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Institution	Date	Title	Author
國家衛生研究院	2025-08	Targeting SARS-CoV-2 RNA-dependent RNA polymerase with the coumarin derivative BPR2-D2: Evidence from cell-based and enzymatic studies	Tang, WF;Tsai, HP;Chin, YF;Tsai, SK;Lin, CC;Ngo, ST;Liang, PH;Jheng, JR;Hsieh, CF;Lee, JC;Chang, YH;Chang, TY;Lin, CY;Lin, GH;Cai, JY;Chen, YL;Chen, YS;Liu, PC;Yang, CM;Shadbahr, T;Tang, J;Wang, LY;Chen, CC;Hsu, SC;Lee, HY;Wang, WC;Thai, QM;Pham, MQ;Horng, JT
國家衛生研究院	2024-04	BPR3P0128, a non-nucleoside RNA-dependent RNA polymerase inhibitor, inhibits SARS-CoV-2 variants of concern and exerts synergistic antiviral activity in combination with remdesivir	Tang, WF;Chang, YH;Lin, CC;Jheng, JR;Hsieh, CF;Chin, YF;Chang, TY;Lee, JC;Liang, PH;Lin, CY;Lin, GH;Cai, JY;Chen, YL;Chen, YS;Tsai, SK;Liu, PC;Yang, CM;Shadbahr, T;Tang, J;Hsu, YL;Huang, CH;Wang, LY;Chen, CC;Kau, JH;Hung, YJ;Lee, HY;Wang, WC;Tsai, HP;Horng, JT
國家衛生研究院	2023-04-10	Subunit vaccines with a saponin-based adjuvant boost humoral and cellular immunity to MERS coronavirus	Chang, CC;Algaissi, A;Lai, CC;Chang, CK;Lin, JS;Wang, YS;Chang, BH;Chang, YC;Chen, WT;Fan, YQ;Peng, BH;Chao, CY;Tzeng, SR;Liang, PH;Sung, WC;Hu, AY;Chang, SC;Chang, MF
中山醫學大學	2021	FUT8 Remodeling of EGFR Regulates Epidermal Keratinocyte Proliferation during Psoriasis Development	Kelel, M; Yang, RB; Tsai, TF; Liang, PH; Wu, FY; Huang, YT; Yang, MF; Hsiao, YP; Wang, LF; Tu, CF; Liu, FT; Lee, YLL
中山醫學大學	2021	Kinetic Characterization and Inhibitor Screening for the Proteases Leading to Identification of Drugs against SARS-CoV-2	Kuo, CJ; Chao, TL; Kao, HC; Tsai, YM; Liu, YK; Wang, LHC; Hsieh, MC; Chang, SY; Liang, PH
臺北醫學大學	2014	Galactosylated liposome as a dendritic cell-targeted mucosal vaccine for inducing protective anti-tumor immunity	Jiang, PL;Lin, HJ;Wang, HW;Tsai, WY;Lin, SF;Chien, MY;Liang, PH;Huang, YY;Liu, DZ
國家衛生研究院	2013-11	Synthesis and biological evaluation of novel C-aryl d-glucofuranosides as sodium-dependent glucose co-transporter 2 inhibitors	Lin, TS;Liw, YW;Song, JS;Hsieh, TC;Yeh, HW;Hsu, LC;Lin, CJ;Wu, SH;Liang, PH
臺北醫學大學	2013	Application of galactose-modified liposomes as a potent antigen presenting cell targeted carrier for intranasal immunization	Wang, HW;Jiang, PL;Lin, SF;Lin, HJ;Ou, KL;Deng, WP;Lee, LW;Huang, YY;Liang, PH;Liu, DZ
臺北醫學大學	2013	Application of galactose-modified liposomes as a potent antigen presenting cell targeted carrier for intranasal immunization	Wang, HW;Jiang, PL;Lin, SF;Lin, HJ;Ou, KL;Deng, WP;Lee, LW;Huang, YY;Liang, PH;Liu, DZ
臺北醫學大學	2013	Targeting the XIAP/caspase-7 complex selectively kills caspase-3 deficient malignancies	Lin, YF;Lai, TC;Chang, CK;Chen, CL;Huang, MS;Yang, CJ;Liu, HG;Dong, JJ;Chou, YA;Hsiao, M;Liang, PH
國家衛生研究院	2008-08-01	Design, synthesis, and evaluation of 3C protease inhibitors as anti-enterovirus 71 agents	Kuo, CJ;Shie, JJ;Fang, JM;Yen, GR;Hsu, JTA;Liu, HG;Tseng, SN;Chang, SC;Lee, CY;Shih, SR;Liang, PH
國家衛生研究院	2008-04-01	A mammalian cell-based reverse two-hybrid system for functional analysis of 3C viral protease of human enterovirus 71	Lee, JC; Shih, SR; Chang, TY; Tseng, HY; Shih, YF; Yen, KJ; Chen, WC; Shie, JJ; Fang, JM; Liang, PH; Chao, YS; Hsu, JTA
國家衛生研究院	2008	Structure-based inhibitors exhibit differential activities against Helicobacter pylori and Escherichia coli undecaprenyl pyrophosphate synthases	Kuo, CJ; Guo, RT; Lu, IL; Liu, HG; Wu, SY; Ko, TP; Wang, AHJ; Liang, PH
國家衛生研究院	2007-11	Novel small-molecule inhibitors of transmissible gastroenteritis virus	Yang, CW; Yang, YN; Liang, PH; Chen, CM; Chen, WL; Chang, HY; Chao, YS; Lee, SJ
國家衛生研究院	2007	Crystal structures and computer screened inhibitors of Helicobacter pylori undecaprenyl pyrophosphate synthase	Kuo, CJ;Guo, RT;Lu, IL;Liu, HG;Wu, SY;Ko, TP;Wang, AHJ;Liang, PH
臺北醫學大學	2007	Specific Plant Terpenoids and Lignoids Possess Potent Antiviral Activities against Severe Acute	李慶國; Wen CC; Kuo YH; Jan JT; Liang PH; Wang SY; Liu HG; Lee CK; Chang ST; Kuo CJ; Lee SS; Hou CC;
高雄醫學大學	2007	Pharmacophores and biological activities of SARS viral protease inhibitors	王惠民;梁博煌 ; Wang HM;Liang PH
國家衛生研究院	2006-08-24	Structure-based drug design and structural biology study of novel nonpeptide inhibitors of severe acute respiratory syndrome coronavirus main protease	Lu, IL; Mahindroo, N; Liang, PH; Peng, YH; Kuo, CJ; Tsai, KC; Hsieh, HP; Chao, YS; Wu, SY
國家衛生研究院	2006-06-15	Discovery of a novel family of SARS-CoV protease inhibitors by virtual screening and 3D-QSAR studies	Tsai, KC; Chen, SY; Liang, PH; Lu, IL; Mahindroo, N; Hsieh, HP; Chao, YS; Liu, L; Liu, D; Lien, W; Lin, TH; Wu, SY
國立臺灣大學	2006-03	Stable benzotriazole esters as mechanism-based inactivators of the severe acute respiratory syndrome 3CL protease	Wu, CY; King, KY; Kuo, CJ; Fang, JM; Wu, YT; Ho, MY; Liao, CL; Shie, JJ; Liang, PH; Wong, CH
國家衛生研究院	2005	Inhibition of SARS-CoV 3C-like protease activity by theaflavin-3,3 '- digallate (TF3)	Chen, CN; Lin, CPC; Huang, KK; Chen, WC; Hsieh, HP; Liang, PH; Hsu, JTA
國家衛生研究院	2004-12-10	One site mutation disrupts dimer formation in human DPP-IV proteins	Chien, CH; Huang, LH; Chou, CY; Chen, YS; Han, YS; Chang, GG; Liang, PH; Chen, X
國家衛生研究院	2004-09-10	Evaluation of metal-conjugated compounds as inhibitors of 3CL protease of SARS-CoV	Hsu, JTA; Kuo, CJ; Hsieh, HP; Wang, YC; Huang, KK; Lin, CPC; Huang, PF; Chen, X; Liang, PH
國家衛生研究院	2004-07-23	Characterization of SARS main protease and inhibitor assay using a fluorogenic substrate [Erratum: Biochemical and Biophysical Research Communications. 2004 Jun;318(4):862-867.]	Kuo, CJ; Chi, YH; Hsu, JTA; Liang, PH
國立臺灣大學	2004-07	Small molecules targeting severe acute respiratory syndrome human coronavirus.	Wu, CY; Jan, JT; Ma, SH; Kuo, CJ; Juan, HF; Cheng, YS; Hsu, HH; Huang, HC; Wu, D; Brik, A; Liang, FS; Liu, RS; Fang, JM; Chen, ST; Liang, PH; Wong, CH

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