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Showing items 1-50 of 169 (4 Page(s) Totally)
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| 國家衛生研究院 |
2025-11 |
In vitro and in vivo efficacy of vancomycin against Elizabethkingia species and the impact of increased vancomycin MICs
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Huang, TW;Yeh, TK;Hsu, SY;Tan, MC;Huang, WC;Kuo, SC |
| 國家衛生研究院 |
2025-05-20 |
Structure-based design of potent and selective merTK inhibitors by modulating the conformation of alphaC helix
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Peng, YH;Li, MC;Yen, WC;Yeh, TK;Hsueh, CC;Kuo, FM;Lai, YL;Chang, L;Lee, LC;Chen, PY;Yen, KJ;Chang, TY;Sun, HY;Chang, CY;Hsieh, SH;Yang, CM;Hsieh, HP;Wu, SY |
| 國家衛生研究院 |
2025-05 |
Identification of PTGR2 inhibitors as a new therapeutic strategy for diabetes and obesity
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Chang, YC;Hsieh, ML;Lee, HL;Hee, SW;Chang, CF;Yen, HY;Chen, YA;Chen, YR;Chou, YW;Li, FA;Ke, YY;Chen, SY;Hung, MS;Hung, AF;Huang, JY;Chiu, CH;Lin, SY;Shih, SF;Hsu, CN;Hwang, JJ;Yeh, TK;Cheng, TR;Liao, KC;Laio, D;Lin, SW;Chen, TY;Hu, CM;Vogel, U;Saar, D;Kragelund, BB;Tsou, LK;Tseng, YH;Chuang, LM |
| 國家衛生研究院 |
2025-04-14 |
Osteomyelitis caused by moesziomyces aphidis in an immunocompetent adult: A case report and literature review
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Chen, YY;Yeh, TK;Wu, CJ;Liu, PY |
| 國家衛生研究院 |
2025-04-03 |
Identification of PTGR2 inhibitors as a new therapeutic strategy for diabetes and obesity[Erratum:EMBO Molecular Medicine. 2025 Mar 21;Article in Press.]
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Chang, YC;Hsieh, ML;Lee, HL;Hee, SW;Chang, CF;Yen, HY;Chen, YA;Chen, YR;Chou, YW;Li, FA;Ke, YY;Chen, SY;Hung, MS;Hung, AF;Huang, JY;Chiu, CH;Lin, SY;Shih, SF;Hsu, CN;Hwang, JJ;Yeh, TK;Cheng, TR;Liao, KC;Laio, D;Lin, SW;Chen, TY;Hu, CM;Vogel, U;Saar, D;Kragelund, BB;Tsou, LK;Tseng, YH;Chuang, LM |
| 國家衛生研究院 |
2025-03-10 |
CXCR4 antagonist-loaded nanoparticles reprogram the tumor microenvironment and enhance immunotherapy in hepatocellular carcinoma
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Cheng, SL;Wu, CH;Tsai, YJ;Song, JS;Chen, HM;Yeh, TK;Shen, CT;Chiang, JC;Lee, HM;Huang, KW;Chen, Y;Qiu, JT;Yen, YT;Shia, KS;Chen, Y |
| 國家衛生研究院 |
2025-02-27 |
Orally bioavailable and site-selective covalent STING inhibitor derived from a macrocyclic marine diterpenoid
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Niu, GH;Hsiao, WC;Lee, PH;Zheng, LG;Yang, YS;Huang, WC;Hsieh, CC;Chiu, TY;Wang, JY;Chen, CP;Huang, CL;You, MS;Kuo, YP;Wang, CM;Wen, ZH;Yu, GY;Chen, CT;Chi, YH;Tung, CW;Hsu, SC;Yeh, TK;Sung, PJ;Zhang, MZM;Tsou, LK |
| 國家衛生研究院 |
2024-11-26 |
Development of potent and selective inhibitors of methylenetetrahydrofolate dehydrogenase 2 for targeting acute myeloid leukemia: Sar, structural insights, and biological characterization
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Chang, HH;Lee, LC;Hsu, T;Peng, YH;Huang, CH;Yeh, TK;Lu, CT;Huang, ZT;Hsueh, CC;Kung, FC;Lin, LM;Huang, YC;Wang, YH;Li, LH;Tang, YC;Chang, L;Hsieh, CC;Jiaang, WT;Kuo, CC;Wu, SY |
| 國家衛生研究院 |
2024-11 |
DBPR116, a prodrug of BPRMU191, in combination with naltrexone as a safer opioid analgesic than morphine via peripheral administration
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Lin, SY;Chang, YC;Tien, YW;Kuo, YH;Chang, HF;Ou, LC;Chen, YP;Chang, KH;Hsu, YT;Huang, YC;Yang, CM;Law, PY;Xi, JH;Tao, PL;Loh, HH;Yeh, TK;Zhuang, H;Hsieh, HP;Shih, C;Chen, CT;Yeh, SH;Ueng, SH |
| 國家衛生研究院 |
2024-07-17 |
Discovery of a mu-opioid receptor modulator that in combination with morphinan antagonists induces analgesia
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Huang, YH;Lin, SY;Ou, LC;Huang, WC;Chao, PK;Chang, YC;Chang, HF;Lee, PT;Yeh, TK;Kuo, YH;Tien, YW;Xi, JH;Tao, PL;Chen, PY;Chuang, JY;Shih, C;Chen, CT;Tung, CW;Loh, HH;Ueng, SH;Yeh, SH |
| 國家衛生研究院 |
2024-07-04 |
Development of a humanized antibody targeting extracellular HSP90alpha to suppress endothelial-mesenchymal transition-enhanced tumor growth of pancreatic adenocarcinoma cells
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Fan, CS;Hung, HC;Chen, CC;Chen, LL;Ke, YY;Yeh, TK;Huang, CT;Chang, TY;Yen, KJ;Chen, CH;Chua, KV;Hsu, JTA;Huang, TS |
| 國家衛生研究院 |
2024-06-24 |
Tracing the footprints of MPXV in Asia: Phylogenetic insights and lineage dynamics
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Chen, YC;Liao, YC;Mao, YC;Yeh, TK;Liu, PY |
| 國家衛生研究院 |
2024-06-24 |
Discovery of dual MER/AXL kinase inhibitors as bifunctional small molecules for inhibiting tumor growth and enhancing tumor immune microenvironment
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Li, MC;Lai, YL;Kuo, PH;Reddy, JS;Chen, CM;Manimala, J;Wang, PC;Wu, MS;Chang, CY;Yang, CM;Lin, CY;Huang, YC;Chiu, CH;Chang, L;Lin, WH;Yeh, TK;Yen, WC;Hsieh, HP |
| 國家衛生研究院 |
2024-04-09 |
Discovery of a long half-life AURKA inhibitor to treat MYC-amplified solid tumors as a monotherapy and in combination with everolimus
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Chang, CP;Yeh, TK;Chen, CT;Wang, WP;Chen, YT;Tsai, CH;Chen, YF;Ke, YY;Wang, JY;Chen, CP;Hsieh, TC;Wu, MH;Huang, CL;Chen, YP;Zhuang, H;Chi, YH |
| 國家衛生研究院 |
2023-11-28 |
CDGSH iron sulfur domain 2 activators and use thereof
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Tsai, TF;Lee, JC;Yeh, TK |
| 國家衛生研究院 |
2023-10-05 |
Discovery of tetrasubstituted thiophenes as Cisd2 activators: A potential novel therapeutic option in nonalcoholic fatty liver disease
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Yao, CH;Shen, ZQ;Rajan, YC;Huang, YW;Lin, CY;Song, JS;Shiao, HY;Ke, YY;Fan, YS;Tsai, CH;Yeh, TK;Tsai, TF;Lee, JC |
| 國家衛生研究院 |
2023-10-05 |
A dual nociceptin and mu opioid receptor agonist exhibited robust antinociceptive effect with decreased side effects
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Hsu, YT;Chen, SR;Chang, YC;Chang, HF;Yeh, TK;Chuang, JY;Loh, HH;Hsieh, HP;Ueng, SH;Yeh, SH |
| 國家衛生研究院 |
2023-10 |
Discovery of novel AXL and MER inhibitors as potential anticancer and immune modulator drugs
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Hsieh, HP;Li, MC;Yen, WC;Hsu, JTA;Yeh, TK;Li, WS;Wu, HC |
| 國家衛生研究院 |
2023-02-07 |
Development of furanopyrimidine-based orally active third- generation EGFR inhibitors for the treatment of non-small cell lung cancer
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Li, MC;Coumar, MS;Lin, SY;Lin, YS;Huang, GL;Chen, CH;Lien, TW;Wu, YW;Chen, YT;Chen, CP;Huang, YC;Yeh, KC;Yang, CM;Kalita, B;Pan, SL;Hsu, TA;Yeh, TK;Chen, CT;Hsieh, HP |
| 國家衛生研究院 |
2022-12-05 |
Benzo[b]thiophene-2-carboxamides as novel opioid receptor agonists with potent analgesic effect and reduced constipation
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Kuppusamy, R;Hsu, YT;Ke, YY;Chang, PW;Chang, YC;Chang, HF;Wang, PC;Lin, YH;Huang, YC;Yeh, TK;Chuang, JY;Loh, HH;Shih, C;Chen, CT;Yeh, SH;Ueng, SH |
| 國家衛生研究院 |
2022-12-05 |
2,6-Difluorobenzamide derivatives as store-operated calcium channel (SOC) inhibitors
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Wang, YS;Yeh, TK;Chang, WC;Liou, JP;Liu, YM;Huang, WC |
| 國家衛生研究院 |
2022-10-03 |
Protective effect of CXCR4 antagonist DBPR807 against ischemia-reperfusion injury in a rat and porcine model of myocardial infarction: Potential adjunctive therapy for percutaneous coronary intervention
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Yeh, KC;Lee, CJ;Song, JS;Wu, CH;Yeh, TK;Wu, SH;Hsieh, TC;Chen, YT;Tseng, HY;Huang, CL;Chen, CT;Jan, JJ;Chou, MC;Shia, KS;Chiang, KH |
| 國家衛生研究院 |
2022-09-26 |
Targeting the phosphatidylserine-immune checkpoint with a small-molecule maytansinoid conjugate
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Lo, CF;Chiu, TY;Liu, YT;Pan, PY;Liu, KL;Hsu, CY;Fang, MY;Huang, YC;Yeh, TK;Hsu, TA;Chen, CT;Huang, LR;Tsou, LK |
| 國家衛生研究院 |
2022-07-24 |
Hesperetin promotes longevity and delays aging via activation of Cisd2 in naturally aged mice
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Yeh, CH;Shen, ZQ;Wang, TW;Kao, CH;Teng, YC;Yeh, TK;Lu, CK;Tsai, TF |
| 國家衛生研究院 |
2022-07 |
Rejuvenating hepatic tumor microenvironment immunity with a phosphatidylserine-targeting small molecule drug conjugate
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Huang, KH;Liu, YT;Pan, PY;Lo, CF;Liu, KL;Yeh, TK;Huang, LR;Tsou, LK |
| 國家衛生研究院 |
2022-06-21 |
Synthesis and evaluation of small molecule drug conjugates harnessing thioester-linked maytansinoids
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Lo, CF;Chiu, TY;Liu, YT;Huang, LR;Yeh, TK;Huang, KH;Liu, KL;Hsu, CY;Fang, MY;Huang, YC;Hsu, TA;Chen, CT;Tsou, LK |
| 國家衛生研究院 |
2022-02-15 |
Click chemistry and multicomponent reaction for linker diversification of zinc dipicolylamine-based drug conjugates
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Tsai, CH;Chiu, TY;Chen, CT;Hsu, CY;Tsai, YR;Yeh, TK;Huang, KH;Tsou, LK |
| 國家衛生研究院 |
2022-02-07 |
Development of furanopyrimidine-based orally active third-generation EGFR inhibitors for the treatment of non-small cell lung cancer
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Li, MC;Coumar, MS;Lin, SY;Lin, YS;Huang, GL;Chen, CH;Lien, TW;Wu, YW;Chen, YT;Chen, CP;Huang, YC;Yeh, KC;Yang, CM;Kalita, B;Pan, SL;Hsu, TA;Yeh, TK;Chen, CT;Hsieh, HP |
| 國家衛生研究院 |
2022-02-05 |
Discovery and development of a novel N-(3-bromophenyl)-{[(phenylcarbamoyl)amino]methyl}-N-hydroxythiophene-2-carboximidamide indoleamine 2,3-dioxygenase inhibitor using knowledge-based drug design
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Yeh, TK;Song, JS;Chang, PW;Yu, JC;Chang, CH;Liao, FY;Tien, YW;Kuppusamy, R;Li, AS;Chen, CH;Chen, CW;Lin, LM;Chang, HH;Huang, CH;Yao, JY;Wu, MH;Peng, YH;Hsueh, CC;Hsiao, WC;Chen, PH;Lin, CY;Hsieh, SH;Shih, C;Hung, MS;Wu, SY;Kuo, CC;Ueng, SH |
| 國家衛生研究院 |
2021-10-04 |
Discovery of BPR1R024, an orally active and selective CSF1R inhibitor that exhibits antitumor and immunomodulatory activity in a murine colon tumor model
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Lee, KH;Yen, WC;Lin, WH;Wang, PC;Lai, YL;Su, YC;Chang, CY;Wu, CS;Huang, YC;Yang, CM;Chou, LH;Yeh, TK;Chen, CT;Shih, C;Hsieh, HP |
| 國家衛生研究院 |
2021-08-01 |
DBPR108, a novel dipeptidyl peptidase-4 inhibitor with antihyperglycemic activity
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Yeh, KC;Yeh, TK;Huang, CY;Hu, CB;Wang, MH;Huang, YW;Chou, LH;Ho, HH;Song, JS;Hsu, T;Jiaang, WT;Chao, YS;Chen, CT |
| 國家衛生研究院 |
2021-06-29 |
Design and synthesis of novel orally selective and type II pan-TRK inhibitors to overcome mutations by property-driven optimization
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Li, MC;Lin, WH;Wang, PC;Su, YC;Chen, PY;Fan, CM;Chen, CP;Huang, CL;Chiu, CH;Chang, L;Chen, CT;Yeh, TK;Hsieh, HP |
| 國家衛生研究院 |
2021-05-19 |
Discovery and synthesis of a pyrimidine-based aurora kinase inhibitor to reduce levels of MYC oncoproteins
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Chi, YH;Yeh, TK;Ke, YY;Lin, WH;Tsai, CH;Wang, WP;Chen, YT;Su, YC;Wang, PC;Chen, YF;Wu, ZW;Yeh, JY;Hung, MC;Wu, MH;Wang, JY;Chen, CP;Song, JS;Shih, C;Chen, CT;Chang, CP |
| 國家衛生研究院 |
2021-03-30 |
A highly selective and potent CXCR4 antagonist for hepatocellular carcinoma treatment
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Song, JS;Chang, CC;Wu, CH;Dinh, TK;Jan, JJ;Huang, KW;Chou, MC;Shiue, TY;Yeh, KC;Ke, YY;Yeh, TK;Ta, YNN;Lee, CJ;Huang, JK;Sung, YC;Shia, KS;Chen, Y |
| 國家衛生研究院 |
2021-03-02 |
Discovery of potential neuroprotective agents against paclitaxel-induced peripheral neuropathy
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Chen, YF;Wu, CH;Chen, LH;Lee, HW;Lee, JC;Yeh, TK;Chang, JY;Chou, MC;Wu, HL;Lai, YP;Song, JS;Yeh, KC;Chen, CT;Lee, CJ;Shia, KS;Shen, MR |
| 國家衛生研究院 |
2021-01 |
BPRDP056, a novel small molecule drug conjugate specifically targeting phosphatidylserine for cancer therapy
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Chen, YY;Lo, CF;Chiu, TY;Hsu, CY;Yeh, TK;Chen, CP;Huang, CL;Huang, CY;Wang, MH;Huang, YC;Ho, HH;Chao, YS;Shih, JC;Tsou, LK;Chen, CT |
| 國家衛生研究院 |
2020-10-16 |
Potent and orally active purine-based fetal hemoglobin inducers for treating Beta-thalassemia and sickle cell disease
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Lai, ZS;Yeh, TK;Chou, YC;Hsu, T;Lu, CT;Kung, FC;Hsieh, MY;Lin, CH;Chen, CT;James Shen, CK;Jiaang, WT |
| 國家衛生研究院 |
2020-08 |
BPR6K609: An Aurora kinase inhibitor targeting small cell lung cancer with MYC amplification
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Chi, YH;Chang, CP;Ke, YY;Lin, WH;Wang, WP;Tsai, CH;Chen, YT;Su, YJ;Hung, MC;Wu, ZW;Wu, MH;Yeh, TK;Chen, CP;Song, JS;Chen, CT;Shih, C |
| 國家衛生研究院 |
2020-07-07 |
Overcoming vincristine resistance in cancer: Computational design and discovery of piperine-inspired P-glycoprotein inhibitors
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Syed, SB;Lin, SY;Arya, H;Fu, IH;Yeh, TK;Charles, MRC;Periyasamy, L;Hsieh, HP;Coumar, MS |
| 國家衛生研究院 |
2020-05-23 |
Repurposing old drugs as antiviral agents for coronaviruses
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Yang, CW;Peng, TT;Hsu, HY;Lee, YZ;Wu, SH;Lin, WH;Ke, YY;Hsu, TA;Yeh, TK;Huang, WZ;Lin, JH;Sytwu, HK;Chen, CT;Lee, SJ |
| 國家衛生研究院 |
2020-05-15 |
Artificial intelligence approach fighting COVID-19 with repurposing drugs
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Ke, YY;Peng, TT;Yeh, TK;Huang, WZ;Chang, SE;Wu, SH;Hung, HC;Hsu, TA;Lee, SJ;Song, JS;Lin, WH;Chiang, TJ;Lin, JH;Sytwu, HK;Chen, CT |
| 國家衛生研究院 |
2020-05 |
Drug-like property optimization: Discovery of orally bioavailable quinazoline-based multi-targeted kinase inhibitors
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Lin, SY;Chang, CF;Coumar, MS;Chen, PY;Kuo, FM;Chen, CH;Li, MC;Lin, WH;Kuo, PC;Wang, SY;Li, AS;Lin, CY;Yang, CM;Yeh, TK;Song, JS;Hsu, JTA;Hsieh, HP |
| 國家衛生研究院 |
2020-02-18 |
Impacts of intralipid on nanodrug abraxane therapy and on the innate immune system
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Chen, YJ;Tsai, CY;Cheng, YM;Nieh, SW;Yeh, TK;Chen, CP;Wang, MH;Chou, LH;Chiu, TY;Liu, L;Ho, C;Chen, CT;Liu, TW |
| 國家衛生研究院 |
2020-02-10 |
Unique sulfur-aromatic interactions contribute to the binding of potent imidazothiazole indoleamine 2,3-Dioxygenase inhibitors
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Peng, YH;Liao, FY;Tseng, CT;Kuppusamy, R;Li, AS;Chen, CH;Fan, YS;Wang, SY;Wu, MH;Hsueh, CC;Chang, JY;Lee, LC;Shih, C;Shia, KS;Yeh, TK;Hung, MS;Kuo, CC;Song, JS;Wu, SY;Ueng, SH |
| 國家衛生研究院 |
2020-02-01 |
Protective effects of 10,11-dihydro-5H-dibenzo[b,f]azepine hydroxamates on vascular cognitive impairment
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Kaur, N;Fang, YC;Lee, HY;Singh, A;Nepali, K;Lin, MH;Yeh, TK;Lai, MJ;Chan, L;Tu, YK;Banerjee, S;Hu, CJ;Liou, JP |
| 國家衛生研究院 |
2019-12 |
Identification of a multitargeted tyrosine kinase inhibitor for the treatment of gastrointestinal stromal tumors and acute myeloid leukemia
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Lin, WH;Wu, SY;Yeh, TK;Chen, CT;Song, JS;Shiao, HY;Kuo, CC;Hsu, T;Lu, CT;Wang, PC;Wu, TS;Peng, YH;Lin, HY;Chen, CP;Weng, YL;Kung, FC;Wu, MH;Su, YC;Huang, KW;Chou, LH;Hsueh, CC;Yen, KJ;Kuo, PC;Huang, CL;Chen, LT;Shih, C;Tsai, HJ;Jiaang, WT |
| 國家衛生研究院 |
2019-10 |
Discovery of clinical candidate DBPR112, a furanopyrimidine-based epidermal growth factor receptor inhibitor for the treatment of non-small cell lung cancer
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Hsieh, HP;Chang, JY;Yeh, CT;Lin, SY;Ke, YY;Lin, WH;Hsu, TA;Wu, SY;Yeh, TK |
| 國家衛生研究院 |
2019-09-27 |
Discovery of a furanopyrimidine-based epidermal growth factor receptor inhibitor (DBPR112) as a clinical candidate for the treatment of non-small cell lung cancer
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Lin, SY;Chang Hsu, Y;Peng, YH;Ke, YY;Lin, WH;Sun, HY;Shiao, HY;Kuo, FM;Chen, PY;Lien, TW;Chen, CH;Chu, CY;Wang, SY;Yeh, KC;Chen, CP;Hsu, TA;Wu, SY;Yeh, TK;Chen, CT;Hsieh, HP |
| 國家衛生研究院 |
2019-07-11 |
Linker optimization and therapeutic evaluation of phosphatidylserine-targeting zinc dipicolylamine-based drug conjugates
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Liu, YW;Chen, YY;Hsu, CY;Chiu, TY;Liu, KL;Lo, CF;Fang, MY;Huang, YC;Yeh, TK;Pak, KY;Gray, BD;Hsu, TA;Huang, KH;Shih, C;Shia, KS;Chen, CT;Tsou, LK |
| 國家衛生研究院 |
2019-07-03 |
BPR1M97, a dual mu opioid receptor/nociceptin-orphanin FQ peptide receptor agonist, produces potent antinociceptive effects with safer properties than morphine
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Chao, PK;Chang, HF;Chang, WT;Yeh, TK;Ou, LC;Chuang, JY;Tsu-An Hsu, J;Tao, PL;Loh, HH;Shih, C;Ueng, SH;Yeh, SH |
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