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Institution Date Title Author
國家衛生研究院 2025-07-14 Contribution of prostaglandin E2-induced neuronal excitation to drug resistance in glioblastoma countered by a novel blood-brain barrier crossing celecoxib derivative Shen, CJ;Chen, HC;Lin, CL;Thakur, A;Onuku, R;Chen, IC;Li, HY;Chang, KY;Chuang, JY;Yang, WB;Lin, HY;Shen, YR;Liou, JP;Chang, WC;Hsu, TI
國家衛生研究院 2025-02 Development of BACE2-IN-1/tranylcypromine-based compounds to induce steroidogenesis-dependent neuroprotection Banerjee, S;Hsu, YT;Nguyen, DH;Yeh, SH;Liou, KC;Liu, JJ;Liou, JP;Chuang, JY
國家衛生研究院 2025-01-21 Repurposing linezolid in conjunction with histone deacetylase inhibitor access in the realm of glioblastoma therapies Chen, IC;Lin, HY;Liu, ZY;Cheng, WJ;Yeh, TY;Yang, WB;Tran, HY;Lai, MJ;Wang, CH;Kao, TY;Hung, CY;Huang, YL;Liou, KC;Hsieh, CM;Hsu, T;Liou, JP
國家衛生研究院 2024-04-01 Dual inhibition of CYP17A1 and HDAC6 by abiraterone-installed hydroxamic acid overcomes temozolomide resistance in glioblastoma through inducing DNA damage and oxidative stress Sharma, R;Chiang, YH;Chen, HC;Lin, HY;Yang, WB;Nepali, K;Lai, MJ;Chen, KY;Liou, JP;Hsu, TI
國家衛生研究院 2024-01-29 First-in-class dual EZH2-HSP90 inhibitor eliciting striking antiglioblastoma activity in vitro and in vivo Sharma, S;Wang, SA;Yang, WB;Lin, HY;Lai, MJ;Chen, HC;Kao, TY;Hsu, FL;Nepali, K;Hsu, TI;Liou, JP
國家衛生研究院 2023-08 Design, synthesis, and biological activity of dual monoamine oxidase A and heat shock protein 90 inhibitors, N-Methylpropargylamine-conjugated 4-isopropylresorcinol for glioblastoma Tseng, HJ;Banerjee, S;Qian, B;Lai, MJ;Wu, TY;Hsu, TI;Lin, TE;Hsu, KC;Chuang, KH;Liou, JP;Shih, JC
國家衛生研究院 2023-07-22 The complex role of eicosanoids in the brain: Implications for brain tumor development and therapeutic opportunities Chen, HC;Chang, WC;Chuang, JY;Chang, KY;Liou, JP;Hsu, TI
國家衛生研究院 2022-12-05 2,6-Difluorobenzamide derivatives as store-operated calcium channel (SOC) inhibitors Wang, YS;Yeh, TK;Chang, WC;Liou, JP;Liu, YM;Huang, WC
國家衛生研究院 2022-02-02 HDAC6 involves in regulating the lncRNA-microRNA-mRNA network to promote the proliferation of glioblastoma cells Wu, AC;Yang, WB;Chang, KY;Lee, JS;Liou, JP;Su, RY;Cheng, SM;Hwang, DY;Kikkawa, U;Hsu, TI;Wang, CY;Chang, WC;Chen, PY;Chuang, JY
國家衛生研究院 2021-09-28 Histone deacetylase 6 acts upstream of DNA damage response activation to support the survival of glioblastoma cells Yang, WB;Wu, AC;Hsu, TI;Liou, JP;Lo, WL;Chang, KY;Chen, PY;Kikkawa, U;Yang, ST;Kao, TJ;Chen, RM;Chang, WC;Ko, CY;Chuang, JY
國家衛生研究院 2021-09 Suppression of extracellular vesicle VEGF-C-mediated lymphangiogenesis and pancreatic cancer early dissemination by a selective HDAC1/2 inhibitor Wang, CA;Li, CF;Huang, RC;Li, YH;Liou, JP;Tsai, SJ
國家衛生研究院 2020-04-24 Increased activation of HDAC1/2/6 and Sp1 underlies therapeutic resistance and tumor growth in glioblastoma Yang, WB;Hsu, CC;Hsu, TI;Liou, JP;Chang, KY;Chen, PY;Liu, JJ;Yang, ST;Wang, JY;Yeh, SH;Chen, RM;Chang, WC;Chuang, JY
國家衛生研究院 2020-02-01 Protective effects of 10,11-dihydro-5H-dibenzo[b,f]azepine hydroxamates on vascular cognitive impairment Kaur, N;Fang, YC;Lee, HY;Singh, A;Nepali, K;Lin, MH;Yeh, TK;Lai, MJ;Chan, L;Tu, YK;Banerjee, S;Hu, CJ;Liou, JP
國家衛生研究院 2019-02-21 Synthesis and evaluation of novel 7H-pyrrolo-[2,3-d]pyrimidine derivatives as potential anticancer agents Liu, YM;Chen, CH;Yeh, TK;Liou, JP
國家衛生研究院 2019-01-15 1-Arylsulfonyl indoline-benzamides as a new antitubulin agents, with inhibition of histone deacetylase Lai, MJ;Ojha, R;Lin, MH;Liu, YM;Lee, HY;Lin, TE;Hsu, KC;Chang, CY;Chen, MC;Nepali, K;Chang, JY;Liou, JP
國家衛生研究院 2018-08-23 5-aroylindoles act as selective histone deacetylase 6 inhibitors ameliorating alzheimer's disease phenotypes Lee, HY;Fan, SJ;Huang, FI;Chao, HY;Hsu, KC;Lin, TE;Yeh, TK;Lai, MJ;Li, YH;Huang, HL;Yang, CR;Liou, JP
國家衛生研究院 2018-08-04 Upregulation of Znf179 acetylation by SAHA protects cells against oxidative stress Wu, CC;Lee, PT;Kao, TJ;Chou, SY;Su, RY;Lee, YC;Yeh, SH;Liou, JP;Hsu, TI;Su, TP;Chuang, CK;Chang, WC;Chuang, JY
國家衛生研究院 2018-06-15 2-Aroylquinoline-5,8-diones as potent anticancer agents displaying tubulin and heat shock protein 90 (HSP90) inhibition [Erratum: Organic and Biomolecular Chemistry. 2016 Jan;14(2):716-723.] Nepali, K;Kumar, S;Huang, HL;Kuo, FC;Lee, CH;Kuo, CC;Yeh, TK;Li, YH;Chang, JY;Liou, JP;Lee, HY
國家衛生研究院 2018-03-28 Novel microtubule inhibitor MPT0B098 inhibits hypoxia-induced epithelial-to-mesenchymal transition in head and neck squamous cell carcinoma Tsai, IT;Kuo, CC;Liou, JP;Chang, JY
國家衛生研究院 2017-08-12 Specificity protein 1-modulated superoxide dismutase 2 enhances temozolomide resistance in glioblastoma, which is independent of O6-methylguanine-DNA methyltransferase Chang, KY;Hsu, TI;Hsu, CC;Tsai, SY;Liu, JJ;Chou, SW;Liu, MS;Liou, JP;Ko, CY;Chen, KY;Hung, JJ;Chang, WC;Chuang, CK;Kao, TJ;Chuang, JY
國家衛生研究院 2017-08 Hypoxia-induced downregulation of DUSP-2 phosphatase drives colon cancer stemness Hou, PC;Li, YH;Lin, SC;Lin, SC;Lee, JC;Lin, BW;Liou, JP;Chang, JY;Kuo, CC;Liu, YM;Sun, HS;Tsai, SJ
國家衛生研究院 2016-11-18 Suberoylanilide hydroxamic acid represses glioma stem-like cells Hsu, CC;Chang, WC;Hsu, TI;Liu, JJ;Yeh, SH;Wang, JY;Liou, JP;Ko, CY;Chang, KY;Chuang, JY
國家衛生研究院 2016-07-01 MPT0B098, a microtubule inhibitor, suppresses JAK2/STAT3 signaling pathway through modulation of SOCS3 stability in oral squamous cell carcinoma Peng, HY;Cheng, YC;Hsu, YM;Wu, GH;Kuo, CC;Liou, JP;Chang, JY;Jin, SC;Shiah, SG
國家衛生研究院 2016-01 2-Aroylquinoline-5,8-diones as potent anticancer agents displaying tubulin and heat shock protein 90 (HSP90) inhibition Nepali, K;Kumar, S;Huang, HL;Kuo, FC;Lee, CH;Kuo, CC;Yeh, TK;Li, YH;Chang, JY;Liou, JP;Lee, HY
國家衛生研究院 2015-08 Antimitotic and antivascular activity of heteroaroyl-2-hydroxy-3,4,5-trimethoxybenzenes Lee, HY;Chang, CY;Lai, MJ;Chuang, HY;Kuo, CC;Chang, CY;Chang, JY;Liou, JP
國家衛生研究院 2015-01 1-Arylsulfonyl-5-(N-hydroxyacrylamide)tetrahydroquinolines as potent histone deacetylase inhibitors suppressing the growth of prostate cancer cells Liu, YM;Lee, HY;Chen, CH;Lee, CH;Wang, LT;Pan, SL;Lai, MJ;Yeh, TK;Liou, JP
臺北醫學大學 2015 MT-4 Suppresses Resistant Ovarian Cancer Growth through Targeting Tubulin and HSP27 Pai, HC;Kumar, S;Shen, CC;Liou, JP;Pan, SL;Teng, CM
臺北醫學大學 2015 Novel oral histone deacetylase inhibitor, MPT0E028, displays potent growth-inhibitory activity against human B-cell lymphoma in vitro and in vivo Huang, HL;Peng, CY;Lai, MJ;Chen, CH;Lee, HY;Wang, JC;Liou, JP;Pan, SL;Teng, CM.
臺北醫學大學 2015 1-Arylsulfonyl-5-(N-hydroxyacrylamide)tetrahydroquinolines as potent histone deacetylase inhibitors suppressing the growth of prostate cancer cells Liu, YM;Lee, HY;Chen, CH;Lee, CH;Wang, LT;Pan, SL;Lai, MJ;Yeh, TK;Liou, JP.
中國醫藥大學 2014-12 Novel oral histone deacetylase inhibitor, MPT0E028, displays potent growth-inhibitory activity against human B-cell lymphoma in vitro and in vivo. (Huang HL);彭婕妤(Chieh-Yu Peng);(Lai MJ);(Chen CH);(Lee HY);(Wang JC);(Liou JP)*;(Pan SL)*;(Teng CM)*
國家衛生研究院 2014-09 Concise syntheses of 7-anilino-indoline-N-benzenesulfonamides as antimitotic and vascular disrupting agents Mehndiratta, S;Chiang, YF;Lai, MJ;Lee, HY;Chen, MC;Kuo, CC;Chang, CY;Chang, JY;Liou, JP
國家衛生研究院 2014-05 Azaindolylsulfonamides, with a more selective inhibitory effect on histone deacetylase 6 activity, exhibit antitumor activity in colorectal cancer HCT116 cells Lee, HY;Tsai, AC;Chen, MC;Shen, PJ;Cheng, YC;Kuo, CC;Pan, SL;Liu, YM;Liu, JF;Yeh, TK;Wang, JC;Chang, CY;Chang, JY;Liou, JP
國家衛生研究院 2014-04 Antimitotic and vascular disrupting agents: 2-hydroxy-3,4,5-trimethoxybenzophenones Chang, CY;Chuang, HY;Lee, HY;Yeh, TK;Kuo, CC;Chang, CY;Chang, JY;Liou, JP
國家衛生研究院 2014-04 Orally active microtubule-targeting agent, MPT0B271, for the treatment of human non-small cell lung cancer, alone and in combination with erlotinib Tsai, AC;Wang, CY;Liou, JP;Pai, HC;Hsiao, CJ;Chang, JY;Wang, JC;Teng, CM;Pan, SL
臺北醫學大學 2014 Azaindolylsulfonamides, with a More Selective Inhibitory Effect on Histone Deacetylase 6 Activity, Exhibit Antitumor Activity in Colorectal Cancer HCT116 Cells Lee, HY;Tsai, AC;Chen, MC;Shen, PJ;Cheng, YC;Kuo, CC;Pan, SL;Liu, YM;Liu, JF;Yeh, TK;Wang, JC;Chang, CY;Chang, JY;Liou, JP.
臺北醫學大學 2014 Androgen attenuates cardiac fibroblasts activations through modulations of transforming growth factor-β and angiotensin II signaling Chung, CC;Hsu, RC;YH*, Kao;Liou, JP;Lu, YY;YJ*, Chen
臺北醫學大學 2014 A novel class I HDAC inhibitor, MPT0G030, induces cell apoptosis and differentiation in human colorectal cancer cells via HDAC1/PKCδ and E-cadherin Wang, LT;Liou, JP;Li, YH;Liu, YM;Pan, SL;Teng, CM
臺北醫學大學 2014 Antimitotic and vascular disrupting agents: 2-hydroxy-3,4,5-trimethoxybenzophenones Chang, CY;Chuang, HY;Lee, HY;Yeh, TK;Kuo, CC;Chang, CY;Chang, JY;Liou, JP
臺北醫學大學 2014 Indolyl or Indolinyl hydroxamate compounds Chen, CS;Liou, JP;Liu, HJ;Hung, KS;Shan, PW;Chiu, WT;Teng, CM
臺北醫學大學 2014 Curcumin Suppress Cardiac Fibroblasts Activitiesby Regulating Proliferation, Migration, and the Extracellular Matrix Chung, CC;Kao, YH;Liou, JP;Chen, YJ
臺北醫學大學 2014 Denbinobin upregulates miR-146a expression and attenuates IL-1β-induced upregulation of ICAM-1 and VCAM-1 expressions in osteoarthritis fibroblast-like synoviocytes Yang, CR;Shih, KS;Liou, JP;Wu, YW;Hsieh, IN;Lee, HY;Lin, TC;Wang, JH
臺北醫學大學 2014 In vitro and in vivo anti-tumour effects of MPT0B014, a novel derivative aroylquinoline, and in combination with erlotinib in human non-small-cell lung cancer cells Tsai, AC;Pai, HC;Wang, CY;Liou, JP;Teng, CM;Wang, JC;Pan, SL
臺北醫學大學 2014 Indole-3-ethylsulfamoylphenylacrylamides: Potent histone deacetylase inhibitors with anti-inflammatory activity Mehndiratta, S;Hsieh, YL;Liu, YM;Wang, AW;Lee, HY;Liang, LY;Kumar, S;Teng, CM;CR*, Yang;Liou, JP*.
臺北醫學大學 2014 Intermediary Metabolite Precursor Dimethyl-2-Ketoglutarate Stabilizes Hypoxia-Inducible Factor-1α by Inhibiting Prolyl-4-Hydroxylase PHD2 Hou, P;Kuo, CY;Cheng, CT;Liou, JP;Ann, DK;Chen, Q
臺北醫學大學 2014 K20E, an oxidative-coupling compound of methyl caffeate, exhibits anti-angiogenic activities through down-regulations of VEGF and VEGF receptor-2 Lee, HY;Wang, LT;Li, YH;Pan, SL;Chen, YL;Teng, CM;Liou, JP
臺北醫學大學 2014 Orally active microtubule-targeting agent, MPT0B271, for the treatment of human non-small cell lung cancer, alone and in combination with erlotinib Tsai, AC;Wang, CY;Liou, JP;Pai, HC;Hsiao, CJ;Chang, JY;Wang, JC;Teng, CM;Pan, SL.
臺北醫學大學 2014 Preclinical anti-arthritic study and pharmacokinetic properties of a potent histone deacetylase inhibitor MPT0G009 Hsieh, IN;Liou, JP;Lee, HY;Lai, MJ;Li, YH;Yang, CR
臺北醫學大學 2014 Tubulin inhibitors: a patent review Liu, YM;Chen, HL;Lee, HY;Liou, JP
臺北醫學大學 2014 A novel action mechanism for MPT0G013, a derivative of arylsulfonamide, inhibits tumor angiogenesis through up-regulaiton of TIMP3 expression Wang, CY;Liou, JP;Tsai, AC;Lai, MJ;Liu, YM;Lee, HY;Wang, JC;SL*, Pan;CM*, Teng
臺北醫學大學 2014 In vitro and in vivo antitumor effects of MPT0B014, a novel derivative aroylquinoline, and in combination with erlotinib in human non-small-cell lung cancer cells Tsai, AC;Pai, HC;Wang, CY;Liou, JP;Teng, CM;Wang, JC;Pan, SL

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