究院 |
2014-05 |
Facile identification of dual FLT3-Aurora A inhibitors: A computer-guided drug design approach
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ChangHsu, Y;Ke, YY;Shiao, HY;Lee, CC;Lin, WH;Chen, CH;Yen, KJ;Hsu, JTA;Chang, C;Hsieh, HP |
| 國家衛生研究院 |
2014-05 |
Cover Picture: Facile identification of dual FLT3–aurora a inhibitors: A computer-guided drug design approach (ChemMedChem 5/2014)
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Chang Hsu, Y;Ke, YY;Shiao, HY;Lee, CC;Lin, WH;Chen, CH;Yen, KJ;Hsu, JTA;Chang, C;Hsieh, HP |
| 國家衛生研究院 |
2014-02 |
Epstein-Barr virus BALF3 has nuclease activity and mediates mature virion production during the lytic cycle
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Chiu, SH;Wu, MC;Wu, CC;Chen, YC;Lin, SF;Hsu, JTA;Yang, CS;Tsai, CH;Takada, K;Chen, MR;Chen, JY |
| 國家衛生研究院 |
2014-01-08 |
Evaluation of the antitumor effects of BPR1J-340, a potent and selective FLT3 inhibitor, alone or in combination with an HDAC inhibitor, vorinostat, in AML cancer
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Lin, WH;Yeh, TK;Jiaang, WT;Yen, KJ;Chen, CH;Huang, CT;Yen, SC;Hsieh, SY;Chou, LH;Chen, CP;Chiu, CH;Kao, LC;Chao, YS;Chen, CT;Hsu, JTA |
| 國家衛生研究院 |
2013-12 |
Evolutionarily conserved residues at an oligomerization interface of the influenza A virus neuraminidase are essential for viral survival
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Mok, CK;Chen, GW;Shih, KC;Gong, YN;Lin, SJ;Horng, JT;Hsu, JTA;Chen, CJ;Shih, SR |
| 國家衛生研究院 |
2013-09-22 |
A novel Aurora-A inhibitor, BPR1K0609S1, sensitizes colorectal tumor cells to 5-fluorofracil (5-FU) treatment [Erratum:International Journal of Biological Sciences. 2013 Apr 29;9(4):403-411]
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Shionome, Y;Lin, WH;Shiao, HY;Hsieh, HP;Hsu, JTA;Ouchi, T |
| 國家衛生研究院 |
2013-06 |
Discovery of 3-phenyl-1H-5-pyrazolylamine derivatives containing a urea pharmacophore as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3)
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Lin, WH;Hsu, JTA;Hsieh, SY;Chen, CT;Song, JS;Yen, SC;Hsu, T;Lu, CT;Chen, CH;Chou, LH;Yang, YN;Chiu, CH;Chen, CP;Tseng, YJ;Yen, KJ;Yeh, CF;Chao, YS;Yeh, TK;Jiaang, WT |
| 國家衛生研究院 |
2013-04-29 |
A novel Aurora-A inhibitor, BPR1K0609S1, sensitizes colorectal tumor cells to 5-fluorofracil (5-FU) treatment
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Shionome, Y;Lin, WH;Shiao, HY;Hsieh, HP;Hsu, JTA;Ouchi, T |
| 國家衛生研究院 |
2013-04-07 |
BPR000K, a novel Aurora kinase inhibitor
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Chao, YS;Hsu, JTA;Chen, CT;Yeh, TK;Pan, SL;Hsieh, HP |
| 國家衛生研究院 |
2013-04-07 |
3D-QSAR assisted drug design: Identification of a potent quinazoline based Aurora kinase inhibitor
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Ke, YY;Shiao, HY;Hsu, YC;Chang-Chu, Y;Wang, WC;Lee, YC;Lin, WH;Hsu, JTA;Chang, CW;Lin, CW;Yeh, TK;Chao, YS;Coumar, MS;Hsieh, HP |
| 國家衛生研究院 |
2013-04-07 |
Development drug candidate targeting EGFR kinase: DBPR112
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Sun, HY;Hsu, JTA;Chen, CT;Yeh, TK;Pan, SL;Chao, YS;Hsieh, HP |
| 國家衛生研究院 |
2013-04 |
Design and synthesis of Aurora kinase inhibitors as anticancer agents
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Hsu, YC;Shiao, HY;Lin, WH;Hsu, JTA;Chen, CT;Chao, YS;Hsieh, HP |
| 國家衛生研究院 |
2013-01 |
3D-QSAR-assisted drug design: Identification of a potent quinazoline-based aurora kinase inhibitor
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Ke, YY;Shiao, HY;Hsu, YC;Chu, CY;Wang, WC;Lee, YC;Lin, WH;Chen, CH;Hsu, JTA;Chang, CW;Lin, CW;Yeh, TK;Chao, YS;Coumar, MS;Hsieh, HP |
| 國家衛生研究院 |
2012-12 |
An efficient, mild and scalable synthesis of bioactive compounds containing the angelicin scaffold
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Shiao, HY;Kuo, CC;Horng, JT;Shih, SR;Chang, SY;Liao, CC;Hsu, JTA;Kumar, AP;Chao, YS;Hsieh, HP |
| 國家衛生研究院 |
2012-11 |
BPR1J271, a novel FLT3 inhibitor for treating acute myeloid leukemia
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Chen, CT;Lin, WH;Chou, LH;Chen, CP;Yen, SC;Huang, YL;Yeh, TK;Hsu, JTA;Jiaang, WI;Chao, YS |
| 國家衛生研究院 |
2012-03-25 |
Design, synthesis, and SAR studies of duel FLT-3 and Aurora kinase inhibitors
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Hsieh, HP;Shiao, HY;Lin, WH;Hsu, JTA;Chao, YS |
| 國家衛生研究院 |
2011-03-27 |
Design and synthesis of potent Aurora kinase inhibitors
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Chu, CY;Mohane, CS;Hsu, JTA;Yeh, TK;Chen, CT;Chao, YS;Hsieh, HP |
| 國家衛生研究院 |
2011-03 |
Potent EGFR tyrosine kinase inhibitors as anticancer agents
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Shiao, HY;Chu, CY;Hsu, JTA;Yeh, TK;Hsieh, HP |
| 國家衛生研究院 |
2010-04 |
Inhibition of enterovirus 71 replication and the viral 3D polymerase by aurintricarboxylic acid
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Hung, HC;Chen, TC;Fang, MY;Yen, KJ;Shih, SR;Hsu, JTA;Tseng, CP |
| 國家衛生研究院 |
2010-02-23 |
Pyrazole compound BPR1P0034 with potent and selective anti-influenza virus activity
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Shih, SR;Chu, TY;Reddy, GR;Tseng, SN;Chen, HL;Tang, WF;Wu, MS;Yeh, JY;Chao, YS;Hsu, JTA;Hsieh, HP;Horng, JT |
| 國家衛生研究院 |
2010-02-01 |
Identification, SAR studies, and X-ray Co-crystallographic analysis of a novel furanopyrimidine aurora kinase a inhibitor
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Coumar, MS;Tsai, MT;Chu, CY;Uang, BJ;Lin, WH;Chang, CY;Chang, TY;Leou, JS;Teng, CH;Wu, JS;Fang, MY;Chen, CH;Hsu, JTA;Wu, SY;Chao, YS;Hsieh, HP |
| 國家衛生研究院 |
2009-09 |
Fast-forwarding kinase drug discovery: aurora and EGFR kinase inhibitor lead development
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Hsieh, HP;Coumarrs, MS;Chu, CY;Ho, YL;Tsai, MT;Lin, WH;Chen, CH;Song, JS;Hsu, JTA;Chao, YS |
| 國家衛生研究院 |
2009-02-26 |
Structure-based drug design of novel aurora kinase a inhibitors: Structural basis for potency and specificity
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Coumar, MS;Leou, JS;Shukla, P;Wu, JS;Dixit, AK;Lin, WH;Chang, CY;Lien, TW;Tan, UK;Chen, CH;Hsu, JTA;Chao, YS;Wu, SY;Hsieh, HP |
| 國家衛生研究院 |
2009-02 |
Aurintricarboxylic acid inhibits influenza virus neuraminidase
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Hung, HC;Tseng, CP;Yang, JM;Ju, YW;Tseng, SN;Chen, YF;Chao, YS;Hsieh, HP;Shih, SR;Hsu, JTA |
| 國家衛生研究院 |
2008-12 |
Mana-Hox displays anticancer activity against prostate cancer cells through tubulin depolymerization and DNA damage stress
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Hsiao, CJ;Ho, YF;Hsu, JTA;Chang, WL;Chen, YC;Shen, YC;Lyu, PC;Guh, JH |
| 國家衛生研究院 |
2008-08-01 |
Design, synthesis, and evaluation of 3C protease inhibitors as anti-enterovirus 71 agents
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Kuo, CJ;Shie, JJ;Fang, JM;Yen, GR;Hsu, JTA;Liu, HG;Tseng, SN;Chang, SC;Lee, CY;Shih, SR;Liang, PH |
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