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Institution	Date	Title	Author
國家衛生研究院	2019-12	Identification of a multitargeted tyrosine kinase inhibitor for the treatment of gastrointestinal stromal tumors and acute myeloid leukemia	Lin, WH;Wu, SY;Yeh, TK;Chen, CT;Song, JS;Shiao, HY;Kuo, CC;Hsu, T;Lu, CT;Wang, PC;Wu, TS;Peng, YH;Lin, HY;Chen, CP;Weng, YL;Kung, FC;Wu, MH;Su, YC;Huang, KW;Chou, LH;Hsueh, CC;Yen, KJ;Kuo, PC;Huang, CL;Chen, LT;Shih, C;Tsai, HJ;Jiaang, WT
國家衛生研究院	2019-10	Discovery of clinical candidate DBPR112, a furanopyrimidine-based epidermal growth factor receptor inhibitor for the treatment of non-small cell lung cancer	Hsieh, HP;Chang, JY;Yeh, CT;Lin, SY;Ke, YY;Lin, WH;Hsu, TA;Wu, SY;Yeh, TK
國家衛生研究院	2019-09-27	Discovery of a furanopyrimidine-based epidermal growth factor receptor inhibitor (DBPR112) as a clinical candidate for the treatment of non-small cell lung cancer	Lin, SY;Chang Hsu, Y;Peng, YH;Ke, YY;Lin, WH;Sun, HY;Shiao, HY;Kuo, FM;Chen, PY;Lien, TW;Chen, CH;Chu, CY;Wang, SY;Yeh, KC;Chen, CP;Hsu, TA;Wu, SY;Yeh, TK;Chen, CT;Hsieh, HP
國家衛生研究院	2019-08	The effect of antidementia drugs on mortality in patients with Alzheimer's disease	Lin, WH;Lin, CH;Hou, PH;Lan, TH
國家衛生研究院	2019-07	An Aurora kinase inhibitor BPR6K471 inhibits tumor growth and reduces the cancer stem cell-like properties of small cell lung cancer	Chang, CP;Ke, YY;Lin, WH;Jhuo, DH;Wang, WP;Tsai, CH;Chen, YT;Su, YJ;Hung, MC;Wu, ZW;Kuo, PC;Yeh, TK;Chen, CP;Song, JS;Chen, CT;Shih, C;Chi, YH
國家衛生研究院	2019-04-10	Discovery of Conformational Control Inhibitors Switching off the Activated c-KIT and Targeting a Broad Range of Clinically Relevant c-KIT Mutants	Wu, TS;Lin, WH;Tsai, HJ;Hsueh, CC;Hsu, T;Wang, PC;Lin, HY;Peng, YH;Lu, CT;Lee, LC;Tu, CH;Kung, FC;Shiao, HY;Yeh, TK;Song, JS;Chang, JY;Su, YC;Chen, LT;Chen, CT;Jiaang, WT;Wu, SY
國家衛生研究院	2019-03-13	Genome-wide microarray analysis suggests transcriptomic response may not play a major role in high- to low-altitude acclimation in harvest mouse (Micromys minutus)	Chen, TH;Ma, GC;Lin, WH;Lee, DJ;Wu, SH;Liao, BY;Chen, M;Lin, LK
臺大學術典藏	2018-09-10T05:32:04Z	Clinical and ultrasonographic manifestations in major causes of common carotid artery occlusion	Tsai, C.-F.;Jeng, J.-S.;Lu, C.-J.;Yip, P.-K.Tsai, Cf;Jeng, Js;Lu, Cj;Hwang, Bs;Lin, Wh;Yip, Pk.; Tsai, CF; JIANN-SHING JENG; Chen, Hui-fang; Wu, Ching-yi; Jeng, JS; Lu, CJ; Lin, Keh-chung; Jang, Yuh; Hwang, BS; Lin, WH; Lin, Shih-chieh; Yip, PK.; Cheng, Ju-wen; Chung, Chia-ying; Yan, Yanning
臺大學術典藏	2018-09-10T03:46:20Z	Estimation of contrail frequency and radiative effects over the Taiwan area	Chen, JP;Lin, WH;Lin, RF; Chen, JP; Lin, WH; Lin, RF; JEN-PING CHEN
國家衛生研究院	2018-05-10	Design and synthesis of BPR1K653 derivatives targeting the back pocket of Aurora kinases for selective isoform inhibition	Ke, YY;Chang, CP;Lin, WH;Tsai, CH;Chiu, IC;Wang, WP;Wang, PC;Chen, PY;Lin, WH;Chang, CF;Kuo, PC;Song, JS;Shih, C;Hsieh, HP;Chi, YH
國家衛生研究院	2017-04	Discovery of BPR1K871-a quinazoline based multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, in vitro and in vivo evaluation	Hsieh, HP;Wang, WC;Shiao, HY;Ke, YY;Lin, WH;Hsu, JTA;Chen, CT;Yeh, TK
國家衛生研究院	2016-12	Discovery of BPR1K871, a quinazoline based, multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, in vitro and in vivo evaluation	Chang Hsu, Y;Selvaraj Coumar, M;Wang, WC;Shiao, HY;Ke, YY;Lin, WH;Kuo, CC;Chang, CW;Kuo, FM;Chen, PY;Wang, SY;Li, AS;Chen, CH;Kuo, PC;Chen, CP;Wu, MH;Huang, CL;Yen, KJ;Chang, YI;Hsu, JT;Chen, CT;Yeh, TK;Song, JS;Shih, C;Hsieh, HP
國家衛生研究院	2016-12	Novel cKIT kinase inhibitor, BPRCKJ001, as an advanced therapeutic candidate for GIST	Shiao, HY;Tsai, HJ;Lin, WH;Tsu, TA;Yeh, TK;Chen, CT;Jiaang, WT
國家衛生研究院	2016-11-29	Discovery of novel inhibitors of Aurora kinases with indazole scaffold: In silico fragment-based and knowledge-based drug design	Chang, CF;Lin, WH;Ke, YY;Lin, YS;Wang, WC;Chen, CH;Kuo, PC;Hsu, JTA;Uang, BJ;Hsieh, HP
國家衛生研究院	2016-06-01	A RISK21 matrix for assessing the potential health risk of DDT from flower tea in Taiwan	Lin, YJ;You, SH;Chou, WC;Weng, CY;Chang, HH;Chan, WC;Lin, WH;Chiang, HC;Lin, P
國家衛生研究院	2016-04-12	Pyrazolylamine derivatives reveal the conformational switching between type I and type II binding modes of Anaplastic Lymphoma Kinase (ALK)	Tu, CH;Lin, WH;Peng, YH;Hsu, T;Wu, JS;Chang, CY;Lu, CT;Lyu, PC;Shih, C;Jiaang, WT;Wu, SY
國家衛生研究院	2016-02-09	Pyrazole compounds and thiazole compounds as protein kinases inhibitors	Jiaang, WT;Hsu, TA;Lin, WH;Chao, YS
國家衛生研究院	2015-08	Optimization of quinazoline-based kinase inhibitors: Identification of a dual FLT3/AURKA kinase inhibitor for the treatment of acute myeloid leukemia	Hsieh, HP;Hsu, YC;Ke, YY;Shiao, HY;Chang, CW;Lin, WH;Hsu, TA;Yeh, TK;Chen, CT
國家衛生研究院	2015-07-22	作为酪胺酸激酶抑制剂的稠合双环及多环嘧啶化合物	Hsieh, HP;Coumar, MS;Hsu, TA;Lin, WH;Chen, YR;Chao, YS
國家衛生研究院	2015-07	Identification of a potent 5-phenyl-thiazol-2-ylamine-based inhibitor of FLT3 with activity against drug resistance-conferring point mutations	Chen, CT;Hsu, JTA;Lin, WH;Lu, CT;Yen, SC;Hsu, T;Huang, YL;Song, JS;Chen, CH;Chou, LH;Yen, KJ;Chen, CP;Kuo, PC;Huang, CL;Eugene Liu, H;Chao, YS;Yeh, TK;Jiaang, WT
國家衛生研究院	2015-06-29	Homology modeling of DFG-in FMS-like tyrosine kinase 3 (FLT3) and structure-based virtual screening for inhibitor identification	Ke, YY;Singh, VK;Coumar, MS;Hsu, YC;Wang, WC;Song, JS;Chen, CH;Lin, WH;Wu, SH;Hsu, JT;Shih, C;Hsieh, HP
國家衛生研究院	2015-01	Modulation of both activator protein-1 and nuclear factor-kappa B signal transduction of human T cells by amiodarone	Cheng, SM;Lin, WH;Lin, CS;Ho, LJ;Tsai, TN;Wu, CH;Lai, JH;Yang, SP
國家衛生研究院	2015-01	Identification of ligand efficient, fragment-like hits from an HTS library: Structure-based virtual screening and docking investigations of 2H- and 3H-pyrazolo tautomers for Aurora kinase A selectivity	Sarvagalla, S;Singh, VK;Ke, YY;Shiao, HY;Lin, WH;Hsieh, HP;Hsu, JTA;Coumar, MS
國立交通大學	2014-12-08T15:37:07Z	PUML and PGML: Device-independent UI and logic markup languages on small and mobile appliances	Kao, TH; Chen, YY; Tsai, TH; Chou, HJ; Lin, WH; Yuan, SM
國家衛生研究院	2014-10	Optimization of 5,6-fused pyrimidine-based kinase inhibitors by computer-aided drug design for the treatment of AML	Hsu, YC;Shiao, HY;Ke, YY;Hsu, JTA;Lin, WH;Chen, CH;Hsieh, HP
國家衛生研究院	2014-10	Novel irreversible EGFR tyrosine kinase inhibitor, DBPR112, as a therapeutic candidate for lung adenocarcinoma	Shiao, HY;Hsu, TA;Lin, WH;Yang, TT;Hsieh, HF;Chen, CT;Yeh, TK;Hsieh, HP
國家衛生研究院	2014-08	Ligand efficiency based approach for efficient virtual screening of compound libraries	Ke, YY;Coumar, MS;Shiao, HY;Wang, WC;Chen, CW;Song, JS;Chen, CH;Lin, WH;Wu, SH;Hsu, JT;Chang, CM;Hsieh, HP
國家衛生研究院	2014-05	Facile identification of dual FLT3-Aurora A inhibitors: A computer-guided drug design approach	ChangHsu, Y;Ke, YY;Shiao, HY;Lee, CC;Lin, WH;Chen, CH;Yen, KJ;Hsu, JTA;Chang, C;Hsieh, HP
國家衛生研究院	2014-05	Cover Picture: Facile identification of dual FLT3–aurora a inhibitors: A computer-guided drug design approach (ChemMedChem 5/2014)	Chang Hsu, Y;Ke, YY;Shiao, HY;Lee, CC;Lin, WH;Chen, CH;Yen, KJ;Hsu, JTA;Chang, C;Hsieh, HP
國家衛生研究院	2014-04-21	作為蛋白質激酶抑制劑之吡唑化合物及噻唑化合物、其醫藥組成物及用途	Jiaang, WT;Hsu, TA;Lin, WH;Chao, YS
國家衛生研究院	2014-04	Dysregulated interactions between lamin A and SUN1 induce abnormalities in the nuclear envelope and endoplasmic reticulum in progeric laminopathies	Chen, ZJ;Wang, WP;Chen, YC;Wang, JY;Lin, WH;Tai, LA;Liou, GG;Yang, CS;Chi, YH
國家衛生研究院	2014-03	Efficient virtual screening using ligand efficiency based approach	Hsieh, HP;Ke, YY;Coumar, MS;Lin, WH;Wang, WC;Shiao, HY;Hsu, TAJ
國家衛生研究院	2014-01-08	Evaluation of the antitumor effects of BPR1J-340, a potent and selective FLT3 inhibitor, alone or in combination with an HDAC inhibitor, vorinostat, in AML cancer	Lin, WH;Yeh, TK;Jiaang, WT;Yen, KJ;Chen, CH;Huang, CT;Yen, SC;Hsieh, SY;Chou, LH;Chen, CP;Chiu, CH;Kao, LC;Chao, YS;Chen, CT;Hsu, JTA
中山醫學大學	2014	Vimentin is involved in peptidylarginine deiminase 2-induced apoptosis of activated Jurkat cells.	Hsu, PC; YF, Liao; CL, Lin; Lin, WH; GY, Liu; Hung, HC
臺北醫學大學	2014	NSC746364, a G-Quadruplex Stabilizing Agent, Suppresses Cell Growth of A549 Human Lung Cancer Cells through Activation of ATR/Chk1-Dependent Pathway	YL?, Chung;CH?, Pan;Liou, WH;Sheu, MJ;Lin, WH;Chen, Tsung-Chih;Huang, Hsu-Shan;Wu*, Chieh-Hsi
臺北醫學大學	2014	NSC746364, a G-quadruplex stabilizing agent, suppresses cell growth of A549 human lung cancer cells through activation of ATR/Chk1-dependent pathway	Chung, YL;Pan, CH;Lioua, WH;Sheua, MJ;Lin, WH;Chen, TC;Huang, HS;CH*, Wu
國家衛生研究院	2013-09-22	A novel Aurora-A inhibitor, BPR1K0609S1, sensitizes colorectal tumor cells to 5-fluorofracil (5-FU) treatment [Erratum:International Journal of Biological Sciences. 2013 Apr 29;9(4):403-411]	Shionome, Y;Lin, WH;Shiao, HY;Hsieh, HP;Hsu, JTA;Ouchi, T
國家衛生研究院	2013-08-13	Fused bicyclic and tricyclic pyrimidine compounds as tyrosine kinase inhibitors	Hsieh, HP;Coumar, SM;Hsu, TA;Lin, WH;Chen, YR;Chao, YS
國家衛生研究院	2013-06-28	Optimization of ligand and lipophilic efficiency to identify an in vivo active furano-pyrimidine aurora kinase inhibitor	Shiao, HY;Coumar, MS;Chang, CW;Ke, YY;Chi, YH;Chu, CY;Sun, HY;Chen, CH;Lin, WH;Fung, KS;Kuo, PC;Huang, CT;Chang, KY;Lu, CT;Hsu, JT;Chen, CT;Jiaang, WT;Chao, YS;Hsieh, HP
國家衛生研究院	2013-06	Discovery of 3-phenyl-1H-5-pyrazolylamine derivatives containing a urea pharmacophore as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3)	Lin, WH;Hsu, JTA;Hsieh, SY;Chen, CT;Song, JS;Yen, SC;Hsu, T;Lu, CT;Chen, CH;Chou, LH;Yang, YN;Chiu, CH;Chen, CP;Tseng, YJ;Yen, KJ;Yeh, CF;Chao, YS;Yeh, TK;Jiaang, WT
國家衛生研究院	2013-05	Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules	Wu, JM;Chen, CT;Coumar, MS;Lin, WH;Chen, ZJ;Hsu, JT;Peng, YH;Shiao, HY;Chu, CY;Wu, JS;Lin, CT;Chen, CP;Hsueh, CC;Chang, KY;Kao, LP;Huang, CY;Chao, YS;Wu, SY;Hsieh, HP;Chi, YH
國家衛生研究院	2013-05	Protein kinase inhibitor design by targeting the Asp-Phe-Gly (DFG) motif: The role of the DFG motif in the design of epidermal growth factor receptor inhibitors	Peng, YH;Shiao, HY;Tu, CH;Liu, PM;Hsu, JT;Amancha, PK;Wu, JS;Coumar, MS;Chen, CH;Wang, SY;Lin, WH;Sun, HY;Chao, YS;Lyu, PC;Hsieh, HP;Wu, SY
國家衛生研究院	2013-04-29	A novel Aurora-A inhibitor, BPR1K0609S1, sensitizes colorectal tumor cells to 5-fluorofracil (5-FU) treatment	Shionome, Y;Lin, WH;Shiao, HY;Hsieh, HP;Hsu, JTA;Ouchi, T
國家衛生研究院	2013-04-07	3D-QSAR assisted drug design: Identification of a potent quinazoline based Aurora kinase inhibitor	Ke, YY;Shiao, HY;Hsu, YC;Chang-Chu, Y;Wang, WC;Lee, YC;Lin, WH;Hsu, JTA;Chang, CW;Lin, CW;Yeh, TK;Chao, YS;Coumar, MS;Hsieh, HP
國家衛生研究院	2013-04	Design and synthesis of Aurora kinase inhibitors as anticancer agents	Hsu, YC;Shiao, HY;Lin, WH;Hsu, JTA;Chen, CT;Chao, YS;Hsieh, HP
國家衛生研究院	2013-02-11	作為酪胺酸激酶抑制劑之稠合雙環及多環嘧啶化合物	Hsieh, HP;Coumar, MS;Chao, YS;Hsu, TA;Lin, WH;Chen, YR
國家衛生研究院	2013-02	Epstein-Barr virus Zta upregulates matrix metalloproteinases 3 and 9 that synergistically promote cell invasion in vitro	Lan, YY;Yeh, TH;Lin, WH;Wu, SY;Lai, HC;Chang, FH;Takada, K;Chang, Y
國家衛生研究院	2013-01	3D-QSAR-assisted drug design: Identification of a potent quinazoline-based aurora kinase inhibitor	Ke, YY;Shiao, HY;Hsu, YC;Chu, CY;Wang, WC;Lee, YC;Lin, WH;Chen, CH;Hsu, JTA;Chang, CW;Lin, CW;Yeh, TK;Chao, YS;Coumar, MS;Hsieh, HP
國家衛生研究院	2012-11	Estimation of expected life-years saved from successful prevention of end-stage renal disease in elderly patients with diabetes: A nationwide study from Taiwan	Yang, DC;Lee, LJ;Hsu, CC;Chang, YY;Wang, MC;Lin, WH;Chang, CM;Wang, JD
國家衛生研究院	2012-11	BPR1J271, a novel FLT3 inhibitor for treating acute myeloid leukemia	Chen, CT;Lin, WH;Chou, LH;Chen, CP;Yen, SC;Huang, YL;Yeh, TK;Hsu, JTA;Jiaang, WI;Chao, YS

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