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Institution	Date	Title	Author
國家衛生研究院	2014-05	Cover Picture: Facile identification of dual FLT3–aurora a inhibitors: A computer-guided drug design approach (ChemMedChem 5/2014)	Chang Hsu, Y;Ke, YY;Shiao, HY;Lee, CC;Lin, WH;Chen, CH;Yen, KJ;Hsu, JTA;Chang, C;Hsieh, HP
國家衛生研究院	2014-02	Epstein-Barr virus BALF3 has nuclease activity and mediates mature virion production during the lytic cycle	Chiu, SH;Wu, MC;Wu, CC;Chen, YC;Lin, SF;Hsu, JTA;Yang, CS;Tsai, CH;Takada, K;Chen, MR;Chen, JY
國家衛生研究院	2014-01-08	Evaluation of the antitumor effects of BPR1J-340, a potent and selective FLT3 inhibitor, alone or in combination with an HDAC inhibitor, vorinostat, in AML cancer	Lin, WH;Yeh, TK;Jiaang, WT;Yen, KJ;Chen, CH;Huang, CT;Yen, SC;Hsieh, SY;Chou, LH;Chen, CP;Chiu, CH;Kao, LC;Chao, YS;Chen, CT;Hsu, JTA
國家衛生研究院	2013-12	Evolutionarily conserved residues at an oligomerization interface of the influenza A virus neuraminidase are essential for viral survival	Mok, CK;Chen, GW;Shih, KC;Gong, YN;Lin, SJ;Horng, JT;Hsu, JTA;Chen, CJ;Shih, SR
國家衛生研究院	2013-09-22	A novel Aurora-A inhibitor, BPR1K0609S1, sensitizes colorectal tumor cells to 5-fluorofracil (5-FU) treatment [Erratum:International Journal of Biological Sciences. 2013 Apr 29;9(4):403-411]	Shionome, Y;Lin, WH;Shiao, HY;Hsieh, HP;Hsu, JTA;Ouchi, T
國家衛生研究院	2013-06	Discovery of 3-phenyl-1H-5-pyrazolylamine derivatives containing a urea pharmacophore as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3)	Lin, WH;Hsu, JTA;Hsieh, SY;Chen, CT;Song, JS;Yen, SC;Hsu, T;Lu, CT;Chen, CH;Chou, LH;Yang, YN;Chiu, CH;Chen, CP;Tseng, YJ;Yen, KJ;Yeh, CF;Chao, YS;Yeh, TK;Jiaang, WT
國家衛生研究院	2013-04-29	A novel Aurora-A inhibitor, BPR1K0609S1, sensitizes colorectal tumor cells to 5-fluorofracil (5-FU) treatment	Shionome, Y;Lin, WH;Shiao, HY;Hsieh, HP;Hsu, JTA;Ouchi, T
國家衛生研究院	2013-04-07	BPR000K, a novel Aurora kinase inhibitor	Chao, YS;Hsu, JTA;Chen, CT;Yeh, TK;Pan, SL;Hsieh, HP
國家衛生研究院	2013-04-07	3D-QSAR assisted drug design: Identification of a potent quinazoline based Aurora kinase inhibitor	Ke, YY;Shiao, HY;Hsu, YC;Chang-Chu, Y;Wang, WC;Lee, YC;Lin, WH;Hsu, JTA;Chang, CW;Lin, CW;Yeh, TK;Chao, YS;Coumar, MS;Hsieh, HP
國家衛生研究院	2013-04-07	Development drug candidate targeting EGFR kinase: DBPR112	Sun, HY;Hsu, JTA;Chen, CT;Yeh, TK;Pan, SL;Chao, YS;Hsieh, HP
國家衛生研究院	2013-04	Design and synthesis of Aurora kinase inhibitors as anticancer agents	Hsu, YC;Shiao, HY;Lin, WH;Hsu, JTA;Chen, CT;Chao, YS;Hsieh, HP
國家衛生研究院	2013-01	3D-QSAR-assisted drug design: Identification of a potent quinazoline-based aurora kinase inhibitor	Ke, YY;Shiao, HY;Hsu, YC;Chu, CY;Wang, WC;Lee, YC;Lin, WH;Chen, CH;Hsu, JTA;Chang, CW;Lin, CW;Yeh, TK;Chao, YS;Coumar, MS;Hsieh, HP
國家衛生研究院	2012-12	An efficient, mild and scalable synthesis of bioactive compounds containing the angelicin scaffold	Shiao, HY;Kuo, CC;Horng, JT;Shih, SR;Chang, SY;Liao, CC;Hsu, JTA;Kumar, AP;Chao, YS;Hsieh, HP
國家衛生研究院	2012-11	BPR1J271, a novel FLT3 inhibitor for treating acute myeloid leukemia	Chen, CT;Lin, WH;Chou, LH;Chen, CP;Yen, SC;Huang, YL;Yeh, TK;Hsu, JTA;Jiaang, WI;Chao, YS
國家衛生研究院	2012-03-25	Design, synthesis, and SAR studies of duel FLT-3 and Aurora kinase inhibitors	Hsieh, HP;Shiao, HY;Lin, WH;Hsu, JTA;Chao, YS
國家衛生研究院	2011-03-27	Design and synthesis of potent Aurora kinase inhibitors	Chu, CY;Mohane, CS;Hsu, JTA;Yeh, TK;Chen, CT;Chao, YS;Hsieh, HP
國家衛生研究院	2011-03	Potent EGFR tyrosine kinase inhibitors as anticancer agents	Shiao, HY;Chu, CY;Hsu, JTA;Yeh, TK;Hsieh, HP
國家衛生研究院	2010-04	Inhibition of enterovirus 71 replication and the viral 3D polymerase by aurintricarboxylic acid	Hung, HC;Chen, TC;Fang, MY;Yen, KJ;Shih, SR;Hsu, JTA;Tseng, CP
國家衛生研究院	2010-02-23	Pyrazole compound BPR1P0034 with potent and selective anti-influenza virus activity	Shih, SR;Chu, TY;Reddy, GR;Tseng, SN;Chen, HL;Tang, WF;Wu, MS;Yeh, JY;Chao, YS;Hsu, JTA;Hsieh, HP;Horng, JT
國家衛生研究院	2010-02-01	Identification, SAR studies, and X-ray Co-crystallographic analysis of a novel furanopyrimidine aurora kinase a inhibitor	Coumar, MS;Tsai, MT;Chu, CY;Uang, BJ;Lin, WH;Chang, CY;Chang, TY;Leou, JS;Teng, CH;Wu, JS;Fang, MY;Chen, CH;Hsu, JTA;Wu, SY;Chao, YS;Hsieh, HP
國家衛生研究院	2009-09	Fast-forwarding kinase drug discovery: aurora and EGFR kinase inhibitor lead development	Hsieh, HP;Coumarrs, MS;Chu, CY;Ho, YL;Tsai, MT;Lin, WH;Chen, CH;Song, JS;Hsu, JTA;Chao, YS
國家衛生研究院	2009-02-26	Structure-based drug design of novel aurora kinase a inhibitors: Structural basis for potency and specificity	Coumar, MS;Leou, JS;Shukla, P;Wu, JS;Dixit, AK;Lin, WH;Chang, CY;Lien, TW;Tan, UK;Chen, CH;Hsu, JTA;Chao, YS;Wu, SY;Hsieh, HP
國家衛生研究院	2009-02	Aurintricarboxylic acid inhibits influenza virus neuraminidase	Hung, HC;Tseng, CP;Yang, JM;Ju, YW;Tseng, SN;Chen, YF;Chao, YS;Hsieh, HP;Shih, SR;Hsu, JTA
國家衛生研究院	2008-12	Mana-Hox displays anticancer activity against prostate cancer cells through tubulin depolymerization and DNA damage stress	Hsiao, CJ;Ho, YF;Hsu, JTA;Chang, WL;Chen, YC;Shen, YC;Lyu, PC;Guh, JH
國家衛生研究院	2008-08-01	Design, synthesis, and evaluation of 3C protease inhibitors as anti-enterovirus 71 agents	Kuo, CJ;Shie, JJ;Fang, JM;Yen, GR;Hsu, JTA;Liu, HG;Tseng, SN;Chang, SC;Lee, CY;Shih, SR;Liang, PH
國家衛生研究院	2008-07	Anti-HSV activity of digitoxin and its possible mechanisms	Su, CT; Hsu, JTA; Hsieh, HP; Lin, PH; Chen, TC; Kao, CL; Lee, CN; Chang, SY
國家衛生研究院	2008-06-01	A cell-based high-throughput screen for epidermal growth factor receptor pathway inhibitors	Lin, WH; Song, JS; Chang, TY; Chang, CY; Fu, YN; Yeh, CL; Wu, SH; Huang, YW; Fang, MY; Lien, TW; Hsieh, HP; Chao, YS; Huang, SF; Tsai, SF; Wang, LM; Hsu, JTA; Chen, YR
國家衛生研究院	2008-05	Bioassay-guided purification and identification of PPARa/gamma agonists from Chlorella sorokiniana	Chou, YC; Prakash, E; Huang, CF; Lien, TW; Chen, X; Su, IJ; Chao, YS; Hsieh, HP; Hsu, JTA
國家衛生研究院	2008-04-01	A mammalian cell-based reverse two-hybrid system for functional analysis of 3C viral protease of human enterovirus 71	Lee, JC; Shih, SR; Chang, TY; Tseng, HY; Shih, YF; Yen, KJ; Chen, WC; Shie, JJ; Fang, JM; Liang, PH; Chao, YS; Hsu, JTA
國家衛生研究院	2008-03-01	Aurora kinase A inhibitors: Identification, SAR exploration and molecular modeling of 6,7-dihydro-4H-pyrazolo-[1,5-a]pyrrolo[3,4-d]pyrimidine-5,8-dione scaffold	Coumar, MS; Wu, JS; Leou, JS; Tan, UK; Chang, CY; Chang, TY; Lin, WH; Hsu, JTA; Chao, YS; Wu, SY; Hsieh, HP
國家衛生研究院	2007-12	Strategies of development of antiviral agents directed against influenza virus replication	Hsieh, HP;Hsu, JTA
國家衛生研究院	2007-09	Sf-Caspase-I-repressed stable cells: resistance to apoptosis and augmentation of recombinant protein production	Lin, CC; Hsu, JTA; Huang, KL; Tang, HK; Shu, CW; Lai, YK
國家衛生研究院	2007-07	Anti-influenza drug discovery	Hsu, JTA;Hsieh, HP;Hung, HC;Ju, YW;Tseng, SN;Tseng, CP;Yang, JM;Chang, CW;Fang, MY;Lin, CC;Homg, JT;Shih, SR;Chao, YS
國家衛生研究院	2007-02-08	Isocostunolide, a sesquiterpene lactone, induces mitochondrial membrane depolarization and caspase-dependent apoptosis in human melanoma cells	Chen, CN; Huang, HH; Wu, CL; Lin, CPC; Hsu, JTA; Hsieh, HP; Chuang, SE; Lai, GM
國家衛生研究院	2006-11-25	The inhibitory effect of polyunsaturated fatty acids on human CYP enzymes	Yao, HT; Chang, YW; Lan, SJ; Chen, CT; Hsu, JTA; Yeh, TK
國家衛生研究院	2006-10-19	Structural basis for the structure-activity relationships of peroxisome proliferator-activated receptor agonists	Mahindroo, N; Peng, YH; Lin, CH; Tan, UK; Prakash, E; Lien, TW; Lu, IL; Lee, HJ; Hsu, JTA; Chen, X; Liao, CC; Lyu, PC; Chao, YS; Wu, SY; Hsieh, HP
國家衛生研究院	2006-07	Antiviral drug discovery against SARS-CoV	Wu, YS;Lin, WH;Hsu, JTA;Hsieh, HP
國家衛生研究院	2006-05-04	Structure-based drug design of a novel family of PPAR gamma partial agonists: Virtual screening, X-ray crystallography, and in vitro/in vivo biological activities	Lu, IL; Huang, CF; Peng, YH; Lin, YT; Hsieh, HP; Chen, CT; Lien, TW; Lee, HJ; Mahindroo, N; Prakash, E; Yueh, A; Chen, HY; Goparaju, CMV; Chen, X; Liao, CC; Chao, YS; Hsu, JTA; Wu, SY
國家衛生研究院	2006-02-09	Indol-1-yl acetic acids as peroxisome proliferator-activated receptor agonists: Design, synthesis, structural biology, and molecular docking studies	Mahindroo, N; Wang, CC; Liao, CC; Huang, CF; Lu, IL; Lien, TW; Peng, YH; Huang, WJ; Lin, YT; Hsu, MC; Lin, CH; Tsai, CH; Hsu, JTA; Chen, X; Lyu, PC; Chao, YS; Wu, SY; Hsieh, HP
國家衛生研究院	2006-02	Stable RNA interference in Spodoptera frugiperda cells by a DNA vector-based method	Lin, CC; Hsu, JTA; Huang, KL; Tang, HK; Lai, YK
國家衛生研究院	2006-01-01	Synthesis and anti-viral activity of a series of sesquiterpene lactones and analogues in the subgenomic HCV replicon system	Hwang, DR;Wu, YS;Chang, CW;Lien, TW;Chen, WC;Tan, UK;Hsu, JTA;Hsieh, HP
國家衛生研究院	2006	Antiviral drug discovery targeting to viral proteases	Hsu, JTA; Wang, HC; Chen, GW; Shih, SR
國家衛生研究院	2005-11	Emergence of mutation clusters in the HCV genome during sequential viral passages in Sip-L expressing cells	Hwang, DR; Lai, HY; Chang, ML; Hsu, JTA; Yeh, CT
國家衛生研究院	2005-10	Inhibition of hepatitis C virus replication by antimonial compounds	Hwang, DR; Lin, RK; Leu, GZ; Lin, TY; Lien, TW; Yu, MC; Yeh, CT; Hsu, JTA
國家衛生研究院	2005-08-02	Papain-like protease 2 (PLP2) from severe acute respiratory syndrome coronavirus (SARS-CoV): Expression, purification, characterization, and inhibition	Han, YS; Chang, GG; Juo, CG; Lee, HJ; Yeh, SH; Hsu, JTA; Chen, X
國家衛生研究院	2005-08	High-throughput cell-based screening for hepatitis C virus NS3/4A protease inhibitors	Lee, JC; Yu, MC; Lien, TW; Chang, CF; Hsu, JTA
國家衛生研究院	2005-06-05	High-efficiency protein expression mediated by enterovirus 71 internal ribosome entry	Lee, JC; Wu, TY; Huang, CF; Yang, FM; Shih, SR; Hsu, JTA
國家衛生研究院	2005-04-22	Anti-HCV activities of selective polyunsaturated fatty acids [Erratum: Biochemical and Biophysical Research Communications. 2004 May;318(1):275-280.]	Leu, GZ; Lin, TY; Hsu, JTA
國家衛生研究院	2005	Inhibition of SARS-CoV 3C-like protease activity by theaflavin-3,3 '- digallate (TF3)	Chen, CN; Lin, CPC; Huang, KK; Chen, WC; Hsieh, HP; Liang, PH; Hsu, JTA
國家衛生研究院	2004-10	Biosynthesis of human-type N-glycans in heterollogous systems	Betenbaugh, MJ; Tomiya, N; Narang, S; Hsu, JTA; Lee, YC

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