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Showing items 31-80 of 108 (3 Page(s) Totally)
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| 國家衛生研究院 |
2016-04-12 |
Pyrazolylamine derivatives reveal the conformational switching between type I and type II binding modes of Anaplastic Lymphoma Kinase (ALK)
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Tu, CH;Lin, WH;Peng, YH;Hsu, T;Wu, JS;Chang, CY;Lu, CT;Lyu, PC;Shih, C;Jiaang, WT;Wu, SY |
| 國家衛生研究院 |
2016-02-09 |
Pyrazole compounds and thiazole compounds as protein kinases inhibitors
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Jiaang, WT;Hsu, TA;Lin, WH;Chao, YS |
| 國家衛生研究院 |
2015-08 |
Optimization of quinazoline-based kinase inhibitors: Identification of a dual FLT3/AURKA kinase inhibitor for the treatment of acute myeloid leukemia
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Hsieh, HP;Hsu, YC;Ke, YY;Shiao, HY;Chang, CW;Lin, WH;Hsu, TA;Yeh, TK;Chen, CT |
| 國家衛生研究院 |
2015-07-22 |
作为酪胺酸激酶抑制剂的稠合双环及多环嘧啶化合物
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Hsieh, HP;Coumar, MS;Hsu, TA;Lin, WH;Chen, YR;Chao, YS |
| 國家衛生研究院 |
2015-07 |
Identification of a potent 5-phenyl-thiazol-2-ylamine-based inhibitor of FLT3 with activity against drug resistance-conferring point mutations
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Chen, CT;Hsu, JTA;Lin, WH;Lu, CT;Yen, SC;Hsu, T;Huang, YL;Song, JS;Chen, CH;Chou, LH;Yen, KJ;Chen, CP;Kuo, PC;Huang, CL;Eugene Liu, H;Chao, YS;Yeh, TK;Jiaang, WT |
| 國家衛生研究院 |
2015-06-29 |
Homology modeling of DFG-in FMS-like tyrosine kinase 3 (FLT3) and structure-based virtual screening for inhibitor identification
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Ke, YY;Singh, VK;Coumar, MS;Hsu, YC;Wang, WC;Song, JS;Chen, CH;Lin, WH;Wu, SH;Hsu, JT;Shih, C;Hsieh, HP |
| 國家衛生研究院 |
2015-01 |
Modulation of both activator protein-1 and nuclear factor-kappa B signal transduction of human T cells by amiodarone
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Cheng, SM;Lin, WH;Lin, CS;Ho, LJ;Tsai, TN;Wu, CH;Lai, JH;Yang, SP |
| 國家衛生研究院 |
2015-01 |
Identification of ligand efficient, fragment-like hits from an HTS library: Structure-based virtual screening and docking investigations of 2H- and 3H-pyrazolo tautomers for Aurora kinase A selectivity
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Sarvagalla, S;Singh, VK;Ke, YY;Shiao, HY;Lin, WH;Hsieh, HP;Hsu, JTA;Coumar, MS |
| 國立交通大學 |
2014-12-08T15:37:07Z |
PUML and PGML: Device-independent UI and logic markup languages on small and mobile appliances
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Kao, TH; Chen, YY; Tsai, TH; Chou, HJ; Lin, WH; Yuan, SM |
| 國家衛生研究院 |
2014-10 |
Optimization of 5,6-fused pyrimidine-based kinase inhibitors by computer-aided drug design for the treatment of AML
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Hsu, YC;Shiao, HY;Ke, YY;Hsu, JTA;Lin, WH;Chen, CH;Hsieh, HP |
| 國家衛生研究院 |
2014-10 |
Novel irreversible EGFR tyrosine kinase inhibitor, DBPR112, as a therapeutic candidate for lung adenocarcinoma
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Shiao, HY;Hsu, TA;Lin, WH;Yang, TT;Hsieh, HF;Chen, CT;Yeh, TK;Hsieh, HP |
| 國家衛生研究院 |
2014-08 |
Ligand efficiency based approach for efficient virtual screening of compound libraries
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Ke, YY;Coumar, MS;Shiao, HY;Wang, WC;Chen, CW;Song, JS;Chen, CH;Lin, WH;Wu, SH;Hsu, JT;Chang, CM;Hsieh, HP |
| 國家衛生研究院 |
2014-05 |
Facile identification of dual FLT3-Aurora A inhibitors: A computer-guided drug design approach
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ChangHsu, Y;Ke, YY;Shiao, HY;Lee, CC;Lin, WH;Chen, CH;Yen, KJ;Hsu, JTA;Chang, C;Hsieh, HP |
| 國家衛生研究院 |
2014-05 |
Cover Picture: Facile identification of dual FLT3–aurora a inhibitors: A computer-guided drug design approach (ChemMedChem 5/2014)
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Chang Hsu, Y;Ke, YY;Shiao, HY;Lee, CC;Lin, WH;Chen, CH;Yen, KJ;Hsu, JTA;Chang, C;Hsieh, HP |
| 國家衛生研究院 |
2014-04-21 |
作為蛋白質激酶抑制劑之吡唑化合物及噻唑化合物、其醫藥組成物及用途
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Jiaang, WT;Hsu, TA;Lin, WH;Chao, YS |
| 國家衛生研究院 |
2014-04 |
Dysregulated interactions between lamin A and SUN1 induce abnormalities in the nuclear envelope and endoplasmic reticulum in progeric laminopathies
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Chen, ZJ;Wang, WP;Chen, YC;Wang, JY;Lin, WH;Tai, LA;Liou, GG;Yang, CS;Chi, YH |
| 國家衛生研究院 |
2014-03 |
Efficient virtual screening using ligand efficiency based approach
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Hsieh, HP;Ke, YY;Coumar, MS;Lin, WH;Wang, WC;Shiao, HY;Hsu, TAJ |
| 國家衛生研究院 |
2014-01-08 |
Evaluation of the antitumor effects of BPR1J-340, a potent and selective FLT3 inhibitor, alone or in combination with an HDAC inhibitor, vorinostat, in AML cancer
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Lin, WH;Yeh, TK;Jiaang, WT;Yen, KJ;Chen, CH;Huang, CT;Yen, SC;Hsieh, SY;Chou, LH;Chen, CP;Chiu, CH;Kao, LC;Chao, YS;Chen, CT;Hsu, JTA |
| 中山醫學大學 |
2014 |
Vimentin is involved in peptidylarginine deiminase 2-induced apoptosis of activated Jurkat cells.
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Hsu, PC; YF, Liao; CL, Lin; Lin, WH; GY, Liu; Hung, HC |
| 臺北醫學大學 |
2014 |
NSC746364, a G-Quadruplex Stabilizing Agent, Suppresses Cell Growth of A549 Human Lung Cancer Cells through Activation of ATR/Chk1-Dependent Pathway
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YL?, Chung;CH?, Pan;Liou, WH;Sheu, MJ;Lin, WH;Chen, Tsung-Chih;Huang, Hsu-Shan;Wu*, Chieh-Hsi |
| 臺北醫學大學 |
2014 |
NSC746364, a G-quadruplex stabilizing agent, suppresses cell growth of A549 human lung cancer cells through activation of ATR/Chk1-dependent pathway
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Chung, YL;Pan, CH;Lioua, WH;Sheua, MJ;Lin, WH;Chen, TC;Huang, HS;CH*, Wu |
| 國家衛生研究院 |
2013-09-22 |
A novel Aurora-A inhibitor, BPR1K0609S1, sensitizes colorectal tumor cells to 5-fluorofracil (5-FU) treatment [Erratum:International Journal of Biological Sciences. 2013 Apr 29;9(4):403-411]
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Shionome, Y;Lin, WH;Shiao, HY;Hsieh, HP;Hsu, JTA;Ouchi, T |
| 國家衛生研究院 |
2013-08-13 |
Fused bicyclic and tricyclic pyrimidine compounds as tyrosine kinase inhibitors
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Hsieh, HP;Coumar, SM;Hsu, TA;Lin, WH;Chen, YR;Chao, YS |
| 國家衛生研究院 |
2013-06-28 |
Optimization of ligand and lipophilic efficiency to identify an in vivo active furano-pyrimidine aurora kinase inhibitor
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Shiao, HY;Coumar, MS;Chang, CW;Ke, YY;Chi, YH;Chu, CY;Sun, HY;Chen, CH;Lin, WH;Fung, KS;Kuo, PC;Huang, CT;Chang, KY;Lu, CT;Hsu, JT;Chen, CT;Jiaang, WT;Chao, YS;Hsieh, HP |
| 國家衛生研究院 |
2013-06 |
Discovery of 3-phenyl-1H-5-pyrazolylamine derivatives containing a urea pharmacophore as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3)
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Lin, WH;Hsu, JTA;Hsieh, SY;Chen, CT;Song, JS;Yen, SC;Hsu, T;Lu, CT;Chen, CH;Chou, LH;Yang, YN;Chiu, CH;Chen, CP;Tseng, YJ;Yen, KJ;Yeh, CF;Chao, YS;Yeh, TK;Jiaang, WT |
| 國家衛生研究院 |
2013-05 |
Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules
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Wu, JM;Chen, CT;Coumar, MS;Lin, WH;Chen, ZJ;Hsu, JT;Peng, YH;Shiao, HY;Chu, CY;Wu, JS;Lin, CT;Chen, CP;Hsueh, CC;Chang, KY;Kao, LP;Huang, CY;Chao, YS;Wu, SY;Hsieh, HP;Chi, YH |
| 國家衛生研究院 |
2013-05 |
Protein kinase inhibitor design by targeting the Asp-Phe-Gly (DFG) motif: The role of the DFG motif in the design of epidermal growth factor receptor inhibitors
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Peng, YH;Shiao, HY;Tu, CH;Liu, PM;Hsu, JT;Amancha, PK;Wu, JS;Coumar, MS;Chen, CH;Wang, SY;Lin, WH;Sun, HY;Chao, YS;Lyu, PC;Hsieh, HP;Wu, SY |
| 國家衛生研究院 |
2013-04-29 |
A novel Aurora-A inhibitor, BPR1K0609S1, sensitizes colorectal tumor cells to 5-fluorofracil (5-FU) treatment
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Shionome, Y;Lin, WH;Shiao, HY;Hsieh, HP;Hsu, JTA;Ouchi, T |
| 國家衛生研究院 |
2013-04-07 |
3D-QSAR assisted drug design: Identification of a potent quinazoline based Aurora kinase inhibitor
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Ke, YY;Shiao, HY;Hsu, YC;Chang-Chu, Y;Wang, WC;Lee, YC;Lin, WH;Hsu, JTA;Chang, CW;Lin, CW;Yeh, TK;Chao, YS;Coumar, MS;Hsieh, HP |
| 國家衛生研究院 |
2013-04 |
Design and synthesis of Aurora kinase inhibitors as anticancer agents
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Hsu, YC;Shiao, HY;Lin, WH;Hsu, JTA;Chen, CT;Chao, YS;Hsieh, HP |
| 國家衛生研究院 |
2013-02-11 |
作為酪胺酸激酶抑制劑之稠合雙環及多環嘧啶化合物
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Hsieh, HP;Coumar, MS;Chao, YS;Hsu, TA;Lin, WH;Chen, YR |
| 國家衛生研究院 |
2013-02 |
Epstein-Barr virus Zta upregulates matrix metalloproteinases 3 and 9 that synergistically promote cell invasion in vitro
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Lan, YY;Yeh, TH;Lin, WH;Wu, SY;Lai, HC;Chang, FH;Takada, K;Chang, Y |
| 國家衛生研究院 |
2013-01 |
3D-QSAR-assisted drug design: Identification of a potent quinazoline-based aurora kinase inhibitor
|
Ke, YY;Shiao, HY;Hsu, YC;Chu, CY;Wang, WC;Lee, YC;Lin, WH;Chen, CH;Hsu, JTA;Chang, CW;Lin, CW;Yeh, TK;Chao, YS;Coumar, MS;Hsieh, HP |
| 國家衛生研究院 |
2012-11 |
Estimation of expected life-years saved from successful prevention of end-stage renal disease in elderly patients with diabetes: A nationwide study from Taiwan
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Yang, DC;Lee, LJ;Hsu, CC;Chang, YY;Wang, MC;Lin, WH;Chang, CM;Wang, JD |
| 國家衛生研究院 |
2012-11 |
BPR1J271, a novel FLT3 inhibitor for treating acute myeloid leukemia
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Chen, CT;Lin, WH;Chou, LH;Chen, CP;Yen, SC;Huang, YL;Yeh, TK;Hsu, JTA;Jiaang, WI;Chao, YS |
| 國家衛生研究院 |
2012-06-07 |
3-Phenyl-1H-5-pyrazolylamine-based derivatives as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3)
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Hsu, JT;Yeh, TK;Yen, SC;Chen, CT;Hsieh, SY;Hsu, T;Lu, CT;Chen, CH;Chou, LH;Chiu, CH;Chang, YI;Tseng, YJ;Yen, KR;Chao, YS;Lin, WH;Jiaang, WT |
| 國家衛生研究院 |
2012-06 |
Epstein-Barr virus latent membrane protein 2A promotes invasion of nasopharyngeal carcinoma cells through ERK/Fra-1-mediated induction of matrix metalloproteinase 9
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Lan, YY;Hsiao, JR;Chang, KC;Chang, JSM;Chen, CW;Lai, HC;Wu, SY;Yeh, TH;Chang, FH;Lin, WH;Su, IJ;Chang, Y |
| 國家衛生研究院 |
2012-03-25 |
Design, synthesis, and SAR studies of duel FLT-3 and Aurora kinase inhibitors
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Hsieh, HP;Shiao, HY;Lin, WH;Hsu, JTA;Chao, YS |
| 國家衛生研究院 |
2012-01 |
BPR1J-097, a novel FLT3 kinase inhibitor, exerts potent inhibitory activity against AML
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Lin, WH;Jiaang, WT;Chen, CW;Yen, KJ;Hsieh, SY;Yen, SC;Chen, CP;Chang, KY;Chang, CY;Chang, TY;Huang, YL;Yeh, TK;Chao, YS;Chen, CT;Hsu, JT |
| 國家衛生研究院 |
2012-01 |
A High-throughput cell-based screening for L858R/T790M mutant epidermal growth factor receptor inhibitors
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Lin, WH;Song, JS;Lien, TW;Chang, CY;Wu, SH;Huang, YW;Chang, TY;Fang, MY;Yen, KJ;Chen, CH;Chu, CY;Hsieh, HP;Chen, YR;Chao, YS;Hsu, JT |
| 國家衛生研究院 |
2011-09-23 |
BPR1K653, a novel Aurora Kinase Inhibitor, exhibits potent anti-proliferative activity in P-gp170 (MDR1)-mediated VX680-resistant cancer cells in vitro and in vivo
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Hsieh, HP;Cheung, CHA;Lin, WH;Hsu, TA;Coumar, MS;Chao, YS;Chang, JY |
| 國家衛生研究院 |
2011-08 |
BPR1K653, a novel aurora kinase inhibitor, exhibits potent anti-proliferative activity in MDR1 (P-gp170)-mediated multidrug-resistant cancer cells
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Cheung, CH;Lin, WH;Hsu, TA;Hour, TC;Yeh, TK;Ko, S;Lien, TW;Coumar, MS;Liu, JF;Lai, WY;Shiao, HY;Lee, TR;Hsieh, HP;Chang, JY |
| 國家衛生研究院 |
2011-07 |
Discovery and evaluation of 3-phenyl-1H-5-pyrazolylamine-based derivatives as potent, selective and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3)
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Lin, WH;Hsieh, SY;Yen, SC;Chen, CT;Yeh, TK;Hsu, T;Lu, CT;Chen, CP;Chen, CW;Chou, LH;Huang, YL;Cheng, AH;Chang, YI;Tseng, YJ;Yen, KR;Chao, YS;Hsu, JT;Jiaang, WT |
| 國家衛生研究院 |
2011-06-01 |
Suppression of Stat3 activity sensitizes gefitinib-resistant non small cell lung cancer cells
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Chiu, HC;Chou, DL;Huang, CT;Lin, WH;Lien, TW;Yen, KJ;Hsu, JT |
| 國家衛生研究院 |
2011-05 |
Pharmacokinetic study with novel anticanacer agents, MPTOB124 and MPTOB214
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Hu, OYP;Lin, WH;Li, SC;Huang, PW;Chang, JY |
| 國家衛生研究院 |
2011-04-25 |
Diosgenin, a plant-derived sapogenin, exhibits antiviral activity in vitro against hepatitis C virus
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Wang, YJ;Pan, KL;Hsieh, TC;Chang, TY;Lin, WH;Hsu, JT |
| 國家衛生研究院 |
2010-10-28 |
Design and synthesis of tetrahydropyridothieno[2,3-d]pyrimidine scaffold based epidermal growth factor receptor (EGFR) kinase inhibitors: the role of side chain chirality and michael acceptor group for maximal potency
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Wu, CH;Coumar, MS;Chu, CY;Lin, WH;Chen, YR;Chen, CT;Shiao, HY;Rafi, S;Wang, SY;Hsu, H;Chen, CH;Chang, CY;Chang, TY;Lien, TW;Fang, MY;Yeh, KC;Chen, CP;Yeh, TK;Hsieh, SH;Hsu, JT;Liao, CC;Chao, YS;Hsieh, HP |
| 國家衛生研究院 |
2010-10 |
Structural basis for the improved potency of peroxisome proliferator-activated receptor (PPAR) agonists
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Peng, YH;Coumar, MS;Leou, JS;Wu, JS;Shiao, HY;Lin, CH;Lin, WH;Lien, TW;Chen, X;Hsu, JT;Chao, YS;Huang, CF;Lyu, PC;Hsieh, HP;Wu, SY |
| 國家衛生研究院 |
2010-08 |
SLC2A10 genetic polymorphism predicts development of peripheral arterial disease in patients with type 2 diabetes. SLC2A10 and PAD in type 2 diabetes
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Jiang, YD;Chang, YC;Chiu, YF;Chang, TJ;Li, HY;Lin, WH;Yuan, HY;Chen, YT;Chuang, LM |
| 國家衛生研究院 |
2010-08 |
Lead optimization of furanopyrimidine Aurora kinase inhibitors: Development of in vivo active agents in tumor xenograft models
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Hsieh, HP;Chu, CY;Coumar, MS;Lin, WH;Chen, CT;Hsu, TA;Wu, SY;Chao, YS |
Showing items 31-80 of 108 (3 Page(s) Totally)
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