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Institution Date Title Author
國家衛生研究院 2024-06-17 Tumor promoting effect of PDLIM2 downregulation involves mitochondrial ROS, oncometabolite accumulations and HIF-1alpha activation Yang, JX;Chuang, YC;Tseng, JC;Liu, YL;Lai, CY;Lee, AYL;Huang, CYF;Hong, YR;Chuang, TH
國家衛生研究院 2023-07-31 Metastasis and immunosuppression promoted by mtDNA and PD-L1 in extracellular vesicles are reversed by WGP beta-glucan in oral squamous cell carcinoma Ko, HH;Peng, HH;Cheng, AN;Chou, HYE;Hou, HH;Kuo, WT;Liu, WW;Kuo, MYP;Lee, AYL;Cheng, SJ
國家衛生研究院 2023-03-16 Mitochondrial Lon-induced mitophagy benefits hypoxic resistance via Ca2+-dependent FUNDC1 phosphorylation at the ER-mitochondria interface Ponneri Babuharisankar, A;Kuo, CL;Chou, HY;Tangeda, V;Fan, CC;Chen, CH;Kao, YH;Lee, AYL
國家衛生研究院 2022-07-27 A Fc-VEGF chimeric fusion enhances PD-L1 immunotherapy via inducing immune reprogramming and infiltration in the immunosuppressive tumor microenvironment Kuo, CL;Chou, HY;Lien, HW;Yeh, CA;Wang, JR;Chen, CH;Fan, CC;Hsu, CP;Kao, TY;Ko, TM;Lee, AYL
國家衛生研究院 2022-03-16 Lon upregulation contributes to cisplatin resistance by triggering NCLX-mediated mitochondrial Ca2+ release in cancer cells Tangeda, V;Lo, YK;Babuharisankar, AP;Chou, HY;Kuo, CL;Kao, YH;Lee, AYL;Chang, JY
國家衛生研究院 2021-03 Insulin-like growth factor binding protein 3 promotes radiosensitivity of oral squamous cell carcinoma cells via positive feedback on NF-kappa B/IL-6/ROS signaling Wang, SH;Chen, YL;Hsiao, JR;Tsai, FY;Jiang, SS;Lee, AYL;Tsai, HJ;Chen, YW
國家衛生研究院 2021-02 IGFBP3 promotes radiosensitivity of OSCC via appositive feedback of NF kappa B/IL-6/ROS signaling Wang, SH;Chen, YL;Hsiao, JR;Tsai, FY;Jiang, SS;Lee, AYL;Tsai, HJ;Chen, YW
國家衛生研究院 2020-12-11 Establishment of an immunocompetent metastasis rat model with hepatocyte cancer stem cells Wu, S;Tseng, IC;Huang, WC;Su, CW;Lai, YH;Lin, C;Lee, AYL;Kuo, CY;Su, LY;Lee, MC;Hsu, TC;Yu, CH
國家衛生研究院 2019-07-11 USP17 mediates macrophage-promoted inflammation and stemness in lung cancer cells by regulating TRAF2/TRAF3 complex formation[Erratum: Oncogene. 2018 Dec 6;37(49):6327-6340.] Lu, CH;Yeh, DW;Lai, CY;Liu, YL;Huang, LR;Lee, AYL;Jin, SLC;Chuang, TH
國家衛生研究院 2018-12 Lon-ROS axis induces mtDNA release that activate cGAS-STING-IFN signaling and pack in exosome in tumor microenvironment Cheng, AN;Cheng, LC;Lee, AYL
國家衛生研究院 2018-11 AXL phosphorylates and up-regulates TNS2 and its implications in IRS-1-associated metabolism in cancer cells Cheng, LC;Chen, YL;Cheng, AN;Lee, AYL;Cho, CY;Huang, JS;Chuang, SE
國家衛生研究院 2018-10 Identification of novel Cdc7 kinase inhibitors as anti-cancer agents that target the interaction with Dbf4 by the fragment complementation and drug repositioning approach Cheng, AN;Lo, YK;Lin, YS;Tang, TK;Hsu, CH;Hsu, JTA;Lee, AYL
國家衛生研究院 2018-01 Lon restrains apoptosis via sequestering p53 in mitochondria under oxidative stress Sung, YJ;Lee, AYL
國家衛生研究院 2017-12 Cdc7-Dbf4-mediated phosphorylation of HSP90-S164 stabilizes HSP90-HCLK2-MRN complex to enhance ATR/ATM signaling that overcomes replication stress in cancer Cheng, AN;Fan, CC;Lo, YK;Kuo, CL;Wang, HC;Lien, IH;Lin, SY;Chen, CH;Jiang, SS;Chang, IS;Juan, HF;Lyu, PC;Lee, AYL
國家衛生研究院 2016-08-02 Warfarin and coumarin-like Murraya paniculata extract down-regulate EpCAM-mediated cell adhesion: Individual components versus mixture for studying botanical metastatic chemopreventives Shao, JW;Zhou, SX;Jiang, Z;Chi, T;Ma, J;Kuo, ML;Lee, AYL;Jia, L
國家衛生研究院 2016-01 The novel VEGF121-VEGF165 fusion attenuates angiogenesis and drug resistance via targeting VEGFR2-HIF-1alpha-VEGF165/Lon signaling through PI3K-AKT-mTOR pathway Tsai, JL;Lee, YM;Pan, CY;Lee, AYL
國家衛生研究院 2014-10 Discovery of ATR kinase inhibitors from natural products Wang, HC;Lee, AYL;Wu, CC;Wu, YC
國家衛生研究院 2013-10 Expression of E-cadherin, Twist, and p53 and their prognostic value in patients with oral squamous cell carcinoma Fan, CC;Wang, TY;Cheng, YA;Jiang, SS;Cheng, CW;Lee, AYL;Kao, TY
國家衛生研究院 2013-09 Increased Cdc7 expression is a marker of oral squamous cell carcinoma and overexpression of Cdc7 contributes to the resistance to DNA-damaging agents Cheng, AN;Jiang, SS;Fan, CC;Lo, YK;Kuo, CY;Chen, CH;Liu, YL;Lee, CC;Chen, WS;Huang, TS;Wang, TY;Lee, AYL
國家衛生研究院 2012-04 Deregulated Cdc7/Dbf4 expression promotes DNA repair and checkpoint recovery to enhance survival and associates with poor prognosis in OSCC Cheng, AN;Lo, YK;Jiang, SS;Lee, AYL
國家衛生研究院 2012-01-20 Dbf4 is direct downstream target of ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3-related (ATR) protein to regulate intra-S-phase checkpoint Lee, AYL;Chiba, T;Truong, LN;Cheng, AN;Do, J;Cho, MJ;Chen, L;Wu, X
國家衛生研究院 2010-12 Obtusilactone A and (-)-sesamin induce apoptosis in human lung cancer cells by inhibiting mitochondrial Lon protease and activating DNA damage checkpoints Wang, HH;Cheng, KC;Lin, CJ;Hsu, SW;Fang, WC;Hsu, TF;Chiu, CC;Chang, HH;Hsu, CH;Lee, AYL
國家衛生研究院 2010-06 Antioxidants from the leaves of cinnamomum kotoense Cheng, KC;Hsueh, MC;Chang, HC;Lee, AYL;Wang, HM;Chen, CY
國家衛生研究院 2010-02 4 beta-hydroxywithanolide E from physalis peruviana (golden berry) inhibits growth of human lung cancer cells through DNA damage, apoptosis and G(2)/M arrest Yen, CY;Chiu, CC;Chang, FR;Chen, JYF;Hwang, CC;Hseu, YC;Yang, HL;Lee, AYL;Tsai, MT;Guo, ZL;Cheng, YS;Liu, YC;Lan, YH;Chang, YC;Ko, YC;Chang, HW;Wu, YC

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