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机构 日期 题名 作者
國家衛生研究院 2024-07-17 Discovery of a mu-opioid receptor modulator that in combination with morphinan antagonists induces analgesia Huang, YH;Lin, SY;Ou, LC;Huang, WC;Chao, PK;Chang, YC;Chang, HF;Lee, PT;Yeh, TK;Kuo, YH;Tien, YW;Xi, JH;Tao, PL;Chen, PY;Chuang, JY;Shih, C;Chen, CT;Tung, CW;Loh, HH;Ueng, SH;Yeh, SH
國家衛生研究院 2024-07-04 Development of a humanized antibody targeting extracellular HSP90alpha to suppress endothelial-mesenchymal transition-enhanced tumor growth of pancreatic adenocarcinoma cells Fan, CS;Hung, HC;Chen, CC;Chen, LL;Ke, YY;Yeh, TK;Huang, CT;Chang, TY;Yen, KJ;Chen, CH;Chua, KV;Hsu, JTA;Huang, TS
國家衛生研究院 2024-06-24 Tracing the footprints of MPXV in Asia: Phylogenetic insights and lineage dynamics Chen, YC;Liao, YC;Mao, YC;Yeh, TK;Liu, PY
國家衛生研究院 2024-06-24 Discovery of dual MER/AXL kinase inhibitors as bifunctional small molecules for inhibiting tumor growth and enhancing tumor immune microenvironment Li, MC;Lai, YL;Kuo, PH;Reddy, JS;Chen, CM;Manimala, J;Wang, PC;Wu, MS;Chang, CY;Yang, CM;Lin, CY;Huang, YC;Chiu, CH;Chang, L;Lin, WH;Yeh, TK;Yen, WC;Hsieh, HP
國家衛生研究院 2024-04-09 Discovery of a long half-life AURKA inhibitor to treat MYC-amplified solid tumors as a monotherapy and in combination with everolimus Chang, CP;Yeh, TK;Chen, CT;Wang, WP;Chen, YT;Tsai, CH;Chen, YF;Ke, YY;Wang, JY;Chen, CP;Hsieh, TC;Wu, MH;Huang, CL;Chen, YP;Zhuang, H;Chi, YH
國家衛生研究院 2023-10-05 Discovery of tetrasubstituted thiophenes as Cisd2 activators: A potential novel therapeutic option in nonalcoholic fatty liver disease Yao, CH;Shen, ZQ;Rajan, YC;Huang, YW;Lin, CY;Song, JS;Shiao, HY;Ke, YY;Fan, YS;Tsai, CH;Yeh, TK;Tsai, TF;Lee, JC
國家衛生研究院 2023-10-05 A dual nociceptin and mu opioid receptor agonist exhibited robust antinociceptive effect with decreased side effects Hsu, YT;Chen, SR;Chang, YC;Chang, HF;Yeh, TK;Chuang, JY;Loh, HH;Hsieh, HP;Ueng, SH;Yeh, SH
國家衛生研究院 2023-10 Discovery of novel AXL and MER inhibitors as potential anticancer and immune modulator drugs Hsieh, HP;Li, MC;Yen, WC;Hsu, JTA;Yeh, TK;Li, WS;Wu, HC
國家衛生研究院 2023-02-07 Development of furanopyrimidine-based orally active third- generation EGFR inhibitors for the treatment of non-small cell lung cancer Li, MC;Coumar, MS;Lin, SY;Lin, YS;Huang, GL;Chen, CH;Lien, TW;Wu, YW;Chen, YT;Chen, CP;Huang, YC;Yeh, KC;Yang, CM;Kalita, B;Pan, SL;Hsu, TA;Yeh, TK;Chen, CT;Hsieh, HP
國家衛生研究院 2022-12-05 Benzo[b]thiophene-2-carboxamides as novel opioid receptor agonists with potent analgesic effect and reduced constipation Kuppusamy, R;Hsu, YT;Ke, YY;Chang, PW;Chang, YC;Chang, HF;Wang, PC;Lin, YH;Huang, YC;Yeh, TK;Chuang, JY;Loh, HH;Shih, C;Chen, CT;Yeh, SH;Ueng, SH
國家衛生研究院 2022-12-05 2,6-Difluorobenzamide derivatives as store-operated calcium channel (SOC) inhibitors Wang, YS;Yeh, TK;Chang, WC;Liou, JP;Liu, YM;Huang, WC
國家衛生研究院 2022-10-03 Protective effect of CXCR4 antagonist DBPR807 against ischemia-reperfusion injury in a rat and porcine model of myocardial infarction: Potential adjunctive therapy for percutaneous coronary intervention Yeh, KC;Lee, CJ;Song, JS;Wu, CH;Yeh, TK;Wu, SH;Hsieh, TC;Chen, YT;Tseng, HY;Huang, CL;Chen, CT;Jan, JJ;Chou, MC;Shia, KS;Chiang, KH
國家衛生研究院 2022-09-26 Targeting the phosphatidylserine-immune checkpoint with a small-molecule maytansinoid conjugate Lo, CF;Chiu, TY;Liu, YT;Pan, PY;Liu, KL;Hsu, CY;Fang, MY;Huang, YC;Yeh, TK;Hsu, TA;Chen, CT;Huang, LR;Tsou, LK
國家衛生研究院 2022-07-24 Hesperetin promotes longevity and delays aging via activation of Cisd2 in naturally aged mice Yeh, CH;Shen, ZQ;Wang, TW;Kao, CH;Teng, YC;Yeh, TK;Lu, CK;Tsai, TF
國家衛生研究院 2022-07 Rejuvenating hepatic tumor microenvironment immunity with a phosphatidylserine-targeting small molecule drug conjugate Huang, KH;Liu, YT;Pan, PY;Lo, CF;Liu, KL;Yeh, TK;Huang, LR;Tsou, LK
國家衛生研究院 2022-06-21 Synthesis and evaluation of small molecule drug conjugates harnessing thioester-linked maytansinoids Lo, CF;Chiu, TY;Liu, YT;Huang, LR;Yeh, TK;Huang, KH;Liu, KL;Hsu, CY;Fang, MY;Huang, YC;Hsu, TA;Chen, CT;Tsou, LK
國家衛生研究院 2022-02-15 Click chemistry and multicomponent reaction for linker diversification of zinc dipicolylamine-based drug conjugates Tsai, CH;Chiu, TY;Chen, CT;Hsu, CY;Tsai, YR;Yeh, TK;Huang, KH;Tsou, LK
國家衛生研究院 2022-02-07 Development of furanopyrimidine-based orally active third-generation EGFR inhibitors for the treatment of non-small cell lung cancer Li, MC;Coumar, MS;Lin, SY;Lin, YS;Huang, GL;Chen, CH;Lien, TW;Wu, YW;Chen, YT;Chen, CP;Huang, YC;Yeh, KC;Yang, CM;Kalita, B;Pan, SL;Hsu, TA;Yeh, TK;Chen, CT;Hsieh, HP
國家衛生研究院 2022-02-05 Discovery and development of a novel N-(3-bromophenyl)-{[(phenylcarbamoyl)amino]methyl}-N-hydroxythiophene-2-carboximidamide indoleamine 2,3-dioxygenase inhibitor using knowledge-based drug design Yeh, TK;Song, JS;Chang, PW;Yu, JC;Chang, CH;Liao, FY;Tien, YW;Kuppusamy, R;Li, AS;Chen, CH;Chen, CW;Lin, LM;Chang, HH;Huang, CH;Yao, JY;Wu, MH;Peng, YH;Hsueh, CC;Hsiao, WC;Chen, PH;Lin, CY;Hsieh, SH;Shih, C;Hung, MS;Wu, SY;Kuo, CC;Ueng, SH
國家衛生研究院 2021-10-04 Discovery of BPR1R024, an orally active and selective CSF1R inhibitor that exhibits antitumor and immunomodulatory activity in a murine colon tumor model Lee, KH;Yen, WC;Lin, WH;Wang, PC;Lai, YL;Su, YC;Chang, CY;Wu, CS;Huang, YC;Yang, CM;Chou, LH;Yeh, TK;Chen, CT;Shih, C;Hsieh, HP
國家衛生研究院 2021-08-01 DBPR108, a novel dipeptidyl peptidase-4 inhibitor with antihyperglycemic activity Yeh, KC;Yeh, TK;Huang, CY;Hu, CB;Wang, MH;Huang, YW;Chou, LH;Ho, HH;Song, JS;Hsu, T;Jiaang, WT;Chao, YS;Chen, CT
國家衛生研究院 2021-06-29 Design and synthesis of novel orally selective and type II pan-TRK inhibitors to overcome mutations by property-driven optimization Li, MC;Lin, WH;Wang, PC;Su, YC;Chen, PY;Fan, CM;Chen, CP;Huang, CL;Chiu, CH;Chang, L;Chen, CT;Yeh, TK;Hsieh, HP
國家衛生研究院 2021-05-19 Discovery and synthesis of a pyrimidine-based aurora kinase inhibitor to reduce levels of MYC oncoproteins Chi, YH;Yeh, TK;Ke, YY;Lin, WH;Tsai, CH;Wang, WP;Chen, YT;Su, YC;Wang, PC;Chen, YF;Wu, ZW;Yeh, JY;Hung, MC;Wu, MH;Wang, JY;Chen, CP;Song, JS;Shih, C;Chen, CT;Chang, CP
國家衛生研究院 2021-03-30 A highly selective and potent CXCR4 antagonist for hepatocellular carcinoma treatment Song, JS;Chang, CC;Wu, CH;Dinh, TK;Jan, JJ;Huang, KW;Chou, MC;Shiue, TY;Yeh, KC;Ke, YY;Yeh, TK;Ta, YNN;Lee, CJ;Huang, JK;Sung, YC;Shia, KS;Chen, Y
國家衛生研究院 2021-03-02 Discovery of potential neuroprotective agents against paclitaxel-induced peripheral neuropathy Chen, YF;Wu, CH;Chen, LH;Lee, HW;Lee, JC;Yeh, TK;Chang, JY;Chou, MC;Wu, HL;Lai, YP;Song, JS;Yeh, KC;Chen, CT;Lee, CJ;Shia, KS;Shen, MR

显示项目 1-25 / 159 (共7页)
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