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"hsieh hp"的相关文件
显示项目 31-80 / 265 (共6页)
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| 國家衛生研究院 |
2021-06-29 |
Design and synthesis of novel orally selective and type II pan-TRK inhibitors to overcome mutations by property-driven optimization
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Li, MC;Lin, WH;Wang, PC;Su, YC;Chen, PY;Fan, CM;Chen, CP;Huang, CL;Chiu, CH;Chang, L;Chen, CT;Yeh, TK;Hsieh, HP |
| 國家衛生研究院 |
2021-04-16 |
Development of a robust scale-up synthetic route for BPR1K871: A clinical candidate for the treatment of acute myeloid leukemia and solid tumors
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Reddy, JS;Chen, CM;Coumar, MS;Sun, HY;Sun, N;Hsieh, HP |
| 國家衛生研究院 |
2021-04-13 |
Chlorinated briarane diterpenoids from octocoral Briareum stechei (Kükenthal, 1908)
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Huynh, TH;Lee, GH;Tanaka, J;Hsieh, HP;Kelvin Tsou, L;Zhang, MM;Kuo, TJ;Wen, ZH;Lu, CK;Sung, PJ |
| 國家衛生研究院 |
2021-02-22 |
Mimicking H3 substrate arginine in the design of G9a lysine methyltransferase inhibitors for cancer therapy: A computational study for structure-based drug design
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Chandar Charles, MR;Li, MC;Hsieh, HP;Coumar, MS |
| 國家衛生研究院 |
2021-01-31 |
Briarenols W-Z: Chlorine-containing polyoxygenated briaranes from octocoral briareum stechei (Kükenthal, 1908)
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Chen, YY;Zhang, YL;Lee, GH;Tsou, LK;Zhang, MM;Hsieh, HP;Chen, JJ;Ko, CY;Wen, ZH;Sung, PJ |
| 國家衛生研究院 |
2021-01-15 |
One-pot synthesis of dibenzo[b,f]oxepines and total synthesis of bauhinoxepin C
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Taweesak, P;Thongaram, P;Kraikruan, P;Thanetchaiyakup, A;Chuanopparat, N;Hsieh, HP;Uang, BJ;Ngernmeesri, P |
| 中山醫學大學 |
2021 |
Chlorinated briarane diterpenoids from octocoral Briareum stechei (Kukenthal, 1908)
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Huynh, TH; Lee, GH; Tanaka, J; Hsieh, HP; Tsou, LK; Zhang, MZM; Kuo, TJ; Wen, ZH; Lu, CK; Sung, PJ |
| 國家衛生研究院 |
2020-12-10 |
Tumor-agnostic inhibitors in oncology: A new phase for precision medicine
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Li, MC;Hsieh, HP |
| 國家衛生研究院 |
2020-07-07 |
Overcoming vincristine resistance in cancer: Computational design and discovery of piperine-inspired P-glycoprotein inhibitors
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Syed, SB;Lin, SY;Arya, H;Fu, IH;Yeh, TK;Charles, MRC;Periyasamy, L;Hsieh, HP;Coumar, MS |
| 國家衛生研究院 |
2020-05 |
Drug-like property optimization: Discovery of orally bioavailable quinazoline-based multi-targeted kinase inhibitors
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Lin, SY;Chang, CF;Coumar, MS;Chen, PY;Kuo, FM;Chen, CH;Li, MC;Lin, WH;Kuo, PC;Wang, SY;Li, AS;Lin, CY;Yang, CM;Yeh, TK;Song, JS;Hsu, JTA;Hsieh, HP |
| 國家衛生研究院 |
2020-03-01 |
A selective Aurora-A 5'-UTR siRNA inhibits tumor growth and metastasis
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Lai, CH;Chen, RY;Hsieh, HP;Tsai, SJ;Chang, KC;Yen, CJ;Huang, YC;Liu, YW;Lee, JC;Lai, YC;Hung, LY;Lin, BW |
| 國家衛生研究院 |
2020-01 |
Identification of novel quinoline inhibitor for EHMT2/G9a through virtual screening
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Chandar Charles, MR;Mahesh, A;Lin, SY;Hsieh, HP;Dhayalan, A;Coumar, MS |
| 國家衛生研究院 |
2019-10-08 |
Identification of two novel small compounds that inhibit liver cancer formation in zebrafish and analysis of their conjugation to nanodiamonds to further reduce toxicity
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Tseng, PH;Sie, ZL;Liu, MC;Lin, HS;Yang, WY;Lin, TY;Hsieh, HP;Hung, SC;Cheng, CL;Wang, HD;Chang, HH;Yuh, CH |
| 國家衛生研究院 |
2019-10 |
The molecular mechanisms of EpCAM in regulating tumor progression and development of anti-EpCAM antibodies for colon cancer diagnosis and therapy
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Wu, HC;Liang, KH;Hsieh, HP;Li, WS |
| 國家衛生研究院 |
2019-10 |
Discovery of clinical candidate DBPR112, a furanopyrimidine-based epidermal growth factor receptor inhibitor for the treatment of non-small cell lung cancer
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Hsieh, HP;Chang, JY;Yeh, CT;Lin, SY;Ke, YY;Lin, WH;Hsu, TA;Wu, SY;Yeh, TK |
| 國家衛生研究院 |
2019-09-28 |
Design of drug-like hepsin inhibitors against prostate cancer and kidney stones
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Blay, V;Li, MC;Ho, SP;Stoller, ML;Hsieh, HP;Houston, DR |
| 國家衛生研究院 |
2019-09-27 |
Discovery of a furanopyrimidine-based epidermal growth factor receptor inhibitor (DBPR112) as a clinical candidate for the treatment of non-small cell lung cancer
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Lin, SY;Chang Hsu, Y;Peng, YH;Ke, YY;Lin, WH;Sun, HY;Shiao, HY;Kuo, FM;Chen, PY;Lien, TW;Chen, CH;Chu, CY;Wang, SY;Yeh, KC;Chen, CP;Hsu, TA;Wu, SY;Yeh, TK;Chen, CT;Hsieh, HP |
| 國家衛生研究院 |
2019-09 |
Design of a potent anticancer lead inspired by natural products from traditional Indian medicine
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Arya, H;Yadav, CS;Lin, SY;Syed, SB;Charles, MRC;Kannadasan, S;Hsieh, HP;Singh, SS;Gajurel, PR;Coumar, MS |
| 國家衛生研究院 |
2019-07-21 |
Lysosomal cysteine protease cathepsin S is involved in cancer cell motility by regulating store-operated Ca(2+) entry
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Lin, HH;Chen, SJ;Shen, MR;Huang, YT;Hsieh, HP;Lin, SY;Lin, CC;Chang, WW;Chang, JY |
| 國家衛生研究院 |
2019-07 |
Dual Kit/Aur inhibitors as chemosensitizing agents for the treatment of melanoma: Design, synthesis, docking studies and functional investigation
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Quattrini, L;Coviello, V;Sartini, S;Di Desidero, T;Orlandi, P;Ke, YY;Liu, KL;Hsieh, HP;Bocci, G;La Motta, C |
| 國家衛生研究院 |
2019-05-29 |
Insights for the design of protein lysine methyltransferase G9a inhibitors
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Charles, MRC;Dhayalan, A;Hsieh, HP;Coumar, MS |
| 國家衛生研究院 |
2018-11 |
Biomimetic Syntheses of (±)‐Isopalhinine A, (±)‐Palhinine A, and (±)‐Palhinine D
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Chen, CM;Shiao, HY;Uang, BJ;Hsieh, HP |
| 國家衛生研究院 |
2018-07-26 |
Delineating the active site architecture of G9a lysine methyltransferase through substrate and inhibitor binding mode analysis: A molecular dynamics study
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M, RCC;Hsieh, HP;Coumar, MS |
| 國家衛生研究院 |
2018-07 |
Clinical candidate DBPR112: A novel epidermal growth factor receptor inhibitor as a promising treatment for non-small cell lung cancer
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Hsieh, HP;Chang, JY;Kuo, CC;Hsu, J |
| 國家衛生研究院 |
2018-07 |
Blockage of EGFR signaling repurposes tumor metabolism through suppression of glycolysis and Kreb cycle in head and neck cancer
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Kuo, CC;Chang, JY;Hsieh, HP;Kung, HJ;Chang, HH;Huang, CH;Kuo, CC;Ke, YY |
| 國家衛生研究院 |
2018-05-10 |
Design and synthesis of BPR1K653 derivatives targeting the back pocket of Aurora kinases for selective isoform inhibition
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Ke, YY;Chang, CP;Lin, WH;Tsai, CH;Chiu, IC;Wang, WP;Wang, PC;Chen, PY;Lin, WH;Chang, CF;Kuo, PC;Song, JS;Shih, C;Hsieh, HP;Chi, YH |
| 國家衛生研究院 |
2018-01 |
Discovery and development of DBPR112 as a clinical candidate: A novel EGFR inhibitor for non-small cell lung cancer
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Hsieh, HP;Hsu, JTA;Yeh, TK;Chen, CT |
| 國家衛生研究院 |
2017-08-11 |
Targeting P-glycoprotein: Investigation of piperine analogs for overcoming drug resistance in cancer
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Syed, SB;Arya, H;Fu, IH;Yeh, TK;Periyasamy, L;Hsieh, HP;Coumar, MS |
| 國家衛生研究院 |
2017-07 |
Drug repurposing for chronic myeloid leukemia: In silico and in vitro investigation of DrugBank database for allosteric Bcr-Abl inhibitors
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Singh, VK;Chang, HH;Kuo, CC;Shiao, HY;Hsieh, HP;Coumar, MS |
| 國家衛生研究院 |
2017-04 |
Toward the total syntheses of natural products containing trans-decalin skeleton from masked o-benzoquinone
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Li, MC;Shiao, HY;Hsieh, HP |
| 國家衛生研究院 |
2017-04 |
Discovery of BPR1K871-a quinazoline based multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, in vitro and in vivo evaluation
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Hsieh, HP;Wang, WC;Shiao, HY;Ke, YY;Lin, WH;Hsu, JTA;Chen, CT;Yeh, TK |
| 國家衛生研究院 |
2017-04 |
One-pot tandem oxidative dearomatization/ 4+3 cycloaddition: Masked o-benzoquinone with diaza-oxyallyl cation
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Lee, KH;Hsieh, HP |
| 國家衛生研究院 |
2017-01-13 |
Fused bicyclic pyrimidine compounds as aurora kinase inhibitors
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Hsieh, HP;Coumar, MS;Hsu, TA;Wu, SY;Chao, YS |
| 國家衛生研究院 |
2016-12 |
Discovery of BPR1K871, a quinazoline based, multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, in vitro and in vivo evaluation
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Chang Hsu, Y;Selvaraj Coumar, M;Wang, WC;Shiao, HY;Ke, YY;Lin, WH;Kuo, CC;Chang, CW;Kuo, FM;Chen, PY;Wang, SY;Li, AS;Chen, CH;Kuo, PC;Chen, CP;Wu, MH;Huang, CL;Yen, KJ;Chang, YI;Hsu, JT;Chen, CT;Yeh, TK;Song, JS;Shih, C;Hsieh, HP |
| 國家衛生研究院 |
2016-11-29 |
Discovery of novel inhibitors of Aurora kinases with indazole scaffold: In silico fragment-based and knowledge-based drug design
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Chang, CF;Lin, WH;Ke, YY;Lin, YS;Wang, WC;Chen, CH;Kuo, PC;Hsu, JTA;Uang, BJ;Hsieh, HP |
| 國家衛生研究院 |
2016-11-23 |
Fused bicyclic pyrimidine compounds as aurora kinase inhibitors
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Hsieh, HP;Coumar, MS;Hsu, TA;Wu, SY;Chao, YS |
| 國家衛生研究院 |
2016-07 |
Therapeutic polymeric nanoparticles and the methods of making and using thereof: A patent evaluation of WO2015036792
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Sarvagalla, S;Hsieh, HP;Coumar, MS |
| 國家衛生研究院 |
2016-06-07 |
Fused bicyclic pyrimidine compounds as aurora kinase inhibitors
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Hsieh, HP;Coumar, MS;Hsu, TA;Wu, SY;Chao, YS |
| 國家衛生研究院 |
2016-03 |
Disruption of protein-protein interactions: Hot spot detection, structure-based virtual screening and in vitro testing for the anti-cancer drug target survivin
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Sarvagalla, S;Cheung, CHA;Tsai, JY;Hsieh, HP;Coumar, MS |
| 國家衛生研究院 |
2015-08-20 |
Fused bicyclic pyrimidine compounds as Aurora kinase inhibitors
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Coumar, MS;Chao, YS;Hsu, TA;Wu, SY;Hsieh, HP |
| 國家衛生研究院 |
2015-08 |
BPR2P001S0, a Coumarin derivative, induced cell cycle arrest in A549 through inhibiting PDPK1 activity
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Lin, PH;Jao, TM;Hung, YL;Hsieh, HP;Yang, YC;Chang, SY |
| 國家衛生研究院 |
2015-08 |
Optimization of quinazoline-based kinase inhibitors: Identification of a dual FLT3/AURKA kinase inhibitor for the treatment of acute myeloid leukemia
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Hsieh, HP;Hsu, YC;Ke, YY;Shiao, HY;Chang, CW;Lin, WH;Hsu, TA;Yeh, TK;Chen, CT |
| 國家衛生研究院 |
2015-08 |
Optimization of furanopyrimidine-based kinase inhibitors: Identification of a BTK kinase inhibitor for the treatment of B cell lymphoma
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Wang, WC;Hsu, YC;Shiao, HY;Hung, HC;Kuo, CC;Lee, JC;Hsu, TA;Hsieh, HP |
| 國家衛生研究院 |
2015-08 |
Discovery of 2,4-diaminopyrimidines bearing a unique pharmacophore as anaplastic lymphoma kinase inhibitors
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Shiao, HY;Wang, WC;Hsu, YC;Ke, YY;Hsu, TA;Hsieh, HP |
| 國家衛生研究院 |
2015-07-31 |
作為極光激酶抑制劑的稠合雙環嘧啶化合物
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Hsieh, HP;Coumar, MS;Wu, SY;Hsu, TA;Chao, YS |
| 國家衛生研究院 |
2015-07-22 |
作为酪胺酸激酶抑制剂的稠合双环及多环嘧啶化合物
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Hsieh, HP;Coumar, MS;Hsu, TA;Lin, WH;Chen, YR;Chao, YS |
| 國家衛生研究院 |
2015-06-29 |
Homology modeling of DFG-in FMS-like tyrosine kinase 3 (FLT3) and structure-based virtual screening for inhibitor identification
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Ke, YY;Singh, VK;Coumar, MS;Hsu, YC;Wang, WC;Song, JS;Chen, CH;Lin, WH;Wu, SH;Hsu, JT;Shih, C;Hsieh, HP |
| 國家衛生研究院 |
2015-04-14 |
Fused multicyclic compounds as protein kinase inhibitors
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Hsieh, HP;Coumar, MS;Chao, YS |
| 國家衛生研究院 |
2015-02 |
Function-oriented development of CXCR4 antagonists as selective human immunodeficiency virus (HIV)-1 entry inhibitors
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Wu, CH;Wang, CJ;Chang, CP;Cheng, YC;Song, JS;Jan, JJ;Chou, MC;Ke, YY;Ma, J;Wong, YC;Hsieh, TC;Tien, YC;Gullen, EA;Lo, CF;Cheng, CY;Liu, YW;Sadani, AA;Tsai, CH;Hsieh, HP;Tsou, LK;Shia, KS |
| 國家衛生研究院 |
2015-01 |
Identification of ligand efficient, fragment-like hits from an HTS library: Structure-based virtual screening and docking investigations of 2H- and 3H-pyrazolo tautomers for Aurora kinase A selectivity
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Sarvagalla, S;Singh, VK;Ke, YY;Shiao, HY;Lin, WH;Hsieh, HP;Hsu, JTA;Coumar, MS |
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