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显示项目 26-50 / 108 (共5页)
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机构 日期 题名 作者
國家衛生研究院 2017-04 Discovery of BPR1K871-a quinazoline based multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, in vitro and in vivo evaluation Hsieh, HP;Wang, WC;Shiao, HY;Ke, YY;Lin, WH;Hsu, JTA;Chen, CT;Yeh, TK
國家衛生研究院 2016-12 Discovery of BPR1K871, a quinazoline based, multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, in vitro and in vivo evaluation Chang Hsu, Y;Selvaraj Coumar, M;Wang, WC;Shiao, HY;Ke, YY;Lin, WH;Kuo, CC;Chang, CW;Kuo, FM;Chen, PY;Wang, SY;Li, AS;Chen, CH;Kuo, PC;Chen, CP;Wu, MH;Huang, CL;Yen, KJ;Chang, YI;Hsu, JT;Chen, CT;Yeh, TK;Song, JS;Shih, C;Hsieh, HP
國家衛生研究院 2016-12 Novel cKIT kinase inhibitor, BPRCKJ001, as an advanced therapeutic candidate for GIST Shiao, HY;Tsai, HJ;Lin, WH;Tsu, TA;Yeh, TK;Chen, CT;Jiaang, WT
國家衛生研究院 2016-11-29 Discovery of novel inhibitors of Aurora kinases with indazole scaffold: In silico fragment-based and knowledge-based drug design Chang, CF;Lin, WH;Ke, YY;Lin, YS;Wang, WC;Chen, CH;Kuo, PC;Hsu, JTA;Uang, BJ;Hsieh, HP
國家衛生研究院 2016-06-01 A RISK21 matrix for assessing the potential health risk of DDT from flower tea in Taiwan Lin, YJ;You, SH;Chou, WC;Weng, CY;Chang, HH;Chan, WC;Lin, WH;Chiang, HC;Lin, P
國家衛生研究院 2016-04-12 Pyrazolylamine derivatives reveal the conformational switching between type I and type II binding modes of Anaplastic Lymphoma Kinase (ALK) Tu, CH;Lin, WH;Peng, YH;Hsu, T;Wu, JS;Chang, CY;Lu, CT;Lyu, PC;Shih, C;Jiaang, WT;Wu, SY
國家衛生研究院 2016-02-09 Pyrazole compounds and thiazole compounds as protein kinases inhibitors Jiaang, WT;Hsu, TA;Lin, WH;Chao, YS
國家衛生研究院 2015-08 Optimization of quinazoline-based kinase inhibitors: Identification of a dual FLT3/AURKA kinase inhibitor for the treatment of acute myeloid leukemia Hsieh, HP;Hsu, YC;Ke, YY;Shiao, HY;Chang, CW;Lin, WH;Hsu, TA;Yeh, TK;Chen, CT
國家衛生研究院 2015-07-22 作为酪胺酸激酶抑制剂的稠合双环及多环嘧啶化合物 Hsieh, HP;Coumar, MS;Hsu, TA;Lin, WH;Chen, YR;Chao, YS
國家衛生研究院 2015-07 Identification of a potent 5-phenyl-thiazol-2-ylamine-based inhibitor of FLT3 with activity against drug resistance-conferring point mutations Chen, CT;Hsu, JTA;Lin, WH;Lu, CT;Yen, SC;Hsu, T;Huang, YL;Song, JS;Chen, CH;Chou, LH;Yen, KJ;Chen, CP;Kuo, PC;Huang, CL;Eugene Liu, H;Chao, YS;Yeh, TK;Jiaang, WT
國家衛生研究院 2015-06-29 Homology modeling of DFG-in FMS-like tyrosine kinase 3 (FLT3) and structure-based virtual screening for inhibitor identification Ke, YY;Singh, VK;Coumar, MS;Hsu, YC;Wang, WC;Song, JS;Chen, CH;Lin, WH;Wu, SH;Hsu, JT;Shih, C;Hsieh, HP
國家衛生研究院 2015-01 Modulation of both activator protein-1 and nuclear factor-kappa B signal transduction of human T cells by amiodarone Cheng, SM;Lin, WH;Lin, CS;Ho, LJ;Tsai, TN;Wu, CH;Lai, JH;Yang, SP
國家衛生研究院 2015-01 Identification of ligand efficient, fragment-like hits from an HTS library: Structure-based virtual screening and docking investigations of 2H- and 3H-pyrazolo tautomers for Aurora kinase A selectivity Sarvagalla, S;Singh, VK;Ke, YY;Shiao, HY;Lin, WH;Hsieh, HP;Hsu, JTA;Coumar, MS
國立交通大學 2014-12-08T15:37:07Z PUML and PGML: Device-independent UI and logic markup languages on small and mobile appliances Kao, TH; Chen, YY; Tsai, TH; Chou, HJ; Lin, WH; Yuan, SM
國家衛生研究院 2014-10 Optimization of 5,6-fused pyrimidine-based kinase inhibitors by computer-aided drug design for the treatment of AML Hsu, YC;Shiao, HY;Ke, YY;Hsu, JTA;Lin, WH;Chen, CH;Hsieh, HP
國家衛生研究院 2014-10 Novel irreversible EGFR tyrosine kinase inhibitor, DBPR112, as a therapeutic candidate for lung adenocarcinoma Shiao, HY;Hsu, TA;Lin, WH;Yang, TT;Hsieh, HF;Chen, CT;Yeh, TK;Hsieh, HP
國家衛生研究院 2014-08 Ligand efficiency based approach for efficient virtual screening of compound libraries Ke, YY;Coumar, MS;Shiao, HY;Wang, WC;Chen, CW;Song, JS;Chen, CH;Lin, WH;Wu, SH;Hsu, JT;Chang, CM;Hsieh, HP
國家衛生研究院 2014-05 Facile identification of dual FLT3-Aurora A inhibitors: A computer-guided drug design approach ChangHsu, Y;Ke, YY;Shiao, HY;Lee, CC;Lin, WH;Chen, CH;Yen, KJ;Hsu, JTA;Chang, C;Hsieh, HP
國家衛生研究院 2014-05 Cover Picture: Facile identification of dual FLT3–aurora a inhibitors: A computer-guided drug design approach (ChemMedChem 5/2014) Chang Hsu, Y;Ke, YY;Shiao, HY;Lee, CC;Lin, WH;Chen, CH;Yen, KJ;Hsu, JTA;Chang, C;Hsieh, HP
國家衛生研究院 2014-04-21 作為蛋白質激酶抑制劑之吡唑化合物及噻唑化合物、其醫藥組成物及用途 Jiaang, WT;Hsu, TA;Lin, WH;Chao, YS
國家衛生研究院 2014-04 Dysregulated interactions between lamin A and SUN1 induce abnormalities in the nuclear envelope and endoplasmic reticulum in progeric laminopathies Chen, ZJ;Wang, WP;Chen, YC;Wang, JY;Lin, WH;Tai, LA;Liou, GG;Yang, CS;Chi, YH
國家衛生研究院 2014-03 Efficient virtual screening using ligand efficiency based approach Hsieh, HP;Ke, YY;Coumar, MS;Lin, WH;Wang, WC;Shiao, HY;Hsu, TAJ
國家衛生研究院 2014-01-08 Evaluation of the antitumor effects of BPR1J-340, a potent and selective FLT3 inhibitor, alone or in combination with an HDAC inhibitor, vorinostat, in AML cancer Lin, WH;Yeh, TK;Jiaang, WT;Yen, KJ;Chen, CH;Huang, CT;Yen, SC;Hsieh, SY;Chou, LH;Chen, CP;Chiu, CH;Kao, LC;Chao, YS;Chen, CT;Hsu, JTA
中山醫學大學 2014 Vimentin is involved in peptidylarginine deiminase 2-induced apoptosis of activated Jurkat cells. Hsu, PC; YF, Liao; CL, Lin; Lin, WH; GY, Liu; Hung, HC
臺北醫學大學 2014 NSC746364, a G-Quadruplex Stabilizing Agent, Suppresses Cell Growth of A549 Human Lung Cancer Cells through Activation of ATR/Chk1-Dependent Pathway YL?, Chung;CH?, Pan;Liou, WH;Sheu, MJ;Lin, WH;Chen, Tsung-Chih;Huang, Hsu-Shan;Wu*, Chieh-Hsi

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